LOCUS       NM_016895               1781 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus adenylate kinase 2 (Ak2), transcript variant 2, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_016895 XM_913616 XM_922826 XM_922831 XM_922834
VERSION     NM_016895.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Ito,C., Makino,T., Mutoh,T., Kikkawa,M. and Toshimori,K.
  TITLE     The association of ODF4 with AK1 and AK2 in mice is essential for
            fertility through its contribution to flagellar shape
  JOURNAL   Sci Rep 13 (1), 2969 (2023)
   PUBMED   36804949
  REMARK    GeneRIF: The association of ODF4 with AK1 and AK2 in mice is
            essential for fertility through its contribution to flagellar
            shape.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Kim,H., Jeong,M., Na,D.H., Ryu,S.H., Jeong,E.I., Jung,K., Kang,J.,
            Lee,H.J., Sim,T., Yu,D.Y., Yu,H.C., Cho,B.H. and Jung,Y.K.
  TITLE     AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis
  JOURNAL   Cell Death Dis 13 (5), 469 (2022)
   PUBMED   35585049
  REMARK    GeneRIF: AK2 is an AMP-sensing negative regulator of BRAF in
            tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Zhang,S., Yamada,S., Park,S., Klepinin,A., Kaambre,T., Terzic,A.
            and Dzeja,P.
  TITLE     Adenylate kinase AK2 isoform integral in embryo and adult heart
            homeostasis
  JOURNAL   Biochem Biophys Res Commun 546, 59-64 (2021)
   PUBMED   33571905
  REMARK    GeneRIF: Adenylate kinase AK2 isoform integral in embryo and adult
            heart homeostasis.
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Liu,H., Pu,Y., Amina,Q., Wang,Q., Zhang,M., Song,J., Guo,J. and
            Mardan,M.
  TITLE     Prognostic and therapeutic potential of Adenylate kinase 2 in lung
            adenocarcinoma
  JOURNAL   Sci Rep 9 (1), 17757 (2019)
   PUBMED   31780678
  REMARK    GeneRIF: Prognostic and therapeutic potential of Adenylate kinase 2
            in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Vadnais,M.L., Cao,W., Aghajanian,H.K., Haig-Ladewig,L., Lin,A.M.,
            Al-Alao,O. and Gerton,G.L.
  TITLE     Adenine nucleotide metabolism and a role for AMP in modulating
            flagellar waveforms in mouse sperm
  JOURNAL   Biol Reprod 90 (6), 128 (2014)
   PUBMED   24740601
  REMARK    GeneRIF: In addition to AK1 and AK2, which we previously
            demonstrated are present in outer dense fibers and mitochondrial
            sheath of the mouse sperm tail, we show that another AK, AK8, is
            present in a third flagellar compartment, the axoneme.
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Tanabe,T., Yamada,M., Noma,T., Kajii,T. and Nakazawa,A.
  TITLE     Tissue-specific and developmentally regulated expression of the
            genes encoding adenylate kinase isozymes
  JOURNAL   J Biochem 113 (2), 200-207 (1993)
   PUBMED   8468325
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Homologous genes for enolase, phosphogluconate dehydrogenase,
            phosphoglucomutase, and adenylate kinase are syntenic on mouse
            chromosome 4 and human chromosome 1p
  JOURNAL   Proc Natl Acad Sci U S A 75 (5), 2382-2386 (1978)
   PUBMED   209463
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607086.19.
            
            On Sep 21, 2012 this sequence version replaced NM_016895.3.
            
            Transcript Variant: This variant (2) contains an alternate 3'
            terminal exon, compared to variant 1. It encodes isoform b which
            has a shorter C-terminus, compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008610.1, AK168056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AL607086.19        131468-131680
            214-339             AL607086.19        137378-137503
            340-450             AL607086.19        140395-140505
            451-545             AL607086.19        140618-140712
            546-618             AL607086.19        145957-146029
            619-814             AL607086.19        146278-146473
            815-1781            AL607086.19        148807-149773
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.62 cM"
     gene            1..1781
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /note="adenylate kinase 2"
                     /db_xref="GeneID:11637"
                     /db_xref="MGI:MGI:87978"
     exon            1..213
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..819
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /EC_number="2.7.4.3"
                     /note="isoform b is encoded by transcript variant 2;
                     adenylate kinase 2, mitochondrial; AK 2; ATP-AMP
                     transphosphorylase 2; ATP:AMP phosphotransferase;
                     adenylate monophosphate kinase"
                     /codon_start=1
                     /product="adenylate kinase 2, mitochondrial isoform b"
                     /protein_id="NP_058591.2"
                     /db_xref="CCDS:CCDS18679.1"
                     /db_xref="GeneID:11637"
                     /db_xref="MGI:MGI:87978"
                     /translation="MAPNVLASEPEIPKGIRAVLLGPPGAGKGTQAPKLAENFCVCHL
                     ATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLLDGFP
                     RTVRQAEMLDDLMEKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPK
                     EPMKDDITGEPLIRRSDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDI
                     VFASILAAFSKATS"
     exon            214..339
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /inference="alignment:Splign:2.1.0"
     exon            340..450
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /inference="alignment:Splign:2.1.0"
     exon            451..545
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /inference="alignment:Splign:2.1.0"
     exon            546..618
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /inference="alignment:Splign:2.1.0"
     exon            619..814
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1781
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1758..1763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /note="hexamer: AATAAA"
     polyA_site      1781
                     /gene="Ak2"
                     /gene_synonym="Ak-2; D4Ertd220e"
                     /note="major polyA site"
ORIGIN      
        1 agagagggtt gacggatgcg gcgagcgacc agtgtgagcc cggagtagga tgtacgctgg
       61 cctggaagcg ctagacctgt gaggtgtgcg gctggctgtt ggagtgaagc tttggaagac
      121 atggctccca acgtgttggc ttccgaaccg gagattccga agggcatccg ggccgtgttg
      181 ctggggccgc ccggggctgg caaggggacg caggcaccca aactggctga aaacttttgt
      241 gtctgtcatt tggccaccgg ggacatgctg agagccatgg tagcttctgg ctcagagcta
      301 ggaaaaaagc tgaaggcgac aatggatgca gggaaactgg tgagtgacga aatggttgtg
      361 gagctaattg agaagaattt ggagactcct tcgtgcaaaa atggctttct tctagatggc
      421 ttccctcgga ctgtgaggca ggctgaaatg cttgatgacc tcatggagaa gaggaaagag
      481 aagctcgatt cagtcattga gttcagcatc caagactcgc tgctgatccg gaggatcact
      541 gggaggctga ttcaccccaa gagtggccgg tcctaccatg aggaattcaa ccctccaaag
      601 gagcccatga aagatgatat cactggggag cccctgatcc gcaggtcaga tgacaacgag
      661 aaagccttga agacccgcct ggaggcctac cacactcaga ccactccgct cgtggagtac
      721 tacaggaaac gcggcattca ctgcgccatc gatgcgtccc agacccctga catcgtgttt
      781 gcgagcatcc tggcagcctt ctccaaagcc acatcctagt aacagaaggc caggcgagac
      841 cgcacccctg ctcatctccc cgccgtggga tccctgctct taggtgctgg gcagagggaa
      901 gagggtggtc atgggaagga aggatggatg gatggtgagg gaggtgggga ggggctcctc
      961 gagagaagat tggaacagtg gcagtgttat aattagtaag gttttttttt tttacacata
     1021 gatgagaatt tttaaagtat aagcaaggga aaagattaat ttaaaaaaaa aaaaaaactg
     1081 tgattggagt gcattggtgc agataaggag acatggtatt atttttaagc agtcagcctc
     1141 tgcttttctc tggaccacaa agctaatgct ctctaagaga cctcagcttc tacataagaa
     1201 cctcatggat ccccaggccc agagcacagc agtcaggctg ggcctgtgca tcccgtgcag
     1261 aggagggggc tgctgactgc cgggggctcc ccactccata aagcgagaag actgacctgc
     1321 gcggatggaa gagacggggt gtgaggttat gggtgccgct cagcagacca tctctcctgg
     1381 aattgtgggg agcaagggga aacagatccc acacttaaga cttcagagtt gcttgctcta
     1441 gtgacaaagc cttcagccac tcagcactcc ctagtcttaa aaccttgcct tcattcatcc
     1501 acgggaccct tttagataac tgaacaaggc ctaggagtgt agctcagtgg cgtgtgtgtg
     1561 cctggctctg taaagccccg gcttcagtcc tctacaggga agggttgggg gaaaagctaa
     1621 aatgtcttaa gctaagtcat ccaaggattg tccccctcac ctcctgggac tgggattgcc
     1681 cgacaacact gtgatgtatt tctcaatgag gtgcctttca taactgacca aatgctgcca
     1741 tgtttggccc ctgagtcaat aaaatatgtt gaaaatttgt a
//
