LOCUS       NM_145144               2967 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus allograft inflammatory factor 1-like (Aif1l), mRNA.
ACCESSION   NM_145144
VERSION     NM_145144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2967)
  AUTHORS   Parikh,D., Jayakumar,S., Oliveira-Paula,G.H., Almonte,V.,
            Riascos-Bernal,D.F. and Sibinga,N.E.S.
  TITLE     Allograft inflammatory factor-1-like is a situational regulator of
            leptin levels, hyperphagia, and obesity
  JOURNAL   iScience 25 (10), 105058 (2022)
   PUBMED   36134334
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2967)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2967)
  AUTHORS   Parikh,D., Riascos-Bernal,D.F., Egana-Gorrono,L., Jayakumar,S.,
            Almonte,V., Chinnasamy,P. and Sibinga,N.E.S.
  TITLE     Allograft inflammatory factor-1-like is not essential for age
            dependent weight gain or HFD-induced obesity and glucose
            insensitivity
  JOURNAL   Sci Rep 10 (1), 3594 (2020)
   PUBMED   32107417
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2967)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2967)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2967)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   8  (bases 1 to 2967)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC024599.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024599.1, AK028955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.95 cM"
     gene            1..2967
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /note="allograft inflammatory factor 1-like"
                     /db_xref="GeneID:108897"
                     /db_xref="MGI:MGI:1919598"
     exon            1..79
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..501
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /note="ionized calcium binding adapter molecule 2"
                     /codon_start=1
                     /product="allograft inflammatory factor 1-like"
                     /protein_id="NP_660126.1"
                     /db_xref="CCDS:CCDS15904.1"
                     /db_xref="GeneID:108897"
                     /db_xref="MGI:MGI:1919598"
                     /translation="MSVALSNRFQGGKAFGLLKARQEKRLEEINREFLCDQKYSDEEN
                     LPEKLAAFKEKYMEFDLNNEGEIDLMSLKRMMEKLGVPKTHLEMKKMISEVTGGVSDT
                     ISYRDFVNMMLGKRSAVLKLVMMFEGKANESSPKPAGPPPERDIASLP"
     exon            80..141
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..208
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..250
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..413
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..2953
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /note="hexamer: ATTACA"
     polyA_site      1350
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /note="major polyA site"
     regulatory      2935..2940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /note="hexamer: AATAAA"
     polyA_site      2953
                     /gene="Aif1l"
                     /gene_synonym="2810003C17Rik; Iba2"
                     /note="major polyA site"
ORIGIN      
        1 cttttcctcc ctgttgtccc tggccttgtc cggagtcggg ctcataccat gtcggtcgca
       61 ctcagcaaca ggttccaagg agggaaggcg ttcggtttgc tcaaagcccg gcaggagaag
      121 aggctcgagg agatcaatcg ggagttcctc tgtgaccaga agtacagtga tgaagagaac
      181 ctgccggaaa agctcgcagc cttcaaagag aaatacatgg agtttgacct gaataatgaa
      241 ggcgagattg atctgatgtc tttaaagagg atgatggaga agctgggggt ccccaagacc
      301 cacctggaga tgaagaagat gatctcggag gtgacagggg gtgtcagtga caccatctcc
      361 taccgagact ttgtgaatat gatgctgggc aagcggtcgg ctgtcctcaa gctggtcatg
      421 atgtttgaag gaaaagccaa cgagagcagc ccgaagccag ctggcccacc tccagagcga
      481 gacatcgcca gcctgccttg aggacccacc cggaccttcc gggctgccat ccctgcccct
      541 gcctctccct ctgcgctctg ccatcttgac tcattgtgtt aggtctcctg ggttatgccc
      601 cagtggactc attttttttt tttctctatg taagcacatg ttacctgact taatgaggct
      661 gggaatcccg agcctcaggc ccctctgctc cctgctgctc tgccctcttt gtacaaaagg
      721 gctaacatca aaccaaaaac tggagagggc agggaggctg caaacctcgt tcccatgttt
      781 gaagagggcc tgtccgtcag ttcatctttc tcagcttcta aattaaattc aggctgcaag
      841 ctgctctcgg aagatccaga gcaggcacag agctccaggg ctccctagtg tcttagggac
      901 atgcttccag tgccgctgga ccttctagca gcggctactc agtggctaga cacacaactg
      961 attccctttt gttcttgccc ttgtccattc tcagcgacat gacgcaaggt ggggaggaaa
     1021 gaacaacctt tgggtacttc agaggaacca gaaggaaccg ctcctttaca gacagctcag
     1081 agggacagtg taatggcact gtcccttgct agagcagtag aggggtttgg aggcagaggt
     1141 gaggtcagtg gtgtgaggga gtcctacttt cagggtggat gctgagggca ccagggtaga
     1201 agtggagtca agtgttgaac ctcaaacaga gaacaggctg tctgattgca cagtgcccca
     1261 atccggctat ttactgtcct gccctactct cccctccctt cactccctca gttatttatc
     1321 gagtgtgtat tacaagcttt aagttctctt gctttgtctc catgtgtgct atgtccaact
     1381 cctagctccc ttttcaaatc cctcaagtcc tggagcttgg ggattagatg gaggtaacat
     1441 ggcagatttt agctgggcca gtccttccat ttcactgctg gcctccaggg gttaagtgcc
     1501 ttgctgaagg ttggtggggg ctatcagaga gtgtggactg gagacccgct ctaggctgca
     1561 ttggtcaaag gaaagggtag agagcagcat ttcccagcct gatacttgag gaaggtgtgg
     1621 tctccacgga acaccttggg tcaggactca ccctcctgag ggcctccagg ttggcagtga
     1681 gatttcagta agcaccaagc ctagctttgc agattgtctt ccttacagct tcctgactgg
     1741 tcttcagaga ccatttccaa gaattcatgc agcaaagtat caaatgtctt acccgagtgg
     1801 ggaacctcag ccttgaccct gcttgtgttc tggaaccatt tactctgggc actcaggacg
     1861 agacagtcac tcatcacaca tatttatcaa gcacctgctc aatgacacga gtccagaacc
     1921 cggcagtgaa atggactgat gtatgaaatt tatgtctact ggggaatcac tcccagccaa
     1981 tctagccaat gactatgata tggagtgggg gggagtgcaa gaggtgagta ccatgtagtc
     2041 ccagggattc cagctgggct cataatttgg caagtgtcag aggagcctct gtaaaacctt
     2101 aagtggaaaa gacagggaag cgttgagcta atgtgctttt cctgtggctc ttgttccaca
     2161 gtccaatacc cagggtgctg ttcccacagc agtgagagag agagagagtg aagcaaacag
     2221 ggcatggaat ggttagctcc agttcgtcct ctggtctcaa ccagttcagt tcaggagaga
     2281 gatcatttcg ctatgactgg ctgattttca gccctaggag ctgcttcaaa tgcacagtct
     2341 agttgaagtt taaaccccag cattcctccc tataaatata aaatcctgtc taccctcacc
     2401 ccatcctttg acttattttt cttttaagat tagcatctct gcccccattt cctcctgcct
     2461 tccttctctg agcgggctgg gaccttggac tgcattgggt ccctattcta tgtgacagag
     2521 gaaggaagaa tcagccggct cagtgggtcc acaactcatg agcttacaca ccacctccat
     2581 aaaggagtgt gccactgacc tctgcagagc acagaaagag gcagtggtct gaagatcaat
     2641 ctatgggaag acttaagaat gaccctttaa tggaggagtt ggcatatatt tcaagttgtg
     2701 tctgttggtt ccagggtttt taacctctct agttaagggc ttagctttct tgggacatcg
     2761 gctgccttat ttctgaaaaa gaccaaatgt aactggtgta accagcagtt tggggattgc
     2821 caagtatggc tttgccctgt gactcaaaag atgtttgtaa ggtagatttg ggtgagtgcc
     2881 attattgtgt gcatgtgtgt atgtatggat gggatgtggt ctcctgcaga ctgaaataaa
     2941 ctagagcaat ttaaaaaaaa aaaaaaa
//
