LOCUS       NM_001284300            1534 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus apoptosis-inducing factor, mitochondrion-associated 2
            (Aifm2), transcript variant 4, mRNA.
ACCESSION   NM_001284300
VERSION     NM_001284300.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Yang,M., Shen,Z., Zhang,X., Song,Z., Zhang,Y., Lin,Z. and Chen,L.
  TITLE     Ferroptosis of macrophages facilitates bone loss in apical
            periodontitis via NRF2/FSP1/ROS pathway
  JOURNAL   Free Radic Biol Med 208, 334-347 (2023)
   PUBMED   37619958
  REMARK    GeneRIF: Ferroptosis of macrophages facilitates bone loss in apical
            periodontitis via NRF2/FSP1/ROS pathway.
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Mishima,E., Ito,J., Wu,Z., Nakamura,T., Wahida,A., Doll,S.,
            Tonnus,W., Nepachalovich,P., Eggenhofer,E., Aldrovandi,M.,
            Henkelmann,B., Yamada,K.I., Wanninger,J., Zilka,O., Sato,E.,
            Feederle,R., Hass,D., Maida,A., Mourao,A.S.D., Linkermann,A.,
            Geissler,E.K., Nakagawa,K., Abe,T., Fedorova,M., Proneth,B.,
            Pratt,D.A. and Conrad,M.
  TITLE     A non-canonical vitamin K cycle is a potent ferroptosis suppressor
  JOURNAL   Nature 608 (7924), 778-783 (2022)
   PUBMED   35922516
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Tonnus,W., Meyer,C., Steinebach,C., Belavgeni,A., von
            Massenhausen,A., Gonzalez,N.Z., Maremonti,F., Gembardt,F.,
            Himmerkus,N., Latk,M., Locke,S., Marschner,J., Li,W., Short,S.,
            Doll,S., Ingold,I., Proneth,B., Daniel,C., Kabgani,N., Kramann,R.,
            Motika,S., Hergenrother,P.J., Bornstein,S.R., Hugo,C., Becker,J.U.,
            Amann,K., Anders,H.J., Kreisel,D., Pratt,D., Gutschow,M., Conrad,M.
            and Linkermann,A.
  TITLE     Dysfunction of the key ferroptosis-surveilling systems
            hypersensitizes mice to tubular necrosis during acute kidney injury
  JOURNAL   Nat Commun 12 (1), 4402 (2021)
   PUBMED   34285231
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Xue,L., Guo,W., Li,L., Ou,S., Zhu,T., Cai,L., Ding,W. and Wu,W.
  TITLE     Metabolomic profiling identifies a novel mechanism for heat
            stroke-related acute kidney injury
  JOURNAL   Mol Med Rep 23 (4) (2021)
   PUBMED   33655337
  REMARK    GeneRIF: Metabolomic profiling identifies a novel mechanism for
            heat strokerelated acute kidney injury.
REFERENCE   6  (bases 1 to 1534)
  AUTHORS   Miriyala,S., Thippakorn,C., Chaiswing,L., Xu,Y., Noel,T.,
            Tovmasyan,A., Batinic-Haberle,I., Vander Kooi,C.W., Chi,W.,
            Latif,A.A., Panchatcharam,M., Prachayasittikul,V.,
            Butterfield,D.A., Vore,M., Moscow,J. and St Clair,D.K.
  TITLE     Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial
            stress signaling
  JOURNAL   Free Radic Biol Med 91, 68-80 (2016)
   PUBMED   26689472
  REMARK    GeneRIF: 4-hydroxy-2-nonenal adduction of AIFm2 shifts the function
            of AIFm2 from an NADH oxidoreductase to a proapototic protein.
REFERENCE   7  (bases 1 to 1534)
  AUTHORS   Kojima,N., Tanaka,Y., Kulkeaw,K., Nakanishi,Y., Shirasawa,S. and
            Sugiyama,D.
  TITLE     Apoptosis-inducing Factor, Mitochondrion-associated 2, Regulates
            Klf1 in a Mouse Erythroleukemia Cell Line
  JOURNAL   Anticancer Res 35 (8), 4493-4499 (2015)
   PUBMED   26168492
  REMARK    GeneRIF: Aifm2 may function in differentiation of erythroid murine
            erythroleukemia line cells in vitro.
REFERENCE   8  (bases 1 to 1534)
  AUTHORS   Zhou,Y., Feng,X. and Koh,D.W.
  TITLE     Activation of cell death mediated by apoptosis-inducing factor due
            to the absence of poly(ADP-ribose) glycohydrolase
  JOURNAL   Biochemistry 50 (14), 2850-2859 (2011)
   PUBMED   21366272
  REMARK    GeneRIF: Results demonstrate nuclear AIF translocation only in
            PARG-null TS cells, which demonstrates the presence of AIF-mediated
            cell death.
REFERENCE   9  (bases 1 to 1534)
  AUTHORS   Mei,J., Webb,S., Zhang,B. and Shu,H.B.
  TITLE     The p53-inducible apoptotic protein AMID is not required for normal
            development and tumor suppression
  JOURNAL   Oncogene 25 (6), 849-856 (2006)
   PUBMED   16186796
  REMARK    GeneRIF: AMID is not required for normal development and
            p53-mediated tumor suppression.
REFERENCE   10 (bases 1 to 1534)
  AUTHORS   Kichina,J.V., Zeremski,M., Aris,L., Gurova,K.V., Walker,E.,
            Franks,R., Nikitin,A.Y., Kiyokawa,H. and Gudkov,A.V.
  TITLE     Targeted disruption of the mouse ing1 locus results in reduced body
            size, hypersensitivity to radiation and elevated incidence of
            lymphomas
  JOURNAL   Oncogene 25 (6), 857-866 (2006)
   PUBMED   16170338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB847470.1, AK017403.1 and BC038129.1.
            
            Transcript Variant: This variant (4) encodes the shorter isoform
            (2). Variants 2, 3 and 4 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017403.1, SRR5189682.59570.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BB847470.1         2-3
            3-813               AK017403.1         1-811
            814-1081            BC038129.1         807-1074
            1082-1506           AK017403.1         1079-1503
            1507-1534           BC038129.1         1324-1351
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.27 cM"
     gene            1..1534
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /note="apoptosis-inducing factor, mitochondrion-associated
                     2"
                     /db_xref="GeneID:71361"
                     /db_xref="MGI:MGI:1918611"
     exon            1..90
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            91..289
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1233
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /note="isoform 2 is encoded by transcript variant 4;
                     apoptosis-inducing factor (AIF)-like
                     mitochondrion-associated inducer of death;
                     apoptosis-inducing factor-like mitchondrion-associated
                     inducer of death; apoptosis-inducing factor 2;
                     apoptosis-inducing factor-like mitochondrion-associated
                     inducer of death; apoptosis-inducing factor homologous
                     mitochondrion-associated inducer of death; p53-responsive
                     gene 3 protein; ferroptosis suppressor protein 1"
                     /codon_start=1
                     /product="ferroptosis suppressor protein 1 isoform 2"
                     /protein_id="NP_001271229.1"
                     /db_xref="CCDS:CCDS23884.1"
                     /db_xref="GeneID:71361"
                     /db_xref="MGI:MGI:1918611"
                     /translation="MGSQVSVDTGAVHVVIVGGGFGGIAAASQLQALNVPFMLVDMKD
                     SFHHNVAALRASVESGFAKKTFISYSATFKDNFRQGKVIGIDLKNRMVLLQGGEALPF
                     SHLILATGSTGPFPGKFNEVSCQQAAIQAYEDMVKQIQRSQFIVVVGGGSAGVEMAAE
                     IKTEYPEKEVTLIHSRVPLADKELLPCVRQEVKEILLRKGVQLLLSERVSNLEELPRN
                     EYREYIKVETDKGTEVATNMVIVCNGIKINSSAYRSAFESRLASNGALKVNEFLQVEG
                     YSNIYAIGDCADTKEPKMAYHAGLHANVAVANIVNSMKQRPLKAYKPGALTFLLSMGR
                     NDGVGQISGFYVGRLMVRLAKSRDLLISTSWKTMRQSPP"
     exon            290..405
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            406..525
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            526..618
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            619..727
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            728..880
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1081
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1257
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1512
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="Aifm2"
                     /gene_synonym="5430437E11Rik; Amid; D730001I10Rik; FSP1;
                     PRG3"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggggc tgcgacccgg agacagtgat gggcacgccc cgacacgggg cctcagcgcc
       61 ggaagacgcg aggaccaagg accgctacag ctcccaagtg ccaagttcaa gatggggtcc
      121 caggtctcgg tggatacagg agccgtgcac gtggtgatcg tgggcggggg cttcggaggg
      181 atagcggctg ccagccagct gcaggcgctg aatgtcccct tcatgctggt ggatatgaag
      241 gactccttcc accacaatgt ggcagccctc cgggcctccg tggagagcgg gttcgccaaa
      301 aagacattca tttcgtactc tgcgaccttc aaggacaact tccgccaggg caaagtgatt
      361 ggcatagact tgaagaaccg gatggtgttg ctacagggtg gcgaggcctt gcccttctca
      421 catcttatcc tggccacagg cagcaccgga cccttccctg gcaagtttaa cgaggtgtcc
      481 tgccagcagg cagccatcca ggcctatgag gacatggtga agcagatcca gcgctcacaa
      541 ttcatcgtgg tggtgggagg cggctctgca ggagtagaga tggcagcaga gattaaaacc
      601 gagtaccctg agaaggaggt cactcttatc cactccagag tacccctggc cgacaaggaa
      661 ctcctgccct gtgtgcggca ggaagtgaag gagatcctcc tccggaaggg tgtgcagctg
      721 ctgctgagtg agcgggtgag caacctggag gaactgcctc gcaatgagta tcgggagtac
      781 atcaaggtgg agacagacaa gggcacggag gtggccacca acatggtgat tgtgtgcaat
      841 gggatcaaga tcaacagctc tgcctaccgc agtgcatttg agagtaggct ggctagcaat
      901 ggtgctctga aagtgaacga gttcctccag gtggaaggtt acagcaatat ttatgccatt
      961 ggtgactgtg ccgataccaa ggagcccaag atggcctacc acgctggcct gcatgccaat
     1021 gttgccgtgg ccaacatcgt caactccatg aagcagaggc cactcaaagc ttacaagcca
     1081 ggtgcgctga cattcctcct gtccatgggc agaaatgatg gcgtgggtca gatcagtggc
     1141 ttctacgtag gccgcctcat ggtgcggctg gccaagagca gggaccttct catctccaca
     1201 agctggaaaa ccatgcggca gtctccaccg tgacagggag gctgcgtggg agtcgagaga
     1261 ctgaccaacc accggcagct ttgtccccgg ctctgctgct gtggacacca gccaggaagc
     1321 tcaccctctc tgagggaagg atcaactacc tgcaggaagc cggccatgtg agaactctac
     1381 agagcatggc gggactcttc agtgacaggc cttgtgttat ttctttataa ccgtctggat
     1441 gaatctgtct gtggggaacg cggttgtcca gaaggaggaa aatatcgcaa taaagggcta
     1501 tgttataaga aaaaaaaaaa aaaaaaaaaa aaaa
//
