LOCUS       NM_001013779            2541 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus absent in melanoma 2 (Aim2), mRNA.
ACCESSION   NM_001013779 XM_357160
VERSION     NM_001013779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Chen,Y., Li,H., Wang,J., Yang,S., Su,Z., Wang,W., Rao,C. and Hou,L.
  TITLE     The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast
            proliferation during early development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39555938
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Cao,J., Roth,S., Zhang,S., Kopczak,A., Mami,S., Asare,Y.,
            Georgakis,M.K., Messerer,D., Horn,A., Shemer,R., Jacqmarcq,C.,
            Picot,A., Green,J.P., Schlegl,C., Li,X., Tomas,L., Dutsch,A.,
            Liman,T.G., Endres,M., Wernsdorf,S.R., Furle,C., Carofiglio,O.,
            Zhu,J., Brough,D., Hornung,V., Dichgans,M., Vivien,D., Schulz,C.,
            Dor,Y., Tiedt,S., Sager,H.B., Grosse,G.M. and Liesz,A.
  CONSRTM   DEMDAS Study Group
  TITLE     DNA-sensing inflammasomes cause recurrent atherosclerotic stroke
  JOURNAL   Nature 633 (8029), 433-441 (2024)
   PUBMED   39112714
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Moran,E.A., Salas-Briceno,K., Zhao,W., Enya,T., Aguilera,A.N.,
            Acosta,I., Alonzo,F., Kiani,D., Behnsen,J., Alvarez,C., Keane,T.M.,
            Adams,D.J., Lilue,J. and Ross,S.R.
  TITLE     IFI207, a young and fast-evolving protein, controls retroviral
            replication via the STING pathway
  JOURNAL   mBio 15 (7), e0120924 (2024)
   PUBMED   38860764
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Ma,Z., Lou,Y., Wang,N., Zhao,Y., Zhang,S., Zhang,M., Li,J., Xu,Q.,
            He,A. and Yu,S.
  TITLE     Absent in Melanoma 2 Mediates Inflammasome Signaling Activation
            against Clostridium perfringens Infection
  JOURNAL   Int J Mol Sci 25 (12), 6571 (2024)
   PUBMED   38928277
  REMARK    GeneRIF: Absent in Melanoma 2 Mediates Inflammasome Signaling
            Activation against Clostridium perfringens Infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Fernandes-Alnemri,T., Yu,J.W., Datta,P., Wu,J. and Alnemri,E.S.
  TITLE     AIM2 activates the inflammasome and cell death in response to
            cytoplasmic DNA
  JOURNAL   Nature 458 (7237), 509-513 (2009)
   PUBMED   19158676
  REMARK    GeneRIF: identification of AIM2 as an important inflammasome
            component that senses potentially dangerous cytoplasmic DNA,
            leading to activation of the ASC pyroptosome and caspase-1
REFERENCE   7  (bases 1 to 2541)
  AUTHORS   Hornung,V., Ablasser,A., Charrel-Dennis,M., Bauernfeind,F.,
            Horvath,G., Caffrey,D.R., Latz,E. and Fitzgerald,K.A.
  TITLE     AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating
            inflammasome with ASC
  JOURNAL   Nature 458 (7237), 514-518 (2009)
   PUBMED   19158675
  REMARK    GeneRIF: observations identify AIM2 as a new receptor for
            cytoplasmic DNA, which forms an inflammasome with the ligand and
            ASC to activate caspase-1
REFERENCE   8  (bases 1 to 2541)
  AUTHORS   Roberts,T.L., Idris,A., Dunn,J.A., Kelly,G.M., Burnton,C.M.,
            Hodgson,S., Hardy,L.L., Garceau,V., Sweet,M.J., Ross,I.L.,
            Hume,D.A. and Stacey,K.J.
  TITLE     HIN-200 proteins regulate caspase activation in response to foreign
            cytoplasmic DNA
  JOURNAL   Science 323 (5917), 1057-1060 (2009)
   PUBMED   19131592
  REMARK    GeneRIF: study showed p202 is an inhibitor of DNA-induced caspase
            activation; conversely AIM2 was required for caspase activation by
            cytoplasmic dsDNA; work indicates HIN-200 proteins can act as
            pattern recognition receptors mediating response to cytoplasmic
            dsDNA
REFERENCE   9  (bases 1 to 2541)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   10 (bases 1 to 2541)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084073.22, AK050724.1 and DT921984.1.
            
            On Dec 14, 2007 this sequence version replaced NM_001013779.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC084073.22        112286-112368
            84-223              AC084073.22        119441-119580
            224-696             AK050724.1         224-696
            697-868             DT921984.1         223-394
            869-1282            AC084073.22        153589-154002
            1283-1471           AC084073.22        155541-155729
            1472-2541           AC084073.22        156653-157722
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.33 cM"
     gene            1..2541
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /note="absent in melanoma 2"
                     /db_xref="GeneID:383619"
                     /db_xref="MGI:MGI:2686159"
     exon            1..83
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     exon            84..223
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     exon            224..344
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     exon            345..434
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     exon            435..716
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..1519
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /note="ifi-210; interferon-inducible protein 210;
                     interferon-inducible protein p210"
                     /codon_start=1
                     /product="interferon-inducible protein AIM2"
                     /protein_id="NP_001013801.2"
                     /db_xref="CCDS:CCDS15529.2"
                     /db_xref="GeneID:383619"
                     /db_xref="MGI:MGI:2686159"
                     /translation="MESEYREMLLLTGLDHITEEELKRFKYFALTEFQIARSTLDVAD
                     RTELADHLIQSAGAASAVTKAINIFQKLNYMHIANALEEKKKEAERKLMTNTKKRGTQ
                     KVENRSQAENCSAASATRSDNDFKEQAATEVCPQAKPQKKQMVAEQEAIREDLQKDPL
                     VVTVLKAINPFECETQEGRQEIFHATVATETDFFFVKVLNAQFKDKFIPKRTIKISNY
                     LWHSNFMEVTSSSVVVDVESNHEVPNNVVKRARETPRISKLKIQPCGTIVNGLFKVQK
                     ITEEKDRVLYGIHDKTGTMEVLVLGNPSKTKCEEGDKIRLTFFEVSKNGVKIQLKSGP
                     CSFFKVIKAAKPKTDMKSVE"
     exon            717..868
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1282
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1471
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..2541
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /note="hexamer: AATAAA"
     polyA_site      2207
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /note="major polyA site"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /note="hexamer: AATAAA"
     polyA_site      2480
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
ORIGIN      
        1 ttcctgtcct gtctgccgcc atgcttcctt aactagctgc taggtttttt ccttgtcgtg
       61 atgaaatcca ccctcatgga cctacactac cgaactggac tgctggtata ttcatgaagt
      121 gcttatgagt ggatcgagca gcccctatgg attcctgtga acagaactgc tgatttacta
      181 acaacgcaga tggaagttgc ttcaaagaac aacttctgaa caggtattgt tgcccattct
      241 gtgaataata caaaggcagt gggaacaaga cagtacagag gacttgattc aggagacttg
      301 aggtctggcc gcatagtcat cctttagaag ctgggtggcg tcaggaagtt ttcctttttc
      361 tcaatgtaaa gtgaagaaaa aaaatccagt gtttctcaac tgtactgcta ttcctattta
      421 gctattgtat ctaggctgat cctgggactg tgagatggag agtgagtacc gggaaatgct
      481 gttgttgacc ggcctggacc acatcacgga ggaagaactg aaacggttca agtactttgc
      541 tttgactgag tttcagattg ccaggagcac actcgacgtg gcagatagga cagagttagc
      601 tgaccacctg attcaaagtg caggtgcggc gtctgcagtg accaaggcca ttaatatttt
      661 ccagaagttg aattatatgc atattgcaaa tgctcttgaa gagaaaaaga aagaagctga
      721 acgtaaactc atgaccaata caaagaagag aggaacacag aaggtagaaa atagaagtca
      781 agctgaaaac tgctctgctg cctctgccac ccgcagtgac aatgacttta aggaacaggc
      841 tgctacagaa gtctgtcctc aagctaagcc tcagaagaaa cagatggtgg cagaacagga
      901 agccatcaga gaagatttac agaaagatcc acttgttgtc acggtgctga aagctataaa
      961 tccctttgag tgtgagactc aggaaggaag acaagagata tttcatgcaa cagtggccac
     1021 ggagacagat tttttctttg taaaagtttt aaacgcacag tttaaagata aatttatccc
     1081 aaagaggaca attaaaatat caaactacct ttggcacagt aacttcatgg aggtcaccag
     1141 ttcctcagtt gtggttgatg ttgaatctaa ccacgaagtc ccaaataacg ttgttaagag
     1201 agccagggaa actcccagga ttagtaaact gaagattcag ccatgtggaa caattgtgaa
     1261 tgggctgttt aaagtccaga agataacaga ggaaaaagat agagtactgt atggtataca
     1321 tgataaaaca gggacaatgg aggtgttggt gctgggaaac ccaagcaaaa caaagtgcga
     1381 ggaaggagac aagattagac tcacgttctt tgaggtgtca aaaaatggag tgaaaattca
     1441 gttgaaatct ggaccttgta gcttttttaa ggttattaag gctgcaaagc caaaaactga
     1501 catgaaaagt gtggagtgaa gtcacctcat ttgaaaaacc ttttcctgaa gaatcctgat
     1561 gctgctcctt gaactagact gaactacctg aggatagcat tttacaacct catcatcata
     1621 ttgtattact tagaaaagga caaatactca aaaaacatct gaaaaatata tgtaaactta
     1681 ttattaatta agttattaag actgcccaac ctggggatcc atcctatata caaccaccaa
     1741 acccagacac tattgcatat gccagcaaga ttttgctgac aggatcctga tatagctctc
     1801 tcttgtgagg ctctgccagt gactgacaag tacagaagca gatgctcaca gtcatctatt
     1861 ggatggaaca cagggcccct aataaaggag ctagagaaag tacccaagca gcaagtggtc
     1921 tgcaacgcta taggaggaac aacaacatga actaaccagt accccccaga actgtgtctc
     1981 cagttgcata tgtagcagaa gatggcctgg ccggtcatca atgggaggag aggcccttgg
     2041 tcttgcaaag atcatatgcc ccagtacagg ggaatgccag ggccaggcag caggagtgga
     2101 tgtgggtggg ttggggagtg tgtgtggggg gtgttatagg ggactttcgg gatagcattt
     2161 gaaatgtaaa tgaagaaaat atctaataaa attgttgctt tgtctaaggt ttgagatatc
     2221 attcttctct acatagacac tgagggtata agtatggcgg gattgcagat gtgacagcag
     2281 ggccttgtcg gagagacgcc tgtgggtgat agagaagatt ggtgatatat aattttttaa
     2341 tttaaaaatt ttaaatttcc ttttggggag gaggttacag gtggaggagg gtgggtatga
     2401 tagtactaag aaatcagtga tattggggta tgtgatgtga aattccctag cactcaataa
     2461 aagaattatg tttttaaaaa gaaagattgt tgataaataa ataaatatga ttttactcat
     2521 gattcagaaa gttagaaaaa a
//
