LOCUS       NM_009645               2413 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus activation-induced cytidine deaminase (Aicda), mRNA.
ACCESSION   NM_009645
VERSION     NM_009645.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Kabrani,E., Rahjouei,A., Berruezo-Llacuna,M., Ebeling,S., Saha,T.,
            Altwasser,R., Delgado-Benito,V., Pavri,R. and Di Virgilio,M.
  TITLE     RIF1 integrates DNA repair and transcriptional requirements during
            the establishment of humoral immune responses
  JOURNAL   Nat Commun 16 (1), 777 (2025)
   PUBMED   39824820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2413)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   4  (bases 1 to 2413)
  AUTHORS   Xu,T., Zhang,T., Xu,C., Yang,F., Zhang,W. and Huang,C.
  TITLE     Notch2 signaling governs activated B cells to form memory B cells
  JOURNAL   Cell Rep 43 (7), 114454 (2024)
   PUBMED   38990721
REFERENCE   5  (bases 1 to 2413)
  AUTHORS   von Loeffelholz,C., Winkler,R., Weigel,C., Piskor,E.M., Vivas,W.,
            Rauchfuss,F., Settmacher,U., Rubio,I., Weis,S., Graler,M.H.,
            Bauer,M. and Kosan,C.
  TITLE     Increased peritoneal B1-like cells during acute phase of human
            septic peritonitis
  JOURNAL   iScience 27 (7), 110133 (2024)
   PUBMED   38984201
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2413)
  AUTHORS   Okazaki,I.M., Kinoshita,K., Muramatsu,M., Yoshikawa,K. and Honjo,T.
  TITLE     The AID enzyme induces class switch recombination in fibroblasts
  JOURNAL   Nature 416 (6878), 340-345 (2002)
   PUBMED   11875397
  REMARK    GeneRIF: ectopic expression of AID induces CSR in an artificial
            switch construct in fibroblasts at a level comparable to that in
            stimulated B cells
REFERENCE   7  (bases 1 to 2413)
  AUTHORS   Nagaoka,H., Muramatsu,M., Yamamura,N., Kinoshita,K. and Honjo,T.
  TITLE     Activation-induced deaminase (AID)-directed hypermutation in the
            immunoglobulin Smu region: implication of AID involvement in a
            common step of class switch recombination and somatic hypermutation
  JOURNAL   J Exp Med 195 (4), 529-534 (2002)
   PUBMED   11854365
  REMARK    GeneRIF: B cell stimulation which induces class switch
            recombination (CSR) but not somatic hypermutation (SHM), leads to
            AID-dependent accumulation of SHM-like point mutations in the
            switch mu region, uncoupled with CSR
REFERENCE   8  (bases 1 to 2413)
  AUTHORS   Muramatsu,M., Kinoshita,K., Fagarasan,S., Yamada,S., Shinkai,Y. and
            Honjo,T.
  TITLE     Class switch recombination and hypermutation require
            activation-induced cytidine deaminase (AID), a potential RNA
            editing enzyme
  JOURNAL   Cell 102 (5), 553-563 (2000)
   PUBMED   11007474
REFERENCE   9  (bases 1 to 2413)
  AUTHORS   Muto,T., Muramatsu,M., Taniwaki,M., Kinoshita,K. and Honjo,T.
  TITLE     Isolation, tissue distribution, and chromosomal localization of the
            human activation-induced cytidine deaminase (AID) gene
  JOURNAL   Genomics 68 (1), 85-88 (2000)
   PUBMED   10950930
REFERENCE   10 (bases 1 to 2413)
  AUTHORS   Muramatsu,M., Sankaranand,V.S., Anant,S., Sugai,M., Kinoshita,K.,
            Davidson,N.O. and Honjo,T.
  TITLE     Specific expression of activation-induced cytidine deaminase (AID),
            a novel member of the RNA-editing deaminase family in germinal
            center B cells
  JOURNAL   J Biol Chem 274 (26), 18470-18476 (1999)
   PUBMED   10373455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ161825.1, AF132979.1 and BB221671.2.
            
            On Nov 14, 2006 this sequence version replaced NM_009645.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF132979.1, SRR4048178.4505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               CJ161825.1         10-392
            384-910             AF132979.1         383-909
            911-1159            BB221671.2         298-546
            1160-2413           AF132979.1         1159-2412
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.65 cM"
     gene            1..2413
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /note="activation-induced cytidine deaminase"
                     /db_xref="GeneID:11628"
                     /db_xref="MGI:MGI:1342279"
     exon            1..101
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..690
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /EC_number="3.5.4.38"
                     /note="cytidine aminohydrolase; activation induced
                     deaminase"
                     /codon_start=1
                     /product="single-stranded DNA cytosine deaminase"
                     /protein_id="NP_033775.1"
                     /db_xref="CCDS:CCDS20497.1"
                     /db_xref="GeneID:11628"
                     /db_xref="MGI:MGI:1342279"
                     /translation="MDSLLMKQKKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSCSL
                     DFGHLRNKSGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAEFLRWNP
                     NLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIGIMTFKDYFYCWNTFVENRERTFK
                     AWEGLHENSVRLTRQLRRILLPLYEVDDLRDAFRMLGF"
     exon            102..249
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /inference="alignment:Splign:2.1.0"
     exon            250..520
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..636
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..2397
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1276..1281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /note="hexamer: AATAAA"
     polyA_site      1296
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /note="major polyA site"
     regulatory      2371..2376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /note="hexamer: AATAAA"
     polyA_site      2397
                     /gene="Aicda"
                     /gene_synonym="Aid; Arp2"
                     /note="major polyA site"
ORIGIN      
        1 gtcacacaac agcactgaag cagccttgct tgaagcaagc ttcctttggc ctaagacttt
       61 gagggagtca agaaagtcac gctggagacc gatatggaca gccttctgat gaagcaaaag
      121 aagtttcttt accatttcaa aaatgtccgc tgggccaagg gacggcatga gacctacctc
      181 tgctacgtgg tgaagaggag agatagtgcc acctcctgct cactggactt cggccacctt
      241 cgcaacaagt ctggctgcca cgtggaattg ttgttcctac gctacatctc agactgggac
      301 ctggacccgg gccggtgtta ccgcgtcacc tggttcacct cctggagccc gtgctatgac
      361 tgtgcccggc acgtggctga gtttctgaga tggaacccta acctcagcct gaggattttc
      421 accgcgcgcc tctacttctg tgaagaccgc aaggctgagc ctgaggggct gcggagactg
      481 caccgcgctg gggtccagat cgggatcatg accttcaaag actattttta ctgctggaat
      541 acatttgtag aaaatcgtga aagaactttc aaagcctggg aagggctaca tgaaaattct
      601 gtccggctaa ccagacaact tcggcgcatc cttttgccct tgtacgaagt cgatgacttg
      661 cgagatgcat ttcgtatgtt gggattttga aagcaacctc ctggaatgtc acacgtgatg
      721 aaatttctct gaagagactg gatagaaaaa caacccttca actacatgtt tttcttctta
      781 agtactcact tttataagtg tagggggaaa ttatatgact ttttaaaaaa tacttgagct
      841 gcacaggacc gccagagcaa tgatgtaact gagcttgctg tgcaacatcg ccatctactg
      901 gggaacagca gaacttccag actttgggtc gtgaatgatg ctcttttttt tcaacagcat
      961 ggaaaagcat atggagacga ccacacagtt tgttacaccc accctgtgtt ccttgattca
     1021 tttgaattct caggggtatc agtgacggat tcttctattc tttccctcta aggctcactt
     1081 tcaggggtcc ttttctgaca aggtcacggg gctgtcctac agtctctgtc tgagcaatca
     1141 caagccattc tctcaaaagc attaatactc aggcacatgc tgtatgtttt cactgtccgt
     1201 cgtgtttttc acatttgtat gtgaaagggc ttggggtggg atttgaagaa tgcacgatcg
     1261 cctctgggtg atttcaataa aggatcttaa aatgcagatg aggactacga agaaatcact
     1321 ctgaaaatga gttcacgcct caagaagcaa atcccctgga aacacagact ctttttcatt
     1381 tttaatgtca ttagtttact cacagtctta tcaagaagaa gagttcaagg gttcaaccca
     1441 attttcagat cgcgtccctt aaacatcagt aattctgtta aagggatcaa acatccttat
     1501 ttcttaacta actggtgcct tgctgtagag aaaggagcaa agcgcccaga tccaaagtat
     1561 atagttatca tagccaggaa ccgctactcg ttttccatta caaatggcaa attcttcccc
     1621 gggctctcct catagtgcct gagacggacc acggaggtga tgaacctccg gattctctgg
     1681 cccaacacgg tggaagctct gcaagggcgc agagacagaa tgcggcagaa attgcccccg
     1741 agtcccaact ctcctttcct tgcgaccttg ggaacaagac ttaaaggagc ctgtgactta
     1801 gaaacttcta gtaatgggta cctgggagtc gtttgagtat ggggcagtga tttattctct
     1861 gtgatggatg ccaacacggt taaacagaat ttttagtttt tatatgtgtg tgatgctgct
     1921 cccccaaatt gttaactgtg taagagggtg gcaaaatagg gaaagtggca ttcacctata
     1981 gttccagcat tcaggaagct gaggcaggag gattgtaaat ttgaggccag tctgagctgt
     2041 aaggtgagac cctatttcaa acaacacagc cagaattggg ttctggtaaa tcatacttaa
     2101 caagggaaaa atgcaagacg caagaccgtg gcaaggaaat gacgctttgc ccaacgaaat
     2161 gtaggaaacc aacatagact cccagtttgt ccctctttat gtctggtctc cctaacaacg
     2221 atctttgcta atgagaaaaa tattagaaaa aaatatccct gtgcaattat cacccagtcg
     2281 ccattataat gcaattaaaa ggcccacaag aaatcctgta tacacgaccg ttatttattg
     2341 tatgtaagtt gctgaggaag aggagaaaaa aataaagatc atccattcct tcctgcaaaa
     2401 aaaaaaaaaa aaa
//
