LOCUS       NM_053245               1586 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus aryl hydrocarbon receptor-interacting protein-like 1
            (Aipl1), mRNA.
ACCESSION   NM_053245
VERSION     NM_053245.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Yadav,R.P., Boyd,K. and Artemyev,N.O.
  TITLE     Molecular insights into the maturation of phosphodiesterase 6 by
            the specialized chaperone complex of HSP90 with AIPL1
  JOURNAL   J Biol Chem 298 (3), 101620 (2022)
   PUBMED   35065964
  REMARK    GeneRIF: Molecular insights into the maturation of
            phosphodiesterase 6 by the specialized chaperone complex of HSP90
            with AIPL1.
REFERENCE   2  (bases 1 to 1586)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1586)
  AUTHORS   Bisbach,C.M., Hass,D.T., Robbings,B.M., Rountree,A.M., Sadilek,M.,
            Sweet,I.R. and Hurley,J.B.
  TITLE     Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the
            O2-Rich Pigment Epithelium
  JOURNAL   Cell Rep 31 (5), 107606 (2020)
   PUBMED   32375026
REFERENCE   4  (bases 1 to 1586)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1586)
  AUTHORS   Yadav,R.P., Boyd,K., Yu,L. and Artemyev,N.O.
  TITLE     Interaction of the tetratricopeptide repeat domain of aryl
            hydrocarbon receptor-interacting protein-like 1 with the regulatory
            Pgamma subunit of phosphodiesterase 6
  JOURNAL   J Biol Chem 294 (43), 15795-15807 (2019)
   PUBMED   31488544
  REMARK    GeneRIF: This study sheds new light on the versatility of
            tetratricopeptide repeat domain (TPR) domains in protein folding by
            describing a novel TPR-protein binding partner, Pgamma, and
            revealing that this subunit imparts AIPL1 selectivity for its
            client.
REFERENCE   6  (bases 1 to 1586)
  AUTHORS   Liu,X., Bulgakov,O.V., Wen,X.H., Woodruff,M.L., Pawlyk,B., Yang,J.,
            Fain,G.L., Sandberg,M.A., Makino,C.L. and Li,T.
  TITLE     AIPL1, the protein that is defective in Leber congenital amaurosis,
            is essential for the biosynthesis of retinal rod cGMP
            phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 101 (38), 13903-13908 (2004)
   PUBMED   15365173
  REMARK    GeneRIF: Loss of AIPL1 would result in a condition that phenocopies
            retinal degenerations in the rd mouse and in a subgroup of human
            Erratum:[Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):515]
REFERENCE   7  (bases 1 to 1586)
  AUTHORS   Ramamurthy,V., Roberts,M., van den Akker,F., Niemi,G., Reh,T.A. and
            Hurley,J.B.
  TITLE     AIPL1, a protein implicated in Leber's congenital amaurosis,
            interacts with and aids in processing of farnesylated proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (22), 12630-12635 (2003)
   PUBMED   14555765
REFERENCE   8  (bases 1 to 1586)
  AUTHORS   Akey,D.T., Zhu,X., Dyer,M., Li,A., Sorensen,A., Blackshaw,S.,
            Fukuda-Kamitani,T., Daiger,S.P., Craft,C.M., Kamitani,T. and
            Sohocki,M.M.
  TITLE     The inherited blindness associated protein AIPL1 interacts with the
            cell cycle regulator protein NUB1
  JOURNAL   Hum Mol Genet 11 (22), 2723-2733 (2002)
   PUBMED   12374762
  REMARK    Erratum:[Hum Mol Genet. 2003 Feb 15;12(4):451]
REFERENCE   9  (bases 1 to 1586)
  AUTHORS   Sohocki,M.M., Sullivan,L.S., Tirpak,D.L. and Daiger,S.P.
  TITLE     Comparative analysis of aryl-hydrocarbon receptor interacting
            protein-like 1 (Aipl1), a gene associated with inherited retinal
            disease in humans
  JOURNAL   Mamm Genome 12 (7), 566-568 (2001)
   PUBMED   11420621
REFERENCE   10 (bases 1 to 1586)
  AUTHORS   Sohocki,M.M., Bowne,S.J., Sullivan,L.S., Blackshaw,S., Cepko,C.L.,
            Payne,A.M., Bhattacharya,S.S., Khaliq,S., Qasim Mehdi,S.,
            Birch,D.G., Harrison,W.R., Elder,F.F., Heckenlively,J.R. and
            Daiger,S.P.
  TITLE     Mutations in a new photoreceptor-pineal gene on 17p cause Leber
            congenital amaurosis
  JOURNAL   Nat Genet 24 (1), 79-83 (2000)
   PUBMED   10615133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK618559.1, AF296412.1, AK020825.1 and BF464935.1.
            
            On Jan 18, 2008 this sequence version replaced NM_053245.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF296412.1, BU505146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-623               CK618559.1         1-623
            624-1097            AF296412.1         573-1046
            1098-1568           AK020825.1         246-716
            1569-1586           BF464935.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.81 cM"
     gene            1..1586
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /note="aryl hydrocarbon receptor-interacting protein-like
                     1"
                     /db_xref="GeneID:114230"
                     /db_xref="MGI:MGI:2148800"
     exon            1..147
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1038
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /codon_start=1
                     /product="aryl-hydrocarbon-interacting protein-like 1"
                     /protein_id="NP_444475.2"
                     /db_xref="CCDS:CCDS24976.1"
                     /db_xref="GeneID:114230"
                     /db_xref="MGI:MGI:2148800"
                     /translation="MDVSLLLNVEGVKKTILHGGTGELPSFITGSRVTFHFRTMKCDD
                     ERTVIDDSKQVGQPMSIIIGNMFKLEVWETLLTSMRLGEVAEFWCDTIHTGVYPMLSR
                     SLRQVAEGKDPTSWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLVFLIELLQVEAPN
                     EYQRETWNLNNEERMQAVPLLHGEGNRLYKLGRYDQAATKYQEAIVCLRNLQTKEKPW
                     EVEWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYMRARAHAE
                     VWNAEEAKADLEKVLELEPSMRKAVLRELRLLESRLADKQEEERQRCRSMLG"
     exon            148..327
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            328..516
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..693
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..835
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1575
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /note="putative"
     polyA_site      1568
                     /gene="Aipl1"
                     /gene_synonym="A930007I01Rik"
                     /note="putative"
ORIGIN      
        1 tgctttggta ggattatcta ggcctgaaca aacctctccc ctacctgcag catggacgtc
       61 tctctactcc tcaatgtgga gggtgtcaag aagaccattc tgcatggggg gacgggagag
      121 ctccccagct tcatcactgg ctctcgagtg acctttcatt tccgcacaat gaagtgtgat
      181 gacgagcgca cggtgatcga tgacagcaag caggtgggcc agcccatgag catcatcatc
      241 ggcaacatgt tcaagctgga ggtgtgggag acgctgctga cctccatgcg gctgggcgag
      301 gtggctgagt tctggtgcga caccattcac acaggggtct accctatgtt gtcccgcagt
      361 ctgcggcagg tggctgaggg caaggacccc acaagctggc atgtgcacac gtgcgggttg
      421 gccaacatgt ttgcatacca cacgctgggc tacgaggacc tggatgagct gcagaaagag
      481 ccacagcctc ttgtcttcct gattgaactg ttgcaggtgg aggccccaaa tgagtaccag
      541 agggagacgt ggaacctgaa taatgaagag aggatgcagg cggtacctct tcttcatgga
      601 gaaggcaaca ggctctacaa gctgggacgc tatgatcagg ccgccaccaa gtaccaggag
      661 gccattgtgt gcctgaggaa ccttcagacc aaggagaagc cctgggaggt tgagtggctg
      721 aagctggaga agatgatcaa caccctgatc ctcaactact gccagtgcct gctgaagaag
      781 gaggagtact acgaggtgtt ggagcacacc agcgacattc tacgacacca cccagggatc
      841 gtgaaggcct actatatgcg cgcacgtgct cacgcagagg tgtggaacgc tgaggaggcc
      901 aaggcggacc tggagaaagt gctggagttg gagccatcca tgcgcaaggc ggtgctcagg
      961 gaactgcggc tgctggagag ccgcctggcg gacaaacagg aggaggagcg gcagcgctgc
     1021 cggagcatgc tgggctaggc tgggctggat tccactgagt tagactgggt taggttgggt
     1081 gggagctgcg ggttgaagcc ctggggcgag ggctggggct atggactggg tatcggtagg
     1141 cacgctgctc ctcttgctgc agggtacccc aggggaggtg ttcttggcta ccaggaggct
     1201 accagtgact tctctgcatt ctcacagccc gtgggctacc cgtgcagcaa gcatagattg
     1261 ggcatccctg gttcaattaa ccaggtcttt gatgtcactt ttaagcgcat atccgtatta
     1321 aatcacatta agactaatgt cttagggctg gggatatagc tcagtggtag agagcttgtt
     1381 tagcaaacct ggagccctgg ggttgatttc tgacacaaat aaatagatgc acacataaat
     1441 aaatgcattt tgtgagatca aagtcataga tgcccatgga aaatcaaagc ccctccccca
     1501 aacctcaaat taacaaaggg cacaggacaa ctaccattcc ttagctcagt tgtaataaac
     1561 aaacttttaa aaaaaaaaaa aaaaaa
//
