LOCUS       NM_181732               3293 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus axin interactor, dorsalization associated (Aida),
            mRNA.
ACCESSION   NM_181732
VERSION     NM_181732.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Shi,M., Huang,X.Y., Ren,X.Y., Wei,X.Y., Ma,Y., Lin,Z.Z., Liu,D.T.,
            Song,L., Zhao,T.J., Li,G., Yao,L., Zhu,M., Zhang,C., Xie,C., Wu,Y.,
            Wu,H.M., Fan,L.P., Ou,J., Zhan,Y.H., Lin,S.Y. and Lin,S.C.
  TITLE     AIDA directly connects sympathetic innervation to adaptive
            thermogenesis by UCP1
  JOURNAL   Nat Cell Biol 23 (3), 268-277 (2021)
   PUBMED   33664495
  REMARK    GeneRIF: AIDA directly connects sympathetic innervation to adaptive
            thermogenesis by UCP1.
REFERENCE   2  (bases 1 to 3293)
  AUTHORS   Luo,H., Jiang,M., Lian,G., Liu,Q., Shi,M., Li,T.Y., Song,L., Ye,J.,
            He,Y., Yao,L., Zhang,C., Lin,Z.Z., Zhang,C.S., Zhao,T.J., Jia,W.P.,
            Li,P., Lin,S.Y. and Lin,S.C.
  TITLE     AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes
            by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity
  JOURNAL   Cell Metab 27 (4), 843-853 (2018)
   PUBMED   29617643
  REMARK    GeneRIF: AIDA plays a central role in coordinating the abundance of
            the enzymes for triacylglycerol synthesis.
REFERENCE   3  (bases 1 to 3293)
  AUTHORS   Rui,Y., Xu,Z., Xiong,B., Cao,Y., Lin,S., Zhang,M., Chan,S.C.,
            Luo,W., Han,Y., Lu,Z., Ye,Z., Zhou,H.M., Han,J., Meng,A. and
            Lin,S.C.
  TITLE     A beta-catenin-independent dorsalization pathway activated by
            Axin/JNK signaling and antagonized by aida
  JOURNAL   Dev Cell 13 (2), 268-282 (2007)
   PUBMED   17681137
  REMARK    GeneRIF: Aida blocks Axin-mediated JNK activation by disrupting
            Axin homodimerization. In zebrafish embryos, the dorsalization
            induced by axin could be repressed by aida. This activity of aida
            is conferred by its ability to block Axin-mediated JNK activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK081494.1, BC086763.1 and BY511767.1.
            
            On Sep 5, 2007 this sequence version replaced NM_181732.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149788.1, AK081494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AK081494.1         2-477
            477-2401            BC086763.1         182-2106
            2402-2968           AK081494.1         2403-2969
            2969-3293           BY511767.1         91-415
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3293
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /note="axin interactor, dorsalization associated"
                     /db_xref="GeneID:108909"
                     /db_xref="MGI:MGI:1919737"
     exon            1..569
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..1377
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /note="axin interaction partner and dorsalization
                     antagonist"
                     /codon_start=1
                     /product="axin interactor, dorsalization-associated
                     protein"
                     /protein_id="NP_859421.1"
                     /db_xref="CCDS:CCDS56663.1"
                     /db_xref="GeneID:108909"
                     /db_xref="MGI:MGI:1919737"
                     /translation="MSEVTRSLLQRWGASLRRGADFDSWGQLVEAIDEYQILARHLQK
                     EAQAQHNNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKLEDLKKLEPILKNIL
                     TYNKEFPFDVQPIPLRRILAPGEEENLEFEEDEEGGAGAGPPDSFSARVPGTLLPRLP
                     SEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVH
                     FNVDIELQKHVERLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYK
                     KPTDFKRKKLQLLTKKPLYLHLHQSLHKE"
     exon            570..639
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            640..693
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..748
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            749..812
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..916
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1039
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1162
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1280
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..3293
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2406
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /note="major polyA site"
     regulatory      2948..2953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2970
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /note="major polyA site"
     regulatory      3097..3102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3116
                     /gene="Aida"
                     /gene_synonym="2610208M17Rik"
ORIGIN      
        1 ggagaccgca ccagctgcgg aggcggccga gcgtgtctct gaggggcggg ttcggtcccg
       61 ctgtcgcggc cccgtcggtt ctctccgtct ccctaccctc tctaaacttc gtctgctctt
      121 acctcttgag cttctgtctg ggccctagag atgtagcctg gggtccccaa accaaggccg
      181 aatgccactg tagctatggc ggcccccgag gattggggcg gcctcaacct aactggggcg
      241 tggcttgggg gcgtggcctc ggcggggcgg ccgccttgga gctgcaaagt ttggctgtgg
      301 cggcaaatgg gtttgggcgg ctcctcggcg ggtggcggtg gtggccttag cggttcctcc
      361 tggccctgtt aatgtcaggg ccaagcccgg ggaggatggc gccctagagc ctggccttgc
      421 tggggtaggg gcgggagggg gccggggcgg ggaccggcca tgtcggaggt gacccggagt
      481 ctgctgcagc gctggggcgc cagtcttagg agaggcgccg acttcgactc ttggggccag
      541 ctggtggagg cgatagacga gtatcagata ttagcaagac acttacagaa ggaggcccaa
      601 gctcaacaca ataattctga atttacagaa gaacaaaaga aaaccatagg caaaattgcg
      661 acatgtttgg aattgcgaag tgcagcatta cagtccacac agtcccaaga agagtttaaa
      721 ctggaggacc tgaagaagct agaaccaatc ctgaagaata ttcttacata taataaagaa
      781 ttcccatttg atgttcagcc tattccatta agacgtattt tagcacctgg tgaagaagag
      841 aatttggaat ttgaagaaga tgaagaaggt ggtgctggag cagggcctcc tgattctttc
      901 tctgctagag ttcctggtac tttattgcca cggttgccat cggaaccagg gatgacgtta
      961 ctcaccatca ggattgagaa aattggtttg aaagatgcgg ggcagtgcat cgatccctac
     1021 atcacagtca gcgtgaaaga tttgaatggc atagatttaa ctcccgtaca agacactcct
     1081 gtggcttcaa ggaaagaaga tacttacgtt cactttaatg tggacattga gctccagaaa
     1141 cacgttgaaa ggttaaccaa aggtgcggcc attttctttg aattcaaaca ttacaagcct
     1201 aaaaagaggt ttaccagcac taagtgtttt gccttcatgg agatggatga aattaaacct
     1261 gggccaatcg taatagaact atacaagaaa cccactgact ttaaaagaaa gaaattgcaa
     1321 ttgttgacca agaaaccact ttatcttcat ctacatcaaa gtttgcacaa ggaatgatcc
     1381 tgatacaaat aaccaagaac ttgtgtgaat tttaccactc agaacccatc atagctctga
     1441 gtagcataat cacccttcaa caggcaggaa gtgagccctt caacaggcag gaagtgagcc
     1501 ctacccacgc cagctgacca agcgagtcta ttgcacagcc ggaccccaga acaaaagttc
     1561 agcacatcac tgacctatca ctcctttgga tacaggttta ttgtagattt ggaaacgttt
     1621 tcacttttct attaattgtg caatgaatag tctattttct cattgcctct actcccctgt
     1681 ttcccggaca gcactgttgt agatgtgcag aacttcagac aatgcagcaa taagaatgtg
     1741 caagagtcta cgtctctgct cacttctgct ccagtatgct cttctggttt caatgccacg
     1801 ctgtgagttg aagtgggtag aactgctctg agaggaactg gactagttac attgcctagc
     1861 aaagtctcct tagaagagac ctagcctggt gccatgggtc tcctgcatag aaagtgtgac
     1921 ctggccagat gagcatccca ccctgagtgt tccccggatg accagactga tttcctgaag
     1981 agagcacgtg tatcgtcagg tggattatct gctcttctct attgtactgc taattctttc
     2041 tggtagttct agggttaacg ttggaaccat ctcagaataa ctatggattt gaaaatgtgt
     2101 ttacagtatc ttttaaactg tatcatttag gaacagttga gtcagatgtc aagatgttgc
     2161 gggataactg ctgctttcct gaccacccgt tgtgagacct taagaccccg tacctctcct
     2221 tagtatgcaa aaatctggaa agactgtcta ttttttttta atataggtag ataggattgc
     2281 catttatttc ctatttagat atacagtcat tcatccatat gaaaatatgc aggtcactag
     2341 tttattttga atggactatt tacttttggt gtaacaaggc ataaataaaa ctttgaaagc
     2401 acatgatgga tggttgttac acagagcatt aggactcatg aggggctttc tgtgggttag
     2461 acatgccata tactttaata ttcacatgtc agtgacctca ccacaccatt caatatactt
     2521 gctttttcaa gtaaataacc acaaggaaga tgtcttaaac ttgtccttca agagatctag
     2581 tcttggcttt cattcagcac ctactaggcc actgtttact agatggagct taataaaaac
     2641 tgtatttcag gttcaacctg aaaaaaaatc cacaaccaaa ttaatcttga ttgggtagtt
     2701 ccaactgcta aaatcatccc atctataata gctctagggg gaggagattt ttgccttaaa
     2761 ttagctcact ctcccactca ggctttgagt tgtaggtccc caggctgtaa gctcctgggg
     2821 caagagttgt agctgtcatg gaagggtcta aggtacttgg cagtactctg tacctgggga
     2881 gtactcagta cattttgttt gatattgctg actagacata aaaattaatt ccttaaaacc
     2941 tattattatt aaaacgtagc aaagactgta cattgtcctt tctcatttct tacagatcat
     3001 aaaagacaaa tagcaaggtg gtaattttct gtgctacagc actgatcatt cacacagcat
     3061 ggcatatatg aaccacaaat gcctgccgtc agggttaata aagcacttta gtggaacatg
     3121 atattaaaaa ctaaagctcg ccaggcactg gtggtgcaca tctttaatcc cagcactcgg
     3181 gaggcagagg caggcagatt tctgagtttg aggctagcct ggtctacaga gtgtgttcca
     3241 ggacagccag ggctacacag agaaaccctg tcttgaaaaa aaaccaacta acc
//
