LOCUS       NM_172391               3697 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus AHA1, activator of heat shock protein ATPase 2
            (Ahsa2), transcript variant 1, mRNA.
ACCESSION   NM_172391
VERSION     NM_172391.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   Li,X., Li,L., Li,J., Sipple,J., Schick,J., Mehta,P.A., Davies,S.M.,
            Dasgupta,B., Waclaw,R.R. and Pang,Q.
  TITLE     Concomitant inactivation of foxo3a and fancc or fancd2 reveals a
            two-tier protection from oxidative stress-induced hydrocephalus
  JOURNAL   Antioxid Redox Signal 21 (12), 1675-1692 (2014)
   PUBMED   24483844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ147821.1, AK137116.1 and AK034661.1.
            
            [WARNING] On Dec 6, 2024 this sequence was replaced by NM_172391.5.
            
            On Mar 15, 2014 this sequence version replaced NM_172391.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.83808.1, AK093945.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                CJ147821.1         2-91
            91-3026             AK137116.1         2-2937
            3027-3697           AK034661.1         406-1076
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.32 cM"
     gene            1..3697
                     /gene="Ahsa2"
                     /note="AHA1, activator of heat shock protein ATPase 2"
                     /db_xref="GeneID:268390"
                     /db_xref="MGI:MGI:1916133"
     exon            1..265
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1181
                     /gene="Ahsa2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activator of 90 kDa heat shock protein ATPase homolog 2"
                     /codon_start=1
                     /product="activator of 90 kDa heat shock protein ATPase
                     homolog 2 isoform 1"
                     /protein_id="NP_765979.3"
                     /db_xref="CCDS:CCDS24476.1"
                     /db_xref="GeneID:268390"
                     /db_xref="MGI:MGI:1916133"
                     /translation="MAKWGQGDPRWIVEEREDGTNVNNWHWTERDATIWSKGKLRELL
                     VGIAMENEAGRCEISELKQVEGEASCNSRKGKLIFFYEWNIKLAWKGTVKESGAKHKG
                     LIEIPSLSEENEINDTEVNVSKKKGDGEILKDLMRTTGTAKVREALGEYLKALKTEFT
                     TGMILPTKAVATQELTLQRKLNENKLQASPVALGVRIPTVALHLTELFDTTVEQLYSI
                     FTVKELVQKFSKSPAVLEAERGGKFQMFDGNISGEYVELVTNRKIIMKWRCRNWPEEH
                     YATVELNFVPAPGQTELQLDCKGVPVCKEENMKFCWQKQHFEEIKGLLELTAQNA"
     exon            266..456
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..542
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..657
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..746
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..854
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..956
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1008
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..3697
                     /gene="Ahsa2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1819..1824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahsa2"
                     /note="hexamer: AATAAA"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahsa2"
                     /note="hexamer: AATAAA"
     polyA_site      1843
                     /gene="Ahsa2"
                     /note="major polyA site"
     polyA_site      1849
                     /gene="Ahsa2"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahsa2"
                     /note="hexamer: AATAAA"
     polyA_site      3033
                     /gene="Ahsa2"
ORIGIN      
        1 agagtcgatg tggggtggag ctggctgcgg ggagcggaca gcggggggcg gggcaggctg
       61 tggccggggc ggcccggggc ggggacttct ggcactttct gggagctgcg ggcgatcggc
      121 tcacagacct tctggccgga aacccgcgcg ctcccgctac cagggccgtc gtcgtcagcg
      181 ccgccatggc caagtggggc cagggggacc cgcgctggat cgtggaggag cgggaggacg
      241 ggaccaacgt gaacaactgg cactggacag agcgggatgc caccatttgg tccaagggga
      301 agctccgaga gctcctggtt ggcattgcta tggagaatga ggctggccga tgtgagatca
      361 gtgagttgaa acaggtggaa ggtgaggctt catgtaacag ccgcaaaggg aagcttattt
      421 tcttctatga gtggaacatc aagctggcct ggaaaggtac agttaaagaa tctggtgcaa
      481 aacacaaggg acttattgaa atacccagcc tttctgaaga aaacgaaatc aatgacactg
      541 aggtgaacgt gagtaaaaag aaaggagatg gggaaatact gaaggatctc atgagaacga
      601 caggcaccgc caaggtcagg gaggcccttg gagagtacct gaaggcactc aagacggaat
      661 ttacaacagg aatgatctta ccaacaaaag ctgtagcaac ccaggaactg actcttcaga
      721 ggaaactgaa tgaaaacaag ctgcaggctt ctccagtggc actgggtgtg aggattccca
      781 cagtagcttt gcacttgaca gagctgtttg acacgacagt agaacagctg tacagtatct
      841 tcactgtaaa agaattggtg caaaaattct ccaaatctcc tgctgtatta gaagctgaaa
      901 ggggagggaa attccagatg tttgacggga acatcagtgg agaatatgtg gaactggtaa
      961 caaataggaa aatcatcatg aaatggagat gtaggaactg gccagaagaa cactatgcaa
     1021 cagttgaact gaattttgtg cctgctccag ggcaaacgga attacaattg gactgcaagg
     1081 gagttcctgt ctgtaaagag gaaaatatga aattctgttg gcagaagcag cacttcgaag
     1141 aaataaaagg tttacttgag cttaccgccc agaatgcttg aattagttag gtttttataa
     1201 ggacatcctt tttaaaatag aaacctgtcc tgtttactca cctctttttt tcttccttaa
     1261 aaagtccttt ccctcaaggc ccttaattta ttttgtattg gatgaaattc atgaaacaac
     1321 acaatttaaa agcattgttt gaaatattct agatgctgca ttgagtgaaa tcgggtgtca
     1381 tatctcacct tccatgggtg ttcctctgag ataagtaggt aggctgagct aaggctggtc
     1441 ataggctgct acttgattgc tacaattgat ttaagcttaa gacaaataaa tggcatgcta
     1501 tactattcct ttattctaag ccagtttcca aggtgtttcc agagtgttgc tgtgagggct
     1561 aggtggctgc attctgttac acttctctgg ctctccttga tgtcttccaa atagccacac
     1621 acttcgggat tggagggatg agacatctgt atggtaaatt aactgttttg gatgcaagag
     1681 gacttctcaa atagcagaaa ggccacgtgg ttccctttca gtctccttac tgctgtcatt
     1741 tgaagaaaca aacgacttat gtaacaaagg aaaagtgatc acagtcagtt tataagtaca
     1801 cagaacagca gtcatgtcaa taaaaataaa accattattt ttacatcaag tgtgctttat
     1861 ttcctccaca ggtattctgt taaataaagc accatttata tactgccagg ccacagctaa
     1921 agaggattct ttacagaatc aaatttcttg tggttgttcc gtatacaagt aaacttaatt
     1981 ttgataataa gaaccacagc gatcagaggc aatctgcctc tcttatttta aggtacaaaa
     2041 ctggcacaga ggacaccata ttatacacag taaaaatgct gtaagtttaa attacatcat
     2101 acagggtcag agccctgctt ctcccagaaa gccatattaa atgaaagcca ctacagtgaa
     2161 ctcttaatta cataaaacat atccattatc tgattgccct ttagaaagta tacagaagat
     2221 gcacattttt tttttcatct ggaattctgc ctgaccaaga attgaagcct ataaatctat
     2281 cttgccattc aagcagagag cactggacaa actgaagcac aaaacaaagg agcaaacttg
     2341 acaaacagca taggggaggg cacgtgagaa tagacatgcc acgtctaatg tcaagaagca
     2401 gcttggtttc ctttgccaga tatccttgtg accacatgga ttgttgattc aatggtccta
     2461 cacagggtat ctaaaatgtc gtgttgctgc atatgactaa tgaggcctct ggaatggcca
     2521 caactgaggg acacagcagc ttcagggtcc tgggaggaca aagcttgacc atcacagctt
     2581 ctcagatcag ctaagtcaga cagaactgcg gagatggacg ttgaagggaa ttcggattca
     2641 tcttcagcta gtgtagtatc cttggaacag tggtctttaa actctttaca gtcgtcaaac
     2701 ctgccattgt tagactgttc ctctgcatgc tgtgaccgga tatgtgaacc atcttctgaa
     2761 aatgaagatg ggccttccat tcgatactct ttgacagagc tgttttcagg agacggaaga
     2821 tcttgctctg tccctgggtc aataatcgat gagtctcttg tctcattgtc tgaggtgcta
     2881 gtgggggtca ggacctccct ggtctctgtt tttatgtcac caatgcaact gtctacagtg
     2941 tgctcctcat cactgctcac tcgccgtctt ttaacaggag ttgctccttc gtcatctgtg
     3001 gggggaaaat acaataaaat aacctgaaac agagggcact gaaatcctat tgggggtgat
     3061 tatgagggaa gacaattttg ttgttagagg tcaacattaa ggacttgcac tactaggcaa
     3121 gagcaacatg ccacacctcc aagcttgtct tcatcctccc agccacccct cagcccaaat
     3181 cccaggcaag acttagttga tacagctaac ctttagtttt tctttctttg gcttcttgct
     3241 cttggagtga gtttctctgc tgcagacaag tcctacactt gtttaaaagc tcttgcagag
     3301 ttgggatcag agctgggttt aactgtttgg gagtgtgtac tgacaggagc aaagcaagtg
     3361 ccctcaggtc ctacaaaaac ccagatagga agagttcaaa tcctgaaggc aacatttgga
     3421 taaaacttca tttaaatgaa gatgtttatt tcccaggaat ctattttggt ttctctggta
     3481 atgtggagta acgctacagc cagcattaag acgtggtatt ccactagttg agtgattcaa
     3541 gtggctcata aacatcttgt tagttagggg tgctgctgaa taacagttgt tgtgtgtcta
     3601 tgttgagtag gtcagagtaa agacgtaagt cagaaaccaa ataatgcagc ttacacttaa
     3661 atagtaattt caaaattaaa cctcccttgg tgcatca
//
