LOCUS       NM_010590               3503 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ajuba LIM protein (Ajuba), mRNA.
ACCESSION   NM_010590
VERSION     NM_010590.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3503)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3503)
  AUTHORS   Dommann,N., Gavini,J., Sanchez-Taltavull,D., Baier,F.A., Birrer,F.,
            Loforese,G., Candinas,D. and Stroka,D.
  TITLE     LIM protein Ajuba promotes liver cell proliferation through its
            involvement in DNA replication and DNA damage control
  JOURNAL   FEBS Lett 596 (14), 1746-1764 (2022)
   PUBMED   35535434
  REMARK    GeneRIF: LIM protein Ajuba promotes liver cell proliferation
            through its involvement in DNA replication and DNA damage control.
REFERENCE   3  (bases 1 to 3503)
  AUTHORS   Ponia,S.S., Robertson,S.J., McNally,K.L., Subramanian,G.,
            Sturdevant,G.L., Lewis,M., Jessop,F., Kendall,C., Gallegos,D.,
            Hay,A., Schwartz,C., Rosenke,R., Saturday,G., Bosio,C.M.,
            Martens,C. and Best,S.M.
  TITLE     Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1
            signaling, PKR-dependent inflammation, and viral invasion of
            tissues
  JOURNAL   Cell Rep 37 (4), 109888 (2021)
   PUBMED   34706234
  REMARK    GeneRIF: Mitophagy antagonism by ZIKV reveals Ajuba as a regulator
            of PINK1 signaling, PKR-dependent inflammation, and viral invasion
            of tissues.
REFERENCE   4  (bases 1 to 3503)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3503)
  AUTHORS   Loganathan,S.K., Schleicher,K., Malik,A., Quevedo,R., Langille,E.,
            Teng,K., Oh,R.H., Rathod,B., Tsai,R., Samavarchi-Tehrani,P.,
            Pugh,T.J., Gingras,A.C. and Schramek,D.
  TITLE     Rare driver mutations in head and neck squamous cell carcinomas
            converge on NOTCH signaling
  JOURNAL   Science 367 (6483), 1264-1269 (2020)
   PUBMED   32165588
REFERENCE   6  (bases 1 to 3503)
  AUTHORS   Feng,Y. and Longmore,G.D.
  TITLE     The LIM protein Ajuba influences interleukin-1-induced NF-kappaB
            activation by affecting the assembly and activity of the protein
            kinase Czeta/p62/TRAF6 signaling complex
  JOURNAL   Mol Cell Biol 25 (10), 4010-4022 (2005)
   PUBMED   15870274
  REMARK    GeneRIF: This paper presents evidence indicating that the human and
            mouse Ajuba is a new cytosolic component of the IL-1 signaling
            pathway, influencing the assembly and activity of the
            aPKC/p62/TRAF6 multiprotein signaling complex.
REFERENCE   7  (bases 1 to 3503)
  AUTHORS   Kisseleva,M., Feng,Y., Ward,M., Song,C., Anderson,R.A. and
            Longmore,G.D.
  TITLE     The LIM protein Ajuba regulates phosphatidylinositol
            4,5-bisphosphate levels in migrating cells through an interaction
            with and activation of PIPKI alpha
  JOURNAL   Mol Cell Biol 25 (10), 3956-3966 (2005)
   PUBMED   15870270
REFERENCE   8  (bases 1 to 3503)
  AUTHORS   Pratt,S.J., Epple,H., Ward,M., Feng,Y., Braga,V.M. and
            Longmore,G.D.
  TITLE     The LIM protein Ajuba influences p130Cas localization and Rac1
            activity during cell migration
  JOURNAL   J Cell Biol 168 (5), 813-824 (2005)
   PUBMED   15728191
REFERENCE   9  (bases 1 to 3503)
  AUTHORS   Marie,H., Pratt,S.J., Betson,M., Epple,H., Kittler,J.T., Meek,L.,
            Moss,S.J., Troyanovsky,S., Attwell,D., Longmore,G.D. and Braga,V.M.
  TITLE     The LIM protein Ajuba is recruited to cadherin-dependent cell
            junctions through an association with alpha-catenin
  JOURNAL   J Biol Chem 278 (2), 1220-1228 (2003)
   PUBMED   12417594
REFERENCE   10 (bases 1 to 3503)
  AUTHORS   Goyal,R.K., Lin,P., Kanungo,J., Payne,A.S., Muslin,A.J. and
            Longmore,G.D.
  TITLE     Ajuba, a novel LIM protein, interacts with Grb2, augments
            mitogen-activated protein kinase activity in fibroblasts, and
            promotes meiotic maturation of Xenopus oocytes in a Grb2- and
            Ras-dependent manner
  JOURNAL   Mol Cell Biol 19 (6), 4379-4389 (1999)
   PUBMED   10330178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164433.4.
            
            On Mar 24, 2011 this sequence version replaced NM_010590.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011035.1, SRR15390195.435355.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1430              AC164433.4         5774-7203
            1431-1532           AC164433.4         9942-10043
            1533-1600           AC164433.4         11602-11669
            1601-1663           AC164433.4         11772-11834
            1664-1794           AC164433.4         12928-13058
            1795-1846           AC164433.4         13139-13190
            1847-1915           AC164433.4         13891-13959
            1916-3503           AC164433.4         14379-15966
FEATURES             Location/Qualifiers
     source          1..3503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.84 cM"
     gene            1..3503
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /note="ajuba LIM protein"
                     /db_xref="GeneID:16475"
                     /db_xref="MGI:MGI:1341886"
     exon            1..1430
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..2041
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /note="protein ajuba"
                     /codon_start=1
                     /product="LIM domain-containing protein ajuba"
                     /protein_id="NP_034720.2"
                     /db_xref="CCDS:CCDS27093.1"
                     /db_xref="GeneID:16475"
                     /db_xref="MGI:MGI:1341886"
                     /translation="MERLGEKASRLLEKLRLSDSGSAKFGRRKGEASRSGSDGTPGAG
                     KGRLSGLGGPRKSGHRGANGGPGDEPLEPAREQGPLDAERNARGSFEAQRFEGSFPGG
                     PPPTRALPLPLSSPPDFRLETTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGAS
                     GAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGLPLTTAPAGYPGGAPSAYPELHA
                     ALDRLCAHRSVGFGCQESRHSYPPALGSPGALTGAVVGTAGPLERRGAQPGRHSVTGY
                     GDCAAGARYQDELTALLRLTVATGGREAGARGEPSGIEPSGLEESPGPFVPEASRSRI
                     REPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNG
                     SVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGVPF
                     TVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDC
                     RMQLSDEEGCCCFPLDGHLLCHGCHMQRLSARQPSTNYI"
     exon            1431..1532
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1600
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1663
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1794
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1846
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1915
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..3503
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3482..3487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /note="hexamer: AATACA"
     polyA_site      3500
                     /gene="Ajuba"
                     /gene_synonym="Jub"
                     /note="major polyA site"
ORIGIN      
        1 ggaaatcctt gcgcggacac ctcaacccgg ggtgcacacc gcgctccgcc cttcccggaa
       61 agtagatccg gccaggcaga caaaagtttg gagaagttgg gtccgtgcaa gtgagagcca
      121 ggggggcggg ccgggccggc gggcggtggc gcgagcggac gcgtggacag acctgcggag
      181 gacagccgct accgtgggcc ctgccagccg cgcgcggacc ctctcgctgg ggcatgcttc
      241 gggatcgcgg gcacccggca cctgggccgc tcgctgagcc cccgtgagtg acttgcatcc
      301 caggaatccg agccccgggg aactcgagcc cggcctctgg ccgaaacact gcagcgtgcc
      361 gggcgaggag ggggctgcag gccccagatc cgtgggcatg gaacggttag gggagaaagc
      421 cagtcgtctg ctagaaaagt tgagactctc ggactccggc agcgccaagt tcggccgcag
      481 aaagggcgaa gcgagccggt ctgggtctga tgggaccccc ggagcaggca agggacgctt
      541 aagcgggttg gggggaccta ggaagtcagg acaccgtgga gcgaatgggg ggcctggaga
      601 tgaacctttg gaaccggcca gggagcaagg gcccctggac gccgagcgga acgcacgcgg
      661 ctcctttgaa gcgcagcgct tcgaagggtc ctttcccggg gggccgccgc ccactcgagc
      721 cctgcctctg cctctgtcgt cgcctcctga ttttcggctg gagaccacgg ctccagccct
      781 tagccctcgc tccagcttcg ccagtagctc ggccagcgat gcgagcaagc catctagccc
      841 ccggggcagc ctgctgctgg acggagccgg ggccagcgga gccggaggta gccggccgtg
      901 cagcaatcgg accagcggca tcagcatggg ctacgaccag cgccacggga gcccgctgcc
      961 cgcggggccg tgcctattcg gcctcccgct gaccactgct cctgcgggct accctggagg
     1021 ggctccgtcc gcctacccgg agctccacgc tgccctggac cgactatgtg cccatcggtc
     1081 cgtgggattc ggctgccagg agagccgtca ctcgtacccc ccggccctgg gcagccccgg
     1141 agctctaacc ggagccgtgg tgggaacagc gggtcctttg gagagacgtg gggcgcaacc
     1201 cggacgacac tcggttacag gctacgggga ctgcgccgcg ggggcccgtt accaggacga
     1261 gctaacagca ttgctgcgtt tgaccgtggc taccggtggg cgagaagcgg gtgctcgcgg
     1321 ggaaccctcg gggattgagc cgtcgggtct ggaggagtct cctggtccct tcgttccaga
     1381 ggcctcccga tcacggatac gggagccaga ggccagagaa gattactttg gcacctgtat
     1441 caagtgcaac aaaggtatct atgggcagag caatgcctgc caggccctgg acagcctcta
     1501 ccacacccag tgctttgtct gctgctcctg tggacgaact ttgcggtgca aggctttcta
     1561 cagcgtcaat ggctctgtct actgtgagga agactatctg ttttcagggt ttcaggaggc
     1621 agctgagaag tgctgtgtct gcggccactt gattctagag aagatcctcc aggccatggg
     1681 gaagtcctat cacccgggct gcttccgatg catcgtatgt aacaagtgcc tggacggcgt
     1741 ccccttcact gtggacttct ccaaccaggt gtactgtgtt accgactacc acaaaaatta
     1801 cgccccgaaa tgtgcagcct gcggacaacc catcctcccc tcagagggct gtgaggacat
     1861 tgtgagggtg atatccatgg accgtgatta tcactttgag tgctaccact gtgaggactg
     1921 ccgcatgcag ctgagtgacg aggaaggttg ctgctgtttc cctcttgatg gacatttgct
     1981 ctgccacggc tgtcacatgc agcgcctcag tgcccggcag ccctctacca actatatctg
     2041 agctgacgtt actgctgcca ccaccactgt ggagaaactc tctggccagc ggaggcaagg
     2101 agtgtattct gcaatccttg tgaagaggtc tctggggagg ccccgaaggc cagagaccca
     2161 aagatcctaa cattccaaat gggctgcgga ggaggaacct tctggttgcc gggagagttg
     2221 actggtgttc attgcgtgca gcctgtgcta cagtagatgg gatgtagcac acgcaggcgg
     2281 gtttcagtac ttcctgaacg ccagattata atgtattttt ccagtgtatg tttctatata
     2341 cgtcacacaa tgttctggtg ctggatcaca tgagggcatc acagaaacca cccccagtct
     2401 gttgtaccct atgcatggag tcagtggaac ctttcccacg ggatcctatc tttgtctgcg
     2461 ctaagggctg gaagccctgg actttgtgat gagccatttc ttggctctct ccctaaggac
     2521 tagagagctc cccgtgtctg tctgctggga ctgggaccag ctctggggga ccttgctgcc
     2581 tgtgttgcct gtttctcagg gacctgggga ggctaactgg ggcctgtccc tggttgctgt
     2641 tttgctcttc tgggggaaga aatgagcagg tttctggatg tgaaacttgc cggtgagtag
     2701 gatgtccctg aagcatcagg ctagccccac tccccctgtt taagtgcact gagcctgtag
     2761 cccagcatat gtggatacat tgtagccacg tgtgcctgtg cacctccctc cctactcctc
     2821 ttttctcagg tgacttacgc ttagttccct agcagtagcc tatcttttga gacccctttt
     2881 taaaagggat cctgcattgg atctgacctg ttacaacccc accactcaag gcattgggga
     2941 agctggagag aagaaaaata ggttgacttg gttctagccg cttggctgaa acttgaattc
     3001 cccttaagca ggatgtctta aagccaggtc acttgctggc tggaactcaa gttcatttga
     3061 tgaccaggtt gccaagagtc ctgtccccta ctgagtgttc ttatagctgc ctacatgttt
     3121 tgttcttttc attgcactga gcattcagtg attcctgcct gttcatcaag agtatgtcag
     3181 aggtttgttt ggtttttggt ttttcgagac agggtttctc tgtatagctc tggctgtcct
     3241 ggaactcact ctgtagacca ggctggcctt gaactcagaa atccgcctgc ctctgcctcc
     3301 caagcgtggg attaaaggcg tgcgccacca cgcctggctt acttcagagt tattagcaac
     3361 ctacatttat caactttgtg gcactttgtg atacaaatgt tccctgcctc cttgggtgtc
     3421 ttcctactat gccattattt ctctgacact taagaaagaa aaagttgaaa ttctagcagt
     3481 aaatacagtt gatgcagaca ctt
//
