LOCUS       NM_001291070            2302 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus apoptosis-inducing factor, mitochondrion-associated 3
            (Aifm3), transcript variant 1, mRNA.
ACCESSION   NM_001291070
VERSION     NM_001291070.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Racedo,S.E., McDonald-McGinn,D.M., Chung,J.H., Goldmuntz,E.,
            Zackai,E., Emanuel,B.S., Zhou,B., Funke,B. and Morrow,B.E.
  TITLE     Mouse and human CRKL is dosage sensitive for cardiac outflow tract
            formation
  JOURNAL   Am J Hum Genet 96 (2), 235-244 (2015)
   PUBMED   25658046
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Chinta,S.J., Rane,A., Yadava,N., Andersen,J.K., Nicholls,D.G. and
            Polster,B.M.
  TITLE     Reactive oxygen species regulation by AIF- and complex I-depleted
            brain mitochondria
  JOURNAL   Free Radic Biol Med 46 (7), 939-947 (2009)
   PUBMED   19280713
  REMARK    GeneRIF: AIF-deficient mice display similar rates of H2O2 release
            and protein carbonyl modifications in brain mitochondria compared
            to WT controls
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158809.1, AK012958.1 and AI835101.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            CDS exon combination :: AK158809.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164131, SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2090              AK158809.1         69-2158
            2091-2248           AK012958.1         1597-1754
            2249-2302           AI835101.1         1-54                c
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.84 cM"
     gene            1..2302
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /note="apoptosis-inducing factor, mitochondrion-associated
                     3"
                     /db_xref="GeneID:72168"
                     /db_xref="MGI:MGI:1919418"
     exon            1..183
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1970
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apoptosis-inducing factor 3; apoptosis-inducing factor
                     like; apoptosis-inducing factor-like protein"
                     /codon_start=1
                     /product="apoptosis-inducing factor 3 isoform 1"
                     /protein_id="NP_001277999.1"
                     /db_xref="CCDS:CCDS79430.1"
                     /db_xref="GeneID:72168"
                     /db_xref="MGI:MGI:1919418"
                     /translation="MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNG
                     TARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEF
                     HALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEK
                     EKVTIRASKQALQLQRRTKVMAKCISPSAGHSSSTNVLIVGAGAAGLVCAETLRQEGF
                     SDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEMLTEAQVVTVDVR
                     NKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDVENVFTIRTPEDANRVLRLARGRN
                     AVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFY
                     MQTEVSELRAQEGKLQEVVLKSSKVLRADVCVLGIGAVPATGFLRQSGIGLDSRGFIP
                     VNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEIN
                     TVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKSDEVIAVASMNYDPI
                     VSKVAEVLASGRAIRKREVELFMLHSKTGDMSWLTGKGS"
     exon            184..397
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            398..507
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            508..617
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            618..662
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            663..759
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            760..872
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            873..959
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1051
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1182
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1298
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1370
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1434
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1511
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1629
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1728
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1804
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1909
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1930
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2286
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /note="hexamer: ATTAAA"
     polyA_site      2286
                     /gene="Aifm3"
                     /gene_synonym="2810401C16Rik; Aifl"
                     /note="major polyA site"
ORIGIN      
        1 gtcctaaagc tgtctagctg gcatggcagc tctagcgtct ctgagggcca cagggggtcc
       61 agtcctgcag ggcacatcct agaccttgga cagctggaca gcctgccatc gtgctcccac
      121 cagccaggcc agatcccagg ccaccgttca ccatgggcgg ctgcttctcc aagcccaagc
      181 cagtggagct caagattgaa gtggtgctgc cagagaaaga gcggggcaag gaggagctgt
      241 cagccagcgg aaagggcagc ccccggggtt accagggcaa cggcacagca cgccacttcc
      301 atgctgaaga gcggctgccc accccacaac cctatcccag ccctcaggac tgtgtggagg
      361 ctactgtctg ccatgtcaag gacctcgaga atggccagat gcgggaagtg gagctgggct
      421 ggggaaaggt gttgctggtg aaggacaatg gggaattcca tgccctgggc cataagtgtc
      481 ctcactatgg agcgcccctg gtgaaaggtg tactgtcccg gggacgtgtg cgctgcccct
      541 ggcatggtgc ctgcttcaac attagtactg gggacctaga ggacttccca ggcctggaca
      601 gcctgcataa gttccaggtg aagattgaga aggagaaggt gaccattcgg gcaagcaagc
      661 aggccctgca gctacagcgg aggacaaagg tgatggccaa gtgtatctct ccaagtgctg
      721 gccacagcag tagcaccaac gtgctcatag tgggtgcagg tgctgctggc ctagtgtgtg
      781 cagaaacact gaggcaggag ggcttctcag accggattgt cctttgcaca ctggatcgac
      841 atctgcccta tgaccgggcc aagctcagca agtccctgga tgcacaaccc gaacagctgg
      901 ccctgagacc caaggaattc ttccgggcct atggcattga gatgctcact gaggctcagg
      961 tagtcacagt ggacgtgaga aataagaagg ttgtgttcaa ggatggcttc aagctagagt
     1021 acagcaagct gctgctggca ccaggaagta gccctaagac cctgacctgc aaagggaaag
     1081 atgtagagaa tgtgttcacc attcgcacgc ccgaggatgc caaccgcgtg ctgcggctcg
     1141 cccggggccg caatgctgtt gttgtgggag caggctttct gggaatggag gttgctgctt
     1201 atctgactga gaaagcccac tcagtatccg tggtagagct ggaggagaca cccttccgga
     1261 ggttcctggg ggaacgtgtt ggtcgtgcac ttatgaagat gtttgaaaac aaccgggtga
     1321 agttctatat gcagacagag gtgtcagagt tgcgggctca agagggcaag ctgcaggagg
     1381 tggtgctgaa gagcagcaaa gtcctgcgag cagatgtctg cgtgttaggc attggtgcgg
     1441 tgcctgccac aggcttcctg aggcagagtg gcattggtct ggattcccga ggtttcatcc
     1501 cagtcaacaa gatgatgcag accaacgtcc caggagtgtt tgctgcaggt gatgctgtca
     1561 cctttcctct tgcctggagg aacaatcgga aagtgaacat cccacactgg cagatggctc
     1621 acgcccaggg gcgggtagca gctcagaaca tgctggcaca ggaggctgag atcaacacgg
     1681 taccctatct gtggactgcc atgttcggca aaagccttcg ctatgctggc tacggagaag
     1741 gcttcgatga tgtcatcatt cagggggatc tggaggagct gaagtttgtg gctttttata
     1801 ccaaaagtga cgaagtgatt gctgtggcca gcatgaacta cgatcccatc gtatccaagg
     1861 tggctgaggt gctagcctca ggtcgagcca tccggaagcg ggaggtggag ttgtttatgc
     1921 tacacagcaa aaccggtgac atgtcttggc tcacaggaaa aggatcctga gctctcctgt
     1981 ggtggacttg ggcaggcctc tggggtacca aggtcagaga ccaagtcctg gggcaagtgc
     2041 caactccaat ttcccaggat ccctcactgt ggaatctgag tcctccaagg cttgccttga
     2101 cctgtctgcc tcgcctccag ccaggctacc acagcctcca gaagatggtc cattcctaat
     2161 gcctcagctg tcactgacag ctgggtgtag aggcaggaca ggctctgcct tggtttcctc
     2221 tactaggacg attttcccag caagcccctt caacattacc ttaaaattaa aacgcatgtc
     2281 tcagcaaaaa aaaaaaaaaa aa
//
