LOCUS       NM_001033874            1584 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus adenylate kinase 8 (Ak8), mRNA.
ACCESSION   NM_001033874 XM_130050
VERSION     NM_001033874.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Dougherty,G.W., Mizuno,K., Nothe-Menchen,T., Ikawa,Y., Boldt,K.,
            Ta-Shma,A., Aprea,I., Minegishi,K., Pang,Y.P., Pennekamp,P.,
            Loges,N.T., Raidt,J., Hjeij,R., Wallmeier,J., Mussaffi,H.,
            Perles,Z., Elpeleg,O., Rabert,F., Shiratori,H., Letteboer,S.J.,
            Horn,N., Young,S., Strunker,T., Stumme,F., Werner,C., Olbrich,H.,
            Takaoka,K., Ide,T., Twan,W.K., Biebach,L., Grosse-Onnebrink,J.,
            Klinkenbusch,J.A., Praveen,K., Bracht,D.C., Hoben,I.M., Junger,K.,
            Gutzlaff,J., Cindric,S., Aviram,M., Kaiser,T., Memari,Y.,
            Dzeja,P.P., Dworniczak,B., Ueffing,M., Roepman,R., Bartscherer,K.,
            Katsanis,N., Davis,E.E., Amirav,I., Hamada,H. and Omran,H.
  TITLE     CFAP45 deficiency causes situs abnormalities and asthenospermia by
            disrupting an axonemal adenine nucleotide homeostasis module
  JOURNAL   Nat Commun 11 (1), 5520 (2020)
   PUBMED   33139725
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Vadnais,M.L., Cao,W., Aghajanian,H.K., Haig-Ladewig,L., Lin,A.M.,
            Al-Alao,O. and Gerton,G.L.
  TITLE     Adenine nucleotide metabolism and a role for AMP in modulating
            flagellar waveforms in mouse sperm
  JOURNAL   Biol Reprod 90 (6), 128 (2014)
   PUBMED   24740601
  REMARK    GeneRIF: In addition to AK1 and AK2, which we previously
            demonstrated are present in outer dense fibers and mitochondrial
            sheath of the mouse sperm tail, we show that another AK, AK8, is
            present in a third flagellar compartment, the axoneme.
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Kisseleva,T., Cong,M., Paik,Y., Scholten,D., Jiang,C., Benner,C.,
            Iwaisako,K., Moore-Morris,T., Scott,B., Tsukamoto,H., Evans,S.M.,
            Dillmann,W., Glass,C.K. and Brenner,D.A.
  TITLE     Myofibroblasts revert to an inactive phenotype during regression of
            liver fibrosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (24), 9448-9453 (2012)
   PUBMED   22566629
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Vogel,P., Read,R.W., Hansen,G.M., Payne,B.J., Small,D., Sands,A.T.
            and Zambrowicz,B.P.
  TITLE     Congenital hydrocephalus in genetically engineered mice
  JOURNAL   Vet Pathol 49 (1), 166-181 (2012)
   PUBMED   21746835
  REMARK    GeneRIF: Congenital hydrocephalus and rhinosinusitis in Ak8 null
            mice
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY100469.1, BC109352.2 and AB046266.1.
            
            On Jul 24, 2007 this sequence version replaced NM_001033874.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100481.1, AK004439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY100469.1         2-14
            14-1550             BC109352.2         1-1537
            1551-1584           AB046266.1         569-602
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..1584
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /note="adenylate kinase 8"
                     /db_xref="GeneID:68870"
                     /db_xref="MGI:MGI:1916120"
     exon            1..114
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1470
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /EC_number="2.7.4.3"
                     /EC_number="2.7.4.6"
                     /note="putative adenylate kinase-like protein C9orf98
                     homolog; Adenylate kinase isoenzyme 4, mitochondrial
                     (ATP-AMP transphosphorylase); ATP-AMP transphosphorylase
                     8"
                     /codon_start=1
                     /product="adenylate kinase 8"
                     /protein_id="NP_001029046.2"
                     /db_xref="CCDS:CCDS15846.1"
                     /db_xref="GeneID:68870"
                     /db_xref="MGI:MGI:1916120"
                     /translation="MDATTAPHRIPPEMPQYGEDYYIFEMMQNMLEQLLIHQPEDPIS
                     FMITHLRRNNDNVPKVVILGPPASGKTTIAMWLCKHLNSNLITKESLLEREFSRLSVE
                     AKSYYQVYKKIPNSILVSLVQERLNEDDCLRKGWILDGIPERREQALMIQTLGLAPKH
                     VIVLNAPDTVLIERNVGKRIDPVTGEIYHTTFDWPPEPEIQNRLRQPEGISEIETAKK
                     LLEYHRHIIRILPSYPKILKTISSDQPCVDVFYQALTYVQSGHRCNAPFTPKVLLCGP
                     LGSGKRLQATLLAQKYGLVNISCGQLLKEAVAAKSSFGELIQPFFEKRMTVPDSIITK
                     VLADRMEQQDCIQKGWVLHGFPRDLDQARMLNSMGYNPNRVFFLSVPLDSILERLTLR
                     RTDPVTGERFHLMYKPPPTIEVQVRLLQNPKDSEEYIKLQTDLFYRNSGDLEQYYDRA
                     IIVNGDQDPYTVFEYIESGIINPLPRKVT"
     exon            115..199
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            200..249
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            250..363
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            364..432
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            433..514
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            515..586
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            587..787
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            788..919
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1009
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1151
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1232
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1570
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /note="hexamer: AATAAA"
     polyA_site      1570
                     /gene="Ak8"
                     /gene_synonym="1190002A17Rik; AK 8"
                     /note="major polyA site"
ORIGIN      
        1 gttactaagg agcggagcgc tgtcggaaac atggatgcaa ccacagcccc tcatcgcatt
       61 cccccggaaa tgcctcagta cggggaagac tactacattt tcgagatgat gcagaacatg
      121 ttggagcagc tcctgatcca ccagccggag gaccccatca gcttcatgat cactcacctg
      181 cgcaggaaca atgataatgt gccgaaggtt gtgatattag gtccgcctgc ctcagggaaa
      241 accaccatcg ccatgtggct ctgcaaacat ctaaacagca acctcatcac caaggagagc
      301 ttactagaaa gagagttttc ccgtctgtct gtggaagcca agagttacta ccaggtttac
      361 aagaagattc ccaattcgat tcttgtcagt cttgtccagg agcgtctgaa tgaagatgac
      421 tgcctcagaa agggctggat cctggacggc atccctgaga ggcgggagca ggctctgatg
      481 atccagaccc tggggctggc gcccaagcac gtcattgtgc ttaatgctcc agacactgtc
      541 ctgatcgaga gaaatgtggg caagcggatc gaccctgtca ccggagagat ctatcacacc
      601 accttcgact ggccccctga gcctgaaata cagaacaggc tgagacagcc ggagggcatc
      661 tcggagatcg aaacggcgaa gaagctgctg gagtaccaca ggcacatcat caggattctt
      721 ccttcttacc caaaaatcct gaaaaccatc agctcagacc agccgtgtgt ggatgtcttc
      781 taccaggctc tgacctatgt ccaatctggc catcgatgca atgccccatt cacccccaag
      841 gtgctgctgt gtgggccgtt gggcagcggg aagagactgc aggctaccct tctggcccag
      901 aaatatggcc ttgtaaacat cagctgcggg cagctgctga aggaggctgt ggcagccaag
      961 tcaagcttcg gggagctcat ccagccattc tttgaaaaga ggatgacagt tccagacagt
     1021 atcatcacca aagttctggc tgatcgaatg gagcaacaag attgcatcca gaaagggtgg
     1081 gtgctgcacg gcttcccaag agacctggac caggcccgga tgctgaactc catgggctac
     1141 aatcccaaca gggtcttctt cctgagtgtg ccactggatt ccattctgga gcggctgacg
     1201 ctgagaagga cagaccctgt cacaggagaa aggttccacc tcatgtacaa gccccctccc
     1261 accatagagg tccaggtccg cctcctgcag aaccccaagg attcagagga gtacatcaag
     1321 ctccaaacgg acctgttcta caggaactct ggggatctgg agcagtacta cgatcgagcc
     1381 atcattgtca acggagacca ggacccatac acagtttttg agtatataga gagcgggatc
     1441 attaatcctc tgcccaggaa agttacctga tatgtgcgaa gccaggagca agccctgaag
     1501 acattcaaag cccctgccct caaccttcat cagaccccat ccagccaata aagatgctag
     1561 tcacaacctc aaaaaaaaaa aaaa
//
