LOCUS       NM_031185               6262 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus A kinase anchor protein 12 (Akap12), mRNA.
ACCESSION   NM_031185 XM_987919
VERSION     NM_031185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6262)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   2  (bases 1 to 6262)
  AUTHORS   Qasim,H., Rajaei,M., Xu,Y., Reyes-Alcaraz,A., Abdelnasser,H.Y.,
            Stewart,M.D., Lahiri,S.K., Wehrens,X.H.T. and McConnell,B.K.
  TITLE     AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac
            Dysfunction
  JOURNAL   Circ Res 134 (8), 1006-1022 (2024)
   PUBMED   38506047
  REMARK    GeneRIF: AKAP12 Upregulation Associates With PDE8A to Accelerate
            Cardiac Dysfunction.
REFERENCE   3  (bases 1 to 6262)
  AUTHORS   Miller,K.A., Degan,S., Wang,Y., Cohen,J., Ku,S.Y., Goodrich,D.W.
            and Gelman,I.H.
  TITLE     PTEN-regulated PI3K-p110 and AKT isoform plasticity controls
            metastatic prostate cancer progression
  JOURNAL   Oncogene 43 (1), 22-34 (2024)
   PUBMED   37875657
  REMARK    Erratum:[Oncogene. 2024 Jan;43(1):76. doi:
            10.1038/s41388-023-02920-2.. PMID: 38097735]
REFERENCE   4  (bases 1 to 6262)
  AUTHORS   Ni,Y., Cao,J., Yuan,J. and Ning,X.
  TITLE     Loss of AKAP12 aggravates rheumatoid arthritis-like symptoms and
            cardiac damage in collagen-induced arthritis mice
  JOURNAL   Exp Anim 72 (2), 242-252 (2023)
   PUBMED   36464273
  REMARK    GeneRIF: Loss of AKAP12 aggravates rheumatoid arthritis-like
            symptoms and cardiac damage in collagen-induced arthritis mice.
REFERENCE   5  (bases 1 to 6262)
  AUTHORS   Ramani,K., Mavila,N., Abeynayake,A., Tomasi,M.L., Wang,J.,
            Matsuda,M. and Seki,E.
  TITLE     Targeting A-kinase anchoring protein 12 phosphorylation in hepatic
            stellate cells regulates liver injury and fibrosis in mouse models
  JOURNAL   Elife 11, e78430 (2022)
   PUBMED   36193675
  REMARK    GeneRIF: Targeting A-kinase anchoring protein 12 phosphorylation in
            hepatic stellate cells regulates liver injury and fibrosis in mouse
            models.
            Erratum:[Elife. 2023 Apr 18;12:e88586. doi: 10.7554/eLife.88586..
            PMID: 37071069]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6262)
  AUTHORS   Klingbeil,P., Frazzetto,G. and Bouwmeester,T.
  TITLE     Xgravin-like (Xgl), a novel putative a-kinase anchoring protein
            (AKAP) expressed during embryonic development in Xenopus
  JOURNAL   Mech Dev 100 (2), 323-326 (2001)
   PUBMED   11165490
REFERENCE   7  (bases 1 to 6262)
  AUTHORS   Gelman,I.H., Tombler,E. and Vargas,J. Jr.
  TITLE     A role for SSeCKS, a major protein kinase C substrate with tumour
            suppressor activity, in cytoskeletal architecture, formation of
            migratory processes, and cell migration during embryogenesis
  JOURNAL   Histochem J 32 (1), 13-26 (2000)
   PUBMED   10805381
REFERENCE   8  (bases 1 to 6262)
  AUTHORS   Taketo,M.M., Araki,Y., Matsunaga,A., Yokoi,A., Tsuchida,J.,
            Nishina,Y., Nozaki,M., Tanaka,H., Koga,M., Uchida,K., Matsumiya,K.,
            Okuyama,A., Rochelle,J.M., Nishimune,Y., Matsui,M. and Seldin,M.F.
  TITLE     Mapping of eight testis-specific genes to mouse chromosomes
  JOURNAL   Genomics 46 (1), 138-142 (1997)
   PUBMED   9403069
REFERENCE   9  (bases 1 to 6262)
  AUTHORS   Camus,A., Kress,C., Babinet,C. and Barra,J.
  TITLE     Unexpected behavior of a gene trap vector comprising a fusion
            between the Sh ble and the lacZ genes
  JOURNAL   Mol Reprod Dev 45 (3), 255-263 (1996)
   PUBMED   8916035
REFERENCE   10 (bases 1 to 6262)
  AUTHORS   Frankfort,B.J. and Gelman,I.H.
  TITLE     Identification of novel cellular genes transcriptionally suppressed
            by v-src
  JOURNAL   Biochem Biophys Res Commun 206 (3), 916-926 (1995)
   PUBMED   7832805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD540754.1, AB051563.1 and AI836130.1.
            
            On Apr 7, 2009 this sequence version replaced NM_031185.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF326228.1, AB025278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               CD540754.1         1-340
            341-6059            AB051563.1         292-6010
            6060-6262           AI836130.1         1-203               c
FEATURES             Location/Qualifiers
     source          1..6262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.06 cM"
     gene            1..6262
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /note="A kinase anchor protein 12"
                     /db_xref="GeneID:83397"
                     /db_xref="MGI:MGI:1932576"
     exon            1..340
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..5245
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /note="gercelin; AKAP-12; src-suppressed C kinase
                     substrate; germ cell lineage protein gercelin; v-src
                     suppressed transcript 5; testis specific gene A12; A
                     kinase (PRKA) anchor protein (gravin) 12"
                     /codon_start=1
                     /product="A-kinase anchor protein 12"
                     /protein_id="NP_112462.1"
                     /db_xref="CCDS:CCDS56673.1"
                     /db_xref="GeneID:83397"
                     /db_xref="MGI:MGI:1932576"
                     /translation="MGAGSSTEQRSPEQPAESDTPSELELSGHGPAAEASGAAGDPAD
                     ADPATKLPQKNGQLSAVNGVAEQEDVHVQEESQDGQEEEVTVEDVGQRESEDVKEKDR
                     AKEMAASSTVVEDITKDEQEETPEIIEQIPASESNVEEMAQAAESQANDVGFKKVFKF
                     VGFKFTVKKDKNEKSDTVQLLTVKKDEGEGAEASVGAGDHQEPGVETVGESASKESEL
                     KQSTEKQEGTLKQAQSSTEIPLQAESGQGTEEEAAKDGEENREKEPTKPLESPTSPVS
                     NETTSSFKKFFTHGWAGWRKKTSFKKPKEDDLETSEKRKEQEAEKVDEEEGEKTEPAP
                     AEEQEPAEGTDQARLSADYEKVELPLEDQVGDLEALSEKCAPLATEVFDEKTEAHQEV
                     VAEVHVSTVEKMTKGQGGAEVEGDVVVEGSGESLPPEKLAETQEVPQEAEPVEELMKT
                     KEVCVSGGDHTQLTDLSPEEKMLPKHPEGIVSEVEMLSSQERIKVQGSPLKKLFSSSG
                     LKKLSGKKQKGKRGGGGGDEEPGEYQHIQTESPESADEQKGESSASSPEEPEEIACLE
                     KGPSEAPQEAEAEEGATSDGEKKREGITPWASFKKMVTPKKRVRRPSESDKEEELDKV
                     KSATLSSTESTASGMQDEVRAVGEEQRSEEPKRRVDTSVSWEALICVGSSKKRARKAS
                     SSDDEGGPRTLGGDGHRAEEASKDKEADALPASTQEQDQAHGSSSPEPAGSPSEGEGV
                     STWESFKRLVTPRKKSKSKLEERAEDSGAEQLASEIEPSREESWVSIKKFIPGRRKKR
                     ADGKQEQAAVEDSGPGEINEDDPDVPAVVPLSEYDAVEREKLEAQRAQENVELPQLKG
                     AVYVSEELSKTLVHTVSVAVIDGTRAVTSAEERSPSWISASMTEPLEHAEGVATPPVG
                     EVTEKDITAEATPALAQTLPGGKDAHDDIVTSEVDFTSEAVTAAETTEALRAEELTEA
                     SGAEETTDMVSAVSQLSDSPDTTEEATPVQEVEGGMLDTEEQERQTQAVLQAVADKVK
                     EDSQVPATQTLQRAGPKALEKVEEVEEDSEVLATEKEKDVVPEGPVQEAETEHLAQGS
                     ETVQATPESLEVPEVTEDVDRATTCQVIKHQQLMEQAVAPESSETLTDSETNGSTPLA
                     DSDTPNGTQQDETVDSQDSNAIAAVKQSQVTEEEAAAAQTEGPSTPSSFPAQEEHREK
                     PGRDVLEPTQALAAGAVPILAKAEVGQEGEAGQFDGEKVKDGQCVKELEVPVHTGPNS
                     QKTADLTRDSEVMEVARCQETESNEEQSISPEKREMGTDVEKEETETKTEQASEEHEQ
                     ETAAPEHEGTHPKPVLTADMPHSERGKALGSLEGSPSLPDQDKADCIEVQVQSSDTPV
                     TQTTEAVKKVEETVATSEMDESLECAGAQSLPAEKLSETGGYGTLQHGEDTVPQGPES
                     QAESIPIIVTPAPESILHSDLQREVSASQKQRSDEDNKPDAGPDAAGKESAAREKILR
                     AEPEILELESKSNKIVQSVIQTAVDQFARTETAPETHASDLQNQVPVMQADSQGAQQM
                     LDKDESDLQVSPQDGTLSAVAQEGLAVSDSSEGMSKASEMITTLAVESASVKESVEKL
                     PLQCKDEKEHAADGPQHQSLAKAEADASGNLTKESPDTNGPKLTEEGDALKEEMNKAQ
                     TEEDDLQEPKGDLTES"
     exon            341..455
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /inference="alignment:Splign:2.1.0"
     exon            456..5253
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /inference="alignment:Splign:2.1.0"
     exon            5254..6247
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6223..6228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /note="hexamer: AATAAA"
     polyA_site      6245
                     /gene="Akap12"
                     /gene_synonym="Srcs5; SSeCKS; Tsga12"
                     /note="major polyA site"
ORIGIN      
        1 cttttaagga gtttgccacg agcgcgtccc cttcattctc agtccgggtg tgttctcagc
       61 aggatcgtgg agagcgggtg ctcctcaccc cttagtccct gtggtcctgg gcgcacatct
      121 cctcgcccct ctgcttctcc gcggtcccag gaagacggct agccggcgag agtaggaaag
      181 ccactgagcc atgggtgcag gcagttccac cgagcagcgg agccccgagc agccggcgga
      241 gagcgacacg ccgagcgagc tggagctcag tggccatggg cccgcagcgg aagcgtcggg
      301 agcagctgga gatcccgctg acgcggaccc cgccaccaag ctcccacaga agaatggtca
      361 gctgtctgcc gtcaatggtg tagctgaaca agaagatgtc cacgtccaag aggaaagcca
      421 ggatgggcaa gaggaagaag tcactgttga agatgttgga cagagagagt cagaagatgt
      481 gaaagaaaaa gaccgagcta aagaaatggc agccagttcc acagttgttg aagatatcac
      541 aaaggacgag caggaggaaa caccggaaat aatcgaacag atccctgctt cagagagcaa
      601 tgtggaagaa atggcgcagg ctgctgagtc ccaagctaat gacgtcggct tcaagaaggt
      661 atttaaattt gttggtttta aattcacggt gaagaaggat aaaaacgaaa agtcagatac
      721 cgtccagcta ctcactgtca agaaggatga aggcgaaggg gcagaagcct ccgtcggagc
      781 aggagaccac caagagcccg gagtggagac cgtcggcgaa tcagcatcca aagaaagtga
      841 gctgaagcaa tccacagaga agcaagaagg caccctgaag caagcacaga gcagcacaga
      901 aattcccctt caagccgaat ctggtcaagg gaccgaggaa gaagcagcca aagatggaga
      961 agaaaaccga gagaaagaac ctaccaagcc cctagaatct ccgaccagcc ctgtcagcaa
     1021 tgagacaaca tcttccttca agaaattctt cactcacggc tgggccggct ggcgcaagaa
     1081 gaccagcttc aagaaaccaa aggaagatga tctggaaact tccgagaaga gaaaggagca
     1141 agaggctgaa aaagtagacg aggaagaagg ggaaaagaca gagccagccc cagccgagga
     1201 gcaggagcct gcagaaggca cagaccaggc caggttgtca gccgactatg agaaggtgga
     1261 gttgcctttg gaagaccagg tcggtgacct ggaggcattg tcggagaagt gtgctccttt
     1321 ggcaacggaa gtgtttgatg agaagacgga agcccaccaa gaagttgttg cagaggtcca
     1381 cgtgagcacc gtggagaaga tgacgaaagg gcaaggagga gcagaggtgg aaggggatgt
     1441 ggtggtggaa ggatcgggag aatccttgcc ccctgagaaa ctggctgaga cccaggaggt
     1501 cccccaggaa gctgagcctg tggaggagct gatgaagacc aaagaagtat gcgtctctgg
     1561 gggtgaccat actcagctga cagatctaag tcctgaagag aagatgctac ccaaacaccc
     1621 cgaaggcatt gtcagtgagg tggagatgct gtcctctcag gagagaatca aggtacaggg
     1681 aagtcccctg aagaagctct tcagcagttc gggcttaaag aagctctccg ggaagaagca
     1741 gaaggggaag agaggaggag gcgggggaga tgaagagcca ggagaatacc aacacattca
     1801 aaccgagtcc ccagagagtg ctgacgagca gaagggagag agctctgcct cttcccctga
     1861 agagcccgag gagatcgcgt gtctggagaa ggggccatcg gaagcacccc aggaagcgga
     1921 agctgaggaa ggagcgactt ccgacggaga gaagaaaagg gaagggatca ccccctgggc
     1981 atccttcaaa aagatggtga cacccaagaa acgggtccga agaccttctg agagcgacaa
     2041 ggaagaagag ctggataagg tcaagagtgc caccttgtcc tccacggaga gcacggcgtc
     2101 tggaatgcag gatgaggtca gagcggttgg cgaggagcaa aggtcagagg agccaaagcg
     2161 cagggtggat acttcagtgt cttgggaggc gttgatttgt gtcggatcgt ccaagaagag
     2221 agcgaggaag gcatcctctt cagatgatga aggagggcca agaacactgg gaggggatgg
     2281 ccacagagcg gaggaggcta gcaaagacaa agaagcagat gctcttcctg ccagcaccca
     2341 ggaacaagac caagcgcacg gaagttcctc acccgagcca gctggaagcc cttctgaagg
     2401 ggagggcgtc tccacctggg agtcatttaa gagattagtc actccacgaa aaaaatccaa
     2461 gtcaaaactg gaagagagag ccgaagactc cggtgcagag cagttggcct ccgagatcga
     2521 accaagtaga gaggaatctt gggtttccat taagaaattt attcctggac ggcggaagaa
     2581 aagggcagat gggaagcaag aacaggccgc cgttgaagac tcggggccag gagagatcaa
     2641 tgaggacgac cccgacgtcc cagctgttgt gcctctgtct gagtacgatg cggtagagag
     2701 agagaagctg gaagcgcagc gagctcagga gaacgtggag ctgccccagc tgaagggggc
     2761 tgtgtatgtg tctgaggagc ttagtaagac tctggttcac accgtgagtg tcgcggtcat
     2821 tgatgggacc agggcagtca ccagtgccga agagcggtcc ccttcgtgga tatctgcttc
     2881 catgacagaa cctcttgagc acgcagaggg agtggccaca ccgcctgttg gagaggtcac
     2941 tgaaaaagac atcactgcag aagcaactcc tgcactcgcc cagactttac cagggggcaa
     3001 agatgcccat gacgacatag tcaccagtga agtggatttt acctcagaag cagtgacagc
     3061 cgcagaaacc acagaggcgc tccgcgctga agaacttacc gaagcatcag gggcagaaga
     3121 gaccacagac atggtgtctg cagtttccca gctgtccgac tccccggaca ccacagagga
     3181 agccacccca gttcaggagg tagagggtgg catgctagat acggaagaac aggagcgcca
     3241 gacgcaggcc gtcctccaag ccgttgcaga caaagtgaaa gaggactccc aggtgcctgc
     3301 aacccagact ctgcagagag cagggccgaa agcactggag aaggtggagg aggtagagga
     3361 ggactccgag gtgctggcta ccgagaaaga gaaggatgtt gtgccggaag gacccgtgca
     3421 ggaagctgaa actgagcatc ttgcacaggg ctccgagact gtacaggcta ccccagagag
     3481 ccttgaagtt cctgaagtca cagaggatgt agaccgtgcc accacatgcc aggttatcaa
     3541 gcaccagcag ctgatggaac aggctgtggc ccctgagtca tctgaaacct tgacagacag
     3601 tgagacaaat ggaagtactc ccctcgcaga ttcagacact ccaaacggga cacagcaaga
     3661 cgagaccgtt gacagccagg acagtaatgc cattgccgcc gtcaagcagt cacaggtcac
     3721 tgaagaggag gcagctgctg ctcagacgga ggggccttca acaccatcta gttttccagc
     3781 ccaggaagaa cacagggaaa aaccaggaag ggatgttcta gaacccacac aagcgctggc
     3841 tgccggggca gtgcctattc tggcaaaggc tgaggtgggt caagagggtg aggctggcca
     3901 gtttgatgga gaaaaagtca aagacggaca gtgtgttaaa gaactggagg tgcctgtgca
     3961 cactggaccc aacagtcaaa agactgctga cttgacacgt gacagtgaag taatggaagt
     4021 ggccagatgt caggaaactg agagtaatga agaacagagt attagcccgg agaaaagaga
     4081 gatgggaacc gacgttgaaa aggaggaaac agagaccaag acagagcaag ccagtgaaga
     4141 acatgagcag gaaacagctg ctcctgagca tgaaggaacc caccctaagc cagtcctgac
     4201 agctgacatg cctcactcag agaggggaaa ggcactgggc agccttgaag gaagcccttc
     4261 tctcccagac caagacaaag cagattgcat agaggttcaa gttcaaagct cagacacacc
     4321 agtcactcaa acaaccgaag ctgtgaaaaa ggtcgaagaa actgtggcaa cttcagagat
     4381 ggatgaaagt ttggagtgtg caggtgcgca atcattacca gctgagaagc tctccgaaac
     4441 cggtggctac gggactcttc agcatggaga ggacaccgtg ccccaggggc ctgagtctca
     4501 ggcagagtcc atcccaataa tagtaactcc tgctcctgaa agcatcctac attctgacct
     4561 tcaaagagaa gtgagcgcat cccagaaaca gagatcagat gaagataaca agccagatgc
     4621 tggtcctgat gctgccggca aggagagtgc agcaagagag aaaatcctca gggctgaacc
     4681 tgagatcttg gaacttgaga gtaagagcaa taagattgtc cagagtgtca tccagacagc
     4741 cgtcgaccag tttgcacgta cagaaacagc ccccgaaacc cacgcttctg atttacagaa
     4801 tcaggttcct gtgatgcagg ctgacagcca gggagcacaa cagatgctgg acaaagatga
     4861 aagcgacctt caagtctccc cccaagatgg aacactcagt gccgtagccc aggaaggact
     4921 tgcggtttct gatagttctg aaggcatgag caaggcttca gaaatgatca ccacgcttgc
     4981 agttgaaagt gccagtgtca aagaaagtgt tgagaagctg cctcttcagt gcaaagatga
     5041 aaaggaacat gctgctgacg gcccccagca ccaaagctta gccaaggcag aggcggatgc
     5101 ctctggaaat ctaaccaaag agtccccaga caccaacgga ccaaagctaa ccgaggaagg
     5161 agatgccctg aaagaagaaa tgaacaaggc ccagacagaa gaggacgacc tacaggagcc
     5221 aaagggagac ctgacagaat cctaagacgt gagttgctca ttgtaaaact agaatgtgaa
     5281 gtgaagtcac ggaacaagat gctgctgttg ggaccttgag accaaaattt cagagccctt
     5341 gaggtgcaga gagcagagcc gtccaatgat ttcaaccctg cagagcaccc cgacaatcct
     5401 gaggctgcat cgggagctag agccagctaa catttcctct tttcaagact gcccttgatt
     5461 tgccccttgg tgccatgtat ttcagagtta aggtcctgct ttctccacct ggaaccaatg
     5521 tcggcaatac ctagtcccac ttctcaaact ggagcctcct cctttatgta tttatatgta
     5581 tgttttatgt agtcctcctc ctgtacctat tgtatatttt ttttctaagg tttaagcaca
     5641 tgccttttgt attatgcagt atataatggg tgtgcagcca tagcgaagct ttgagaagcc
     5701 ccaagcctca actgtaacct gcagcaaaca gagaaataac attcctggca ggaagataca
     5761 agtcttttta aagtttactg atgcttaact ctgtgggctc gtagtcctct gaaagtggtt
     5821 gttttcctat gcacagtgag ctcagaaata aaaactccat tttgagacat tcagaatgtc
     5881 ccaacattac gacaacattt tttttttttt tttctaatcc agtccaggtt ggaaagaagt
     5941 ctccttagtg tcagattaag ccccatctct taacaatatg gacagatgag tgtgccatgg
     6001 ccatgagcta tttcctaacg cagaaggaat ttgttgttac tttttggatt gtactcttct
     6061 aggctggacc gaattcatat gcagattgaa gtgagacctg ctctttacag atggtatttt
     6121 gatagatact ggagtttgtc tgtattatat ctgtgcccct tcttttaaga acaatgttac
     6181 attatgttcc tttggataaa ttgtgatttg acaactgatt tcaataaaaa tatttgcttc
     6241 acttataaaa aaaaaaaaaa aa
//
