LOCUS       NM_001171000            5215 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus S-adenosylhomocysteine hydrolase-like 2 (Ahcyl2),
            transcript variant 2, mRNA.
ACCESSION   NM_001171000
VERSION     NM_001171000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5215)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5215)
  AUTHORS   Kawaai,K., Ando,H., Satoh,N., Yamada,H., Ogawa,N., Hirose,M.,
            Mizutani,A., Bonneau,B., Seki,G. and Mikoshiba,K.
  TITLE     Splicing variation of Long-IRBIT determines the target selectivity
            of IRBIT family proteins
  JOURNAL   Proc Natl Acad Sci U S A 114 (15), 3921-3926 (2017)
   PUBMED   28348216
  REMARK    GeneRIF: Long-Irbit splice variants have different N-terminal
            sequences and a common C-terminal region, which is involved in
            multimerization of IRBIT and Long-IRBIT.N-terminal splicing of
            Long-IRBIT changed the protein stability.
REFERENCE   3  (bases 1 to 5215)
  AUTHORS   Ando,H., Mizutani,A. and Mikoshiba,K.
  TITLE     An IRBIT homologue lacks binding activity to inositol
            1,4,5-trisphosphate receptor due to the unique N-terminal appendage
  JOURNAL   J Neurochem 109 (2), 539-550 (2009)
   PUBMED   19220705
REFERENCE   4  (bases 1 to 5215)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY733512.1, CA751283.1, BC079660.1 and BC059255.1.
            
            On Aug 2, 2011 this sequence version replaced NM_001171000.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (2) that is 1 aa shorter than isoform 1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               BY733512.1         1-210
            211-873             CA751283.1         1-663
            874-1083            BC079660.1         787-996
            1084-5215           BC059255.1         259-4390
FEATURES             Location/Qualifiers
     source          1..5215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..5215
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /note="S-adenosylhomocysteine hydrolase-like 2"
                     /db_xref="GeneID:74340"
                     /db_xref="MGI:MGI:1921590"
     exon            1..464
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1934
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /EC_number="3.13.2.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     putative adenosylhomocysteinase 3;
                     S-adenosyl-L-homocysteine hydrolase 3; long-IRBIT;
                     S-adenosylhomocysteine hydrolase-like protein 2; clone
                     MNCb-5555"
                     /codon_start=1
                     /product="putative adenosylhomocysteinase 3 isoform 2"
                     /protein_id="NP_001164471.2"
                     /db_xref="CCDS:CCDS57416.1"
                     /db_xref="GeneID:74340"
                     /db_xref="MGI:MGI:1921590"
                     /translation="MSVQVVSAAAAAKVPEVELKDLSPSEAEPQLGLSAAAVGAMVPP
                     AGGGDPEAPAPAPAAERPPAPGPGSGPTAALSPAAGKVPQASAMKRSDPHHQHQRHRD
                     GGEALVSPDGTVTEAPRTVKKIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSA
                     ASYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKR
                     AQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESG
                     FPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIV
                     EESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFG
                     GKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVD
                     IVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHV
                     IWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLL
                     PKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY"
     exon            465..573
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            574..717
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            718..818
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            819..921
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1016
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1123
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1240
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1304
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1393
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1464
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1559
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1658
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1727
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1806
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1927
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..5198
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2077..2082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /note="hexamer: ATTAAA"
     polyA_site      2103
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
     regulatory      5177..5182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /note="hexamer: AATAAA"
     polyA_site      5198
                     /gene="Ahcyl2"
                     /gene_synonym="4631427C17Rik; Adohcyase3; mKIAA0828"
                     /note="major polyA site"
ORIGIN      
        1 ggggtatggg ggagggaagg ggaagggagg cgggaggcgg ggccgagtgg gagctggtgc
       61 gagagtcaga gtcggcggtt gcagtggagg cggtgatgtc ggtgcaggtt gtgtcagcag
      121 cggcagccgc caaggtgcct gaggtggagc tgaaggatct gagcccctcc gaggcggagc
      181 cccagttggg actgagcgcg gcggccgtgg gcgccatggt acccccagcg ggtggcgggg
      241 acccagaggc tccagctccg gctcccgcgg cggagcggcc cccggccccc ggcccgggct
      301 cggggcccac cgcggctctg agccctgcgg ccgggaaggt ccctcaagcg tccgccatga
      361 agcggagcga ccctcatcac cagcaccagc ggcatcgcga cggcggcgag gccttggtca
      421 gccccgacgg cacggtcacc gaggcgccgc gcacggtcaa gaagattcag tttgctgacc
      481 agaagcagga attcaacaaa cgtcccacca aaatcggacg tcgctctttg tctcgttcca
      541 tctctcagtc atctactgac agctatagct cagctgcctc atatacagat agctctgacg
      601 atgagacatc ccccagggac aagcagcaaa agaactctaa gggaagtagc gacttctgtg
      661 tcaagaacat caaacaagcg gagtttggac gcagagaaat tgaaattgct gagcaagaga
      721 tgcctgcctt gatggcttta aggaagagag cccaaggaga aaagcctttg gctggagcca
      781 aaattgtggg ttgtacgcac atcactgctc agacagccgt gcttatggag acactgggtg
      841 ctctgggggc acagtgccga tgggctgcct gcaacatcta ctccaccctc aatgaagtgg
      901 ctgctgctct cgcagaaagt gggtttcccg tctttgcctg gaaaggagaa tcagaagatg
      961 acttttggtg gtgcattgac agatgcgtga atgtggaggg ctggcagcca aacatgatac
     1021 tggatgatgg aggagatctg actcactgga tttataaaaa gtatcccaac atgtttaaaa
     1081 aaatcaaagg catagtcgag gagagtgtta ctggagtcca taggctgtac caactgtcca
     1141 aagctgggaa gctgtgtgtt cccgccatga acgtcaatga ctcagtcact aagcagaaat
     1201 ttgataacct ctactgttgc cgtgaatcta ttcttgacgg acttaaaagg acaacagata
     1261 tgatgtttgg tggaaagcag gtggtggtct gtggctatgg agaggtggga aaggggtgct
     1321 gcgctgctct gaaagccatg ggctccattg tgtacgtgac tgagattgac cccatctgtg
     1381 ccctgcaagc ctgtatggat ggattccgac tagtgaagct gaatgaagtc atccgacagg
     1441 tcgacattgt tattacttgc acagggaaca agaatgtggt aaccagagag cacttggacc
     1501 gtatgaagaa tagctgcatc gtttgtaaca tgggccattc caacaccgag attgatgtgg
     1561 ccagcctgcg gacaccagaa ctgacctggg agagagtaag atcccaagtt gatcatgtga
     1621 tatggcctga tggcaagagg atagtactgc tggcagaggg ccgtctactg aatctcagct
     1681 gctccacagt gcctacattt gtgctctcca tcactgctac cactcaggct ctcgccttga
     1741 tagaacttta caatgctcct gagggtcgct ataagcaaga tgtgtacctg ctacccaaga
     1801 aaatggatga gtatgtggca agcctacacc tgcccacctt tgatgcccac ctgacagagc
     1861 taacagatga acaagccaag tatctgggac tcaacaagaa tggacccttc aagcctaact
     1921 actacaggta ttaagttcct gtaatgcaag ccagaagaca tgttaaagaa tagaaccaag
     1981 ccttttctca aatactatcc aaggaagaac ctagcaagct gcttctccaa tcagagctgc
     2041 ccgccgtgct catcctgtgt gttaggttat ttatttatta aaatctagaa tcctgtgcct
     2101 gtagccttgg cccagagtgt ggttactaac tcgtggggcc gtgagagcca cagaggacag
     2161 gctgaggaag gaaagaaatg ggctagccat tcctcgtgca tcactcgcat tattgcccat
     2221 taatggaatc cccagcgatg accatgttct ctccaggctc aggagttagt tcagggatgc
     2281 cagactcctt gttacttagg gttttctgaa tacatttcag cagctgcctt tctcaaagct
     2341 ttggtccttt cccaggtgag gccttttgga agccactgaa ttaataaggc ctgaattctc
     2401 agccttgata gttactgtca ctgccttcct tataaaaagg ctggggaggc aggagtggta
     2461 aggtcttgta agctgcacca agaactcagc tgtgcctgtg tccgtgccta ctgggatctc
     2521 ttctcttacc caggacttct ttcttctcct tgactaacta tatccatttc aatgctttct
     2581 ggctctaaga gggttgtgac tccatgatct taacagctct ggtgttggtc aggcatttgt
     2641 tttactttct aaccctacta aactctgctc aggaagtagc cagccagctc cactgggacc
     2701 catagttctg ctttcttccc atttaactgg actgtttcct aggaagcccc ctagatgggc
     2761 actgtcagag aaggagagcc ccgtatgaac agtgcttctg ttgtgcctga aatgatgctt
     2821 ggagctgagt tggcgaaggt gtttgctaga gatttggggg cttcagactt tagagtgggc
     2881 tatagcttga tatcctaaag aaagaagttt ttccaggaaa gactttgcag cctggctgca
     2941 gaagacagga gactttgtaa agtgtgtcga gatgatgaaa cctagtttga gggctggagg
     3001 ttagctcagt ggtaaagcac ttgcctggca tgagtaaggc cctgtgctca atcgctggga
     3061 actaggggaa gggatggggc actagtttga acctcatcag acattcatcc ctttggctgt
     3121 tagccttggt gaaagtgaga tctgcagtct gatagcttat ctttctttgc tgctgctgct
     3181 gctgccgcgc tgtatcgtta ttatgatctg gccccttctg tttaaggatt ctgtttcaga
     3241 gagtttctta agtaactcca gcattataaa ataataatgt aaacagtgtg aagtttctca
     3301 ttctacccaa gagtgatatc ctttggagat agactgagtg gtttcgaggt ttccactggg
     3361 atcatttgat ttcaagaatt aacctggagt gaccctagga atcttgagtt gaatgagtcc
     3421 ctctcatggc cctccctatt tagaagtctc ctgtttgttc cccatgtgtc ttttacattg
     3481 atacatcttt tacattgtat caagagcaag gtcattccaa cagaggacac ccagaatcac
     3541 tgaaaccttc ctctagatct tctcccctgg ctccaccatc tctgctgtcc cttggtcttt
     3601 gtgtgtgccc tggaagctag tctggaagtg tccttatttt ctaagatagg gaaacagaac
     3661 ttgggtaggt ggctggtttg ccttatggta tacattctgg ctcaccccag aagatggact
     3721 cttgccagga cagcatctgt ggctgtattc tgttgtataa ggaagatcag aaacactgaa
     3781 gaccttaccg agataggccg ttctgtttgc ctcattctga tttctgtatt agcggaatgc
     3841 atcaatcact ctcccactac catatctgtt ttgttttttg ttttttgttt ttttgttatt
     3901 gttgttgggg ttgttgttgt tttgagatag tcttgctctg taacccaggc tggactcaaa
     3961 gtcacggcag ttctcctgcc ttggcctcct gaggccatgt gctactatgt ctggcctcat
     4021 aattggatct ctttagtgaa agattcatat ctctgtgcct cattttatgt ccagagcaga
     4081 ttccgttagg caggtatctg gcttgggccc caagtcatat cctggtgatt ttctgcaaag
     4141 cctagctctc tacagagctt cttatggctg ccacaccata gggaagagat cccctccaag
     4201 taaaaaagga gccacatggg tttctaagtt acgttgtacc tgactgccca tagtgaggta
     4261 tctgcctgtg agttacagat gacatctatt cccttctctc tggagacttc tgtgtcatca
     4321 accattaaga aagtagccag aaataggatg taagacagtg ataggacact tgattagcat
     4381 gtgccaggcc ctggggcgaa tgaatcccag tacagcaggc ttgtggagag ttgggaagaa
     4441 agaagatagc ccaggttctg ccctaatgct ggaaccaaat cattgtttcc tctaaccttg
     4501 gaataagagc aaatttcttc ttattccaac tcttcctttt acaagcactc tagctacctg
     4561 gagacaagga agagaagact ggttgtctct ggttatgtgg ccctgggcag agggaaatac
     4621 accacttgtc tacaatgaat ttgtgctact tcaaggtctt cttgctgttt tagtggaaat
     4681 attgttttct ttttcttgtt aaacaaaaat gcctctaatc taccttccct ctgccctcct
     4741 ccctcctcat gttcccctcc tgggagagcc aggctcccca cggccacaca ctcctgcaaa
     4801 gctttttctg ctgcttggct tttctctgaa aagatctgaa attgctgctc ctgtgctttt
     4861 cctcagaatt aacttttgtc atggtttaaa ataaatcaga atgcattgtt gcattaagct
     4921 tttttaataa aggaaaatta tggaaagaaa ataggtaaca ccagcaaatt atatattgac
     4981 attgacaagt ctaaacatat atatacttat atatgtaaaa cacatccata tctatacaaa
     5041 taatcatcta gttcttactg tcatcttact gaaaggaaca aagcctctaa ggatcaccag
     5101 ttctgagaag ctcttggaaa tctctatgtc taagtgattg tattagatca gcaataatga
     5161 ctatgtaatc tcaaaaaata aagtattctt aaaactgaaa aaaaaaaaaa aaaaa
//
