LOCUS       NM_013464               5494 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus aryl-hydrocarbon receptor (Ahr), transcript variant 1,
            mRNA.
ACCESSION   NM_013464
VERSION     NM_013464.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5494)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 5494)
  AUTHORS   Orlowska,K., Nault,R., Ara,J., LaPres,J.J., Harkema,J.,
            Demireva,E.Y., Xie,H., Wilson,R.H., Bradfield,C.A., Yap,D.,
            Joshi,A., Elferink,C.J. and Zacharewski,T.
  TITLE     Disruption of canonical AHR-mediated induction of hepatocyte PKM2
            expression compromises antioxidant defenses and increases
            TCDD-induced hepatotoxicity
  JOURNAL   Redox Biol 77, 103405 (2024)
   PUBMED   39490313
REFERENCE   3  (bases 1 to 5494)
  AUTHORS   Wu,N., Li,J., Li,L., Yang,L., Dong,L., Shen,C., Sha,S., Fu,Y.,
            Dong,E., Zheng,F., Tan,Z. and Tao,J.
  TITLE     MerTK+ macrophages promote melanoma progression and immunotherapy
            resistance through AhR-ALKAL1 activation
  JOURNAL   Sci Adv 10 (40), eado8366 (2024)
   PUBMED   39365866
  REMARK    GeneRIF: MerTK[+] macrophages promote melanoma progression and
            immunotherapy resistance through AhR-ALKAL1 activation.
REFERENCE   4  (bases 1 to 5494)
  AUTHORS   Garcia-Villatoro,E.L., Bomstein,Z.S., Allred,K.F., Callaway,E.S.,
            Safe,S., Chapkin,R.S., Jayaraman,A. and Allred,C.D.
  TITLE     Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor
            Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid
            Tissue Formation
  JOURNAL   Int J Mol Sci 25 (18), 10153 (2024)
   PUBMED   39337636
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5494)
  AUTHORS   Serna,E., Verdu,D., Valls,A., Belenguer-Varea,A.,
            Tarazona-Santabalbina,F.J., Borras,C. and Vina,J.
  TITLE     Involvement of Aryl Hydrocarbon Receptor in Longevity and
            Healthspan: Insights from Humans, Mice, and C. elegans
  JOURNAL   Int J Mol Sci 25 (18), 9943 (2024)
   PUBMED   39337431
  REMARK    GeneRIF: Involvement of Aryl Hydrocarbon Receptor in Longevity and
            Healthspan: Insights from Humans, Mice, and C. elegans.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5494)
  AUTHORS   Okey,A.B., Bondy,G.P., Mason,M.E., Kahl,G.F., Eisen,H.J.,
            Guenthner,T.M. and Nebert,D.W.
  TITLE     Regulatory gene product of the Ah locus. Characterization of the
            cytosolic inducer-receptor complex and evidence for its nuclear
            translocation
  JOURNAL   J Biol Chem 254 (22), 11636-11648 (1979)
   PUBMED   500663
REFERENCE   7  (bases 1 to 5494)
  AUTHORS   Levitt,R.C., Fysh,J.M., Jensen,N.M. and Nebert,D.W.
  TITLE     The Ah locus: biochemical basis for genetic differences in brain
            tumor formation in mice
  JOURNAL   Genetics 92 (4), 1205-1210 (1979)
   PUBMED   520822
REFERENCE   8  (bases 1 to 5494)
  AUTHORS   Wood,A.W. and Taylor,B.A.
  TITLE     Genetic regulation of coumarin hydroxylase activity in mice.
            Evidence for single locus control on chromosome
  JOURNAL   J Biol Chem 254 (13), 5647-5651 (1979)
   PUBMED   447675
REFERENCE   9  (bases 1 to 5494)
  AUTHORS   Kouri,R.E., Rude,T.H., Joglekar,R., Dansette,P.M., Jerina,D.M.,
            Atlas,S.A., Owens,I.S. and Nebert,D.W.
  TITLE     2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing
            3-methylcholanthrene-initiated subcutaneous tumors in mice
            genetically 'nonresponsive' at Ah locus
  JOURNAL   Cancer Res 38 (9), 2777-2783 (1978)
   PUBMED   679184
REFERENCE   10 (bases 1 to 5494)
  AUTHORS   Thorgeirsson,S.S. and Nebert,D.W.
  TITLE     The Ah locus and the metabolism of chemical carcinogens and other
            foreign compounds
  JOURNAL   Adv Cancer Res 25, 149-193 (1977)
   PUBMED   405846
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK153678.1.
            
            On Apr 6, 2007 this sequence version replaced NM_013464.3.
            
            Summary: The protein encoded by this gene is a ligand-activated
            helix-loop-helix transcription factor involved in the regulation of
            biological responses to planar aromatic hydrocarbons. This receptor
            has been shown to regulate xenobiotic-metabolizing enzymes such as
            cytochrome P450. Before ligand binding, the encoded protein is
            sequestered in the cytoplasm; upon ligand binding, this protein
            moves to the nucleus and stimulates transcription of target genes.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153678.1, AK155380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5494              AK153678.1         2-5495
FEATURES             Location/Qualifiers
     source          1..5494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 15.78 cM"
     gene            1..5494
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /note="aryl-hydrocarbon receptor"
                     /db_xref="GeneID:11622"
                     /db_xref="MGI:MGI:105043"
     exon            1..428
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..2784
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /note="isoform 1 is encoded by transcript variant 1; ah
                     receptor; dioxin receptor"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor isoform 1"
                     /protein_id="NP_038492.1"
                     /db_xref="CCDS:CCDS36434.1"
                     /db_xref="GeneID:11622"
                     /db_xref="MGI:MGI:105043"
                     /translation="MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNT
                     ELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRA
                     QIRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELI
                     HTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRL
                     RCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRT
                     KNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADILHCAESHIRM
                     IKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKR
                     STSLPFMFATGEAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPSSL
                     MSALIQQDESIYLCPPSSPALLDSHFLMGSVSKCGSWQDSFAAAGSEAALKHEQIGHA
                     QDVNLALSGGPSELFPDNKNNDLYSIMRNLGIDFEDIRSMQNEEFFRTDSTAAGEVDF
                     KDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPPPQ
                     ALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTPPVSFNCPQQELKHYQLFSSLQG
                     TAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLDFPGRDFEPSLHPTTSNLDFV
                     SCLQVPENQSHGINSQSAMVSPQAYYAGAMSMYQCQPGPQRTPVDQTQYSSEIPGSQA
                     FLSKVQS"
     exon            429..616
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            617..720
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            721..810
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            811..922
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1053
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1256
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1366
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1508
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..2772
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..5494
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5100..5105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /note="hexamer: AATAAA"
     polyA_site      5121
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
ORIGIN      
        1 gtgtgtgcgc tccctttgac gctcggtgcc ccacgcgtgt cccggagagg ctcagcccgg
       61 agcgacccgg aggacgaact ggtggacgga ctcgggggtg gctgccaggc agggttgtga
      121 gcgacgccgc ggcacagcgc gggagccggg aagccctaga gcactgcggc ccctcctgac
      181 cctcgggacc gggcgcggct agcgtgcggg tttctcctcc gcggccagct cgggcagccc
      241 gagtctcctc tgtcgcccgc acctgcgcgt cgcggtcgtc ccgccctcgg cggcggctca
      301 cctgggcgca gcgcgggcag ggcgccgcct ccgggacgca ggtggagcgg gcagggcgcg
      361 ggcaccatga gcagcggcgc caacatcacc tatgccagcc gcaagcggcg caagccggtg
      421 cagaaaacag taaagcccat ccccgctgaa ggaattaagt caaatccttc taagcgacac
      481 agagaccggc tgaacacaga gttagaccgc ctggccagcc tgctgccctt cccgcaagat
      541 gttattaata agctggacaa actctctgtt cttaggctca gcgtcagcta cctgagggcc
      601 aagagcttct ttgatgttgc attaaagtcc acccctgctg acagaaatgg aggccaggac
      661 cagtgtagag cacaaatcag agactggcag gatttgcaag aaggagagtt cttgttacag
      721 gcgctgaatg gctttgtgct ggttgtcaca gcagatgcct tggtcttcta tgcttcctcc
      781 actatccaag attacctggg ctttcagcag tctgatgtca tccatcagag cgtatatgag
      841 ctcatccata cagaagaccg ggcggaattc cagcgccagc ttcactgggc tctaaaccca
      901 gactctgcac aaggagtgga cgaagcccat ggccctccac aggcagcagt ctattatacc
      961 ccagaccagc ttcctccaga gaacgcttct ttcatggaga ggtgcttcag gtgccggctg
     1021 aggtgcctgc tggataattc atctggtttt ctggcaatga atttccaagg gaggttaaag
     1081 tatcttcatg gacagaacaa gaaagggaag gacggagcgc tgcttcctcc acaactggct
     1141 ttgtttgcaa tagctactcc acttcagcca ccctccatcc tggaaattcg aaccaaaaac
     1201 ttcatcttca ggaccaaaca caagctagac ttcacaccta ttggttgtga tgccaaaggg
     1261 cagcttattc tgggctatac agaagtagag ctgtgcacaa gaggatcggg gtaccagttc
     1321 atccatgctg cagacatact tcactgtgca gaatcccaca tccgcatgat taagactgga
     1381 gaaagtggca tgacagtttt ccggcttctt gcaaaacaca gtcgctggag gtgggtccag
     1441 tccaatgcac gcttgattta cagaaatgga agaccagatt acatcatcgc cactcagaga
     1501 ccactgacgg atgaagaagg acgagagcat ttacagaagc gaagtacgtc gctgcccttc
     1561 atgtttgcta ccggagaggc tgtgttgtac gagatctcca gccctttctc tcccataatg
     1621 gatcccctac caatacgcac caaaagcaac actagcagga aagactgggc tccccagtca
     1681 accccaagta aggattcttt ccaccccagt tctcttatga gtgccctcat ccagcaggat
     1741 gagtccatct atctgtgtcc tccttcaagc cctgcgctgt tagacagcca ttttctcatg
     1801 ggctccgtga gcaagtgcgg gagttggcaa gacagctttg cggccgcagg aagtgaggct
     1861 gcgctgaaac atgagcaaat tggccatgct caggacgtga accttgcact ctctggcggc
     1921 ccctcagagc tctttccgga taataaaaat aatgacttgt acagcatcat gaggaacctt
     1981 gggattgatt ttgaagatat cagaagcatg cagaacgagg agttcttcag aactgactcc
     2041 accgctgctg gtgaggttga cttcaaagac atcgacataa cggacgaaat cctgacctac
     2101 gtgcaggatt ccctgaacaa ttcaactttg ctgaactcgg cttgccagca gcagcctgtg
     2161 actcagcacc taagctgtat gctgcaggag cgcctgcaac tagagcaaca gcaacagctt
     2221 cagcagcccc cgccgcaggc tctggagccc cagcagcagc tgtgtcagat ggtgtgcccc
     2281 cagcaagatc tgggtccgaa gcacacgcaa atcaacggca cgtttgcaag ttggaacccc
     2341 acccctcccg tgtctttcaa ctgtccccag caggaactaa agcactatca gctcttttcc
     2401 agcttacagg ggactgctca ggaatttccc tacaaaccag aggtggacag tgtgccttac
     2461 acacagaact ttgctccctg taatcagcct ctgcttccag aacattccaa gagtgtgcag
     2521 ttggacttcc ctggaaggga ttttgaaccg tccctgcatc ccactacttc taatttagat
     2581 tttgtcagtt gtttacaagt tcctgaaaac caaagtcatg ggataaactc acagtccgcc
     2641 atggtcagtc ctcaggcata ctatgctggg gccatgtcca tgtatcagtg ccagccaggg
     2701 ccacagcgca cccctgtgga ccagacgcag tacagctctg aaattccagg ttctcaggca
     2761 ttcctaagca aggtgcagag ttgaggtgtt ttcaatgaaa cctattcgtc cgacttgagc
     2821 agcattggcc acgctgctca gaccactggc catctccatc acctggcgga agcccggcct
     2881 cttcccgata tcacacccgg tggattcctg tagctcccat gccaggatga aattcattca
     2941 ggaacaggat accagaactg tgagggttgg acatcagtac actttctcca aaacagattt
     3001 cgattcttgt gtttagagaa ggagtttaaa acccgtacct gagatgctcc ctatacgatg
     3061 ggagagctcg gacggagcac atgggaggag ttcaggcacc tcagagtgca cagtgtttac
     3121 tgtgaaaaat tctcgggttc cctgctcagt aacttcagca ggaaaaacag ggaggtattt
     3181 ggagctttga acttctggat tcttgttagt ataccaaata cggagttaca ggactaaccg
     3241 atttcctata ttttttaacc tctgtttttg tcccagaagt taaagtaaat ggtttggtgc
     3301 ttttctcaaa agaaaatctc aatgctttct ttctgcactg ttaatataag tgcctcactt
     3361 tttgttgttg ttgttgttgt tttctgattt ttttcttttt ttctatctac ctgtaacaca
     3421 atagggtatg tattttatat gaaatatttt ttatcttttt tgaattaata ttctttctgc
     3481 acaaagaaag tttcccgaat cccaaccttt ctatgacccc gctgtgtgtg tgcactactc
     3541 atcctttcct tcagataaag agtaattgat aactcaaagt ccactattta ttgtgtaata
     3601 tacctgcttc tggccgttag atgttcctct gtgccttatg ttgaaaaatt tgaaaaataa
     3661 catgttgccc aaattattta attattacat actattagag agtagcactt gtattttaac
     3721 cgtgttttct gagacgtgag ataacgctgc tgctgaaggt ttcccagaaa cctccacgat
     3781 gagatcagaa ggccaccgta gaaagtgcta aaggtgccta tgtccactac gctgcagtga
     3841 ggggaggtgg cgtgtgtcaa gcctgttagc tatattaagc agagcactca tttcactctg
     3901 tctaaattat ctttgaaaaa ctgtctgtaa tcctgtttgt gatattgact ttataaattc
     3961 cacttcttat actagtggaa gctattcatt tttctcatat ttgaggagtg ttaagatgga
     4021 agatgccatg tcaggtgcaa ggtgttttaa tgactgaaat gaatggtgca ttgtataaac
     4081 ataacgaaca aaataatctg taaaatattc gcagttttca tttaagaata gttcttacct
     4141 catatgcatt ttttcagtgt atcttgtaaa gaaatcaagt agtaaattga agcttttacg
     4201 ttggcattaa gataaagata aatacaattt gttcacctcc ataccttaag ttgtttatgt
     4261 gatacaccct ttgctgccaa tatggcaaat gtgtcactct gccaaatgca ctgttctcaa
     4321 acggcttaaa gaaaaaatgc tggtgtctgc cattgtctct gttcttgctt agatatgata
     4381 tatgaaggat gtggtcctgg atctgttttt catatgttat ataaaaagct gatgagatcc
     4441 caaactgaga tgtattcaaa tccagaagtg gttctcaacc tgtgctctgt ggctcccgtg
     4501 ggagatagac tgaccctttc acaggggtcc cctaagacca ttggaaaaca cagatatttg
     4561 catcacaatt tataacagta gggaaattac agttttaaag tagcaatgaa aataatttta
     4621 tggttggggt cctgagcaac tgtattcaag ggtcacagca ttagaaaggt tgagatccac
     4681 tgaaatgttg actcttcttt ttttctttta gaaaattaat gtatgtaaac atgcctttgg
     4741 gaaaaagatc tcttctatgc attttcagtc aaaattctga atctctagga ttaagcattg
     4801 aaaaacaact gtctaaaaca tttcacaatt tttttccagc atgaggtgtc accaaggatt
     4861 tagactggtg gtctgaatta gtatcccact tttctatgta aacttttcat taaaagttgt
     4921 catagaaacc attttgtcag tctcttctgc atgttaccaa atattcagtt aaaaaaaaga
     4981 agacaacttt ggacactgag agtatggtgg catttaatta cacacttatc aaactgaaag
     5041 tcttaaaaac aatattgtgt gttcttatct atataaaaat agctaaaaca tctaagaata
     5101 ataaaatcac attaaactgc ctatttgttt gtctgtattg ccaagtgcca aatggaaaga
     5161 ccacttagag caccactaga ctgagggatt aacttctaga tgaaattcta agactcttgt
     5221 gtatgtctga ttgaagttct tcttttctag gtgtttctta cagcacctga acacttaacc
     5281 aatatgccag tgtatcaact tttcaattgt tactatgcac aagctagttt gagtatcaat
     5341 agatcttagg tctacatagc tccttgctgt cctttaaact gttacttgct tacatatgcc
     5401 atgcatagat ttttgttaaa gtatgattta taatgtcctt aaatatcaaa ggaaatgtaa
     5461 acagtgatat atgataataa actaaccacc aaat
//
