LOCUS       NM_013465               1478 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus alpha-2-HS-glycoprotein (Ahsg), transcript variant 1,
            mRNA.
ACCESSION   NM_013465 XM_358793
VERSION     NM_013465.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Xu,Z., Wang,W., Yang,T., Li,L., Ma,X., Chen,J., Wang,J., Huang,Y.,
            Gould,J., Lu,H., Du,W., Sahu,S.K., Yang,F., Li,Z., Hu,Q., Hua,C.,
            Hu,S., Liu,Y., Cai,J., You,L., Zhang,Y., Li,Y., Zeng,W., Chen,A.,
            Wang,B., Liu,L., Chen,F., Ma,K., Xu,X. and Wei,X.
  TITLE     STOmicsDB: a comprehensive database for spatial transcriptomics
            data sharing, analysis and visualization
  JOURNAL   Nucleic Acids Res 52 (D1), D1053-D1061 (2024)
   PUBMED   37953328
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Sidheeque Hassan,V., Hanifa,M., Navik,U. and Bali,A.
  TITLE     Exogenous fetuin-A protects against sepsis-induced myocardial
            injury by inhibiting oxidative stress and inflammation in mice
  JOURNAL   Fundam Clin Pharmacol 37 (3), 607-617 (2023)
   PUBMED   36647295
  REMARK    GeneRIF: Exogenous fetuin-A protects against sepsis-induced
            myocardial injury by inhibiting oxidative stress and inflammation
            in mice.
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Nag,S., Mandal,S., Majumdar,T., Mukhopadhyay,S. and Kundu,R.
  TITLE     FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells
            through TLR4-NFkB pathway
  JOURNAL   Biochem Biophys Res Commun 647, 55-61 (2023)
   PUBMED   36716646
  REMARK    GeneRIF: FFA-Fetuin-A regulates DPP-IV expression in pancreatic
            beta cells through TLR4-NFkB pathway.
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Mukhuty,A., Fouzder,C. and Kundu,R.
  TITLE     Fetuin-A secretion from beta-cells leads to accumulation of
            macrophages in islets, aggravates inflammation and impairs insulin
            secretion
  JOURNAL   J Cell Sci 134 (21) (2021)
   PUBMED   34643217
  REMARK    GeneRIF: Fetuin-A secretion from beta-cells leads to accumulation
            of macrophages in islets, aggravates inflammation and impairs
            insulin secretion.
REFERENCE   6  (bases 1 to 1478)
  AUTHORS   Tsujimura,T., Morii,E., Nozaki,M., Hashimoto,K., Moriyama,Y.,
            Takebayashi,K., Kondo,T., Kanakura,Y. and Kitamura,Y.
  TITLE     Involvement of transcription factor encoded by the mi locus in the
            expression of c-kit receptor tyrosine kinase in cultured mast cells
            of mice
  JOURNAL   Blood 88 (4), 1225-1233 (1996)
   PUBMED   8695840
REFERENCE   7  (bases 1 to 1478)
  AUTHORS   Demetriou,M., Binkert,C., Sukhu,B., Tenenbaum,H.C. and Dennis,J.W.
  TITLE     Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta
            type II receptor mimic and cytokine antagonist
  JOURNAL   J Biol Chem 271 (22), 12755-12761 (1996)
   PUBMED   8662721
REFERENCE   8  (bases 1 to 1478)
  AUTHORS   Salier,J.P., Chan,P., Raguenez,G., Zwingman,T. and Erickson,R.P.
  TITLE     Developmentally regulated transcription of the four liver-specific
            genes for inter-alpha-inhibitor family in mouse
  JOURNAL   Biochem J 296 (Pt 1) (Pt 1), 85-91 (1993)
   PUBMED   7504460
REFERENCE   9  (bases 1 to 1478)
  AUTHORS   Yamamoto,K. and Sinohara,H.
  TITLE     Isolation and characterization of mouse countertrypin, a new
            trypsin inhibitor belonging to the mammalian fetuin family
  JOURNAL   J Biol Chem 268 (24), 17750-17753 (1993)
   PUBMED   7688730
REFERENCE   10 (bases 1 to 1478)
  AUTHORS   Yang,F., Chen,Z.L., Bergeron,J.M., Cupples,R.L. and Friedrichs,W.E.
  TITLE     Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice:
            identification and developmental regulation of the gene
  JOURNAL   Biochim Biophys Acta 1130 (2), 149-156 (1992)
   PUBMED   1373325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT027991.8.
            
            On Feb 13, 2023 this sequence version replaced NM_013465.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019822.1, AK167709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               CT027991.8         123707-123991       c
            286-396             CT027991.8         121599-121709       c
            397-481             CT027991.8         121155-121239       c
            482-645             CT027991.8         120677-120840       c
            646-747             CT027991.8         119425-119526       c
            748-831             CT027991.8         117823-117906       c
            832-1478            CT027991.8         116591-117237       c
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.74 cM"
     gene            1..1478
                     /gene="Ahsg"
                     /note="alpha-2-HS-glycoprotein"
                     /db_xref="GeneID:11625"
                     /db_xref="MGI:MGI:107189"
     exon            1..285
                     /gene="Ahsg"
                     /inference="alignment:Splign:2.1.0"
     exon            286..396
                     /gene="Ahsg"
                     /inference="alignment:Splign:2.1.0"
     exon            397..481
                     /gene="Ahsg"
                     /inference="alignment:Splign:2.1.0"
     exon            482..645
                     /gene="Ahsg"
                     /inference="alignment:Splign:2.1.0"
     exon            646..747
                     /gene="Ahsg"
                     /inference="alignment:Splign:2.1.0"
     exon            748..831
                     /gene="Ahsg"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1478
                     /gene="Ahsg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahsg"
                     /note="hexamer: AATAAG"
     polyA_site      1478
                     /gene="Ahsg"
                     /note="major polyA site"
ORIGIN      
        1 ctagctctcc aagctgatta tccgggctgc tcctgacatt tgcccatttt ccagggcctc
       61 tctggagcaa ccatgaagtc cctggtcttg ctcctttgtt ttgctcagct ctggggctgc
      121 caatccgctc cacaaggtac aggactgggt tttagagaat tggcttgtga tgatccagaa
      181 gcagagcaag tagctttgtt ggccgtggac tacctcaata atcatcttct tcagggattc
      241 aaacaggtct tgaatcagat cgacaaagtc aaggtgtggt ctcggcggcc cttcggagtg
      301 gtgtatgaga tggaagttga cacactggag accacttgcc atgctttgga ccccaccccg
      361 ctggcaaact gttctgtgag gcagctgact gagcacgcgg tggagggaga ctgtgacttc
      421 cacatcctga aacaagacgg ccagttcagg gtgatgcaca cccagtgtca ttccacccca
      481 gactctgcag aggacgttcg taagttgtgc ccacggtgcc cactcctgac tccgttcaac
      541 gataccaacg tggtccacac cgtcaacact gccctggctg ccttcaacac acagaataat
      601 ggaacctatt ttaaactggt ggagatttcc cgggctcaaa atgtgcctct cccagtgtct
      661 actctggtgg agtttgtaat agctgccact gactgtactg caaaagaagt cacagatcca
      721 gccaaatgca acctgctggc agagaagcaa catggcttct gcaaggcaaa tctcatgcat
      781 aatcttggtg gggaagaagt ttcagtggcc tgcaagttat tccaaacaca gccccagcca
      841 gccaatgcca acgcagtagg tcccgtaccc acagcgaatg cagccctacc agctgaccca
      901 cctgcatctg tggtggtggg acctgtggtg gttccacgag gactttcaga ccaccgaact
      961 taccacgacc tacgccacgc cttctctcct gtggcctcgg tggagtcggc ctcgggagaa
     1021 actcttcatt ctcctaaggt gggccagcct ggtgctgctg gtccagtgtc ccccatgtgc
     1081 ccagggagga tcagacactt caaaatctag gcttgattcg gggaagtaag gttttggcag
     1141 acaggacata gccaccactg aagctggggg cggggagggg gtggcttgtc cactgacaaa
     1201 gcaataccac atcacagctc gaattccagg tctcttcatt cctcagagaa caggggcaga
     1261 gaggtaatgg tcaaatttga tgaaaggcat aaagccagca gcaacactgg cactggtggg
     1321 gtgacaaatg actgccattg tttctctgcc ttcccactga cctcatataa aacagttgca
     1381 accacgactc tgaaaggtgc tcttgccaat cttcaatcta gccataaata aaagtgccca
     1441 cacgagcttt ctcaaataag aaggctctga gccaaaaa
//
