LOCUS       NM_001164503            9416 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus A kinase anchor protein 11 (Akap11), transcript
            variant 1, mRNA.
ACCESSION   NM_001164503 XM_001002157 XM_915278
VERSION     NM_001164503.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9416)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9416)
  AUTHORS   Aryal,S., Bonanno,K., Song,B., Mani,D.R., Keshishian,H., Carr,S.A.,
            Sheng,M. and Dejanovic,B.
  TITLE     Deep proteomics identifies shared molecular pathway alterations in
            synapses of patients with schizophrenia and bipolar disorder and
            mouse model
  JOURNAL   Cell Rep 42 (5), 112497 (2023)
   PUBMED   37171958
REFERENCE   3  (bases 1 to 9416)
  AUTHORS   Herzog,L.E., Wang,L., Yu,E., Choi,S., Farsi,Z., Song,B.J., Pan,J.Q.
            and Sheng,M.
  TITLE     Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show
            EEG abnormalities in common with schizophrenia patients
  JOURNAL   Transl Psychiatry 13 (1), 92 (2023)
   PUBMED   36914641
  REMARK    GeneRIF: Mouse mutants in schizophrenia risk genes GRIN2A and
            AKAP11 show EEG abnormalities in common with schizophrenia
            patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9416)
  AUTHORS   Gopalan,J., Omar,M.H., Roy,A., Cruz,N.M., Falcone,J., Jones,K.N.,
            Forbush,K.A., Himmelfarb,J., Freedman,B.S. and Scott,J.D.
  TITLE     Targeting an anchored phosphatase-deacetylase unit restores renal
            ciliary homeostasis
  JOURNAL   Elife 10, e67828 (2021)
   PUBMED   34250905
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9416)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   6  (bases 1 to 9416)
  AUTHORS   Logue,J.S., Whiting,J.L., Tunquist,B., Langeberg,L.K. and
            Scott,J.D.
  TITLE     Anchored protein kinase A recruitment of active Rac GTPase
  JOURNAL   J Biol Chem 286 (25), 22113-22121 (2011)
   PUBMED   21460214
  REMARK    GeneRIF: IQGAP2 and AKAP220 act synergistically to sustain
            PKA-mediated recruitment of effectors such as Rac GTPases that
            impact the actin cytoskeleton
REFERENCE   7  (bases 1 to 9416)
  AUTHORS   Day,M.E., Gaietta,G.M., Sastri,M., Koller,A., Mackey,M.R.,
            Scott,J.D., Perkins,G.A., Ellisman,M.H. and Taylor,S.S.
  TITLE     Isoform-specific targeting of PKA to multivesicular bodies
  JOURNAL   J Cell Biol 193 (2), 347-363 (2011)
   PUBMED   21502359
REFERENCE   8  (bases 1 to 9416)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   9  (bases 1 to 9416)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 9416)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161608.5, AK158300.1, AK032821.1 and AK164604.1.
            
            On or before Aug 30, 2009 this sequence version replaced
            XM_915278.3, XM_001002157.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.23965.1,
                                           SRR10223970.17167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC161608.5         151335-151414       c
            81-1134             AK158300.1         2-1055
            1135-4987           AC161608.5         124714-128566       c
            4988-5485           AK032821.1         668-1165
            5486-5488           AK164604.1         1016-1018
            5489-6014           AK032821.1         1169-1694
            6015-9416           AC161608.5         106800-110201       c
FEATURES             Location/Qualifiers
     source          1..9416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 41.46 cM"
     gene            1..9416
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /note="A kinase anchor protein 11"
                     /db_xref="GeneID:219181"
                     /db_xref="MGI:MGI:2684060"
     exon            1..149
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            150..261
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..5886
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /note="isoform 1 is encoded by transcript variant 1; A
                     kinase (PRKA) anchor protein 11"
                     /codon_start=1
                     /product="A-kinase anchor protein 11 isoform 1"
                     /protein_id="NP_001157975.1"
                     /db_xref="CCDS:CCDS49549.1"
                     /db_xref="GeneID:219181"
                     /db_xref="MGI:MGI:2684060"
                     /translation="MAAFQPLRSSHLKSKASVRKSFSEDVFRSVKSLLQSEKELCSVS
                     GGECLNQDEHPQLTEVTFLGFNEETDAAHIQDLAAVSLELPDLLNSLHFCSLSENEII
                     CMKDTSKSSNVSSSPLNQSHHSGMLCVMRVSPTLPGLRIDFIFSLLSKYAAGIRHTLD
                     MHAHPQHHLETTDEDDDDTNQSVSSIEDDFVTAFEQLEEEENAKLYNDEINIATLRSR
                     CDAASQTTSGHHLESHDLKVLVSYGSPKSLAKPSPSVNVLGRKEAASVKTSVTTSVSE
                     PWTQRSLYRCPSASDKDKDTQETFFPSPVYSSESECSSPSPVIFLDEEGYQKSLKAKL
                     ELPEIPVTKDDVEDSDSEVSEFFDSFDQFDELEQTLETYLLMEDPIIGKSSQKIGHKY
                     EKSCMNPQKFKFERPALPANVRKPTPRKPESPYGHLSDAPDSPRPVMTSEDSGLFSPI
                     RTSAFSPPGSCTPAEWFCQTDTSENRNHENYCTYEDYANNLSCEVLGSVLHTQHANTM
                     SDINSIKRGRNHTVTFKYGDSDQKSKCKKSSVITGSVQKFAADLVGKSLGSAFKDLQK
                     GVSSCTNTLCHLAVKLTSSVFQMAFNELRRQCAFSLKERAIGSLASLLVSDALSNALK
                     DLQYVKKQMFTNTVARFAADLAEELVFEGIMEVCQFSCPQTPASSQCQSFDFEDKVVK
                     SYAKDLSESVIQEAFIELSQTNVTFTTKAAVNVSMGNVKYVSAESVSPTQTFTFSSSF
                     SGQAVMMTKPMQEHKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHMSSTLYPSKCL
                     SSEPSKASGGSTQEHIAIERSAEEVDCLRSTCLPSELNPCNQNDFKPTNGDIDRQSPS
                     KLMSGPVIISNFSAAMVHTIVNETLESMTSFKATKTIDTNADYLTKTIKGKACSPSLC
                     DQAAPQENKASSKDMFAEQLSKSIIKHSLDKSKSMLPNRDKKPGSKEHVLVLGEESQM
                     TLGETPKFLDFSDNSPHRSLLVGNYCVAECKDSVGFGFSLEALPPCSMMTNQKSDLKE
                     VVKDKEVTRHNLNNTALEPMPFGQESSFRHSQTFSSAVLTCVDGLHEEDKQKIRDRNV
                     IPDTPPSTPLVPSQTSSEWDIKTLSKQLKGELAKEFAPATPPSTPHNSSVGSLSENEQ
                     TTIEKEEFMLKLMRSLSEEVESSEGEEHPGMHVKAEHPGKKVQFAEAFATHIISLATE
                     AAASHLDHETTQEFKVQNPHLNVPSQRNVLPALSHSDESIQTCTFASDMAADVIAEAE
                     KIANARSCMLFRHERNICHVEGGRGKAEEKLDVEDVAHPREVDTCVLSLPSGMPGLTY
                     KYPSCESVTDEYAGHVIQVLQQQGGSGELIMEQYASRLAYRSVTAAAREAAKTVKMKC
                     GSKLFPLHGCHGKTNKELLVFSSKERHQEVDRQRKRNGSHLCKYQTCERTQDPCRNEL
                     SELYSFSASLASSITRDAKKQLTAPKVDLPKSSTDGCFFEKSECVDSSENVTGPERSK
                     SCQPLQSHGFCQNTGYLSGYSCAENAQAIEQYARKVVGDTLELSLGPTVFHNSETTAS
                     ADRITYAEKLSPLINEACRYCDLKEFHGCTRNSAQLFSKQSPCASAKPSSRSKLSSIR
                     QKSRIFHLDVPQIHVNLDKRAVLAEKIVAEAIEKAERELSNTSLAADSGIGQDGISFA
                     ESLTTEIMTTAVTNAGHAVSSSREIEDFQSTESLGSQQMNLSVGEDSTGSWSNLSFED
                     DHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGSDDGDDEQEDGVE
                     DLQQNGKTLLIMNIDMEPGAVDPQLRIILQWLIASEAEVAELYFQDSAKKEFILLSKQ
                     LQEKGWKVGDVLQAVLKYYEVVEKPSREERCKSLFDWLLENAQNRLQTSMLV"
     exon            262..378
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            379..426
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            427..561
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            562..826
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            827..5267
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5268..5423
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5424..5507
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5508..5554
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5555..5715
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     exon            5716..9416
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6681..6686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /note="hexamer: AATAAA"
     polyA_site      6708
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /note="major polyA site"
     regulatory      9395..9400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /note="hexamer: AATAAA"
     polyA_site      9416
                     /gene="Akap11"
                     /gene_synonym="6330501D17Rik; AKAP220; Gm80; mKIAA0629;
                     PRKA11"
                     /note="major polyA site"
ORIGIN      
        1 gagtgggcgg cgtggggagg cggcggcggt ggcgtcgcgg gctggggcgg gcgaggggga
       61 gcgccgctgc gctgcggctc gcgccaccgg gcgttgcggg ccgtgacggg aggctgacat
      121 gcccgggagc tgagaggctg tgccgcctgg tgttgtgtgg atttactctc cagctacatt
      181 acacactgca gtaatacagt tatggcggct ttccagcccc tcaggagtag tcacctaaag
      241 agcaaagcgt ctgtccgaaa aagcttcagt gaagatgtgt tccggtctgt aaagtcttta
      301 ttacagagcg agaaggagct atgcagtgta tcaggaggag agtgtttaaa ccaggatgag
      361 cacccccagt taactgaggt cacgtttctg ggctttaatg aagaaacaga tgctgctcat
      421 atacaggatc tagctgcagt ttcattggaa cttccagatc ttctgaattc gctccatttt
      481 tgcagtctaa gtgaaaatga aatcatttgt atgaaggata ccagtaaatc gtccaatgta
      541 agcagtagtc ctctaaatca gagtcatcat tcgggaatgc tttgtgtcat gagagtgtca
      601 cctacattac cgggactcag aattgatttt atctttagtc tcctaagtaa atatgctgct
      661 ggcataagac acaccctgga catgcacgcg catccgcagc accaccttga gaccactgat
      721 gaagatgatg atgataccaa ccagtctgtg tcttccatag aggatgactt tgtcactgct
      781 tttgagcagt tagaggagga agaaaatgca aagctatata atgatgaaat aaatattgct
      841 acactaagga gccggtgtga tgctgcttct cagactactt caggccacca tttagaaagc
      901 catgatttaa aagtgctggt tagttatgga tcaccgaagt cactggctaa gccctcacct
      961 tcagtaaatg tactgggacg caaggaagct gcttctgtga aaacatctgt tacaacatcg
     1021 gtttcagagc cctggaccca gaggagtctc tacaggtgcc ccagtgcctc cgataaagac
     1081 aaggacacac aggagacatt ctttccttct cctgtctact cctcagagtc tgagtgctca
     1141 agcccaagtc ctgtgatttt tttggatgaa gagggatatc aaaaaagttt aaaagcgaaa
     1201 cttgagctgc ctgaaattcc tgtgacaaaa gatgatgtag aagattcaga ctcagaagtg
     1261 agtgaatttt ttgatagctt tgatcagttt gatgaactag agcaaacttt ggagacttac
     1321 ttgctcatgg aagatcctat catagggaag tcatcacaga agatagggca caaatatgaa
     1381 aaatcttgta tgaatcctca gaaattcaag tttgagcgtc cagctcttcc agctaatgtt
     1441 agaaagccaa ctcctcgcaa acctgagtct ccgtatggtc acctgtctga tgctccagat
     1501 tcccctcgtc cggtgatgac atcagaggat agtggcttgt tcagccctat tcgaacctca
     1561 gcttttagtc ctcctggaag ctgtactcct gctgaatggt tttgccaaac agatactagt
     1621 gaaaatagga atcatgaaaa ttactgcact tatgaggatt atgcaaataa tctttcgtgt
     1681 gaagtactag gctcagttct tcatactcaa catgcaaaca caatgtcaga tattaatagt
     1741 attaaaaggg gaagaaatca tacggtaact tttaagtatg gagactctga tcaaaaaagt
     1801 aaatgtaaaa aatcttcagt gattacaggt agcgttcaga agtttgcagc agatcttgtg
     1861 gggaaaagtt tgggcagtgc gtttaaagac ttacagaaag gagtttcttc atgtaccaat
     1921 accttatgcc acttagctgt caaattgact tcgtctgtat ttcagatggc atttaatgaa
     1981 cttagaaggc agtgtgcatt ttcactaaaa gaacgagcca ttggtagcct ggccagtctt
     2041 ttggtgagtg atgccttatc aaatgccttg aaagacttac agtatgtaaa aaagcagatg
     2101 tttacaaaca cagttgctag gtttgctgcg gaccttgctg aagaacttgt ttttgaaggt
     2161 atcatggaag tgtgtcagtt ttcatgtcct caaacacctg catcttcaca gtgtcagtca
     2221 tttgactttg aagacaaagt cgtgaagtcc tatgccaaag atttgtctga atctgtaata
     2281 caagaagcat tcatagaact gtcacagact aatgtgacgt ttacaacaaa ggcagcagtt
     2341 aatgtttcta tgggtaatgt caagtatgtg agtgcagaaa gtgtatcacc tacgcagacc
     2401 tttacatttt cctcatcctt cagcggtcaa gcagttatga tgacaaaacc aatgcaggag
     2461 cataagaagg aatacacagt gcagcaggct ttgttttgta cctcaggaat tgtcacttct
     2521 ataccagtgc ccttggccgg tagtgccctt ctcccgtatc atatgtcatc tactttgtat
     2581 ccttccaagt gtctttcatc tgagcctagt aaagcaagtg gtggctctac ccaagaacac
     2641 attgccatag aacgcagtgc agaggaagta gattgtctca gaagtacctg tctaccttca
     2701 gaactcaatc catgcaacca gaatgacttc aaaccaacta atggtgatat tgacaggcag
     2761 agtccttcaa agttaatgag tggccctgta attattagca acttttccgc agcaatggta
     2821 catacaatag taaatgaaac cttagagtcc atgacgtcct tcaaagctac aaaaactatt
     2881 gatacaaatg cagattattt aactaaaaca ataaagggaa aagcctgttc tccttccctt
     2941 tgtgaccaag cagcaccaca ggagaacaaa gctagcagta aggacatgtt tgctgagcag
     3001 ttatcaaagt ctattattaa acattccctg gataaaagca agtcaatgct tccaaataga
     3061 gataaaaaac ccggtagtaa ggaacacgtg cttgttcttg gagaagaatc acagatgacc
     3121 ttgggggaaa ctcccaaatt ccttgacttt tcagataact cacctcatcg ttcactcctg
     3181 gttggaaact attgtgtcgc agaatgtaaa gattctgtgg gttttggatt ttctctagag
     3241 gcactgccac cttgttcaat gatgacaaat cagaaatctg acttaaagga agttgtgaag
     3301 gacaaagaag tgacaaggca caatttgaat aatactgcac ttgagcccat gccttttgga
     3361 caggaaagct ctttccgtca ctcacagact ttctcatctg cagtgcttac ctgtgtagat
     3421 ggtttgcatg aggaagataa gcagaaaatc cgagacagaa atgtaatacc tgatactccc
     3481 ccatcgactc ctttagtgcc atcccagact agttctgaat gggacatcaa aacattaagc
     3541 aaacaactca agggggagtt agccaaagaa tttgcacccg caacaccacc ttcaacgcct
     3601 cacaactcat ctgttggtag tttgtctgag aatgaacaaa ctactataga aaaggaagaa
     3661 tttatgttga agctcatgcg ctctctttca gaagaagttg agagcagtga aggtgaagaa
     3721 cacccaggaa tgcatgtaaa ggcagagcac ccggggaaaa aagtccagtt tgcagaagca
     3781 ttcgccacac acatcatttc tcttgcaact gaagcggcag cctcccactt agatcatgag
     3841 actactcaag aattcaaggt tcaaaaccct cacttaaatg taccaagtca aagaaatgtg
     3901 ctgccagctt taagtcattc cgatgaaagc atacagacgt gcacttttgc aagtgatatg
     3961 gcagctgatg tcattgcaga agccgagaag attgcaaacg ctagaagctg tatgcttttc
     4021 aggcatgaga ggaacatttg tcatgttgaa ggtggccgag gtaaagcaga agagaaactg
     4081 gatgtggaag atgttgcaca tccaagagaa gtcgatactt gtgttctttc attaccaagt
     4141 ggcatgccag gtctgacata caagtatccc agttgtgaaa gtgtgactga tgagtatgca
     4201 gggcatgtta ttcaggtgct ccaacagcaa ggtggcagtg gagagctaat catggagcag
     4261 tatgccagca gactggccta ccggtctgtc actgcagcag ctcgggaagc agctaagaca
     4321 gtgaaaatga agtgcggttc gaaactcttc cctctgcacg gctgtcatgg gaaaacaaac
     4381 aaggaactgt tggtgttctc aagtaaagag cgtcaccaag aagtcgatag acaaagaaaa
     4441 agaaatggca gccatctttg caaataccag acatgtgaaa ggacacagga tccgtgtaga
     4501 aatgaacttt ctgaactgta cagtttttca gcctctcttg ctagcagcat aacaagagat
     4561 gcaaagaaac agctcacagc acctaaagtt gacttgccaa aatcctcaac agatggttgt
     4621 ttttttgaaa aatctgaatg tgttgacagc agtgagaatg ttactggacc agaacgttca
     4681 aagtcttgtc aacctttgca aagccatgga ttttgccaga atacaggcta tctaagtgga
     4741 tatagttgtg cagagaatgc tcaagctata gaacagtatg ctagaaaagt agtgggtgac
     4801 actttagagc taagtttagg acccacagtt tttcataatt cagagaccac agcatcagca
     4861 gatagaatta cttacgcaga aaaattgtca ccgcttataa atgaagcttg cagatactgt
     4921 gaccttaagg aattccatgg ttgcaccaga aattctgctc agctcttttc aaagcagagt
     4981 ccgtgtgcta gtgctaagcc aagttcacgt tcaaaactta gtagcattcg tcagaaatca
     5041 agaatttttc atcttgatgt acctcagatt catgttaatc ttgataaaag ggcagtgctt
     5101 gctgagaaga tagttgctga agctattgag aaagcagaga gagagttgag caacacgagt
     5161 ttggcagctg atagtggaat cggacaagat ggcattagct ttgctgagag ccttactaca
     5221 gaaatcatga caacagctgt gacaaatgct gggcatgctg ttagcagttc aagagaaata
     5281 gaagattttc agtcaactga gtcacttggc agccagcaga tgaatctcag tgttggtgaa
     5341 gacagcacag gtagctggtc caacttaagt tttgaggatg accatcaaga tgaaagcagc
     5401 agtttccatc atctcagtga aagtaatggt aacagcagta gctggagcag tcttggttta
     5461 gaaggagatt tgtatgagga caatttatcc tttccaacat cagacagtga tggatcggat
     5521 gatggagatg acgagcagga ggatggtgtg gaagatttgc agcaaaatgg aaagactctg
     5581 ctaattatga acattgacat ggagcctgga gctgtagacc cgcaattaag gattattctt
     5641 cagtggctca ttgcctctga ggctgaagtt gcagaacttt attttcagga ctctgcaaag
     5701 aaggagttta tattactttc aaagcagtta caagagaaag gatggaaagt gggagatgtc
     5761 ctgcaggctg tgcttaaata ctacgaagtg gtggaaaagc cctcaaggga ggaaagatgc
     5821 aagtcgctgt ttgattggct tttagaaaat gcccagaaca gactccagac cagtatgctt
     5881 gtctagaaag taaagaaatt gatgatttac atgtaggata aaattcaaat gcagaatatt
     5941 aacattttaa ttgaattgag aggaaagtaa gaagctttta aaatgctttc tgtcattaca
     6001 ctgtatatag ttcatacttt tgtaatcttt gtcaagatat tctctttact taatcttctg
     6061 tacatgtgta tgtgttatga ccctgagata atattctgtg aaggacgatc taaccccgcc
     6121 tgaggctggg gcattgtctg acagcatttg tttggatcca catagtgctg ctgctgctgc
     6181 tgttgctgca aacagggctg aggcggcctg cctggcccaa gttatcactt ggctcctttg
     6241 aaaacaggtg gcgtctaatg ataagtcatc tgacatcaag aaagaaaact gaggctgata
     6301 ttttgttgtt tatttatttc tgataagttt tattctttat gtactgttct ttaaaaccag
     6361 ttttatttcc ctagttcagc tattggtact tgtagatttc cccagacctt taatttctta
     6421 gcagactcct gactgattta ggtttctgtg aacatcataa atgagttccc cttgccttcc
     6481 atcaagtgac gttatttgct aatactgcca attgttctga aatgagaagg agcggggtgg
     6541 ggggtggggg gaaggttttg agagagagaa tgtgtgtgtg tgtgtgtgtg cgcgtgcgtg
     6601 agaggataaa ctttaacctt cccactagtt tattctttta ctttagtgtt ttcttagtta
     6661 gaaaaccact attaacatta aataaaacgt ctaaatattg tgcagtaaga attttgtctt
     6721 ttttatttat tccacaaatg aaaattcagg ttgtaaaata aattgaaatt ttaaaaatta
     6781 atgtagaaat gcattcagag gagcctagta gtaattttct gtgttggatt tttgaagaag
     6841 aagaaaaaaa aaaaaccctc ctcacttcac caagagtaat ttcttttagc taagtgtttc
     6901 tcaaccttcc taacactgca accctttaat acagttcctc atgttgtggt gacccccaac
     6961 catcacatta ttttgctgat atttcataac tgtaattttg ctactattac ttggacatat
     7021 tggtgttttc tgatgggggt catgtagccc cagaagaggt tgcaacccac aggtcgagag
     7081 ctgccatttc agcacagaag cacctctccc ccagtaaaat gtgtctggac tgtttcataa
     7141 agtctcttct catgatcttt tttggtctct acattcccta ctgtgttttt tagagattgc
     7201 aggctgctct gagtgaggtg accaggctgt gtctctgtgt ctgagatttg tgaagatggg
     7261 agggtctccc ctaaccgatt ctggaatcta aagcaggtcg tattgcttgg ggctggtgat
     7321 ttttcttcat tacatttttc atttttcctc aagctctgac ttttttagaa gctacagtga
     7381 gtagaagaca cagcacctat caggggactt aggttaattt gaattagtaa ttatggtgaa
     7441 gttattttta tagagatgtc agatttgctt tgactccaga aacaatttaa gtattttgaa
     7501 actacattat aaactgtagt ttttcctcaa ttgaacatag agacacgggg cctgccttaa
     7561 acatacattt ttaaaagttt cttcaagtat tttccagagt ggggaaatgc agggaataat
     7621 acccatgtgc actctcctgc gcttgcacga ggaaccagca cactgcacgt atgtaatttg
     7681 catgatatgt attgcttaga ttaacagtaa aactgacttc taatttcttt gaggtgcaaa
     7741 tgacaatgtt ggttttctaa agttgaaagt gcccaggcgt gtttcagctg ctggtgtagt
     7801 tatttgaggc gagctttaac tctgctcctg gttcctttgc attctggtga agccaagcag
     7861 cgctcactca gtgttcttca ttcagtgcaa cagagacgga gtggacctca cactgcgttg
     7921 gctctgtgca gggacacggg aaacagaagt ttcggcaggg tgcgcagcag tgtaggttga
     7981 ctttctgtaa agaaagcgtt tgagtgtaga gcagtgttgt gggccggaca caggggaagg
     8041 aggcggcttt aaagcacttt gtctttggag catctctatt gagatgcgct ccatcttatc
     8101 acagatttct tgacatattt atattggaac ttgtatactg tcatgcattt tgctcctaat
     8161 gaaatacaat ttactcaaaa ctgttaaaaa gttgtgatgt gcagtgagct gattcttgat
     8221 tcaccagttt taaaggtatt ctgtgatcca cagacagaca gacctttgcc ggaaaaacca
     8281 acaaacaaaa accccacaga agaaatggca gtagagatga gctggctcct tgtggtgtaa
     8341 atctaacatt ataacagcct tcagtgaact catgtagtac ctttgtactt tcagaaatgc
     8401 ttcatttacc cctaaagata tttaatgtga attaattcag ttcatactac tatacctctg
     8461 cttagcaaag gacttatagt gctggtagga agctgtatac tgagtgcact gtgtggaaag
     8521 tgaagagttg gcccatgtga cagctggcag ctctgacagt ggtggtgcat gctctccgtc
     8581 cttgtccaga gcctcatggc tacctgctgt ccaccagtag tgtttctcca cagctacttg
     8641 cagcagcttc tagtcagtgt attattttgt aatttttcaa agaaatcttt acacagagtt
     8701 taaagatgtt gggtccacac acgggtaggg aaaatgctct ccatttaaaa tcatgtctgc
     8761 cagtcagcag cacatgagaa ctgtgggagt gtctgttggg attggaagcg gcgtactcaa
     8821 gtcaagtgcg cttggctcgt cagcacaagc cctgtaggca ccccttgttt actgtgcgcc
     8881 tgctctgcac acacaggcgc ggtgctgctc actcctgcct ctctatttat ttattttgac
     8941 catgtgtaca ttcctttcat agagttagaa ctgcggttct gcaggctcct attgcagtct
     9001 gttgtatggt ttggatacta tttaatgcca ggtttatatg ttgctggatt tgctgccttc
     9061 agttacttgt gctgtgttcc aagcaatctg cattcttgtt cacttaatga atattaagta
     9121 gaagtaactt tgaataattg tggccattta tttgagtttg ctcatttagt gcactaaggt
     9181 cttatactat ataacagtaa ctcctctttt tgctcttgag taatttaatg ttcatttacc
     9241 aaacttggaa tttcaagatg cactaaagtt ttatttagcg gtggctcaaa aaatgtttca
     9301 gaacttactt ttgtaataat ttgcagttaa ttgttctttt gtctttactc ttgttcaagc
     9361 ctgtgatctt tcctctccca gccaagaatt attcaataaa tttaaagaaa tgtcaa
//
