LOCUS       NM_001042541            3758 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus A kinase anchor protein 1 (Akap1), transcript variant
            2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001042541
VERSION     NM_001042541.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Fang,Y., Xu,J. and Huang,R.
  TITLE     AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of
            Cardiomyocyte
  JOURNAL   Heart Surg Forum 27 (1), E028-E037 (2024)
   PUBMED   38286648
  REMARK    GeneRIF: AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of
            Cardiomyocyte.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Qi,B., He,L., Zhao,Y., Zhang,L., He,Y., Li,J., Li,C., Zhang,B.,
            Huang,Q., Xing,J., Li,F., Li,Y. and Ji,L.
  TITLE     Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by
            NDUFS1-mediated mitochondrial dysfunction and apoptosis
  JOURNAL   Diabetologia 63 (5), 1072-1087 (2020)
   PUBMED   32072193
  REMARK    GeneRIF: Akap1 deficiency exacerbates diabetic cardiomyopathy in
            mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Edwards,G., Perkins,G.A., Kim,K.Y., Kong,Y., Lee,Y., Choi,S.H.,
            Liu,Y., Skowronska-Krawczyk,D., Weinreb,R.N., Zangwill,L.,
            Strack,S. and Ju,W.K.
  TITLE     Loss of AKAP1 triggers Drp1 dephosphorylation-mediated
            mitochondrial fission and loss in retinal ganglion cells
  JOURNAL   Cell Death Dis 11 (4), 254 (2020)
   PUBMED   32312949
  REMARK    GeneRIF: Loss of AKAP1 triggers Drp1 dephosphorylation-mediated
            mitochondrial fission and loss in retinal ganglion cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Haushalter,K.J., Schilling,J.M., Song,Y., Sastri,M., Perkins,G.A.,
            Strack,S., Taylor,S.S. and Patel,H.H.
  TITLE     Cardiac ischemia-reperfusion injury induces ROS-dependent loss of
            PKA regulatory subunit RIalpha
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (6), H1231-H1242 (2019)
   PUBMED   31674811
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Zhang,J., Feng,J., Ma,D., Wang,F., Wang,Y., Li,C., Wang,X., Yin,X.,
            Zhang,M., Dagda,R.K. and Zhang,Y.
  TITLE     Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects
            HT22 Cell from Glutamate-Induced Oxidative Stress
  JOURNAL   Mol Neurobiol 56 (8), 5586-5607 (2019)
   PUBMED   30652267
  REMARK    GeneRIF: AKAP121/PKA confers neuroprotection in an in vitro model
            of oxidative stress induced by exposure to excess glutamate.
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Johnson,L.R., Foster,J.A., Haig-Ladewig,L., VanScoy,H., Rubin,C.S.,
            Moss,S.B. and Gerton,G.L.
  TITLE     Assembly of AKAP82, a protein kinase A anchor protein, into the
            fibrous sheath of mouse sperm
  JOURNAL   Dev Biol 192 (2), 340-350 (1997)
   PUBMED   9441672
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Chen,Q., Lin,R.Y. and Rubin,C.S.
  TITLE     Organelle-specific targeting of protein kinase AII (PKAII).
            Molecular and in situ characterization of murine A kinase anchor
            proteins that recruit regulatory subunits of PKAII to the
            cytoplasmic surface of mitochondria
  JOURNAL   J Biol Chem 272 (24), 15247-15257 (1997)
   PUBMED   9182549
REFERENCE   8  (bases 1 to 3758)
  AUTHORS   Huang,L.J., Durick,K., Weiner,J.A., Chun,J. and Taylor,S.S.
  TITLE     Identification of a novel protein kinase A anchoring protein that
            binds both type I and type II regulatory subunits
  JOURNAL   J Biol Chem 272 (12), 8057-8064 (1997)
   PUBMED   9065479
REFERENCE   9  (bases 1 to 3758)
  AUTHORS   Moss,S.B., VanScoy,H. and Gerton,G.L.
  TITLE     Mapping of a haploid transcribed and translated sperm-specific gene
            to the mouse X chromosome
  JOURNAL   Mamm Genome 8 (1), 37-38 (1997)
   PUBMED   9021145
REFERENCE   10 (bases 1 to 3758)
  AUTHORS   Lin,R.Y., Moss,S.B. and Rubin,C.S.
  TITLE     Characterization of S-AKAP84, a novel developmentally regulated A
            kinase anchor protein of male germ cells
  JOURNAL   J Biol Chem 270 (46), 27804-27811 (1995)
   PUBMED   7499250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ167452.1, AK132749.1, AK020371.1 and AL596180.8.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076216.1, BC065135.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               CJ167452.1         17-206
            191-1709            AK132749.1         164-1682
            1710-2877           AK132749.1         1684-2851
            2878-3177           AK020371.1         322-621
            3178-3758           AL596180.8         25460-26040         c
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 54.34 cM"
     gene            1..3758
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /note="A kinase anchor protein 1"
                     /db_xref="GeneID:11640"
                     /db_xref="MGI:MGI:104729"
     exon            1..190
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            191..1797
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1931
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2058
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2186
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2364
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2515
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2583
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2657
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2720
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..3758
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /note="hexamer: CATAAA"
     polyA_site      3758
                     /gene="Akap1"
                     /gene_synonym="Akap; AKAP121; AKAP84; DAKAP1; S-AKAP84"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcgcgcc gcgggcacgt cgttgcgcgt cctcagtatt taatgtctct gtgttcgccc
       61 ggcctgggct agcacgtggg ggagcggccg aagcgccgtg cagcgctgcg gggcagggcc
      121 gctggactag gtggggggcc agggggcggt ggcgggagga ttgagtgcct agacggtcgc
      181 ccaggagcag gtgtagctac ttcacatcga ctgactccaa gatggcaatc cagttgcgtt
      241 cgctcttccc cttggcgttg cccggaatgc tggccctcct tggctggtgg tggtttttct
      301 ctcgtaaaaa agatcggctc agcagcagtg ataagcaggt ggagacactg aaggttggcc
      361 ctgccatcaa ggaccgacgg ctcagtgaag aggcctgtcc tggagtcctg tctgtggccc
      421 ccactgtcac acagcctcct ggaagggaag agcagcgctg tgtggacaag ccttctacag
      481 agcccctggc cttgccgagg actcgccagg ttcgacgaag atcagagtcc tcaggcaacc
      541 tccccagcgt tgcagacacg aggtcgcagc caggaccgtg cagagatgag atcgccaaag
      601 tggaactctc cctgatgggg gacaaagcca aatctattcc tcttggatgt ccgcttctcc
      661 caaaggatgc gtccttcccc tatgaagcag tggaaaggtg taagcaggag tccgcactgg
      721 gcaagactcc tggaagaggc tggccaagcc cgtatgcggc ctctggagag aaagcgagag
      781 agacaggtgg gacagagggg actggagatg ctgtgttggg ggaaaatgta tctgaggaag
      841 gcctattgtc ccaggagtgt gtctcagaag tggagaagag tgagtttcca atcctggccc
      901 ccgggggagg tgagggagaa gaggtgagcc atggcccccc acaggtagct gaacttttaa
      961 agaaggaaga atatattgtt gggaagttgc cgagtagctt tgtggagcca gttcactcag
     1021 agccggttaa ggacgaggat gcgttggaac cccaggtcaa aggtagcagc aatacttcgg
     1081 atagagacct ggctggagag ctggacaaag acgagaccgt gcctgaaaat gaccagatta
     1141 agcaggctgc cttccagctc atctcccagg tgatcttgga agcaactgaa gagtttcggg
     1201 ccaccacagt gggcaagact gtggcacaag tgcacccaac ctcggccact cagcctaagg
     1261 ggaaggagga gagctgtgtt ccagccagcc aggaaactag cttgggacaa gacacctcag
     1321 atcctgcttc caccagaaca ggtgccactg ccagcccttc agcagaagct ctgccaccaa
     1381 agacctatgt aagctgtctc agcagccctc tgtcaggccc caccaaggac cagaagccaa
     1441 agaactctgc acatcacatc tccctggctc cctgcccacc gccagtcacc ccccagaggc
     1501 agtctctgga gggggcaagt aacccgagag gtgatgacaa ctttgtcgcc tgtatggcca
     1561 acaacagcca gagtgtcctt tcagttagct ccttggggca gtgctcagat cctgtcagta
     1621 cttcggggct tgaagactct tgcacagaga ccatctcaag ctccggagac aaagctatga
     1681 ccccaccact gccagtcagt actcagccct tcagcaacgg ggtgctgaag gaggagctgt
     1741 cagacttagg gaccgaggat ggatggacca tggatacaga agcagatcac tcaggaggtt
     1801 ctgacgggaa cagtatggat tcagtggata gctgttgcgg gcttaccaag cccgatagcc
     1861 cccagagtgt ccaggcaggc tccaacccta agaaggttga ccttatcatc tgggagatcg
     1921 aggtgccaaa gcacttagtt ggtcgactga ttggcaagca gggacggtac gtgagttttc
     1981 tgaagcagac atctggtgcc aagatctaca tctccaccct gccttacaca cagaacatcc
     2041 agatctgcca catagaaggc tctcagcacc atgtagacaa agctctgaac ttgattggga
     2101 agaagtttaa ggaactgaac ctcaccaata tctatgcgcc accactgcct tcgctggcac
     2161 tgccttcctt gccgatgacg tcttggctca tgctgcctga tggtatcact gtggaagtca
     2221 tcgtggtcaa ccaggtcaat gctgggcacc tatttgtcca gcagcacaca caccccacct
     2281 tccatgcact gcgcagtctg gaccagcaga tgtacctctg ttactctcag cctggaatcc
     2341 ccaccttgcc caccccagtg gaaatcacgg ttatctgcgc tgcccctggt gcggacgggg
     2401 cctggtggcg agcccaagta gtggcttcct atgaggagac caatgaggtg gagattcgct
     2461 acgtggacta tggtggatat aagagagtga aagtcgacgt gctccggcaa attaggtctg
     2521 actttgtgac cctgccattc caaggagcag aagtccttct ggacagtgtg gttcctctgt
     2581 cagatgatga tcatttttca ccggaggcag acgcagccat gagtgagatg acaggcaata
     2641 cagcactgtt ggcccaggtg acaagctaca gtgcgactgg ccttcctctg attcagctat
     2701 ggagtgtggt tggagatgaa gtggtgttga taaaccggtc gctggtggag cgaggccttg
     2761 cacagtgggt agacagctac tatgccagcc tctgaccttg gctcctgagt tgcttcggtc
     2821 ttctttgcac tgttgagagt gggtttggca cccaggacag agttttaaga gcagagtaac
     2881 aaacactgtt ctcactgagt cttctttccc cattctgtag tcctgtggag gaggagggtc
     2941 ctcccaggag gacctgtgtg ttctttcaaa gccttagagt ggcgctacac cggccagctg
     3001 gcttagctgc aggaaggcct cttagccagg ctattcccat tccatccgct cccttctccc
     3061 cacccaaacc ccacactgca gcaggcaggc cagggcgggt gtggggctgg ctgagaggat
     3121 caattttaga gtctttattc agggagtgag acatggacta attggtatcg attccctgga
     3181 tagctcgctt ggatgaattg atggtgttta gcagttttta tatacttcct ccgggtctct
     3241 aggaactcag acttttttaa acatagatgt aaataaggaa cagtttgtca cacctgaccc
     3301 cagtgagtgg ggggaagggc agctgttatc ttgccaagcc tggttgtaat ttgtaaccat
     3361 tttctatttg ttcgaactct gtaaataata tgtttaaaga tgtaatattt tgtacaagac
     3421 acactggaga acaaagggaa ctcaaaactc ttccacattc ttcccgagga aatcgacgac
     3481 gtccatccgt cccacagagt gggaccgacc gcccctgctg ctccagccag ggcccctgcg
     3541 cttcctgtgc agacaggaag ctgtgtggga gactgtcatt tgggaatttg attttttttt
     3601 ttctgtacga atttaaaaaa aaaagaaaaa aaagaaactt cattgaatta ccttgcagtg
     3661 gtgttgactc ttttatagac tgtctttagc attgtgcaat ttaagaataa cttaaggatc
     3721 ttggacttta cataaatctt gaattgtata aactctaa
//
