LOCUS       NM_001198791            2088 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Mus musculus adenylate kinase 1 (Ak1), transcript variant 3, mRNA.
ACCESSION   NM_001198791
VERSION     NM_001198791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Ito,C., Makino,T., Mutoh,T., Kikkawa,M. and Toshimori,K.
  TITLE     The association of ODF4 with AK1 and AK2 in mice is essential for
            fertility through its contribution to flagellar shape
  JOURNAL   Sci Rep 13 (1), 2969 (2023)
   PUBMED   36804949
  REMARK    GeneRIF: The association of ODF4 with AK1 and AK2 in mice is
            essential for fertility through its contribution to flagellar
            shape.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Rodriguez,C., Sanchez,A., Saenz-Medina,J., Munoz,M., Hernandez,M.,
            Lopez,M., Rivera,L., Contreras,C. and Prieto,D.
  TITLE     Activation of AMP kinase ameliorates kidney vascular dysfunction,
            oxidative stress and inflammation in rodent models of obesity
  JOURNAL   Br J Pharmacol 178 (20), 4085-4103 (2021)
   PUBMED   34192805
  REMARK    GeneRIF: Activation of AMP kinase ameliorates kidney vascular
            dysfunction, oxidative stress and inflammation in rodent models of
            obesity.
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Xie,M., Zhang,G., Zhang,H., Chen,F., Chen,Y., Zhuang,Y., Huang,Z.,
            Zou,F., Liu,M., An,G., Kang,X. and Chen,Z.
  TITLE     Adenylate kinase 1 deficiency disrupts mouse sperm motility under
            conditions of energy stressdagger
  JOURNAL   Biol Reprod 103 (5), 1121-1131 (2020)
   PUBMED   32744313
  REMARK    GeneRIF: Adenylate kinase 1 deficiency disrupts mouse sperm
            motility under conditions of energy stressdagger.
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Sharma,N., Kubaczka,C., Kaiser,S., Nettersheim,D., Mughal,S.S.,
            Riesenberg,S., Holzel,M., Winterhager,E. and Schorle,H.
  TITLE     Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of
            Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest
  JOURNAL   Development 143 (5), 787-798 (2016)
   PUBMED   26811378
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Matsuura,S., Igarashi,M., Tanizawa,Y., Yamada,M., Kishi,F.,
            Kajii,T., Fujii,H., Miwa,S., Sakurai,M. and Nakazawa,A.
  TITLE     Human adenylate kinase deficiency associated with hemolytic anemia.
            A single base substitution affecting solubility and catalytic
            activity of the cytosolic adenylate kinase
  JOURNAL   J Biol Chem 264 (17), 10148-10155 (1989)
   PUBMED   2542324
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Womack,J.E. and Moll,Y.D.
  TITLE     Gene map of the cow: conservation of linkage with mouse and man
  JOURNAL   J Hered 77 (1), 2-7 (1986)
   PUBMED   3082971
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   Satoh,H. and Yoshida,M.C.
  TITLE     Gene mapping in the Chinese hamster and conservation of syntenic
            groups and Q-band homologies between Chinese hamster and mouse
            chromosomes
  JOURNAL   Cytogenet Cell Genet 39 (4), 285-291 (1985)
   PUBMED   3863747
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY130582.1 and BC014802.1.
            
            Transcript Variant: This variant (3) differs at the 5' UTR and 5'
            coding region, compared to variant 1. The encoded protein (isoform
            2) has a shorter, distinct N-terminus compared to isoform 1.
            Variants 2, 3, and 4 encode the same protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014802.1, AK089270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY130582.1         2-57
            57-1218             BC014802.1         1-1162
            1219-2088           BC014802.1         1164-2033
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..2088
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /note="adenylate kinase 1"
                     /db_xref="GeneID:11636"
                     /db_xref="MGI:MGI:87977"
     exon            1..102
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            103..140
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..718
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /EC_number="2.7.4.3"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.4.4"
                     /note="isoform 2 is encoded by transcript variant 3;
                     cytosolic adenylate kinase"
                     /codon_start=1
                     /product="adenylate kinase isoenzyme 1 isoform 2"
                     /protein_id="NP_001185720.1"
                     /db_xref="CCDS:CCDS57167.1"
                     /db_xref="GeneID:11636"
                     /db_xref="MGI:MGI:87977"
                     /translation="MEEKLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLR
                     AEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVDSSNGFLIDGYPREVKQG
                     EEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPV
                     ISFYDKRGIVRKVNAEGTVDTVFSEVCTYLDSLK"
     exon            141..176
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            177..340
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            341..457
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            458..649
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            650..2067
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /note="hexamer: AATAAA"
     regulatory      2046..2051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /note="major polyA site"
     polyA_site      2067
                     /gene="Ak1"
                     /gene_synonym="Ak-1; B430205N08Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgcgtgcgc gctgacagcc ttataaatag tcgcctttgc aggcggctga gaggacaggc
       61 agggcactca ctggccccag cgcccaccac accctccccc agagtgctga cctagctccc
      121 agatctcagc aggatggaag agaagctgaa gaaggccaag atcatctttg tggtgggcgg
      181 acctggctca ggaaagggca cccagtgcga gaagattgta cagaaatatg gctacaccca
      241 cctgtctact ggggacctgc ttcgggcaga agtcagctct ggatcggaga ggggcaagaa
      301 gctgtcggct atcatggaga agggagagct agtgccactg gacacggtgc tggacatgct
      361 ccgagatgct atgttagcca aagtggattc ttccaatggc ttcctgatcg acggctaccc
      421 gagggaggtg aaacagggag aagaatttga acagaagatt ggacagccca cactgctgct
      481 gtatgtggac gcaggcgccg agaccatgac ccaacgactc ctgaagcgag gggagaccag
      541 tggccgcgtg gatgacaacg aggagaccat caagaagcgg ctggagactt attacaatgc
      601 cacagaacct gtcatctcct tctatgacaa gcgtggcatt gtgcgcaagg tcaatgccga
      661 aggcacggtg gacactgtct tctctgaggt ctgcacctat cttgactccc tgaagtaact
      721 ggatcccttg gccagctccc agcccgcccc acccttgctc cctgacccca ggcagcctgg
      781 ctcaagccca gcacctccac cctgccgggc tgtgcacaga cacaggaagc catgttatcc
      841 tgtcccatgg acactaaaga aattgccaag gagggttagg attgctcctt tcctttgctt
      901 ccagttatgg tgattcatgc tgccacagcc ggaggcccca gcgtggccgg cccattcttc
      961 cctgtgcctc agcccagctg tcttgtctcc ctctggctct gctgggatcc taggcccttc
     1021 cttagccagg ctgtgtcaaa gcctaggggt ccctgggttg gcaggctgct ctggggggtc
     1081 tggtgttcac cctgtttctc atagcctcgt tgtgtggctt tggccctaag ccattgtctc
     1141 tctggagtga gttttctttt tttctttctt tctttttctt ttttttcttt ctctgtttct
     1201 ttcttttttt ttttttttaa gacagcatct cgtgtgactt aagctggcct caaccctgtt
     1261 atgtaactaa gggcaacctt aatccttctg cctccacttg tcttcctgtg tgctgagatt
     1321 acaggtgtgt gtgtggacct ccaccactcc tggttttggg ggcactggga atcaagccca
     1381 tggccctgta tacgaggcca gcacgctaca gagtgagctg catcccgggc tgggcaggtt
     1441 ttctgtgcct gactggggtc tggcatgggc aaagggcaaa gggccatggg ctcaccagct
     1501 ggggccacgt ggtcactggg tgccaaggag ctgtgcaatg ggcatacagc taggtgggaa
     1561 gctggggtca ggggtggcct tcctgaagaa ggctcccttg gtatagacct gccaggcctt
     1621 gccatccttt ggctggtttt aaagcttgtc ctgtcacgct atgtcccaac ccttatcctc
     1681 ggcgttaaga caagagcatg cagattaagg agtgtgagct gccatagaca aggatgtggg
     1741 atcaaggacc aggcctggga cccggagagg acacccaggg atgccaagaa gagctggcat
     1801 ctctcttctg ctctttattc tttggtctca ttacacagga agcctctgtt ggtactcact
     1861 tgtcctgggg ccccgtctcc atccctagtg acttcccctg taagcccaga tagcctgtaa
     1921 gccagcagcc atggctgtcc cagggacacc tgcccctggg ggtgacggtg ctcactcctt
     1981 tctgtttact accagtgggg ccacctttcc ttctgcattg cctatttaag ctgtccttta
     2041 aaataaataa atgtatttca gttataaaaa aaaaaaaaaa aaaaaaaa
//
