LOCUS       NM_007926               1122 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aminoacyl tRNA synthetase complex-interacting
            multifunctional protein 1 (Aimp1), transcript variant 1, mRNA.
ACCESSION   NM_007926
VERSION     NM_007926.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1122)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1122)
  AUTHORS   Ranasinghe,A.D.C.U., Lee,D.D. and Schwarz,M.A.
  TITLE     Mechanistic regulation of SPHK1 expression and translocation by
            EMAP II in pulmonary smooth muscle cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (12), 158789 (2020)
   PUBMED   32771459
  REMARK    GeneRIF: Mechanistic regulation of SPHK1 expression and
            translocation by EMAP II in pulmonary smooth muscle cells.
REFERENCE   3  (bases 1 to 1122)
  AUTHORS   Bertrand-Gaday,C., Letheule,M., Blanchet,E., Vernus,B.,
            Pessemesse,L., Bonnet-Garnier,A., Bonnieu,A. and Casas,F.
  TITLE     Transient Changes of Metabolism at the Pronuclear Stage in Mice
            Influences Skeletal Muscle Phenotype in Adulthood
  JOURNAL   Int J Mol Sci 21 (19), 7203 (2020)
   PUBMED   33003470
  REMARK    GeneRIF: Transient Changes of Metabolism at the Pronuclear Stage in
            Mice Influences Skeletal Muscle Phenotype in Adulthood.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1122)
  AUTHORS   Lee,D.D., Hochstetler,A., Sah,E., Xu,H., Lowe,C.W., Santiaguel,S.,
            Thornton,J.L., Pajakowski,A. and Schwarz,M.A.
  TITLE     Influence of aminoacyl-tRNA synthetase complex-interacting
            multifunctional protein 1 on epithelial differentiation and
            organization during lung development
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 319 (2), L369-L379 (2020)
   PUBMED   32579851
  REMARK    GeneRIF: Influence of aminoacyl-tRNA synthetase complex-interacting
            multifunctional protein 1 on epithelial differentiation and
            organization during lung development.
REFERENCE   5  (bases 1 to 1122)
  AUTHORS   Zou,C., Gu,C., Zhao,M., Zhu,D., Wang,N., Yu,J., Yao,Y., Chen,Y.,
            Shi,M., Gu,Q., Qian,Y., Qiu,Q. and Zheng,Z.
  TITLE     The Role of the AIMP1 Pathway in Diabetic Retinopathy:
            AIMP1-Targeted Intervention Study in Diabetic Retinopathy
  JOURNAL   Ophthalmic Res 63 (2), 122-132 (2020)
   PUBMED   31962335
  REMARK    GeneRIF: The Role of the AIMP1 Pathway in Diabetic Retinopathy:
            AIMP1-Targeted Intervention Study in Diabetic Retinopathy.
REFERENCE   6  (bases 1 to 1122)
  AUTHORS   Zhang,F. and Schwarz,M.A.
  TITLE     Temporo-spatial distribution of endothelial-monocyte activating
            polypeptide II, an anti-angiogenic protein, in the mouse embryo
  JOURNAL   Dev Dyn 218 (3), 490-498 (2000)
   PUBMED   10878614
REFERENCE   7  (bases 1 to 1122)
  AUTHORS   Knies,U.E., Kroger,S. and Clauss,M.
  TITLE     Expression of EMAP II in the developing and adult mouse
  JOURNAL   Apoptosis 5 (2), 141-151 (2000)
   PUBMED   11232242
REFERENCE   8  (bases 1 to 1122)
  AUTHORS   Kao,J., Houck,K., Fan,Y., Haehnel,I., Libutti,S.K., Kayton,M.L.,
            Grikscheit,T., Chabot,J., Nowygrod,R., Greenberg,S. et al.
  TITLE     Characterization of a novel tumor-derived cytokine.
            Endothelial-monocyte activating polypeptide II
  JOURNAL   J Biol Chem 269 (40), 25106-25119 (1994)
   PUBMED   7929199
REFERENCE   9  (bases 1 to 1122)
  AUTHORS   Kao,J., Fan,Y.G., Haehnel,I., Brett,J., Greenberg,S., Clauss,M.,
            Kayton,M., Houck,K., Kisiel,W., Seljelid,R. et al.
  TITLE     A peptide derived from the amino terminus of
            endothelial-monocyte-activating polypeptide II modulates
            mononuclear and polymorphonuclear leukocyte functions, defines an
            apparently novel cellular interaction site, and induces an acute
            inflammatory response
  JOURNAL   J Biol Chem 269 (13), 9774-9782 (1994)
   PUBMED   7545917
REFERENCE   10 (bases 1 to 1122)
  AUTHORS   Kao,J., Ryan,J., Brett,G., Chen,J., Shen,H., Fan,Y.G., Godman,G.,
            Familletti,P.C., Wang,F., Pan,Y.C. et al.
  TITLE     Endothelial monocyte-activating polypeptide II. A novel
            tumor-derived polypeptide that activates host-response mechanisms
  JOURNAL   J Biol Chem 267 (28), 20239-20247 (1992)
   PUBMED   1400342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY256548.1, AK133859.1 and BY631162.1.
            
            On Feb 21, 2007 this sequence version replaced NM_007926.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002054.1, U10118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY256548.1         6-54
            50-1115             AK133859.1         3-1068
            1116-1122           BY631162.1         403-409
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 61.48 cM"
     gene            1..1122
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /note="aminoacyl tRNA synthetase complex-interacting
                     multifunctional protein 1"
                     /db_xref="GeneID:13722"
                     /db_xref="MGI:MGI:102774"
     exon            1..87
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1045
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /note="isoform 1 is encoded by transcript variant 1; small
                     inducible cytokine subfamily E, member 1; aminoacyl tRNA
                     synthase complex-interacting multifunctional protein 1;
                     multisynthetase complex auxiliary component p43;
                     multisynthase complex auxiliary component p43; ARS
                     inducible multifunctional protein 1; endothelial monocyte
                     activating polypeptide 2"
                     /codon_start=1
                     /product="aminoacyl tRNA synthase complex-interacting
                     multifunctional protein 1 isoform 1"
                     /protein_id="NP_031952.2"
                     /db_xref="CCDS:CCDS38642.1"
                     /db_xref="GeneID:13722"
                     /db_xref="MGI:MGI:102774"
                     /translation="MFLCRFWGKMATNDAVLKRLEQKGAEADQIIEYLKQQVALLKEK
                     AILQATMREEKKLRVENAKLKKEIEELKQELILAEIHNGVEQVRVRLSTPLQTNCTAS
                     ESVVQSPSVATTASPATKEQIKAGEEKKVKEKTEKKGEKKEKQQSAAASTDSKPIDAS
                     RLDLRIGCIVTAKKHPDADSLYVEEVDVGEAAPRTVVSGLVNHVPLEQMQNRMVVLLC
                     NLKPAKMRGVLSQAMVMCASSPEKVEILAPPNGSVPGDRITFDAFPGEPDKELNPKKK
                     IWEQIQPDLHTNAECVATYKGAPFEVKGKGVCRAQTMANSGIK"
     exon            88..221
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..335
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..500
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..709
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..878
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1122
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1086..1091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="Aimp1"
                     /gene_synonym="9830137A06Rik; AIMP1/p43; Emap2; EMAPII;
                     p43; Scye1"
                     /note="major polyA site"
ORIGIN      
        1 tttctcgctg ccggggactg cgggaggctg gcccttcctt ctcccggctg aggctgctca
       61 agagctgcgg ttgggtcacc gcttcatgtt tctctgccga ttctggggaa agatggcaac
      121 gaatgatgct gttctgaaga ggctggagca gaagggtgca gaggcggatc agatcatcga
      181 atatctcaag cagcaggttg ctcttcttaa ggagaaagca attttgcagg caacaatgag
      241 agaagaaaag aaacttcgag ttgaaaatgc taaactgaaa aaagaaatag aagagctaaa
      301 gcaagagctg attctggcag aaattcataa cggagtggag caagtgcgtg ttcgattgag
      361 tactccactg cagacgaact gtactgcttc tgaaagtgtg gtgcagtctc catcagtagc
      421 aaccaccgcc tctcctgcta caaaagagca gatcaaagcg ggagaagaaa agaaggtgaa
      481 agagaagact gaaaagaaag gagagaaaaa ggagaagcag cagtcggcag cagcaagtac
      541 tgactccaag cctatcgacg catcgcgtct ggatcttcga attggttgta ttgttactgc
      601 caagaagcac cctgatgcag attcactgta tgtggaggaa gtagatgtgg gagaagcagc
      661 cccgcgcacg gtcgtcagcg ggctggtgaa tcatgttcct ctagaacaga tgcaaaatcg
      721 tatggtggtt ttactctgta atctgaagcc tgcaaagatg cggggagttc tgtctcaagc
      781 catggtgatg tgtgccagtt caccagagaa agtggagatt ctggcccctc ccaacgggtc
      841 cgttcctggg gacagaatta cttttgatgc ttttcctgga gagcctgaca aggagctaaa
      901 ccctaagaag aagatctggg agcagatcca gcctgacctg cacaccaatg ctgagtgtgt
      961 ggccacatac aaaggagctc cctttgaggt gaaggggaag ggagtttgca gagcccaaac
     1021 catggccaat agtggaatta aataagtgct ctgtaactga aagacattgg cgaaaactta
     1081 ataacaataa agagaagtgt gtttatcact tacatataaa at
//
