LOCUS       NM_146036               1320 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus AHA1, activator of heat shock protein ATPase 1
            (Ahsa1), transcript variant 1, mRNA.
ACCESSION   NM_146036
VERSION     NM_146036.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Woodford,M.R., Sager,R.A., Marris,E., Dunn,D.M., Blanden,A.R.,
            Murphy,R.L., Rensing,N., Shapiro,O., Panaretou,B., Prodromou,C.,
            Loh,S.N., Gutmann,D.H., Bourboulia,D., Bratslavsky,G., Wong,M. and
            Mollapour,M.
  TITLE     Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates
            folding of kinase and non-kinase clients
  JOURNAL   EMBO J 36 (24), 3650-3665 (2017)
   PUBMED   29127155
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Desjardins,F., Delisle,C. and Gratton,J.P.
  TITLE     Modulation of the cochaperone AHA1 regulates heat-shock protein 90
            and endothelial NO synthase activation by vascular endothelial
            growth factor
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (10), 2484-2492 (2012)
   PUBMED   22859491
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Xu,W., Mollapour,M., Prodromou,C., Wang,S., Scroggins,B.T.,
            Palchick,Z., Beebe,K., Siderius,M., Lee,M.J., Couvillon,A.,
            Trepel,J.B., Miyata,Y., Matts,R. and Neckers,L.
  TITLE     Dynamic tyrosine phosphorylation modulates cycling of the
            HSP90-P50(CDC37)-AHA1 chaperone machine
  JOURNAL   Mol Cell 47 (3), 434-443 (2012)
   PUBMED   22727666
  REMARK    GeneRIF: Hsp90 phosphorylation on tyrosine313 promotes recruitment
            of AHA1, which stimulates Hsp90 ATPase activity, furthering the
            chaperoning process.
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Echeverria,P.C., Bernthaler,A., Dupuis,P., Mayer,B. and Picard,D.
  TITLE     An interaction network predicted from public data as a discovery
            tool: application to the Hsp90 molecular chaperone machine
  JOURNAL   PLoS One 6 (10), e26044 (2011)
   PUBMED   22022502
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151967.6.
            
            On Aug 15, 2018 this sequence version replaced NM_146036.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025552.1, AK076069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC151967.6         160257-160450
            195-385             AC151967.6         161684-161874
            386-468             AC151967.6         163404-163486
            469-586             AC151967.6         163866-163983
            587-675             AC151967.6         164868-164956
            676-804             AC151967.6         166101-166229
            805-906             AC151967.6         166652-166753
            907-958             AC151967.6         166976-167027
            959-1320            AC151967.6         167120-167481
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.47 cM"
     gene            1..1320
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /note="AHA1, activator of heat shock protein ATPase 1"
                     /db_xref="GeneID:217737"
                     /db_xref="MGI:MGI:2387603"
     exon            1..194
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1131
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activator of 90 kDa heat shock protein ATPase homolog 1;
                     AHA1, activator of heat shock 90kDa protein ATPase homolog
                     1; AHA1, activator of heat shock protein ATPase homolog 1"
                     /codon_start=1
                     /product="activator of 90 kDa heat shock protein ATPase
                     homolog 1 isoform 1"
                     /protein_id="NP_666148.1"
                     /db_xref="CCDS:CCDS26075.1"
                     /db_xref="GeneID:217737"
                     /db_xref="MGI:MGI:2387603"
                     /translation="MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTEKLKTLF
                     LAVRVENEEGKCEVTEVNKLDGEASINNRKGKLIFFYEWTIKLNWTGTSKSGVQYKGH
                     VEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEDGVKLLREAVGIYISTLKTEFT
                     QGMILPTVNGESVDPVGQPALKTETCKAKSAPSKSQAKPVGVKIPTCKITLKETFLTS
                     PEELYRVFTTQELVQAFTHAPAALEADRGGKFHMVDGNVTGEFTDLVPEKHIAMKWRF
                     KSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYG
                     ARLF"
     exon            195..385
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     exon            386..468
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     exon            469..586
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     exon            587..675
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     exon            676..804
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     exon            805..906
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     exon            907..958
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1320
                     /gene="Ahsa1"
                     /gene_synonym="p38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgctgtgc tgcttctagt agtttccagg cgctgccagg cggctgggac cgagcggtcc
       61 tcaggctgtg gctgcggctg cttgggagct ggtagcggtg cgataagtga gctgatggcc
      121 aagtggggtg agggagaccc acgctggatc gtggaggagc gggcggacgc caccaacgtc
      181 aacaactggc actggacaga gagagatgct tcaaattggt ccacagagaa actgaaaacc
      241 ctgttcctgg ccgttcgagt agaaaatgaa gagggcaagt gcgaggtgac cgaagtgaac
      301 aagcttgatg gggaggcatc catcaacaac aggaaaggca aacttatctt cttctatgag
      361 tggaccatca aactgaactg gacaggtacc tctaagtcag gagtgcagta caaaggacat
      421 gtggaaatcc ccaatttgtc tgatgaaaat agcgtggatg aagtggagat tagtgtgagc
      481 cttgccaaag atgagcctga cacaaatctc gtggccttaa tgaaggaaga cggggtgaaa
      541 cttctgagag aagcagtggg aatttacatc agcaccctca agacagagtt tactcagggc
      601 atgatcttgc ccacagtgaa tggagagtca gtagatccag tgggccagcc agcactaaag
      661 actgagactt gcaaggctaa gtctgctcct tcaaaaagcc aggccaaacc tgttggtgtc
      721 aaaatcccca cttgtaagat cacccttaaa gaaaccttcc tgacctcccc agaggagctc
      781 tatagagtgt ttaccacgca ggagctggtc caggccttta cccatgcccc cgctgccttg
      841 gaagccgaca gaggtggcaa gtttcacatg gtcgatggca acgtcaccgg ggagtttact
      901 gacctggtcc ccgagaaaca cattgctatg aagtggaggt ttaagtcatg gccagagggg
      961 cactttgcca ccatcacctt gaccttcatt gacaagaatg gagagacaga gctgtgcatg
     1021 gaaggccgtg gcatccctgc tcctgaggaa gagcggacgc ggcaaggctg gcagcggtac
     1081 tactttgagg gcatcaaaca gacctttggc tatggtgcac gcttgtttta gggccagcaa
     1141 caggggttct ggccctgttg aaactttagt ccagccctct cgcaatggct tgtgactcac
     1201 aggattgcac catccccact gctaacttgg ggctggggcc tccctttcac agataccttg
     1261 ggtttgtgca tgttttctgc tgggtgggat ctgagggtga tttctctttt acctgtacat
//
