LOCUS       NM_001172146            1210 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus aminoacyl tRNA synthetase complex-interacting
            multifunctional protein 2 (Aimp2), transcript variant 1, mRNA.
ACCESSION   NM_001172146
VERSION     NM_001172146.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1210)
  AUTHORS   Kook,M.G., Byun,M.R., Lee,S.M., Lee,M.H., Lee,D.H., Lee,H.B.,
            Lee,E.J., Baek,K., Kim,S., Kang,K.S. and Choi,J.W.
  TITLE     Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant
            SOD1-Induced Neuronal Cell Death
  JOURNAL   Mol Neurobiol 60 (1), 145-159 (2023)
   PUBMED   36242734
  REMARK    GeneRIF: Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant
            SOD1-Induced Neuronal Cell Death.
REFERENCE   2  (bases 1 to 1210)
  AUTHORS   Li,R., Li,Y., Tian,M., Zhang,H., Lou,L., Liu,K., Zhang,J., Zhao,Y.,
            Zhang,J., Le,S., Fu,X., Zhou,Y., Li,W., Gao,X. and Nie,Y.
  TITLE     Comparative proteomic profiling reveals a pathogenic role for the
            O-GlcNAcylated AIMP2-PARP1 complex in aging-related hepatic
            steatosis in mice
  JOURNAL   FEBS Lett 596 (1), 128-145 (2022)
   PUBMED   34817071
  REMARK    GeneRIF: Comparative proteomic profiling reveals a pathogenic role
            for the O-GlcNAcylated AIMP2-PARP1 complex in aging-related hepatic
            steatosis in mice.
REFERENCE   3  (bases 1 to 1210)
  AUTHORS   Oh,A.Y., Jung,Y.S., Kim,J., Lee,J.H., Cho,J.H., Chun,H.Y., Park,S.,
            Park,H., Lim,S., Ha,N.C., Park,J.S., Park,C.S., Song,G.Y. and
            Park,B.J.
  TITLE     Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung
            Cancer and Delays Tumor Progression
  JOURNAL   Cancer Res 76 (16), 4791-4804 (2016)
   PUBMED   27302160
  REMARK    GeneRIF: our findings show how DX2 promotes lung cancer progression
            and how its activity may be thwarted as a strategy to treat
            patients with lung cancers exhibiting elevated DX2 levels
REFERENCE   4  (bases 1 to 1210)
  AUTHORS   Yum,M.K., Kang,J.S., Lee,A.E., Jo,Y.W., Seo,J.Y., Kim,H.A.,
            Kim,Y.Y., Seong,J., Lee,E.B., Kim,J.H., Han,J.M., Kim,S. and
            Kong,Y.Y.
  TITLE     AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis
            by Modulating Wnt/beta-Catenin Signaling
  JOURNAL   Cancer Res 76 (15), 4559-4568 (2016)
   PUBMED   27262173
REFERENCE   5  (bases 1 to 1210)
  AUTHORS   Lee,Y., Karuppagounder,S.S., Shin,J.H., Lee,Y.I., Ko,H.S.,
            Swing,D., Jiang,H., Kang,S.U., Lee,B.D., Kang,H.C., Kim,D.,
            Tessarollo,L., Dawson,V.L. and Dawson,T.M.
  TITLE     Parthanatos mediates AIMP2-activated age-dependent dopaminergic
            neuronal loss
  JOURNAL   Nat Neurosci 16 (10), 1392-1400 (2013)
   PUBMED   23974709
  REMARK    Erratum:[Nat Neurosci. 2015 Dec;18(12):1861. doi:
            10.1038/nn1215-1861a.. PMID: 26605883]
REFERENCE   6  (bases 1 to 1210)
  AUTHORS   Choi,J.W., Kim,D.G., Park,M.C., Um,J.Y., Han,J.M., Park,S.G.,
            Choi,E.C. and Kim,S.
  TITLE     AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated
            degradation of TRAF2
  JOURNAL   J Cell Sci 122 (Pt 15), 2710-2715 (2009)
   PUBMED   19584093
REFERENCE   7  (bases 1 to 1210)
  AUTHORS   Wong,E.S., Tan,J.M., Soong,W.E., Hussein,K., Nukina,N.,
            Dawson,V.L., Dawson,T.M., Cuervo,A.M. and Lim,K.L.
  TITLE     Autophagy-mediated clearance of aggresomes is not a universal
            phenomenon
  JOURNAL   Hum Mol Genet 17 (16), 2570-2582 (2008)
   PUBMED   18502787
REFERENCE   8  (bases 1 to 1210)
  AUTHORS   Kim,M.J., Park,B.J., Kang,Y.S., Kim,H.J., Park,J.H., Kang,J.W.,
            Lee,S.W., Han,J.M., Lee,H.W. and Kim,S.
  TITLE     Downregulation of FUSE-binding protein and c-myc by tRNA synthetase
            cofactor p38 is required for lung cell differentiation
  JOURNAL   Nat Genet 34 (3), 330-336 (2003)
   PUBMED   12819782
REFERENCE   9  (bases 1 to 1210)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1210)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202241.1, CF732613.1 and CX566811.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026972.1, SRR7345562.3214272.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BY202241.1         2-79
            79-716              CF732613.1         1-638
            717-1210            CX566811.1         225-718
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.8 cM"
     gene            1..1210
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /note="aminoacyl tRNA synthetase complex-interacting
                     multifunctional protein 2"
                     /db_xref="GeneID:231872"
                     /db_xref="MGI:MGI:2385237"
     exon            1..259
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1087
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     aminoacyl tRNA synthase complex-interacting
                     multifunctional protein 2; protein JTV-1; multisynthetase
                     complex auxiliary component p38; multisynthase complex
                     auxiliary component p38; ARS interacting multifunctional
                     protein 2"
                     /codon_start=1
                     /product="aminoacyl tRNA synthase complex-interacting
                     multifunctional protein 2 isoform 1"
                     /protein_id="NP_001165617.1"
                     /db_xref="CCDS:CCDS51692.1"
                     /db_xref="GeneID:231872"
                     /db_xref="MGI:MGI:2385237"
                     /translation="MPMYQVKPYHGGSAPLHVELPTCMYRLPNVHSKTTSPATDAGHV
                     QETSEPSLQALESRQDDILKRLYELKAAVDGLSKMIHTPDADLDVTNILQADEPTTLA
                     TNTLDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCERYRVLSTVHTHSSVKN
                     VPENLVKCFGEQARKQSRHEYQLGFTLIWKNVPKTQMKFSVQTMCPIEGEGNIARFLF
                     SLFGQKHNAVTLTLIDSWVDIAMFQLREGSSKEKAAVFRSMNSALGRSPWLVGNELTV
                     ADVVLWSVLQQTGGSSGAAPTNVQRWLKSCENLAPFSTALQLLK"
     exon            260..466
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..698
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1185
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1165..1170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /note="hexamer: AATAAA"
     polyA_site      1185
                     /gene="Aimp2"
                     /gene_synonym="Aimp2(p38); Jtv1"
                     /note="major polyA site"
ORIGIN      
        1 ggggacttca ttttccggaa cgccagcagc agagtcagaa agaaggcggc tgctgtctga
       61 ggtggccttg ggtggcttct gagcgttcct gtccctcgcc cgctaccttc cttgggttcc
      121 caccatgccg atgtaccagg taaagcccta tcatggaggc agcgcacctc tgcatgtaga
      181 gcttccaacc tgcatgtacc ggctccccaa cgtgcacagc aagaccacca gccccgccac
      241 cgacgcgggc cacgtgcagg aaacatccga gccttctttg caagcccttg aatctcgcca
      301 agatgatatt ttaaaacgct tgtatgagtt gaaggcagca gtcgatggcc tttcaaagat
      361 gattcacacc ccagatgcag acttggacgt aaccaacatc ctgcaagctg atgagcccac
      421 aactttagcc acaaacacat tggacttgaa ttccgtgctt ggaaaggact atggggcgct
      481 gaaagacatt gtgatcaacg caaacccagc ctccccacca ctgtccctgc ttgtgctgca
      541 caggctgctc tgtgaacgct acagggtcct gtccactgtg cacacacatt cgtctgtcaa
      601 gaatgtgccc gagaatcttg tcaagtgctt cggggagcag gctaggaagc agtcccgcca
      661 cgagtatcag ctgggcttca ctctgatttg gaagaatgtg cccaagacac agatgaagtt
      721 cagtgtacaa accatgtgcc ccattgaagg agaagggaac atcgcacgtt tcctgttctc
      781 tctgtttggc cagaagcata atgctgtcac cctcaccctc atcgatagct gggtggatat
      841 cgccatgttt cagcttcgag aaggcagcag taaagaaaaa gcggccgtgt tccgctctat
      901 gaactccgct ttggggagga gcccgtggct ggttggaaat gagctcactg tggcagatgt
      961 ggtgctgtgg tctgtgctcc agcagactgg gggcagcagt ggggcagcac ccaccaatgt
     1021 gcagcggtgg cttaagtcct gtgaaaacct ggcccccttc agcactgccc ttcagctcct
     1081 taagtgaatt cgagcagctt gtcttgcagg gttcaacaga agaatggtac ggcttccagt
     1141 ctgttgtcag aaagggactt gtccaataaa gtaccatatc atctaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa
//
