LOCUS       NM_030187               3093 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adenylate kinase 7 (Ak7), mRNA.
ACCESSION   NM_030187 XM_911194 XM_994344
VERSION     NM_030187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   4  (bases 1 to 3093)
  AUTHORS   Vogel,P., Read,R.W., Hansen,G.M., Payne,B.J., Small,D., Sands,A.T.
            and Zambrowicz,B.P.
  TITLE     Congenital hydrocephalus in genetically engineered mice
  JOURNAL   Vet Pathol 49 (1), 166-181 (2012)
   PUBMED   21746835
REFERENCE   5  (bases 1 to 3093)
  AUTHORS   Fernandez-Gonzalez,A., Kourembanas,S., Wyatt,T.A. and
            Mitsialis,S.A.
  TITLE     Mutation of murine adenylate kinase 7 underlies a primary ciliary
            dyskinesia phenotype
  JOURNAL   Am J Respir Cell Mol Biol 40 (3), 305-313 (2009)
   PUBMED   18776131
  REMARK    GeneRIF: Data show that a mutation of the adenylate kinase 7 gene
            results in animals with pathological signs characteristic of
            primary ciliary dyskinesia, including ultrastructural ciliary
            defects and decreased ciliary beat frequency in respiratory
            epithelium.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029555.1 and AK019664.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_911194.2, XM_994344.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029555.1, AK019664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AK029555.1         2-188
            188-188             AK019664.1         54-54
            189-368             AK029555.1         190-369
            369-3010            AK019664.1         234-2875
            3011-3093           AK029555.1         3016-3098
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.95 cM"
     gene            1..3093
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /note="adenylate kinase 7"
                     /db_xref="GeneID:78801"
                     /db_xref="MGI:MGI:1926051"
     exon            1..285
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2355
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /EC_number="2.7.4.3"
                     /EC_number="2.7.4.6"
                     /note="putative adenylate kinase 7; ATP-AMP
                     transphosphorylase 7"
                     /codon_start=1
                     /product="adenylate kinase 7"
                     /protein_id="NP_084463.1"
                     /db_xref="CCDS:CCDS49162.1"
                     /db_xref="GeneID:78801"
                     /db_xref="MGI:MGI:1926051"
                     /translation="MAEEEVPATTEKVLKIQRVFINHLDTYSSGNIGKFLANCVAGAS
                     LEEIGEEEEEEDETKSAVAPEAPTTKVKEGTFQIVGTLVKPESVKPDFAVEAYKGISR
                     EDLLSHLMECDAVIYNITENVQQVEEALWAVSALNEEISHFEKRKVFILLSTVMTWAR
                     SKPLDPDDNEVPFTEEDYRRRKHHPNFLDHINAEKIVLKFGKNAKKFATYVVASGLQY
                     GAEGGILHTFFKMAWLGEVPALPVFGDGTNCIPAIHVVDLAGVIQNIIDHVPKLHYLV
                     AVDEAVHTLEDLVKCISKNTGPGKIQKVPKENAFLTKDLTQEYLDHLLVNLRMEALFV
                     KENFNIRWVAQTGFVENINSILKEYKQSRGLLPIKICILGPPAVGKSSISEELAKYYK
                     LHHIKMKDVIAEAIAKLEAIVAPKDSVEGEEEGEEEEEEENVDDAQELLDGIKESMEQ
                     NAGRLEDQYIIRFVKEKLKSMPCRNQGFILDGFPKTYDQAKDLFNQEEEEEEEEIRGK
                     IFPYDKLITPEFVCGLDASDEFLKERVMNLPESVVAGTHYSQDRFLRSLSHYRDINTD
                     DETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGKPRNYGLTDEEKAEEEKK
                     AAEERLAKEAAQTAELEHKEAMEMAEKIARWEEWNKRLEEVKREERELLEVQSVPLRN
                     YLMTYVMPTLMQGLNECCKVRPEDPVDFLAEYLFKNNPEMQ"
     exon            286..477
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            478..586
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            587..681
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            682..792
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            793..873
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            874..962
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1053
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1131
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1281
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1410
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1540
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1669
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1738
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1936
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2157
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2316
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..3093
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3049..3054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /note="hexamer: AATAAA"
     polyA_site      3079
                     /gene="Ak7"
                     /gene_synonym="4930502N02Rik; AK 7"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcac cctatccaga gccctcacca caggacacgc cccgcccaaa agcaagccac
       61 acccctccga gagtccgagc ctcgcctcag ggagcctgac cctttcagcc ttccaaagcc
      121 cagcctctcc tccttagcaa ccgacaggac tctttcacct tagcaactac tacagcttcc
      181 accatggctg aagaggaagt tcctgcgacc accgaaaaag ttctgaagat acagagggta
      241 ttcataaacc atctggacac ctatagcagc ggaaacatag gaaagttcct agctaactgt
      301 gtcgctgggg cttcactgga agagattgga gaggaggagg aggaggagga cgagacaaag
      361 tcagctgtag ctccagaagc ccccactaca aaagtgaagg aaggcacctt ccagatcgtg
      421 ggcaccttgg tcaagccaga gagtgtcaag ccagacttcg ctgtggaggc ttataagggc
      481 atctcccggg aagacctgct ctcgcatctc atggagtgcg atgctgtcat ctataacatc
      541 acagagaatg tgcagcaagt ggaggaagcc ttgtgggcag tctccgcatt gaatgaagaa
      601 atcagccatt ttgaaaagcg aaaggtgttc attttgttgt cgacagtgat gacatgggcg
      661 agatccaaac ccctggaccc tgacgacaac gaggttccct tcacagaaga ggattatcga
      721 agaaggaaac atcaccccaa cttcctggac catatcaacg ctgaaaaaat tgttctcaaa
      781 tttggaaaaa atgccaaaaa gttcgcaact tatgtagtcg cctcaggact tcagtatgga
      841 gcagaaggag gcatcttaca cacgtttttt aagatggcct ggctgggcga ggtccccgca
      901 ctacccgtgt ttggagatgg gaccaattgc attccggcca ttcatgttgt tgacctcgca
      961 ggagtgatcc agaacatcat agaccacgtg cccaagcttc actacctggt ggctgtggat
     1021 gaggctgtgc acaccttgga agacctggtc aagtgcatca gcaaaaatac cggccctgga
     1081 aagatccaga aagtgcccaa agaaaatgct ttcctgacaa aggacttgac acaagagtac
     1141 ctcgaccacc tgctggtcaa cctgagaatg gaagccctgt ttgtgaagga gaactttaac
     1201 atccgctggg tcgcccaaac aggcttcgtg gagaacatca acagcatcct caaagagtac
     1261 aagcaaagcc ggggattact gccaatcaag atctgcatcc ttggtcctcc tgctgtggga
     1321 aaatccagca tctctgaaga gctggccaag tactacaaac tgcatcacat caagatgaag
     1381 gatgtgattg ctgaagccat agccaaactg gaggcgattg tcgcacccaa ggactcagtg
     1441 gaaggagaag aggaaggcga agaggaggag gaggaagaga acgtggatga tgcccaggag
     1501 ctccttgatg gcatcaagga aagcatggag cagaacgcag gtcggctaga agaccaatat
     1561 ataattcgat ttgtgaaaga aaagctcaaa tctatgcctt gtaggaacca aggtttcatt
     1621 ttggatggct tcccaaagac ctatgatcaa gcgaaagacc tgttcaacca ggaagaggaa
     1681 gaggaagaag aagaaatcag aggcaaaata tttccctatg ataaattaat tacacccgag
     1741 tttgtgtgcg gtctggacgc atctgatgag ttcctgaagg agcgggtgat gaatctcccg
     1801 gagagtgtcg tggcaggaac tcactacagc caggaccgat tcctccggtc tctgagccac
     1861 taccgggaca tcaatacaga tgatgagacg gtcttcaact acttcgacga gcttgaaatt
     1921 cacccgatac atatcgatgt aggaaaactt gaagacgccc agaacagact tgctatcaaa
     1981 cagctcatca aagagatcgg gaagcctcgg aattacggct taacagacga agaaaaggca
     2041 gaggaggaga agaaagcagc ggaggaacgc ctggccaagg aggctgctca gacggcagaa
     2101 ctcgaacaca aggaggccat ggagatggcg gagaagatag cccgctggga ggagtggaat
     2161 aaacggctgg aggaagtaaa gcgagaggag agggagctgc tggaggtaca gtccgtcccc
     2221 ctgagaaact acctgatgac gtacgtgatg cccacgctca tgcagggcct caatgaatgc
     2281 tgcaaggtga gacccgaaga ccccgtggat tttctggcag agtatctctt caagaacaat
     2341 cctgaaatgc agtagagcct catcagtgtt gggccacgga acttcagagg gagagcttaa
     2401 gttaaacttg tgatttgaaa aactgctttt aaaaaaatgc ttccctaggg tttttttttg
     2461 gcgggtgggg aggttgggaa tgggagtagc gagggggaat cctaataatg tagaatcatt
     2521 agaaaactac actgcagtga ataactgcta tctcattgaa aggatgtttg gaaagtaaac
     2581 aggaggcaca cttgcattgc tcacagtaaa cacgaggcac acttgcattg ctcacagtaa
     2641 acaccaggca cacttgcatt gctcacagta aacaccaggc acacttgcat ggctcacaga
     2701 tcaatggttt actattactc ttaggtcagt cacaacgctg cacataacac atttgtagta
     2761 acttatgtta caacatgaag ttataggctc caaaggtgtc agaaatgaaa gactttacaa
     2821 tggcccctgc ttgttgaacc tcccatcagg tgtgactgct ttcctgtaag gttgcccgtg
     2881 agtggccagg attctagcca cttagtcaga gaactgaaga gcttatgatg ggacatgcat
     2941 gggtcgaggc aaataatgct acccctgatc accacaaact gcacaaaacc catgtaccgc
     3001 taattaattt ctcagtatag tcatgagttg tgatttctct ccataaaaaa taaaaatctg
     3061 gtaaaatttc tagtattaat tatcctgaag aag
//
