LOCUS       NM_001378499           11290 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus AHNAK nucleoprotein 2 (Ahnak2), transcript variant 2,
            mRNA.
ACCESSION   NM_001378499 XM_030251792
VERSION     NM_001378499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11290)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11290)
  AUTHORS   Zhu,D., Zhang,Q., Li,Q., Wang,G. and Guo,Z.
  TITLE     Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis
            by downregulating the TGF-beta1/Smad3 signaling pathway
  JOURNAL   J Gene Med 24 (9), e3442 (2022)
   PUBMED   35882062
  REMARK    GeneRIF: Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary
            fibrosis by downregulating the TGF-beta1/Smad3 signaling pathway.
REFERENCE   3  (bases 1 to 11290)
  AUTHORS   Kirov,A., Kacer,D., Conley,B.A., Vary,C.P. and Prudovsky,I.
  TITLE     AHNAK2 Participates in the Stress-Induced Nonclassical FGF1
            Secretion Pathway
  JOURNAL   J Cell Biochem 116 (8), 1522-1531 (2015)
   PUBMED   25560297
  REMARK    GeneRIF: Results show that stress functionally associates FGF1 with
            AHNAK2 and both proteins with the cytoskeleton and their
            co-localization in the vicinity of the cell membrane. AHNAK2 seems
            to be an important element of the FGF1 export pathway.
REFERENCE   4  (bases 1 to 11290)
  AUTHORS   Oh,Y.S., Gao,P., Lee,K.W., Ceglia,I., Seo,J.S., Zhang,X., Ahn,J.H.,
            Chait,B.T., Patel,D.J., Kim,Y. and Greengard,P.
  TITLE     SMARCA3, a chromatin-remodeling factor, is required for
            p11-dependent antidepressant action
  JOURNAL   Cell 152 (4), 831-843 (2013)
   PUBMED   23415230
REFERENCE   5  (bases 1 to 11290)
  AUTHORS   Marg,A., Haase,H., Neumann,T., Kouno,M. and Morano,I.
  TITLE     AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects
            transverse skeletal muscle fiber stiffness
  JOURNAL   Biochem Biophys Res Commun 401 (1), 143-148 (2010)
   PUBMED   20833135
  REMARK    GeneRIF: these results demonstrate the exclusive expression of
            AHNAK1 and AHNAK2 in the costameres of adult skeletal muscles.
REFERENCE   6  (bases 1 to 11290)
  AUTHORS   Komuro,A., Masuda,Y., Kobayashi,K., Babbitt,R., Gunel,M.,
            Flavell,R.A. and Marchesi,V.T.
  TITLE     The AHNAKs are a class of giant propeller-like proteins that
            associate with calcium channel proteins of cardiomyocytes and other
            cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (12), 4053-4058 (2004)
   PUBMED   15007166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            MF597757.1.
            
            On Feb 20, 2020 this sequence version replaced XM_030251792.1.
            
            Sequence Note: This RefSeq record was created from the
            NW_019168521.1 genomic patch accession since the reference genomic
            sequence has indels that prevent full representation of the CDS
            from the reference genomic sequence.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.33693.1,
                                           SRR5189679.1252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               MF597757.1         24289-24418         c
            131-186             MF597757.1         16799-16854         c
            187-285             MF597757.1         16577-16675         c
            286-387             MF597757.1         15665-15766         c
            388-529             MF597757.1         14839-14980         c
            530-705             MF597757.1         14392-14567         c
            706-11290           MF597757.1         3687-14271          c
FEATURES             Location/Qualifiers
     source          1..11290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.2 cM"
     gene            1..11290
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /note="AHNAK nucleoprotein 2"
                     /db_xref="GeneID:100041194"
                     /db_xref="MGI:MGI:2144831"
     exon            1..130
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /inference="alignment:Splign:2.1.0"
     exon            131..186
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /inference="alignment:Splign:2.1.0"
     exon            187..285
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /inference="alignment:Splign:2.1.0"
     exon            286..387
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..10581
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="protein AHNAK2 isoform 2"
                     /protein_id="NP_001365428.1"
                     /db_xref="GeneID:100041194"
                     /db_xref="MGI:MGI:2144831"
                     /translation="MSHPEESTEVTLKTDVESGASGYSVTGGGDQGIFVKQVLKDSSA
                     AKLFNLREGDQLLSATIFFDHMKYEDALKILQYSEPYKVQFRIKRKLSASKGEEGAVQ
                     HSQQGQENQDKDIADGCMETPTKTLEEAGDRERLISKSRDGHHRRTQDRFSWPKFQTL
                     RSKQRAGPRRSHSSSEASEHRETRDMSPTSTDTEVHRTADRQERNTGEGRRRRRFLNL
                     RFGMTSGQSPDTSEQKGKDPKDRRGDAGALDGCPTQEDDTKDREVAVEGQRKDKKETT
                     GYMSEKTTQKNMRENYYSMEKDIPGKIDLKTDRHQKKKKQDKKQEKQTKLLQQRGEHT
                     TGLRWEDSWEEVESLEIGIARLSLKDTPEENMEVNIQVPSAKLEGELTLADKDVVAKD
                     SKFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPS
                     ADLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKG
                     PHVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDS
                     KFKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSA
                     DLELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGP
                     HVDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSK
                     FKMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVVPPQVQGDLKTPDLSVQLPSAD
                     LELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPH
                     VDLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKF
                     KMPKFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADL
                     ELKAGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHV
                     DLKGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFK
                     MPEFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLE
                     LKARQVGVKLPEGQLPEAELPAAQAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDL
                     KGPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMP
                     KFKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELK
                     AGQVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLK
                     GPKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPK
                     FKMPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLPSADLELKA
                     GQVGVKLPEGQLPEAELPAAKAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKG
                     PKVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKF
                     KMPSFGVSAPGKPSQEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAG
                     QVGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGP
                     KVDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELSLADKDVAAKDSKFKMPKFK
                     MPSFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAGQ
                     VGVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPK
                     VDVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKM
                     PSFGVSAPGKPSLEASLEVGAPKVEADVVPPQVQGDLKTPDLSVQLPSADLELKAGQV
                     GVKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKV
                     DVKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELALADKDVAAKDSKFKMPKFKMP
                     SFGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAGQVG
                     VKLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVD
                     VKGAKGEVSAPDLEVSLPGVEVDIQAPGAKLEGELSLADKDVAAKDSKFKMPKFKMPS
                     FGVSAPGKPSLEASLEVGAPKVEADVAPPQVQGDLKTPDLSVQLRSADLELKAGQVGV
                     KLPEGQLPEAELPAAQAAAAAGAGLKGHLPKVQMPSLKMPKVDLKGPHVDLKGPKVDV
                     KYPQVDMFDHHDSVRTPNQVGFFPFSDQVGNSRDISTSSCHDSTDAGLSPPFVPSQSL
                     LSYVRPSLSIVDSPHESQGSTLPPFTARVLFPKFHRPKFTLSLPPSESENVLSETESQ
                     AVVHSFVTAHTLSGSVVPQVLSSDAAACSVVGVSSSQPSLSQPPEAPKQEAKDTSFKL
                     PSVKLPSFNWSPKKAAESTGDSQSQETPTPSLSLSSMEMDSQIQSSVSIVESPQHAPL
                     EKDVEKGRSRKLSFSMPRLALPKIKVSKGTASVPHGDMRPSLSGTTSGGDLVVVETAV
                     SDAHVGDTHSKDVTTELHVRSPSTTAELVRSKTELPSSKDDLNVRGDSKSLMTVSASQ
                     PFGELVPPRTEGPLQPSGRQRDNACTMETPEMDPTAKETSTDSNERRFKMPKFRVPGF
                     RRSSSKERDRLGEQEATQKSQTQVISIPLEAEEKAAACVQLSHVPESKVEAHISLETP
                     EEGTSVKPVESPTYADVVKRDLHGTGSRMHSSTVEHSHTHLSTPEFGTHLYKDSVSLV
                     RVSEPQLPPEETGKQQHPGPGGNIPAEMEARTGSLPSQPRGPLRLKASITDVASQVSV
                     VSMSQLWEDSVLTVTFPKLKVPRFSFPAPSSEADVFFPVVREVEASITGPMHTGSPGL
                     WEASILKTGAEDTRMPPASLEQSLEASPISKVRVHIQGSRGESQEVALPSRMERWSAD
                     PLAPGAFCTQIVRESEIPASTIQTPSYGFSLLKVKIPEPPVQACVYTVAPDSQPQESV
                     GGAPSPAAAGGHSAPAEAPPDTGEPFEIISSSVGVPPGPQLADSTSDEEPAEILEFPE
                     DSQEVKVSGMDTKQKPEGKKASLLWSWLPSIGFSSVEEMAAESRDTTQRSPVHVQPTA
                     RLDPELPRKQEKAGWFRFPKLGFSSSPTKKPRNTEDGEGQEEHKPQEETVTFFDARES
                     FSPEEEEEAKSEGTSARPGSEAMVASSARTELVLLEQARDTGDKPIPRPVAK"
     exon            388..529
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /inference="alignment:Splign:2.1.0"
     exon            530..705
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /inference="alignment:Splign:2.1.0"
     exon            706..11290
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11273..11278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /note="hexamer: AATAAA"
     polyA_site      11290
                     /gene="Ahnak2"
                     /gene_synonym="Gm1185; Gm72"
                     /note="major polyA site"
ORIGIN      
        1 agccggccca ggatctcttc tagacaagtt tgggaacgtg tcctcttcgg agaagtggct
       61 gcaccccttc tgcaccctgt cccctcctgg gctcagccct gcagcacctg cccctctcac
      121 cactcagcag tgtctggccg acagctgcag cagcgggagc cagaggctga gacggaagac
      181 gactctgtga ctgaagggcc tgcgggtgag atcattcggc caaggccaca ggggtcctca
      241 cctgtttatg aatacacagc tgaaggtgca ggctttggag gccaggaaaa cagtcaaggc
      301 aggcacagct cctctggcag acgtaggtcc tggtggaaac ggggttcagg ggactccgca
      361 gccttcacca gcatgagcca tccagaggag tcaacagagg tgacactgaa gactgacgtg
      421 gagtcaggag ccagtggcta cagtgtcaca ggtggagggg atcaggggat ctttgtcaag
      481 caagtactga aggactcgtc ggctgcaaag ctgttcaacc tgagagaagg agatcaactg
      541 cttagtgcga ccatattctt tgaccatatg aaatatgaag atgctcttaa aatccttcag
      601 tactcagaac catacaaagt tcagttcaga atcaaacgga aactctcggc cagcaaggga
      661 gaggaagggg ctgttcagca ttcgcagcaa ggccaggaaa atcaggacaa ggacattgct
      721 gatgggtgca tggagacccc tacaaaaact ctagaagaag ctggagaccg agaaaggctt
      781 atttctaagt ccagggacgg acaccatagg cgaacccagg acagattctc ctggccaaaa
      841 tttcaaacct taaggagcaa gcagagggca ggcccccgac gctcacacag ttcttcagaa
      901 gcctcagaac acagggaaac acgagatatg tcccccacaa gcacagacac agaagtccac
      961 aggacagctg acagacagga acggaacaca ggggaaggga gacgaagacg gaggttcctg
     1021 aatttgaggt ttggaatgac atcaggtcag agcccagata caagtgagca gaaaggcaaa
     1081 gaccccaaag acaggagagg agatgctgga gcgctggatg ggtgcccaac acaggaggat
     1141 gacacaaagg acagagaggt ggcagttgaa ggccaaagga aggacaagaa agagacaact
     1201 gggtacatgt ctgaaaaaac cacgcaaaaa aacatgagag agaattacta cagcatggaa
     1261 aaagatatcc caggtaaaat agatttaaaa acagacagac atcaaaagaa gaaaaagcag
     1321 gataaaaaac aggaaaagca gacaaaactg ttgcaacaga gaggtgaaca cacaacagga
     1381 ctgagatggg aagacagttg ggaggaagta gaaagtctag aaattggcat tgcaagactg
     1441 tctctgaaag acacaccaga agaaaacatg gaagtaaata tacaggtccc tagtgccaag
     1501 ctggaggggg agctgaccct ggccgacaag gacgtggtgg ccaaagacag caagttcaag
     1561 atgcccaagt tcaagatgcc ctccttcggc gtgtccgcgc ctggcaagcc cagcctggag
     1621 gcctctctgg aggtgggtgc gcccaaggtg gaggcggacg tggccccgcc ccaagtgcag
     1681 ggcgacctga agacccctga cctgagcgtt cagctgccgt ccgccgacct ggagctcaag
     1741 gccggccagg tgggcgtgaa gctgcccgag ggacagctgc ccgaggcaga gctgcccgcc
     1801 gcccaggctg ctgctgctgc tggggccggc ctgaagggcc acctgcccaa ggtgcagatg
     1861 cccagcctca agatgcccaa ggtggacctc aaggggcccc acgtggacct gaagggcccc
     1921 aaagtggacg tgaagggcgc caagggcgag gtgagcgccc ccgacctgga ggtgtccctg
     1981 cccggcgtgg aggtggacat ccaggcgccc ggtgccaagc tggaggggga gctggccctg
     2041 gccgacaagg acgtggcggc caaagacagc aagttcaaga tgcccaagtt caagatgccc
     2101 tccttcggcg tgtccgcgcc tggcaagccc agcctggagg cctctctgga ggtgggtgcg
     2161 cccaaggtgg aggcggacgt ggccccgccc caagtgcagg gcgacctgaa gacccctgac
     2221 ctgagcgttc agctgccgtc cgccgacctg gagctcaagg ccggccaggt gggcgtgaag
     2281 ctgcccgagg gacagctgcc cgaggcagag ctgcccgccg cccaggctgc tgctgctgct
     2341 ggggccggcc tgaagggcca cctgcccaag gtgcagatgc ccagcctcaa gatgcccaag
     2401 gtggacctca aggggcccca cgtggacctg aagggcccca aagtggacgt gaagggcgcc
     2461 aagggcgagg tgagcgcccc cgacctggag gtgtccctgc ccggcgtgga ggtggacatc
     2521 caggcgcccg gtgccaagct ggagggggag ctggccctgg ccgacaagga cgtggcggcc
     2581 aaagacagca agttcaagat gcccaagttc aagatgccct ccttcggcgt gtccgcgcct
     2641 ggcaagccca gcctggaggc ctctctggag gtgggtgcgc ccaaggtgga ggcagacgtg
     2701 gtcccgcccc aagtgcaggg cgacctgaag acccctgacc tgagcgttca gctgccgtcc
     2761 gccgacctgg agctcaaggc cggccaggtg ggcgtgaagc tgcccgaggg acagctgccc
     2821 gaggcagagc tgcccgccgc ccaggctgct gctgctgctg gggccggcct gaagggccac
     2881 ctgcccaagg tgcagatgcc cagcctcaag atgcccaagg tggacctcaa ggggccccac
     2941 gtggacctga agggccccaa agtggacgtg aagggcgcca agggcgaggt gagcgccccc
     3001 gacctggagg tgtccctgcc cggcgtggag gtggacatcc aggcgcccgg ggccaagctg
     3061 gagggggagc tggccctggc cgacaaggac gtggcggcca aagacagcaa gttcaagatg
     3121 cccaagttca agatgccctc cttcggcgtg tccgcgcctg gcaagcccag cctggaggcc
     3181 tctctggagg tgggtgcgcc caaggtggag gcggacgtgg ccccgcccca agtgcagggc
     3241 gacctgaaga cccctgacct gagcgttcag ctgccgtccg ccgacctgga gctcaaggcc
     3301 ggccaggtgg gcgtgaagct gcccgaggga cagctgcccg aggcagagct gcccgccgcc
     3361 caggctgctg ctgctgctgg ggccggcctg aagggccacc tgcccaaggt gcagatgccc
     3421 agcctcaaga tgcccaaggt ggacctcaag gggccccacg tggacctgaa gggccccaaa
     3481 gtggacgtga agggcgccaa gggcgaggtg agcgcccccg acctggaggt gtccctgccc
     3541 ggcgtggagg tggacatcca ggcgcccggt gccaagctgg agggggagct ggccctggcc
     3601 gacaaggacg tggcggccaa agacagcaag ttcaagatgc ccgagttcaa gatgccctcc
     3661 ttcggcgtgt ccgcgcctgg caagcccagc ctggaggcct ctctggaggt gggtgcgccc
     3721 aaggtggagg cggacgtggc cccgccccaa gtgcagggcg acctgaagac ccctgacctg
     3781 agcgttcagc tgccgtccgc cgacctggag ctcaaggccc gccaggtggg cgtgaagctg
     3841 cccgagggac agctgccgga ggcagagctg cccgccgccc aggctgctgc tgctggggcc
     3901 ggcctgaagg gccacctgcc caaggtgcag atgcccagcc tcaagatgcc caaggtggac
     3961 ctcaagggac cccacgtgga cctgaagggc cccaaagtgg acgtgaaggg cgccaagggc
     4021 gaggtgagcg cccccgacct ggaggtgtcc ctgcccggcg tggaggtgga catccaggcg
     4081 cccggtgcca agctggaggg ggagctggcc ctggccgaca aggacgtggc ggccaaagac
     4141 agcaagttca agatgcccaa gttcaagatg ccctccttcg gcgtgtccgc gcctggcaag
     4201 cccagcctgg aggcctctct ggaggtgggt gcgcccaagg tggaggcgga cgtggccccg
     4261 ccccaagtgc agggcgacct gaagacccct gacctgagcg ttcagctgcc gtccgccgac
     4321 ctggagctca aggccggcca ggtgggcgtg aagctgcccg agggacagct gcccgaggca
     4381 gagctgcccg ccgcccaggc tgctgctgct gctggggccg gcctgaaggg ccacctgccc
     4441 aaggtgcaga tgcccagcct caagatgccc aaggtggacc tcaaggggcc ccacgtggac
     4501 ctgaagggcc ccaaagtgga cgtgaagggc gccaagggcg aggtgagtgc ccccgacctg
     4561 gaggtgtccc tgcccggcgt ggaggtggac atccaggcgc ccggtgccaa gctggagggg
     4621 gagctggccc tggccgacaa ggacgtggct gccaaagaca gcaagttcaa gatgcccaag
     4681 ttcaagatgc cctccttcgg cgtgtccgcg cctggcaagc ccagcctgga ggcctctctg
     4741 gaggtgggtg cgcccaaggt ggaggcggac gtggccccgc cccaagtgca gggcgacctg
     4801 aagacccctg acctgagcgt tcagctgccg tccgccgacc tggagctcaa ggccggccag
     4861 gtgggcgtga agctgcccga gggacagctg cccgaggcag agctgcccgc cgccaaggct
     4921 gctgctgctg ctggggccgg cctgaagggc cacctgccca aggtgcagat gcccagcctc
     4981 aagatgccca aggtggacct caaggggccc cacgtggacc tgaagggccc caaagtggac
     5041 gtgaagggcg ccaagggcga ggtgagcgcc cccgacctgg aggtgtccct gcccggcgtg
     5101 gaggtggaca tccaggcgcc cggtgccaag ctggaggggg agctggccct ggccgacaag
     5161 gacgtggcgg ccaaagacag caagttcaag atgcccaagt tcaagatgcc ctccttcggc
     5221 gtgtccgcgc ctggcaagcc cagccaggag gcctctctgg aggtgggtgc gcccaaggtg
     5281 gaggcggacg tggccccgcc ccaagtgcag ggcgacctga agacccctga cctgagcgtt
     5341 cagctgcggt ccgccgacct ggagctcaag gccggccagg tgggcgtgaa gctgcccgag
     5401 ggacagctgc ccgaggcaga gctgcccgcc gcccaggctg ctgctgctgc tggggccggc
     5461 ctgaagggcc acctgcccaa ggtgcagatg cccagcctca agatgcccaa ggtggacctc
     5521 aaggggcccc acgtggacct gaagggcccc aaagtggacg tgaagggcgc caagggcgag
     5581 gtgagcgccc ccgacctgga ggtgtccctg cccggcgtgg aggtggacat ccaggcgccc
     5641 ggtgccaagc tggaggggga gctctccctg gccgacaagg acgtggcggc caaagacagc
     5701 aagttcaaga tgcccaagtt caagatgccc tccttcggcg tgtccgcgcc tggcaagccc
     5761 agcctggagg cctctctgga ggtgggtgcg cccaaggtgg aggcggacgt ggccccgccc
     5821 caagtgcagg gcgacctgaa gacccctgac ctgagcgttc agctgcggtc cgccgacctg
     5881 gagctcaagg ccggccaggt gggcgtgaag ctgcccgagg gacagctgcc cgaggcagag
     5941 ctgcccgccg cccaggctgc tgctgctgct ggggccggcc tgaagggcca cctgcccaag
     6001 gtgcagatgc ccagcctcaa gatgcccaag gtggacctca aggggcccca cgtggacctg
     6061 aagggcccca aagtggacgt gaagggcgcc aagggcgagg tgagcgcccc cgacctggag
     6121 gtgtccctgc ccggcgtgga ggtggacatc caggcgcccg gtgccaagct ggagggggag
     6181 ctggccctgg ccgacaagga cgtggcggcc aaagacagca agttcaagat gcccaagttc
     6241 aagatgccct cctttggcgt gtccgcgcct ggcaagccca gcctggaggc ctctctggag
     6301 gtgggtgcgc ccaaggtgga ggcagacgtg gtcccgcccc aagtgcaggg cgacctgaag
     6361 acccctgacc tgagcgttca gctgccgtcc gccgacctgg agctcaaggc cggccaggtg
     6421 ggcgtgaagc tgcccgaggg acagctgccc gaggcagagc tgcccgccgc ccaggctgct
     6481 gctgctgctg gggccggcct gaagggccac ctgcccaagg tgcagatgcc cagcctcaag
     6541 atgcccaagg tggacctcaa ggggccccac gtggacctga agggccccaa agtggacgtg
     6601 aagggcgcca agggcgaggt gagcgccccc gacctggagg tgtccctgcc cggcgtggag
     6661 gtggacatcc aggcgcccgg tgccaagctg gagggggagc tggccctggc cgacaaggac
     6721 gtggcggcca aagacagcaa gttcaagatg cccaagttca agatgccctc cttcggcgtg
     6781 tccgcgcctg gcaagcccag cctggaggcc tctctggagg tgggtgcgcc caaggtggag
     6841 gcggacgtgg ccccgcccca agtgcagggc gacctgaaga cccctgacct gagcgttcag
     6901 ctgcggtccg ccgacctgga gctcaaggcc ggccaggtgg gcgtgaagct gcccgaggga
     6961 cagctgcccg aggcagagct gcccgccgcc caggctgctg ctgctgctgg ggccggcctg
     7021 aagggccacc tgcccaaggt gcagatgccc agcctcaaga tgcccaaggt ggacctcaag
     7081 gggccccacg tggacctgaa gggccccaaa gtggacgtga agggcgccaa gggcgaggtg
     7141 agcgcccccg acctggaggt gtccctgccc ggcgtggagg tggacatcca ggcgcccggt
     7201 gccaagctgg agggggagct ctccctggcc gacaaggacg tggcggccaa agacagcaag
     7261 ttcaagatgc ccaagttcaa gatgccctcc ttcggcgtgt ccgcgcctgg caagcccagc
     7321 ctggaggcct ctctggaggt gggtgcgccc aaggtggagg cggacgtggc cccgccccaa
     7381 gtgcagggcg acctgaagac ccctgacctg agcgttcagc tgcggtccgc cgacctggag
     7441 ctcaaggccg gccaggtggg cgtgaagctg cccgagggac agctgcccga ggcagagctg
     7501 cccgccgccc aggctgctgc tgctgctggg gccggcctga agggccacct gcccaaggtg
     7561 cagatgccca gcctcaagat gcccaaggtg gacctcaagg ggccccacgt ggacctgaag
     7621 ggccccaaag tggacgtgaa gtacccccaa gtagatatgt ttgaccacca tgattctgtg
     7681 agaaccccta accaggttgg attttttcca ttttctgatc aagtgggtaa ctcaagggac
     7741 atttctacca gttcgtgcca tgattctact gatgctggtc tttcacctcc ttttgtgcct
     7801 tctcagtcct tgttgtcata tgttcgtcca tctttgagta ttgttgactc tccacacgaa
     7861 tctcaaggta gtacactccc tccttttact gctcgcgtat tgttccccaa atttcacaga
     7921 cctaaattta ccttatctct tccaccttca gagtctgaaa acgttctgtc tgagactgag
     7981 tctcaggctg ttgtccattc ttttgttacg gctcacaccc tgtctggttc agtagtccct
     8041 caggtccttt cttccgatgc tgctgcttgt agtgttgtgg gtgtgtcctc cagtcagcct
     8101 tcactcagtc agccacctga ggcacctaag caagaagcaa aagacacttc cttcaaattg
     8161 cctagcgtca agttaccttc ttttaattgg tctccaaaga aggcagcaga gagtacaggt
     8221 gattctcagt cacaggagac acccacaccc agtctaagtt tgtcctcaat ggaaatggat
     8281 tctcaaattc aaagtagtgt ttccatagtg gaatcccccc agcatgcccc tctggaaaag
     8341 gacgtggaga aaggaagaag ccggaagctg agcttttcca tgccaagact ggcactaccc
     8401 aagataaagg tttctaaggg gacggcttct gtgccacacg gagacatgag gccttcactc
     8461 agtggtacca catctggagg tgatttggta gtcgtagaaa cagctgtcag tgatgcccac
     8521 gttggggaca ctcattcaaa agatgtcacc acagaactcc atgtcagatc cccctcaacc
     8581 acagcagagt tggttaggtc caaaactgag cttccttctt ccaaagatga tctgaatgtc
     8641 agaggtgaca gcaaaagtct catgactgtc tctgcaagtc agccctttgg ggaactggta
     8701 ccacccagaa cagaaggtcc cctgcagcca tccggtagac agagagataa cgcctgcacc
     8761 atggaaaccc ctgagatgga tcccacagca aaggagacgt caacagactc gaatgagcgc
     8821 cggttcaaaa tgcccaagtt cagagttcct ggtttcagac gctcctcatc caaggagcga
     8881 gaccggcttg gagaacagga agccactcaa aagtcacaga ctcaggtcat cagcatcccc
     8941 ttggaggcag aagaaaaagc agcagcctgc gtgcagctgt cccatgtgcc tgagtccaag
     9001 gtagaggcac atatctccct ggagacccca gaggaaggga ccagtgtgaa gcccgtagag
     9061 agcccaacgt atgcagatgt tgtaaaacga gatctccacg ggacaggctc gaggatgcat
     9121 agctccactg ttgagcattc ccacacacat ctgtccaccc ctgagtttgg gacccatcta
     9181 tataaagact ctgtctccct tgtgagggtc tcagaacccc agcttcctcc agaagaaaca
     9241 ggcaagcagc agcatcctgg gccaggagga aatatccctg ctgagatgga ggctagaaca
     9301 ggaagcttgc cttcccagcc gcgagggcct ctgaggctga aggcctccat cactgatgtg
     9361 gcatcccagg tctctgtggt gagcatgagt cagctctggg aggattctgt attgactgtt
     9421 acatttccca aactgaaggt acccaggttc tccttccctg ctcccagctc tgaggctgat
     9481 gtgttctttc ctgtggtgag ggaggtcgaa gccagcatta ctggtcccat gcatacaggt
     9541 agccctgggc tctgggaagc cagcattcta aagacaggcg ccgaggacac cagaatgcca
     9601 ccagcaagcc ttgagcaatc tttggaagca tccccaattt ctaaggtcag agtgcacatt
     9661 caggggtctc gaggtgaaag ccaagaagtc gctcttccta gcaggatgga aaggtggagc
     9721 gctgacccct tagctcctgg agccttttgt acccagattg tgcgggagtc agagatccct
     9781 gcttctacaa tccaaactcc ttcttacgga ttttctttgc tgaaagtgaa aattccagag
     9841 ccccctgtgc aggcctgtgt gtatacagtg gctcctgatt cgcagccgca ggagagtgtg
     9901 ggtggagctc cctcaccagc cgctgcaggg ggacactctg ctcctgctga ggccccacct
     9961 gatactggcg aaccatttga gattatctct tccagtgttg gcgtgcctcc ggggccccaa
    10021 cttgcagaca gcacctctga tgaggagccc gcagagattc ttgagtttcc tgaggacagc
    10081 caggaggtta aggtctctgg catggataca aaacagaaac cagaaggtaa aaaggccagc
    10141 ctgttgtggt cctggcttcc gagtattggg ttttcctccg tggaagagat ggctgctgag
    10201 tccagagaca caacccaaag atcccctgtc cacgtgcagc ctaccgctcg gctggacccc
    10261 gaactgccca ggaaacagga gaaggcgggc tggttccggt ttcccaagtt agggttctcc
    10321 tcttcaccca ctaagaagcc caggaacact gaagacgggg aaggccagga agagcacaag
    10381 ccccaggagg agacagtcac cttttttgat gctcgagaaa gcttttcccc agaggaggag
    10441 gaggaagcca agtcagaggg gacaagtgcc aggcctggtt ctgaagcaat ggtggcatcc
    10501 tctgcgagaa cagaactcgt actgttggaa caggctagag acactggtga caaacctatc
    10561 cccaggcccg tggccaaatg aggtgagagg tccgagtcag tggatgagac cagccaacta
    10621 gaacctgaaa cttagggtct gaaagcaacc ccatagcccc tagaacacgc gattgatctt
    10681 gtgtcaatcc acaggcttaa aaccaaagca gaaataaaca gcacttaacc tgtctcacac
    10741 acagccctcc tatagggaac cgaaatccgc tactttcttc caagctttgg aagcaacgaa
    10801 ggctgccaaa ttgtctggtt ctgggagctc tgttggcctt cgtggggtaa gtcccaagag
    10861 gctgcccaac accacgagag caacgttgtc tctgaagtac ccatgcctgt gtgggtagga
    10921 gcagcttttg gggtaacctc tgccttgccg ctgctgttcc tagtgacctc agccagcagg
    10981 gtgtgtggtg tgtccttcca actcacatac tcgatccttc ctcgactctt tcgctaatgg
    11041 caagctttgg ggcgcagact gtgagggtgt gtacgcgcgg cacaaaggtc tgcactcagt
    11101 ggtacctgcg ggttgcccag cagggttcac acacgggttt accattagac cttggtgtgt
    11161 gtctgtttgt ctgtctgcct gccagtgtgc tactactttc ccagatgtgt acaacttcca
    11221 tgctctgccc agagcacctc atgtacagat tgcagcccat tcagtcacct tcaataaagg
    11281 aagcaatgca
//
