LOCUS       NM_133245                492 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus alpha hemoglobin stabilizing protein (Ahsp), mRNA.
ACCESSION   NM_133245
VERSION     NM_133245.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Han,G., Cao,C., Yang,X., Zhao,G.W., Hu,X.J., Yu,D.L., Yang,R.F.,
            Yang,K., Zhang,Y.Y., Wang,W.T., Liu,X.Z., Xu,P., Liu,X.H., Chen,P.,
            Xue,Z., Liu,D.P. and Lv,X.
  TITLE     Nrf2 expands the intracellular pool of the chaperone AHSP in a
            cellular model of beta-thalassemia
  JOURNAL   Redox Biol 50, 102239 (2022)
   PUBMED   35092867
  REMARK    GeneRIF: Nrf2 expands the intracellular pool of the chaperone AHSP
            in a cellular model of beta-thalassemia.
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 492)
  AUTHORS   Lechauve,C., Butcher,J.T., Freiwan,A., Biwer,L.A., Keith,J.M.,
            Good,M.E., Ackerman,H., Tillman,H.S., Kiger,L., Isakson,B.E. and
            Weiss,M.J.
  TITLE     Endothelial cell alpha-globin and its molecular chaperone
            alpha-hemoglobin-stabilizing protein regulate arteriolar
            contractility
  JOURNAL   J Clin Invest 128 (11), 5073-5082 (2018)
   PUBMED   30295646
  REMARK    GeneRIF: eNOS reduced AHSP-bound alpha-globin approximately 6-fold
            faster than did the major erythrocyte hemoglobin reductases
            (cytochrome B5 reductase plus cytochrome B5). Our data support a
            model whereby redox-sensitive shuttling of EC alpha-globin between
            AHSP and eNOS regulates EC NO degradation and vascular tone.
REFERENCE   4  (bases 1 to 492)
  AUTHORS   Nguyen,A.T., Prado,M.A., Schmidt,P.J., Sendamarai,A.K.,
            Wilson-Grady,J.T., Min,M., Campagna,D.R., Tian,G., Shi,Y.,
            Dederer,V., Kawan,M., Kuehnle,N., Paulo,J.A., Yao,Y., Weiss,M.J.,
            Justice,M.J., Gygi,S.P., Fleming,M.D. and Finley,D.
  TITLE     UBE2O remodels the proteome during terminal erythroid
            differentiation
  JOURNAL   Science 357 (6350) (2017)
   PUBMED   28774900
REFERENCE   5  (bases 1 to 492)
  AUTHORS   Janssen,L., Dupont,L., Bekhouche,M., Noel,A., Leduc,C., Voz,M.,
            Peers,B., Cataldo,D., Apte,S.S., Dubail,J. and Colige,A.
  TITLE     ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and
            regulates placental angiogenesis
  JOURNAL   Angiogenesis 19 (1), 53-65 (2016)
   PUBMED   26446156
REFERENCE   6  (bases 1 to 492)
  AUTHORS   Kong,Y., Zhou,S., Kihm,A.J., Katein,A.M., Yu,X., Gell,D.A.,
            Mackay,J.P., Adachi,K., Foster-Brown,L., Louden,C.S., Gow,A.J. and
            Weiss,M.J.
  TITLE     Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis
            and exacerbates beta-thalassemia
  JOURNAL   J Clin Invest 114 (10), 1457-1466 (2004)
   PUBMED   15545996
  REMARK    GeneRIF: Loss of AHSP impairs erythropoiesis and exacerbates
            beta-thalassemia.
REFERENCE   7  (bases 1 to 492)
  AUTHORS   van Eyll,J.M., Pierreux,C.E., Lemaigre,F.P. and Rousseau,G.G.
  TITLE     Shh-dependent differentiation of intestinal tissue from embryonic
            pancreas by activin A
  JOURNAL   J Cell Sci 117 (Pt 10), 2077-2086 (2004)
   PUBMED   15054113
  REMARK    GeneRIF: activin A does not appear to affect the exocrine or
            endocrine components of the pancreas, but promotes differentiation
            of pancreatic tissue into intestine via a Shh-dependent mechanism
REFERENCE   8  (bases 1 to 492)
  AUTHORS   Kihm,A.J., Kong,Y., Hong,W., Russell,J.E., Rouda,S., Adachi,K.,
            Simon,M.C., Blobel,G.A. and Weiss,M.J.
  TITLE     An abundant erythroid protein that stabilizes free
            alpha-haemoglobin
  JOURNAL   Nature 417 (6890), 758-763 (2002)
   PUBMED   12066189
  REMARK    GeneRIF: An abundant erythroid protein that stabilizes free
            alpha-haemoglobin.
REFERENCE   9  (bases 1 to 492)
  AUTHORS   Miele,G., Manson,J. and Clinton,M.
  TITLE     A novel erythroid-specific marker of transmissible spongiform
            encephalopathies
  JOURNAL   Nat Med 7 (3), 361-364 (2001)
   PUBMED   11231637
REFERENCE   10 (bases 1 to 492)
  AUTHORS   Liu,S., Zhang,Z., Ma,J., Zhang,S. and Xue,S.
  TITLE     [Subtractive cDNA cloning and analysis of murine erythroid terminal
            differentiation related factor]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 21 (2), 94-98 (1999)
   PUBMED   12569662
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from MG954299.1.
            
            On Jul 30, 2020 this sequence version replaced NM_133245.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011084.1, AA032383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                MG954299.1         2990-3055           c
            67-141              MG954299.1         2731-2805           c
            142-492             MG954299.1         2145-2495           c
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..492
                     /gene="Ahsp"
                     /gene_synonym="EDRF; Eraf"
                     /note="alpha hemoglobin stabilizing protein"
                     /db_xref="GeneID:170812"
                     /db_xref="MGI:MGI:2158492"
     exon            1..66
                     /gene="Ahsp"
                     /gene_synonym="EDRF; Eraf"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..375
                     /gene="Ahsp"
                     /gene_synonym="EDRF; Eraf"
                     /note="erythroid-associated factor; erythroid
                     differentiation-related factor"
                     /codon_start=1
                     /product="alpha-hemoglobin-stabilizing protein"
                     /protein_id="NP_573508.1"
                     /db_xref="GeneID:170812"
                     /db_xref="MGI:MGI:2158492"
                     /translation="MAPFQSNKDLISTGIKEFNVLLDQQVFDDPLISEEDMVIVVHDW
                     VNLYTNYYKKLVHGEQEEQDRAMTEFQQELSTLGSQFLAKYRTFLKSKEPPSNTLPSS
                     "
     exon            67..141
                     /gene="Ahsp"
                     /gene_synonym="EDRF; Eraf"
                     /inference="alignment:Splign:2.1.0"
     exon            142..492
                     /gene="Ahsp"
                     /gene_synonym="EDRF; Eraf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcagaag acacacaaac cccgaggatt gtggatgagg cgggctcagc accattagac
       61 ttgaagatgg ccccttttca gagcaataag gatctgatct ccacagggat aaaggagttt
      121 aatgttctgc tggatcagca ggtctttgat gatcctctga tctctgaaga agacatggtg
      181 attgtggttc atgactgggt gaacttgtac accaactatt acaagaagct cgtgcatggg
      241 gagcaggagg agcaagacag ggccatgaca gaattccagc aagagctgag tactctgggc
      301 agccagtttc tagccaaata caggaccttt ctgaagtcca aagagccccc aagcaataca
      361 ctgccctcct cataacttaa agggtctggg catcatgtct tagaacccca aacactcggc
      421 tctgtgttat atcttcagac cgttctccca agatgttgct gtactttgac atgccaataa
      481 agaccaaata ct
//
