LOCUS       NM_009644               4754 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus aryl-hydrocarbon receptor repressor (Ahrr), transcript
            variant 1, mRNA.
ACCESSION   NM_009644
VERSION     NM_009644.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4754)
  AUTHORS   Weighardt,H., Shapiro,M., Mayer,M., Forster,I., Stockinger,B. and
            Diny,N.L.
  TITLE     The AHR repressor limits expression of antimicrobial genes but not
            AHR-dependent genes in intestinal eosinophils
  JOURNAL   J Leukoc Biol 116 (2), 369-378 (2024)
   PUBMED   38701199
REFERENCE   2  (bases 1 to 4754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4754)
  AUTHORS   Panda,S.K., Peng,V., Sudan,R., Ulezko Antonova,A., Di Luccia,B.,
            Ohara,T.E., Fachi,J.L., Grajales-Reyes,G.E., Jaeger,N., Trsan,T.,
            Gilfillan,S., Cella,M. and Colonna,M.
  TITLE     Repression of the aryl-hydrocarbon receptor prevents oxidative
            stress and ferroptosis of intestinal intraepithelial lymphocytes
  JOURNAL   Immunity 56 (4), 797-812 (2023)
   PUBMED   36801011
REFERENCE   4  (bases 1 to 4754)
  AUTHORS   Yoshikawa,Y., Izawa,T., Hamada,Y., Takenaga,H., Wang,Z.,
            Ishimaru,N. and Kamioka,H.
  TITLE     Roles for B[a]P and FICZ in subchondral bone metabolism and
            experimental temporomandibular joint osteoarthritis via the
            AhR/Cyp1a1 signaling axis
  JOURNAL   Sci Rep 11 (1), 14927 (2021)
   PUBMED   34290363
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4754)
  AUTHORS   Merches,K., Schiavi,A., Weighardt,H., Steinwachs,S., Teichweyde,N.,
            Forster,I., Hochrath,K., Schumak,B., Ventura,N., Petzsch,P.,
            Kohrer,K. and Esser,C.
  TITLE     AHR Signaling Dampens Inflammatory Signature in Neonatal Skin
            gammadelta T Cells
  JOURNAL   Int J Mol Sci 21 (6), 2249 (2020)
   PUBMED   32213963
  REMARK    GeneRIF: AHR Signaling Dampens Inflammatory Signature in Neonatal
            Skin gammadelta T Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4754)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 4754)
  AUTHORS   Karchner,S.I., Franks,D.G., Powell,W.H. and Hahn,M.E.
  TITLE     Regulatory interactions among three members of the vertebrate aryl
            hydrocarbon receptor family: AHR repressor, AHR1, and AHR2
  JOURNAL   J Biol Chem 277 (9), 6949-6959 (2002)
   PUBMED   11742002
REFERENCE   8  (bases 1 to 4754)
  AUTHORS   Fujita,H., Kosaki,R., Yoshihashi,H., Ogata,T., Tomita,M.,
            Hasegawa,T., Takahashi,T., Matsuo,N. and Kosaki,K.
  TITLE     Characterization of the aryl hydrocarbon receptor repressor gene
            and association of its Pro185Ala polymorphism with micropenis
  JOURNAL   Teratology 65 (1), 10-18 (2002)
   PUBMED   11835227
REFERENCE   9  (bases 1 to 4754)
  AUTHORS   Baba,T., Mimura,J., Gradin,K., Kuroiwa,A., Watanabe,T., Matsuda,Y.,
            Inazawa,J., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Structure and expression of the Ah receptor repressor gene
  JOURNAL   J Biol Chem 276 (35), 33101-33110 (2001)
   PUBMED   11423533
REFERENCE   10 (bases 1 to 4754)
  AUTHORS   Mimura,J., Ema,M., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Identification of a novel mechanism of regulation of Ah (dioxin)
            receptor function
  JOURNAL   Genes Dev 13 (1), 20-25 (1999)
   PUBMED   9887096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY196943.1, AK155711.1 and
            AK076306.1.
            
            On Nov 30, 2015 this sequence version replaced NM_009644.2.
            
            Summary: This gene encodes a protein that represses aryl
            hydrocarbon receptor-dependent signaling. The encoded protein
            competes with the aryl hydrocarbon receptor transcription factor
            for heterodimerization with the aryl hydrocarbon receptor nuclear
            translocator protein and binding to xenobiotic response element
            (XRE) sequence in many genes. This protein is implicated in the
            regulation of cell growth and differentiation as well as mediating
            dioxin toxicity. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154761.1, AK154152.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY196943.1         1-2
            3-2017              AK155711.1         3-2017
            2018-4097           AK076306.1         230-2309
            4098-4754           AK155711.1         4098-4754
FEATURES             Location/Qualifiers
     source          1..4754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..4754
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /note="aryl-hydrocarbon receptor repressor"
                     /db_xref="GeneID:11624"
                     /db_xref="MGI:MGI:1333776"
     exon            1..101
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            102..174
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            175..356
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            357..454
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            455..544
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            545..674
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            675..808
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1005
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1067
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1206
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..4754
                     /gene="Ahrr"
                     /gene_synonym="mKIAA1234"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagtctgagg ccaggtccca gagatgagag agctgacagc tcctggcctc cgcggctccc
       61 tcagcgggcg cgcccgatct tctgcgcccc gcctgccccg ggatcaaaga tgatgattcc
      121 gtctggagag tgtacatacg ccggtaggaa gagaaggaag cccattcaga agcggaggct
      181 taccatggga gctgagaaat caaatccttc caaacggcac cgggaccgcc tcaatacaga
      241 gctggaccac ctggccagcc tgctgccatt ttcacctgat atcatctcca agctggacaa
      301 gctttctgtc ctgcgcctca gcgttagcta cctcagggta aagagcttct tccaagcctt
      361 gcaggagaca tgtgtatggt cagctccagc cctgtcacct gaagaacact catacagagg
      421 gttccccgtg caggaaggac ggctgctgct ggagtctctc aatggcttcg ctctggtggt
      481 gagtgccgaa gggatgatct tttatgcatc ggcaacaatt gtggactatc tgggctttca
      541 tcagacagat gtcatgcatc aaaacattta tgactacatc catgtggatg accggcagga
      601 cttctgcaga cagctacact gggccatgga ccctcctcag gtggtgtttg ggcagtcccc
      661 acatgctgac acagacaata ctgtcctggg gaagctgctc agggcccaag aaggaggcaa
      721 gggcttgccc tcagagtact cggccttctt gacacgctgc ttcatttgtc gtgttcgctg
      781 cctgctggac agcacctctg gctttctgac catgcagttc caaggaaaac taaaattcct
      841 gtttggacag aagaagaaga caccatcagg aacagccctg cctcctcgac tctcattgtt
      901 ctgcattgtg gcaccagtct tgccttctgt aactgagatg aaaatgaaaa gcacattctt
      961 gaaggcaaag cacagggcag acattgtggt tacgatggac tcaagggcaa aagctgttac
     1021 aagtctatgt gaatcagaat tgcatcccaa actcaattac ttagcaggaa agagcaatgg
     1081 agaaaatggc atttcactgt tcaggggaca aacagatagg agccactggg cccgggctct
     1141 agccagatct tcatgtctgt gcctcagggg tggtcctgac ctgctggacc ccaaggggac
     1201 ttcaggggac agagaagagg aggaccagaa gcacatacta aggagatccc ctggtgcctg
     1261 ggggcagagg gagatgcaca agtacagtta tggtttggag acaccagtac acttgaggca
     1321 cctgaactgg agcacagaac agcgaagtca ggagagcact accaagctga ctcggcagcc
     1381 cagtaagaat gagccatcca cgtgtctggt gccccatggt tcctgtgtgc cctaccctgg
     1441 aagccagggc atgcttagtg ccagcaacat ggcttctttt agagattcac tagaccatcc
     1501 cactggtgcc tactgcagtc agatgaacag acccttgtcg gatatccacc agggccaggt
     1561 ggatccttcc acctgccata tctcccaggg cagtctggga tctaggatcc ctctgactgg
     1621 aatgcagcgc ttcacagctc ggggattttc tacagaggat gcaaaattac ccagcctgcc
     1681 agtgaccata ggcactccat gcaacccagt attgtcactg gatgtgccaa tcaagatgga
     1741 gaatgaatct gggtcccagg atatagttga agctagcaca actagctgtt tgtggctggg
     1801 aaccagcgac atggccagag gacatctggt tggtttccct gccaggatgc acctgaaaac
     1861 agagcccgac tataggcagc aggcctgtac cccacacctt ggtcatggta tgctgggaac
     1921 taatccctac agcagagata ctgttggatc ctgtagggag catgctcctc tttactctgc
     1981 acattgcacc tgcctggatc cagagcctcc tcatcacttc ttcatgtgta gccacagtga
     2041 gagccagcac ccctcattgg accaagactg cagagctcct attgttaagc gtgagcctct
     2101 ggactcacca tcatgggctg ctcctggtca ggtgactgtg cccaggatgt tccctaagag
     2161 tgcctctaaa actgtgatcc catccaaagg ctctgatgga attttcctac cctagagttg
     2221 ctcctctgct ggaaattcag tccttggata atggaacatg atcagagatt cttatagtga
     2281 ccctctttac agaactcagt gggtgaggct gagattccct gtgtgtagcc tagcagtaga
     2341 gcattctgaa tcacatagaa catcagagga ttctcatgca taaacctcaa tctgttcaag
     2401 tggacagcat ttcactttga gaaattaaat gtttaaggaa gtagctaaca gtattctatg
     2461 ctggccaggg ctcaactgat tgtcaaaatg atgtgttcct cgtgtccaag cttgttacac
     2521 ctcctgcctg tatgtagcag gaattcagag gctcttaatc aagacccgag gctgtacttt
     2581 gcataatgat agtcatggaa acaccatggt atttttggtg ggtcgctgag tatggtttat
     2641 gtgccggtgt ctctgagtac atcatatggt agaggccagg aaccagggaa gcacaacaca
     2701 cagaaaagga tgaggccata ctgatgaaga ggcattgccc tggctgttgt cttacagggc
     2761 ttccggtaag agcaaccgtt ctagcccagg gagacttagg gacaaaaagg cagccactat
     2821 ttgttttgaa ttgtaaagac aatgcaatct aattgtagga aatgtggata tcgtgtataa
     2881 aacagaaagg aagagtcacc aggaactgct ggcaaaatga ctatggctgg gggtgcagtt
     2941 gagaatgttc caaggaaggg cttaaactag aaatcctgct ccattagcac aggatccact
     3001 aaacaggtaa aagcctgctg cgctctgcct gtctgtttgg ttcagtcttt ctcagggatg
     3061 aacatccatc tctgatgcta cttcccctga ggtcttagga atggcaagaa tggctggaaa
     3121 ggccttgtgg ctaattctgc taggtagtct cttcagcata gattttcttt ccttcaccta
     3181 tggctccagg gtatcactgc tcaaccattg gccaagtgaa agaagctgtc tggcgatgcc
     3241 tatcacctta tcagaatcaa gttgggtggg caggactagg tcttctgccc aggtttgagc
     3301 tgcttggctc tcaagaagac tcaccatggg accaggatac aactgaagat ctcctagaac
     3361 tgagaatact cactgtgaga gccctggacc ttgtgctctc tctgtcctta gcccacagaa
     3421 gattttcaaa gggcaagatg gaagttgtgc tgtcatagat gtaaggcatg cttatatggc
     3481 cactccagct ttcctattac ctaatgtctg aagccaggat ggtgtcccag ttcttacccc
     3541 tgtgcctagc ctcctgtctc cctcctttcc tcaaactaca ccagtttata cattgcttat
     3601 gcatttctgc caagcatagc ataccttgtg ggtattaatg aataacagca ggtaaaattt
     3661 gagtcttcca caacacttcc tgttctaaac acatgcctag ctcctaaggg caggacatgc
     3721 tcataccact caagtgtctt ccaatctagt atttctctct gaaagtcctt agttatgttc
     3781 ccattctaag tcatactcat catgctacac acttcctaca caaggagcag gggacacagt
     3841 agactgttat gtttcaatgt atacaatatt taccaagttt tctggagaca gtgaaaaaaa
     3901 aacctaggga aagggaccat gaagatggaa ttcagagaca gtattagacc aagtggcatg
     3961 aatcccagca cttgagtgat tgaaacagaa gatgagcagt tcaagcctac atcagacctt
     4021 gtctcaaaca aaataaaaca aaatacatta ctacatattt accatcccct tgctacgtaa
     4081 tcaaagaaga gctgtgtccc cagggaagtc cctatgttct ctgcccaggt actctgaacc
     4141 tttcagatgt acctcatctg cacccctgct gggatgactt accaaatgtg gagcgtgggc
     4201 agctctccag ggccctgggc ttccctgcag gtcaggcttt gtggacactt gagttctgca
     4261 cttggatgtc attttagcag attttgtgtt ttgggggtac cacaccctat ggcaagcttg
     4321 gatacctggt gccaatgctg tctaatgaag atcaaatctc cccaacttgc acttttgctc
     4381 attcatcaca aatctccagt cagcttgcac aggaagcgaa gagaggttgt tcctatttta
     4441 gcatttcacc atatacacta actacaagtt catggttttt tgtgatagct agcttttgcc
     4501 tatatggcta aaaaaaatat caaaaattaa atgtagtgag agatgggctg gggaggaata
     4561 aatacaaagt gcccttatat ttgcagattc gactggggga aagtcctcaa gaactttagg
     4621 catacactac agtgcagctg tctgtgctgt tttcttggtg ctctgtttta acagagaatc
     4681 cagatgcatt tctcatgtgg tggtttgtac tacatttgca aaacttgtgt aaaataaatc
     4741 tcatatttct atgt
//
