LOCUS       NM_001347362            1545 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus androgen-induced 1 (Aig1), transcript variant 2, mRNA.
ACCESSION   NM_001347362 XM_006512811
VERSION     NM_001347362.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   Erikci Ertunc,M., Kok,B.P., Parsons,W.H., Wang,J.G., Tan,D.,
            Donaldson,C.J., Pinto,A.F.M., Vaughan,J.M., Ngo,N., Lum,K.M.,
            Henry,C.L., Coppola,A.R., Niphakis,M.J., Cravatt,B.F., Saez,E. and
            Saghatelian,A.
  TITLE     AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of
            hydroxy fatty acids (FAHFAs) in mice
  JOURNAL   J Biol Chem 295 (18), 5891-5905 (2020)
   PUBMED   32152231
  REMARK    GeneRIF: AIG1 and ADTRP are endogenous hydrolases of fatty acid
            esters of hydroxy fatty acids (FAHFAs) in mice.
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   Nickel,N., Cleven,A., Enders,V., Lisak,D., Schneider,L. and
            Methner,A.
  TITLE     Androgen-inducible gene 1 increases the ER Ca(2+) content and cell
            death susceptibility against oxidative stress
  JOURNAL   Gene 586 (1), 62-68 (2016)
   PUBMED   27040980
  REMARK    GeneRIF: Immunoblotting of mouse tissues demonstrated highest
            expression of AIG1 in the liver, lung and heart. AIG1 has a complex
            genomic organization and expresses several splice variants in a
            tissue-dependent manner; AIG1 over-expression slightly increased
            susceptibility to oxidative stress. These results indicate that
            AIG1 plays a role in the control of the intracellular Ca(2+)
            concentration and cell death susceptibility.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134867.3, AK162306.1, EF410113.1 and BE985785.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_001347362.2.
            
            On Nov 24, 2016 this sequence version replaced XM_006512811.3.
            
            Transcript Variant: This variant (2) lacks contains an alternate 3'
            terminal exon, compared to variant 1. The encoded isoform (2) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035305.1, AK162306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC134867.3         81636-81744
            110-1021            AK162306.1         2-913
            1022-1064           EF410113.1         774-816
            1065-1545           BE985785.1         1-481               c
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 5.08 cM"
     gene            1..1545
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /note="androgen-induced 1"
                     /db_xref="GeneID:66253"
                     /db_xref="MGI:MGI:1913503"
     exon            1..340
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..916
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /note="isoform 2 is encoded by transcript variant 2;
                     androgen-induced gene 1 protein; AIG-1; FAHFA hydrolase
                     AIG1; fatty acid esters of hydroxy fatty acids hydrolase
                     AIG1"
                     /codon_start=1
                     /product="androgen-induced gene 1 protein isoform 2"
                     /protein_id="NP_001334291.1"
                     /db_xref="CCDS:CCDS83682.1"
                     /db_xref="GeneID:66253"
                     /db_xref="MGI:MGI:1913503"
                     /translation="MALVPCQVLRVAILLSYCSILCNYKAIEMPSHQTYGGSWKFLTF
                     IDLVIQAVFFGICVLTDLSSLLTRGSGNQEQERQLRKLISLRDWTLAVLAFPVGVFVV
                     AVFWTIYAYDREMIYPRLLDNFIPGWLNHGMHTTVLPFILIEMRTSHHQYPSRSSGLA
                     AICTFSVGYILWVCWIHHVTGMWVYPFLEHIGSGARIIFFGSTTILMNFLYLLGEVLN
                     SYIWDTQRSIEEEKEKPKLE"
     exon            341..496
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /inference="alignment:Splign:2.1.0"
     exon            497..598
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /inference="alignment:Splign:2.1.0"
     exon            599..714
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /inference="alignment:Splign:2.1.0"
     exon            715..878
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1531
                     /gene="Aig1"
                     /gene_synonym="1500031O19Rik; CGI-103"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcgcgta ggctgcactg ccgccccgcc cgcgcaggtc tccggtgcgc tcggcgccgc
       61 cactgtcccc ggggacgcgc cccgcctcct gcgctccgcc cctcgccgcg ccgcgccccg
      121 gttcccacgg cgcccggcac cgcggagcag ctcgcctgcc ctccccacga gcagcccggc
      181 ggggccaggc cgcgcgaaca tggcgcttgt cccctgccag gtgctgcggg tagcaatcct
      241 gctatcctat tgctccatcc tgtgcaacta caaggccatc gaaatgccct cgcatcagac
      301 ctacggaggc agctggaagt tcctgacctt cattgatctg gttatccagg ccgtgttctt
      361 cggcatctgt gtgctgactg acctctctag tcttctgacc agaggcagcg ggaaccagga
      421 gcaagaacga cagctcagga agctcatctc tctccgggac tggacgctgg ccgtgctggc
      481 cttccctgtc ggggtttttg ttgttgcggt gttctggacc atctatgcct atgacagaga
      541 gatgatatac ccaagattgc ttgacaactt tatcccaggg tggctgaacc atggaatgca
      601 cacaacggtt ttgcccttta tattgatcga gatgagaaca tcccaccatc agtatcccag
      661 caggagcagt ggactcgccg ccatatgcac cttctccgtg ggctatatat tatgggtgtg
      721 ctggatacat catgtcaccg gcatgtgggt gtaccctttc ctggaacata ttggctcagg
      781 agccaggatc atcttctttg ggtcaacaac catcctaatg aatttcctgt acctgcttgg
      841 agaagtacta aacagctata tctgggatac acagagaagt atagaagaag aaaaagagaa
      901 gcctaagctg gaatgagatc caagtctgag aggagaagca gggaggagct gccctggaag
      961 tctttgggcc ctgaacacca ttagtgtgga gacagaactt caaaggagaa cattgcatca
     1021 accctggctc cctgaccctg agagaggaca acttttatat acagatacct gcaaaatagg
     1081 ctatgttgcc tttgaaaaga actcaccctc gttattgtaa atactctatc caagttcatt
     1141 attgatgaca tttcccctct tttctagttt taaaattaaa gttggtcatt gaattttcat
     1201 ttctgcaata ataactccac tttatcaaga aaaaaatcaa gtatatttct tgttgaggaa
     1261 tatgataaaa ttggagggtc aggtgtgggt ggaggcattc atagtcagtc ttaaaggagg
     1321 ctggagtcat gacactagta tacgatgtag acccaggagg attcggggtc agtggttcct
     1381 gtggtgatag tatcaggctt gcttcagatg cgcagtatag taatagtatc tgtttagtca
     1441 aaactctgag tgtgcttgga tccctctgtt tgatctgtca aactcttccc acatgcaatc
     1501 gtgactgtta ataaaaacca accaatccaa aaaaaaaaaa aaaaa
//
