LOCUS       NM_001409899             947 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus allograft inflammatory factor 1 (Aif1), transcript
            variant 4, mRNA.
ACCESSION   NM_001409899 XM_006523503
VERSION     NM_001409899.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Li,C., Zhang,M., Du,Y., Liu,S., Li,D., Zhang,S., Ji,F., Zhang,J.
            and Jiao,J.
  TITLE     Compromised cell competition exhausts neural stem cells pool
  JOURNAL   Cell Prolif 57 (12), e13710 (2024)
   PUBMED   39010274
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Omura,S., Ogawa,R., Kawachi,T., Ogawa,A., Arai,Y., Takayama,N.,
            Masui,A., Kondo,K., Sugimoto,H., Shinohara,H.M., Takahashi,T.,
            Maeda,H. and Ohyama,K.
  TITLE     Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the
            neurovascular unit in the developing mouse hippocampus
  JOURNAL   Front Cell Neurosci 18, 1464402 (2024)
   PUBMED   39484182
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 947)
  AUTHORS   Neumann,E., Cramer,T., Acuna,M.A., Scheurer,L., Beccarini,C.,
            Luscher,B., Wildner,H. and Zeilhofer,H.U.
  TITLE     gamma1 GABAA Receptors in Spinal Nociceptive Circuits
  JOURNAL   J Neurosci 44 (41), e0591242024 (2024)
   PUBMED   39137998
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 947)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 947)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
REFERENCE   6  (bases 1 to 947)
  AUTHORS   Sasaki,Y., Ohsawa,K., Kanazawa,H., Kohsaka,S. and Imai,Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (bases 1 to 947)
  AUTHORS   Ohsawa,K., Imai,Y., Kanazawa,H., Sasaki,Y. and Kohsaka,S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (bases 1 to 947)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (bases 1 to 947)
  AUTHORS   Handel-Fernandez,M.E., Kurimoto,I., Streilein,J.W. and Vincek,V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (bases 1 to 947)
  AUTHORS   Lund,T., Shaikh,S., Kendall,E., Campbell,R.D., Hattori,M.,
            Makino,S. and Cooke,A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            On Jul 25, 2022 this sequence version replaced XM_006523503.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.277632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CR974444.18        111968-111996       c
            30-235              CR974444.18        109065-109270       c
            236-410             CR974444.18        108510-108684       c
            411-472             CR974444.18        108280-108341       c
            473-539             CR974444.18        108123-108189       c
            540-581             CR974444.18        107758-107799       c
            582-744             CR974444.18        107409-107571       c
            745-947             CR974444.18        106986-107188       c
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..947
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /note="allograft inflammatory factor 1"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
     exon            1..29
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     exon            30..235
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..410
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..829
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /note="isoform a is encoded by transcript variant 4;
                     testis specific; ionized calcium binding adapter molecule
                     1"
                     /codon_start=1
                     /product="allograft inflammatory factor 1 isoform a"
                     /protein_id="NP_001396828.1"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
                     /translation="MSQSRDLQGGKAFGLLKAQQEERLEGINKQFLDDPKYSNDEDLP
                     SKLEAFKVKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKRLIREVSSGSEETFS
                     YSDFLRMMLGKRSAILRMILMYEEKNKEHKRPTGPPAKKAISELP"
     exon            411..472
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..539
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..581
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..744
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..947
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      923..928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /note="hexamer: AATAAA"
     polyA_site      947
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /note="major polyA site"
ORIGIN      
        1 agacgaaccc tctgatgtgg tctgcacagg gcgctaggct cagctcaccc cattcctgga
       61 gcagcctgca gacttcatcc tctctcttcc atcccgggga aagtcagcca gtcctcctca
      121 gctgcctgtc ttaacctgca tcatgaagcc tgaggagatt tcaagtaaac cctcccaagc
      181 cccacctcag gatctgggga aagccactgt ctaccgcatc cttggtttga gacagaagct
      241 gatgtggaag tgatgcctgg gagttagcaa gggaatgagt ggaaagggga agtgtgagaa
      301 cggtcccaga agagactggg gagctggtgg agagaggacc cagcggacag actgccagcc
      361 taagacaacc agcgtctgag gagccatgag ccaaagcagg gatttgcagg gaggaaaagc
      421 ttttggactg ctgaaggccc agcaggaaga gaggctggag gggatcaaca agcaattcct
      481 cgatgatccc aaatacagca atgatgagga tctgccgtcc aaacttgaag ccttcaaggt
      541 gaagtacatg gagtttgatc tgaatggaaa tggagatatc gatattatgt ccttgaagcg
      601 aatgctggag aaacttgggg ttcccaagac ccacctagag ctgaagagat taattagaga
      661 ggtgtccagt ggctccgagg agacgttcag ctactctgac tttctcagaa tgatgctggg
      721 caagagatct gccatcttga gaatgattct gatgtatgag gagaaaaaca aagaacacaa
      781 gaggccaact ggtcccccag ccaagaaagc tatctccgag ctgccctgat tggaggtgga
      841 tgtcacacgg tggggctgag tgaggagctt ctgatgacag cagcatggaa aaaagaaaca
      901 gtcgtgagcc agagtcagac taaataaatg acgctcctag tgggtca
//
