LOCUS       NM_009647               4894 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus adenylate kinase 4 (Ak4), transcript variant 4, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_009647 XM_915287
VERSION     NM_009647.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4894)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4894)
  AUTHORS   Chin,W.Y., He,C.Y., Chow,T.W., Yu,Q.Y., Lai,L.C. and Miaw,S.C.
  TITLE     Adenylate Kinase 4 Promotes Inflammatory Gene Expression via
            Hif1alpha and AMPK in Macrophages
  JOURNAL   Front Immunol 12, 630318 (2021)
   PUBMED   33790902
  REMARK    GeneRIF: Adenylate Kinase 4 Promotes Inflammatory Gene Expression
            via Hif1alpha and AMPK in Macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4894)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   4  (bases 1 to 4894)
  AUTHORS   Ouseph,M.M., Li,J., Chen,H.Z., Pecot,T., Wenzel,P., Thompson,J.C.,
            Comstock,G., Chokshi,V., Byrne,M., Forde,B., Chong,J.L., Huang,K.,
            Machiraju,R., de Bruin,A. and Leone,G.
  TITLE     Atypical E2F repressors and activators coordinate placental
            development
  JOURNAL   Dev Cell 22 (4), 849-862 (2012)
   PUBMED   22516201
REFERENCE   5  (bases 1 to 4894)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   6  (bases 1 to 4894)
  AUTHORS   Yoneda,T., Sato,M., Maeda,M. and Takagi,H.
  TITLE     Identification of a novel adenylate kinase system in the brain:
            cloning of the fourth adenylate kinase
  JOURNAL   Brain Res Mol Brain Res 62 (2), 187-195 (1998)
   PUBMED   9813319
REFERENCE   7  (bases 1 to 4894)
  AUTHORS   Sheldon,M., Rice,D.S., D'Arcangelo,G., Yoneshima,H., Nakajima,K.,
            Mikoshiba,K., Howell,B.W., Cooper,J.A., Goldowitz,D. and Curran,T.
  TITLE     Scrambler and yotari disrupt the disabled gene and produce a
            reeler-like phenotype in mice
  JOURNAL   Nature 389 (6652), 730-733 (1997)
   PUBMED   9338784
REFERENCE   8  (bases 1 to 4894)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   9  (bases 1 to 4894)
  AUTHORS   Spies,T. and DeMars,R.
  TITLE     Restored expression of major histocompatibility class I molecules
            by gene transfer of a putative peptide transporter
  JOURNAL   Nature 351 (6324), 323-324 (1991)
   PUBMED   2034277
REFERENCE   10 (bases 1 to 4894)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ087385.1, BC086663.1, AK004491.1, AL845364.4 and AV023306.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_009647.6.
            
            On Apr 20, 2010 this sequence version replaced NM_009647.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086663.1, D85036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               CJ087385.1         1-377
            378-4118            BC086663.1         326-4066
            4119-4541           AK004491.1         837-1259
            4542-4687           AL845364.4         126794-126939       c
            4688-4894           AV023306.1         101-307
FEATURES             Location/Qualifiers
     source          1..4894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 46.84 cM"
     gene            1..4894
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e"
                     /note="adenylate kinase 4"
                     /db_xref="GeneID:11639"
                     /db_xref="MGI:MGI:87979"
     exon            1..263
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..790
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e"
                     /EC_number="2.7.4.10"
                     /EC_number="2.7.4.6"
                     /note="adenylate kinase 3 alpha-like 1; adenylate kinase
                     isoenzyme 4, mitochondrial; ATP-AMP transphosphorylase;
                     adenylate kinase 3-like 1; GTP:AMP phosphotransferase AK4,
                     mitochondrial"
                     /codon_start=1
                     /product="adenylate kinase 4, mitochondrial"
                     /protein_id="NP_033777.1"
                     /db_xref="CCDS:CCDS18394.1"
                     /db_xref="GeneID:11639"
                     /db_xref="MGI:MGI:87979"
                     /translation="MASKLLRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENL
                     KTGTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHWLLDGFPRTLVQAEALDG
                     ICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVQGIDDITGEPLVQQE
                     DDKPEAVAARLRRYKDAAKPVIELYKSRGVLHQFSGTETNRIWPYVYTLFSNKITPIQ
                     SKEAY"
     exon            264..383
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e"
                     /inference="alignment:Splign:2.1.0"
     exon            384..556
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e"
                     /inference="alignment:Splign:2.1.0"
     exon            557..675
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e"
                     /inference="alignment:Splign:2.1.0"
     exon            676..4894
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak-3; Ak-4; Ak3; Ak3l1; D4Ertd274e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttaaagcct ctcctttccc ctgtaggggt ggcaggcgag tccccgcgtg cggagggtgt
       61 cgaggcaggg gctgctgggc aaagtgcgcg ggctgccgtc ctggccaccg ccaaagccat
      121 ggcttccaaa ctcctgcgcg cggtcatcct cgggccgccc ggctctggca agggcaccgt
      181 ttgcgaaagg atcgcccaga actttggcct ccagcatctc tccagcggcc acttgttgcg
      241 ggagaacctc aagaccggca cggaagttgg tgacgtggca aaacagtacc tagaaaaagg
      301 tcttttggtt ccagatcacg tgatcacacg cctaatgatg tcagaactgg agactcggag
      361 tgcccagcac tggctgttag atggattccc gaggacatta gtacaggcag aagccctgga
      421 cggaatctgt gatgtggacc tagtaatcag tttgaatatt ccttttgaga cacttaaaga
      481 tcgtctgagc cgacggtgga ttcacccttc tagcgggagg gtctataacc tggacttcaa
      541 cccacctcaa gtgcagggga ttgatgacat cactggtgag ccacttgtcc aacaggaaga
      601 tgataaacct gaagcagttg ctgccaggct aagacggtac aaggatgcgg caaaaccagt
      661 catcgaactg tacaagagcc gtggagtgct ccaccagttt tctgggacgg agactaacag
      721 aatctggcct tatgtttaca cacttttctc caacaagatc acacctattc aatccaaaga
      781 agcctactga gcctgccatg ggaagaacca agaagacgtg gtcgcccact cgatcacacg
      841 tgtcgtcttg gtgacctggc ccagttagaa gccagctgag atagcttgca gcatcttttc
      901 tagtttcagt gatgaagtaa tgaggaaact ctagtaggta gaaggaattc aggaggaagg
      961 aaaccctcct ctgcctttga aaggggctct gcgggtgcat cacgcccttc acaggaacga
     1021 gtatagactg gatctccacc agtgttgagc cacgtgctag ctatcagagc ctttttgcat
     1081 gcagtggtgg gctctttggt ttatcccacc ttccacaggc tatgaaacca cagcgctgta
     1141 tgcctgagca cttgaagggc tgtggtcctg gcttgtccat tgccatatgc tctgacaagt
     1201 tgacgctaat tgcactcggt ggttgctttt ctccaatgac tgtctctccc tggctctcag
     1261 acatcctcgt ttctgttgtc tgaatcttct cgtctgcttg ctcccttctc aggctattca
     1321 gtctcatgat ggcttctgca tttacccctc gaatttcctt tatacaaact gagaagtagg
     1381 tgactgggtt cagtcttttc cttcttccta ggcactgatc caggtagaag gcttacttgg
     1441 ttaaacagct gctctatctt gagcccactc tgtacctttt attgtttaaa aaaagatccc
     1501 cccaaagtct tcagggttct caaaaaacaa gggaaatgct tacttatgga aaagtggggt
     1561 gattgtatct tctatgtaga agtagtagta attgtatgga aatcactgga ctaatgagat
     1621 ggttgggtgc aagaaaagat gaatattgaa catgctgcta aatattaacg ctgtcagtgt
     1681 ttttcttctg tgagtgacta accagacggc gagaggtcag aaaagggagc aagcctctga
     1741 ggcttggagc atcttgcact agctatacac agcacctgca ctgagtaaga cagctttact
     1801 gttgtgggga tgcagagtcc ttttgtttgt tttcttccta ttccaaagat gcagtctata
     1861 ggtggtcata aagtccagaa atgaagatac taaggtctta tcagtcattg tgtgtcaaga
     1921 aagcatttgt gaagactttc cttcctggat ctcagacttg ctggccacct tgttacaatt
     1981 tttattcttt tctgggaaga acagggaaat ttcttcccac tgccttaaaa aggtgtcctg
     2041 cacctgcctg tccccaggag gtggtctttt attactggtg gtgacttagt gtgacatctc
     2101 atagtctgtg tggggtcagg gtatggggtg ggcttagcac tttagtggat tgagacatta
     2161 ttccattctg aaggtgtcgt gtgttctgtg ctcctgagtc tgtctgcctt cctgtactac
     2221 ctggactccc atggttcctc tcagtcgttt ttttcatgtg catgttctgc ggctgcctta
     2281 gtggagatgc aggccagcat tcccactcgt gttctcagta cagagaagta agcttccaga
     2341 gtgcagctgc acggggcagg tgaccatctg ggcagtgtcg tgatgcagag caccttggaa
     2401 gcttacatct ggatgtcact tggtaggggt tgggtgataa aagcccaggc ttcctggagg
     2461 ggcaggtcgg gagtgggaaa ccctgagatt attcccagga accaagggaa gtagggagtt
     2521 aaagggattc agggtaattc aagagaggta ggaaaacttc aaacttttct tcccctcttg
     2581 tggagtctgg ggagaacaat agggtgtgag cagctccttg cctgcacact gctgtttctc
     2641 tatgcagttc aagctcagta gactacggta gccccagtgg gacaccaggc tcagaagagc
     2701 agcaaggggc aaagacatct tttccaaagt cttgggtgat ttcatgtcta tgggtgtaaa
     2761 ggtgttttct gcagcaggct tggctgattt tgtggaaatg gtcataaata ctgaccgtgt
     2821 cttgacaaag gtgcaatgga agcagcatct ttgccttctc aggcgacaca tggccaagag
     2881 tctgggtgct ctctgaggtt ctgactttac attcatggac tccccgttca gcttgcatcc
     2941 cacaggcctc atgggaaagg ctgcatgttt attcctccag tatttatgac aaaaaaggtg
     3001 ctatgaagga ggccctctga gtaaagtgcg cactctccgg acctttataa gcattgtggt
     3061 gaatcttccc aggcacaacc aatatttcct ataaacaaga gtccaggata tgaagtcttg
     3121 cccaggctct tcatatgagt aaacactaaa gctatgattc agtcccaggt tttcctgctt
     3181 ctgaaaccct tggcctttta caggatgtta tttgtctgtc ttgacctaag caacctgggg
     3241 ccatgagcct gcttaggtct gcttgtggcc tcagggagag tggctgcgtg aggctatttc
     3301 tttttatgct ctttgcctaa gcaaaaggag ttcccagaca caagacgtta aggcaggctg
     3361 ggtttagacc aggtcaatct gcctcaattc taggcgtcag gaagccatat gaaagctgac
     3421 atctactgaa acattaaaat taaccataac ggttaccctt atttttggtg tggcaaactg
     3481 cacaattctt gccagaacaa atgccatcaa ctgcctcagg gcactccttg gtttgactgt
     3541 tctttatgtg gttgggtgtg agggagacag gaagccattg cccaggactc catcctgact
     3601 ccctctagtg acagacagga agcacagtgt cttttaataa aaggctcctg tttaaaacct
     3661 ttgcagggag taccgcacct tctctctggg atttgggaaa agggaagaaa aattgaaaac
     3721 cccaggctct gtgtggactg caagaaatgg tagagctcaa ggcttctcta gtcttatgag
     3781 aacttgtact actgaatttg cgaattttgt ttttttgagc tggaccgatc tctgggggac
     3841 gacgttgagc taggatggca tttcactgtg atcccccaag ttcaagccag tctttaactc
     3901 agtgttggct taagtttccc tggagctggc acgtcagctt ttcttcagtg acagttggtg
     3961 ttcctcttga tttgggtata tgtgcttagt tcagagtctg ttctgtatct gctatcctaa
     4021 ctattcattg tattcattga tttttgtttt gttttgttac cttgcttgaa gattgatttg
     4081 tattgaattt gatagaaata aatgtttttt ccgcttaata tgtgatggaa tttcataaat
     4141 gcattattct ctgttttgct gtttataccc tgtaaagctt cacaggctct ctctgatttg
     4201 taccacttgg gagttcttct gttatccaca gttgtcgata atctgcaaaa agaggcaaac
     4261 agtgtaacaa cctacacaaa gtaatgatgg tgaagcaaac atgcctcggg ttctgtttgt
     4321 tttcccactg tatcgttgct atgtccttgt gccctcctgt tccctgcttg ccccgtcctt
     4381 tacctgttaa acccggagcc ctttgcgagg ttgtctgctg aactggggct gtaagaagtt
     4441 cctaagtgcc ctttcagaag aaacctgaga gaatgaaggc atagcccttt tcccaaccct
     4501 ggtatggccg cctcatctat ggggccttcc atagctgaaa cccactgaaa gcaagttcta
     4561 aactcacgtg tccaggcagg atcggaaagt ccatctggat aggatgactg tgtggtaggt
     4621 tgtcatatgg tcgagatact cacactccct cactgggaga agtttacatc cctgctctct
     4681 gggcttctgc atactggggc attcattgcc ttgctggggg cattaaaatg agtagataca
     4741 ctgtgccact ttagagctgg tactggaaga gtcagaggtc ttgtagtgat atgggcaatg
     4801 ctatggattc ttaaggggga aacagagagc agacatgtac ccagtccata atgggcgagt
     4861 agtatctgaa aataaaattg gggttttaaa agcc
//
