LOCUS       NM_001081277            3034 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus adenylate kinase 5 (Ak5), transcript variant 1, mRNA.
ACCESSION   NM_001081277 NM_153066 XM_884305
VERSION     NM_001081277.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3034)
  AUTHORS   Dzeja,P. and Terzic,A.
  TITLE     Adenylate kinase and AMP signaling networks: metabolic monitoring,
            signal communication and body energy sensing
  JOURNAL   Int J Mol Sci 10 (4), 1729-1772 (2009)
   PUBMED   19468337
  REMARK    Review article
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116720.16 and AC111139.19.
            
            On Jul 21, 2022 this sequence version replaced NM_001081277.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053807.1, SRR1660817.4930.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AC116720.16        92651-92931         c
            282-468             AC116720.16        85367-85553         c
            469-636             AC116720.16        80720-80887         c
            637-806             AC116720.16        78426-78595         c
            807-920             AC116720.16        78226-78339         c
            921-1112            AC116720.16        40709-40900         c
            1113-1203           AC111139.19        66681-66771
            1204-1280           AC111139.19        73332-73408
            1281-1323           AC111139.19        96235-96277
            1324-1368           AC111139.19        100771-100815
            1369-1532           AC111139.19        118425-118588
            1533-1649           AC111139.19        121669-121785
            1650-1841           AC111139.19        127178-127369
            1842-3034           AC111139.19        136110-137302
FEATURES             Location/Qualifiers
     source          1..3034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.16 cM"
     gene            1..3034
                     /gene="Ak5"
                     /note="adenylate kinase 5"
                     /db_xref="GeneID:229949"
                     /db_xref="MGI:MGI:2677491"
     exon            1..281
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1910
                     /gene="Ak5"
                     /EC_number="2.7.4.3"
                     /EC_number="2.7.4.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenylate kinase isoenzyme 5; ATP-AMP transphosphorylase
                     5"
                     /codon_start=1
                     /product="adenylate kinase isoenzyme 5 isoform 1"
                     /protein_id="NP_001074746.1"
                     /db_xref="CCDS:CCDS38675.1"
                     /db_xref="GeneID:229949"
                     /db_xref="MGI:MGI:2677491"
                     /translation="MNTNDAKEYLARRDIPQLFESLLNGLMCSKPEDPIEYLETCLQK
                     VKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIH
                     QFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQY
                     ISVGELLRKKIHSASSNRKWSLIAKIITNGELAPQETTITEIKQKLMQIPDEEGIVID
                     GFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLQKRAEQQGRPDDNLKATQRRLV
                     NFKQNAAPLVKYFQEKGLIVTFDADRDEDAVFHDISVAVDSKLFPNKEAPMDSSDLDP
                     SMMFDAGEIIDTGSDYDNQDDDQLNVFGEDTEGGFMEDLRKCKIIFLMGGPGSGKGTQ
                     CEKLAEKYGFTHLSTGELLRQELTSESERSKLIRDIMERGDLVPSGVVLELLKEAMVA
                     SLGNTKGFLIDGYPREVKQGEEFGRRIGDPHLVICMDCSADTMTNRLLQRSQSSQRGE
                     DGAKSIAKRLEAYHRASIPVVTYYERKTQLRKVNAEGTPEQVFLQLCTAIDSVF"
     exon            282..468
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            469..636
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            637..806
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            807..920
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1112
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1203
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1280
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1323
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1368
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1532
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1649
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1841
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..3034
                     /gene="Ak5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ak5"
                     /note="hexamer: AATAAA"
     polyA_site      3034
                     /gene="Ak5"
                     /note="major polyA site"
ORIGIN      
        1 ggcgctcgcg ctgcctgcgc ccgggaagcc gctgctgctc gctgctggct ggcgcgggga
       61 ccggcgcgga cgcgggggcg acgggagcgc ggactgcaca gctgcccggg agtcgctgag
      121 gggaccccgg cctgagcgca tccaagtgag ggctgcgccc cgccagcccc aacctcggga
      181 gcttcccctc ctgctcccca ctgcacgcgc gccgtacagc catgaacacc aacgacgcca
      241 aggagtacct ggcccggagg gacattcctc agcttttcga gagcctgctc aatggcttga
      301 tgtgttccaa gccagaagac cccatagagt acttggaaac ttgtttacag aaagtcaagg
      361 agctaggagg ctgtgacaag gtgaagtggg acacatttgt cagccaggaa aagaagacgt
      421 taccgcccct aaatggagga caatcacgga gatccttcct ccgaaatgtc atgcctgaaa
      481 attcaaactt tccatatcgg cggtatgacc ggctccctcc aatccaccag ttttccatag
      541 agagtgacac ggacctgtcg gagacggcgg agctgataga agaatatgag gtttttgacc
      601 cgactagacc tcggcccaaa atcattcttg tcataggtgg tccaggaagt ggaaagggta
      661 ctcagagttt gaaaattgca gagcggtatg gattccagta catctcagtg ggagaattat
      721 tgaggaagaa aatccacagt gccagcagca acagaaaatg gagtctgatc gccaagataa
      781 tcaccaatgg ggagctggcc ccacaggaga caacaattac ggagataaaa caaaaattga
      841 tgcaaatacc cgatgaagaa ggcattgtga ttgatggatt cccaagggat gttgcccagg
      901 ctctgtcttt tgaggaccag atctgcaccc ctgacctggt ggtgttcctg gcttgtgcca
      961 accagaggct caaggagagg ttacagaagc gtgcggagca gcaggggcgg ccagatgaca
     1021 acctgaaagc aacccaaagg agactagtga acttcaagca gaatgccgcc ccactagtga
     1081 agtacttcca agagaaggga ctcatcgtga cttttgatgc cgaccgagat gaagacgcag
     1141 tgttccatga catcagcgtg gccgtcgaca gcaagctgtt tccaaacaaa gaggctccga
     1201 tggattcaag tgaccttgac ccttccatga tgtttgatgc tggagagatt attgacacag
     1261 gatcagatta cgataaccag gacgatgatc agctaaatgt atttggagaa gacacagagg
     1321 gaggcttcat ggaggatttg aggaagtgta aaattatttt cttgatgggt ggccctggct
     1381 ctggcaaagg cacccagtgt gagaagctgg cagaaaaata tggcttcacc catctctcta
     1441 ctggtgagct cctgcgccag gaactgacct cagagtcaga aagaagcaaa ctgatccgtg
     1501 acatcatgga gcgtggagat ctggtgccct cgggtgtcgt tctggagctg ctgaaggagg
     1561 ccatggtggc cagcctgggc aacaccaagg gcttcctgat tgacggctac ccccgggaag
     1621 tgaagcaagg ggaagagttt ggacgaagga tcggagaccc acacttggtg atctgcatgg
     1681 actgctcagc agacaccatg actaaccgcc ttcttcagag aagccagagc agccagcggg
     1741 gggaggacgg tgccaagagc attgccaagc gcctggaggc ctaccaccga gcgtccatcc
     1801 ccgtcgtcac ctactacgag aggaaaacac agctacggaa ggtaaatgca gagggaacac
     1861 cagagcaagt ttttcttcag ctctgcacag ctattgactc tgttttctga aggagaaaat
     1921 gcacaactaa gtggaaacag aaatacatgg aattcacccg taacaccttt cgctttgtcc
     1981 ccatccccac ccattctcgc tggctgtgtc cttcccagct catctcctga gaggttctgg
     2041 aaatcatgca tggtacactt cggactgtcc acctttctct cgtgctggca attgtcccca
     2101 ctctggcact cgtctttgga tgaaaagagc agtgtgggat ctgcctgttc cagccctgcc
     2161 tcagggccgg ctgcagtctg atccaccaca cagggacagc atatccctat ttctccatca
     2221 cagcttcctc cttctcatgg gcttatttgt tcctccctga tgtgggttgt tagcatgggg
     2281 acaggcttgg acacctcatc tggtactggc tgcttcctca gttcccatcc atgagagggc
     2341 ccggagccct agtgggcctt ttaaatgtcc tatgggatac aaggtaccaa gccagtggaa
     2401 cctgacagaa atatttcaaa atggcattga tcagcttctc ttagagagca aagcccagac
     2461 aatcagtccc acccactctg ggacactagc tattttgaac agtgtcatag atgctaacaa
     2521 ctctggccaa gcctacaagc cgctcctctc cacatggcag ttcggctcag caattatgta
     2581 ctttagtacc agagaccaga gatcatttaa aagaatgaga gatgatgtta cttcactcac
     2641 tggacaaaac caacttgtag ttttgatctg agacaattac tccctgacat actgccaaat
     2701 aaaaaggaag gaacaatctc tcaaccgatg ccagggaggg cacgcctaga acacggtgtc
     2761 cggcagcgcc tgtgttgtgc ctgtgtcaag ggcctgctcc gtgagtaaat gcatcccagc
     2821 gtgaagcgtg ggtgttttgt gcagagttgc ttgtgtcttc tgaaacccct gcatcttgca
     2881 ctcggtcacc accacattca gtttggtttg catgactctt tcctcaatga gtgagcaaac
     2941 actggtatgg ttccaggaca caactgtatt tttaaaatca ttttttttcc tcaaaacatt
     3001 tatgtacaaa tgaaataaat ggaagccagg atga
//
