LOCUS       NM_016666               2180 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus aryl-hydrocarbon receptor-interacting protein (Aip),
            transcript variant 1, mRNA.
ACCESSION   NM_016666
VERSION     NM_016666.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2180)
  AUTHORS   Garcia-Rendueles,A.R., Chenlo,M., Oroz-Gonjar,F., Solomou,A.,
            Mistry,A., Barry,S., Gaston-Massuet,C., Garcia-Lavandeira,M.,
            Perez-Romero,S., Suarez-Farina,M., Pradilla-Dieste,A., Dieguez,C.,
            Mehlen,P., Korbonits,M. and Alvarez,C.V.
  TITLE     RET signalling provides tumorigenic mechanism and tissue
            specificity for AIP-related somatotrophinomas
  JOURNAL   Oncogene 40 (45), 6354-6368 (2021)
   PUBMED   34588620
  REMARK    GeneRIF: RET signalling provides tumorigenic mechanism and tissue
            specificity for AIP-related somatotrophinomas.
            Erratum:[Oncogene. 2023 Dec;42(49):3655-3656. doi:
            10.1038/s41388-023-02862-9.. PMID: 37932482]
REFERENCE   2  (bases 1 to 2180)
  AUTHORS   Schernthaner-Reiter,M.H., Trivellin,G., Roetzer,T.,
            Hainfellner,J.A., Starost,M.F. and Stratakis,C.A.
  TITLE     Prkar1a haploinsufficiency ameliorates the growth hormone excess
            phenotype in Aip-deficient mice
  JOURNAL   Hum Mol Genet 29 (17), 2951-2961 (2020)
   PUBMED   32821937
  REMARK    GeneRIF: Prkar1a haploinsufficiency ameliorates the growth hormone
            excess phenotype in Aip-deficient mice.
REFERENCE   3  (bases 1 to 2180)
  AUTHORS   Sun,D., Stopka-Farooqui,U., Barry,S., Aksoy,E., Parsonage,G.,
            Vossenkamper,A., Capasso,M., Wan,X., Norris,S., Marshall,J.L.,
            Clear,A., Gribben,J., MacDonald,T.T., Buckley,C.D., Korbonits,M.
            and Haworth,O.
  TITLE     Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal
            Center B Cells through Suppression of BCL6 Degradation
  JOURNAL   Cell Rep 27 (5), 1461-1471 (2019)
   PUBMED   31042473
REFERENCE   4  (bases 1 to 2180)
  AUTHORS   Fukuda,T., Tanaka,T., Hamaguchi,Y., Kawanami,T., Nomiyama,T. and
            Yanase,T.
  TITLE     Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an
            Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted
            Somatotroph Cell Line
  JOURNAL   PLoS One 11 (10), e0164131 (2016)
   PUBMED   27706259
  REMARK    GeneRIF: Results demonstrated that Aip inactivation promoted
            somatotroph tumorigenesis and overproduction of growth hormone
            probably through increased Stat3 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2180)
  AUTHORS   Tuominen,I., Heliovaara,E., Raitila,A., Rautiainen,M.R., Mehine,M.,
            Katainen,R., Donner,I., Aittomaki,V., Lehtonen,H.J., Ahlsten,M.,
            Kivipelto,L., Schalin-Jantti,C., Arola,J., Hautaniemi,S. and
            Karhu,A.
  TITLE     AIP inactivation leads to pituitary tumorigenesis through defective
            Galphai-cAMP signaling
  JOURNAL   Oncogene 34 (9), 1174-1184 (2015)
   PUBMED   24662816
  REMARK    GeneRIF: Results provide novel evidence that AIP has an important
            role in the regulation of cAMP synthesis.
REFERENCE   6  (bases 1 to 2180)
  AUTHORS   Sumanasekera,W.K., Tien,E.S., Turpey,R., Vanden Heuvel,J.P. and
            Perdew,G.H.
  TITLE     Evidence that peroxisome proliferator-activated receptor alpha is
            complexed with the 90-kDa heat shock protein and the hepatitis
            virus B X-associated protein 2
  JOURNAL   J Biol Chem 278 (7), 4467-4473 (2003)
   PUBMED   12482853
  REMARK    GeneRIF: PPARalpha is in a complex with hsp90 and XAP2, and XAP2
            appears to function as a repressor
REFERENCE   7  (bases 1 to 2180)
  AUTHORS   Petrulis,J.R., Kusnadi,A., Ramadoss,P., Hollingshead,B. and
            Perdew,G.H.
  TITLE     The hsp90 Co-chaperone XAP2 alters importin beta recognition of the
            bipartite nuclear localization signal of the Ah receptor and
            represses transcriptional activity
  JOURNAL   J Biol Chem 278 (4), 2677-2685 (2003)
   PUBMED   12431985
  REMARK    GeneRIF: XAP2 hinders importin beta binding to the mAhR complex and
            represses the transactivation potential of the AhR by stabilizing
            the receptor complex and/or blocking nucleocytoplasmic shuttling of
            the AhR complex
REFERENCE   8  (bases 1 to 2180)
  AUTHORS   Carver,L.A., LaPres,J.J., Jain,S., Dunham,E.E. and Bradfield,C.A.
  TITLE     Characterization of the Ah receptor-associated protein, ARA9
  JOURNAL   J Biol Chem 273 (50), 33580-33587 (1998)
   PUBMED   9837941
REFERENCE   9  (bases 1 to 2180)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 2180)
  AUTHORS   Ma,Q. and Whitlock,J.P. Jr.
  TITLE     A novel cytoplasmic protein that interacts with the Ah receptor,
            contains tetratricopeptide repeat motifs, and augments the
            transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   J Biol Chem 272 (14), 8878-8884 (1997)
   PUBMED   9083006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FO082289.1 and AC109138.10.
            
            On Jul 21, 2022 this sequence version replaced NM_016666.3.
            
            Summary: This gene encodes an Hsp90-associated protein that is
            localized to the cytoplasm. The encoded protein interacts with the
            aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor
            RET, inhibits AhR ubiquitination, and regulates the intracellular
            localization of AhR. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85489.1, SRR17253011.9740858.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               FO082289.1         1-144               c
            145-241             AC109138.10        134148-134244       c
            242-451             AC109138.10        129754-129963       c
            452-631             AC109138.10        126505-126684       c
            632-820             AC109138.10        124400-124588       c
            821-997             AC109138.10        123738-123914       c
            998-1139            AC109138.10        123499-123640       c
            1140-2180           AC109138.10        122174-123214       c
FEATURES             Location/Qualifiers
     source          1..2180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.82 cM"
     gene            1..2180
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /note="aryl-hydrocarbon receptor-interacting protein"
                     /db_xref="GeneID:11632"
                     /db_xref="MGI:MGI:109622"
     exon            1..241
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..451
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1345
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /EC_number="5.2.1.8"
                     /codon_start=1
                     /product="AH receptor-interacting protein"
                     /protein_id="NP_057875.1"
                     /db_xref="CCDS:CCDS29415.1"
                     /db_xref="GeneID:11632"
                     /db_xref="MGI:MGI:109622"
                     /translation="MADLIARLREDGIQKRVIQEGRGELPDFQDGTKATFHFRTLHSD
                     NEGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVA
                     KSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESP
                     GTYQQDPWAMTDEEKAKAVPVIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQP
                     GSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHA
                     AVWNAQEAQADFAKVLELDPALAPVVSRELRALETRIRQKDEEDKARFRGIFSH"
     exon            452..631
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..820
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..997
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1139
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..2180
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /note="hexamer: TATAAA"
     polyA_site      1473
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /note="major polyA site"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /note="hexamer: AATAAA"
     polyA_site      2180
                     /gene="Aip"
                     /gene_synonym="Ara9; D19Bwg1412e; Fkbp16; Xap2"
                     /note="major polyA site"
ORIGIN      
        1 cgcccaccaa acagggcccg ccctcacagg gcccgccccg tctccctggg agcgaagatc
       61 tgccctctac aaccgccccg cccttgcccg ctcctcctct gcaggcctga gcagcagaat
      121 gcagagttgc ttcgggatcg cgtcagagtc tcgcgggtag cgggactcgc ggcgcccccc
      181 agaggttccc ttggtgagcg acagccccgg ctgtgaccag gaccgatcta agcttgtgct
      241 ttcaaaatgg cgcttgctca gaagctgccg aggcgctagg agttgccgaa acaggtccgg
      301 aagctaccga gcgagtccgg aagttgccga aagggagcag cggggaagga ggatggcgga
      361 tctcatcgca agacttcgag aggacgggat ccaaaagcgt gtgatacagg agggccgagg
      421 agagttgccg gactttcagg atggcactaa ggccacgttc cactttcgga cgctgcacag
      481 tgacaatgaa ggctccgtta tagatgacag ccgaacacga ggcaagccca tggagctcat
      541 cgttggcaag aagttcaagt tgcctgtgtg ggagaccatc gtgtgcacca tgcgtgaggg
      601 ggagattgcc cagttcctct gtgacatcaa gcacgtagtc ctgtatcctc tagtggccaa
      661 gagcctccgc aacatcgccg agggcaagga ccccctggag ggacagcggc attgctgtgg
      721 gatcgctcag atgcatgaac acagctccct gggtcatgcg gacctggatg ccctgcagca
      781 gaacccacag cctctcatct tccacatcga gatgctgaag gtagagagtc ctggcaccta
      841 tcaacaggac ccatgggcga tgacagatga ggagaaagca aaggcagtac cagtcatcca
      901 ccaagagggc aaccggttgt accgtgaggg ccaggtgaaa gaggctgctg ccaagtacta
      961 tgacgccatc gcctgcctca agaatctgca gatgaaggag cagcctggct cacctgactg
     1021 gatccagttg gacctgcaga tcacaccact gctactcaac tattgccagt gcaagctggt
     1081 ggctcaggag tattatgaag tgttggatca ctgctcctcc atcctcaaca agtatgatga
     1141 caatgtcaag gcttacttca agaggggtaa ggcccatgct gccgtgtgga atgcccagga
     1201 ggcccaggct gactttgcca aggtgttgga gctagaccct gccctggcgc ctgtggtaag
     1261 cagagagctg cgggccctgg agacacggat ccggcagaag gatgaggagg acaaagctcg
     1321 cttccggggc atcttttccc actgacaggg ccccagttct gccctgcctt gccatgccct
     1381 gccctgccct gccaagccca ctgctgccac cacctgtcaa tcccccactg tcactttgcg
     1441 cttctgtgta tataaaggcc ttatttatct ctctggcttt gcagaactaa tctatcttga
     1501 aggctggtca tcactggcta ggggcttggt agtcagtggg aggggtgaga tcaggttctt
     1561 accctagttc ccactggctt gtgctaaggt ctctgggaat ttctttctgg ccaataccag
     1621 cctagggagc ctctagtatt aagtggtaga gaaagcaggc gtggcccaca caggccactc
     1681 tatcatcctt aggttccaca gttcctggct ttagagacag aagtttcctt aggggcagag
     1741 gtgaggggag ttgcaggctc agaagccacg tgactctcat aaactccaac accgtctgag
     1801 gttgggggca ggagaaggaa caggcagact acctaggaaa tgccctaggg actcgcagcc
     1861 agggcttgtg aaagtgaaag tataggagct ccagcctggc tgcctctatg accctgagta
     1921 ggtcctggcc cccttcagca cctcagtgcc ccagacagga aggcccacag tagagtgcag
     1981 ttgtttattt ttataggttc acacactgga aacgctgctg ggccctaacc cactccctcc
     2041 ttcctcccct gggggctggg tcccctaccc ccgacaaagg gaagtaatac tgtggtgtag
     2101 tcatacaggg tgtgggggcc ccagattccc acagtcacca aggccccttg cgagtcaata
     2161 aataacccag ttgcagccaa
//
