LOCUS       NM_145542               3878 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1),
            transcript variant 1, mRNA.
ACCESSION   NM_145542
VERSION     NM_145542.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3878)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3878)
  AUTHORS   Goto,J.I., Fujii,S., Fujiwara,H., Mikoshiba,K. and Yamazaki,Y.
  TITLE     Synaptic plasticity in hippocampal CA1 neurons of mice lacking
            inositol-1,4,5-trisphosphate receptor-binding protein released with
            IP3 (IRBIT)
  JOURNAL   Learn Mem 29 (4), 110-119 (2022)
   PUBMED   35351819
  REMARK    GeneRIF: Synaptic plasticity in hippocampal CA1 neurons of mice
            lacking inositol-1,4,5-trisphosphate receptor-binding protein
            released with IP3 (IRBIT).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3878)
  AUTHORS   Itoh,R., Hatano,N., Murakami,M., Mitsumori,K., Kawasaki,S.,
            Wakagi,T., Kanzaki,Y., Kojima,H., Kawaai,K., Mikoshiba,K.,
            Hamada,K. and Mizutani,A.
  TITLE     Both IRBIT and long-IRBIT bind to and coordinately regulate
            Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal
            degradation of AE2
  JOURNAL   Sci Rep 11 (1), 5990 (2021)
   PUBMED   33727633
  REMARK    GeneRIF: Both IRBIT and long-IRBIT bind to and coordinately
            regulate Cl(-)/HCO3(-) exchanger AE2 activity through modulating
            the lysosomal degradation of AE2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3878)
  AUTHORS   Ando,H., Kawaai,K. and Mikoshiba,K.
  TITLE     IRBIT: a regulator of ion channels and ion transporters
  JOURNAL   Biochim Biophys Acta 1843 (10), 2195-2204 (2014)
   PUBMED   24518248
  REMARK    Review article
REFERENCE   5  (bases 1 to 3878)
  AUTHORS   Yang,D., Shcheynikov,N. and Muallem,S.
  TITLE     IRBIT: it is everywhere
  JOURNAL   Neurochem Res 36 (7), 1166-1174 (2011)
   PUBMED   21152975
  REMARK    Review article
REFERENCE   6  (bases 1 to 3878)
  AUTHORS   Devogelaere,B., Sammels,E. and De Smedt,H.
  TITLE     The IRBIT domain adds new functions to the AHCY family
  JOURNAL   Bioessays 30 (7), 642-652 (2008)
   PUBMED   18536033
  REMARK    Review article
REFERENCE   7  (bases 1 to 3878)
  AUTHORS   Devogelaere,B., Nadif Kasri,N., Derua,R., Waelkens,E.,
            Callewaert,G., Missiaen,L., Parys,J.B. and De Smedt,H.
  TITLE     Binding of IRBIT to the IP3 receptor: determinants and functional
            effects
  JOURNAL   Biochem Biophys Res Commun 343 (1), 49-56 (2006)
   PUBMED   16527252
  REMARK    GeneRIF: IRBIT can directly interact with the IP3R, and that both
            the suppressor domain and the IP3-binding core of the IP3R are
            essential for a strong interaction.
REFERENCE   8  (bases 1 to 3878)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
REFERENCE   9  (bases 1 to 3878)
  AUTHORS   Ando,H., Mizutani,A., Matsu-ura,T. and Mikoshiba,K.
  TITLE     IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding
            protein, is released from the IP3 receptor upon IP3 binding to the
            receptor
  JOURNAL   J Biol Chem 278 (12), 10602-10612 (2003)
   PUBMED   12525476
REFERENCE   10 (bases 1 to 3878)
  AUTHORS   Dekker,J.W., Budhia,S., Angel,N.Z., Cooper,B.J., Clark,G.J.,
            Hart,D.N. and Kato,M.
  TITLE     Identification of an S-adenosylhomocysteine hydrolase-like
            transcript induced during dendritic cell differentiation
  JOURNAL   Immunogenetics 53 (12), 993-1001 (2002)
   PUBMED   11904675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140786.3, CJ162898.1, AB092504.1, AC122902.4, AK004088.1 and
            BQ176498.1.
            
            On Oct 21, 2017 this sequence version replaced NM_145542.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000547.1, BC018218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC140786.3         49781-49792         c
            13-283              CJ162898.1         14-284
            284-1913            AB092504.1         1-1630
            1914-2941           AC122902.4         165170-166197       c
            2942-3855           AK004088.1         349-1262
            3856-3878           BQ176498.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..3878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..3878
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /note="S-adenosylhomocysteine hydrolase-like 1"
                     /db_xref="GeneID:229709"
                     /db_xref="MGI:MGI:2385184"
     exon            1..403
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            404..515
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            516..659
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            660..760
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            761..863
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            864..958
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1065
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1182
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1246
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1335
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1406
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1501
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1600
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1669
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1748
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1869
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..3863
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1920..1925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /note="hexamer: AATAGA"
     polyA_site      1941
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /note="major polyA site"
     regulatory      3836..3841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /note="hexamer: ATTAAA"
     polyA_site      3859
                     /gene="Ahcyl1"
                     /gene_synonym="1110034F20Rik; Ahcy-rs3; DCAL; Irbit"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgtgctt gcgtgtggcg gaggtggctg cgcgggcagg tcggagctgc gtgctgttgc
       61 ttctggttct gtggccgccg tcgctgtccg gcaggctccg gtctcggagc cgacgaggcg
      121 cgcgcgcgcg ggtcccagcc cttcggaagc ccaagcagct cggcgcgggg cctggcggga
      181 aggcgggcga gcgcgtggcc gagggcgccg cgcggacggg cgggcgcccg tgagggaaag
      241 aggcgggggc ggcgggttag ccgcgggccg ggccggccgg gggatgtcga tgcctgacgc
      301 gatgccgctg cccggtgtcg gggaggagct gaaacaggcc aaggagatcg aggacgccga
      361 gaagtactcc ttcatggcca cggtcaccaa ggctcccaag aagcaaatcc agtttgctga
      421 tgacatgcaa gagttcacca aattccctac taagactggc cggagatctt tgtctcgttc
      481 catctcacaa tcctccacag acagctacag ttcagctgca tcctatacag atagctctga
      541 tgatgaggtt tcccctcgag agaagcagca aaccaactcg aagggcagca gcaatttctg
      601 tgtgaagaac atcaagcagg cagagtttgg acgccgggag attgagattg cagagcaaga
      661 catgtctgct ctgatttcac tcaggaaacg tgctcaggga gagaagcctt tggctggtgc
      721 taaaatagtg ggctgtacgc acatcacggc ccagacagcg gtattaattg agaccctttg
      781 tgccctggga gctcagtgcc gctggtctgc ctgcaacatc tattcaactc agaatgaagt
      841 agctgcagca ctggctgagg ctggagtcgc ggtgtttgct tggaagggcg agtcagaaga
      901 tgatttctgg tggtgcattg accgctgtgt caacatggat gggtggcagg ctaacatgat
      961 cctggatgat gggggagact taacccactg ggtttataag aagtatccaa acgtgtttaa
     1021 gaagatccga ggcattgtgg aagagagcgt gactggtgtt cacaggctgt atcagctctc
     1081 caaagctggg aagctctgtg ttccagccat gaatgtcaat gattctgtta ccaaacagaa
     1141 gtttgataac ctgtactgct gccgagaatc cattttggat ggcctgaaga ggaccacgga
     1201 tgtgatgttt ggtgggaaac aggtggtggt gtgtggctat ggtgaggtag gaaagggctg
     1261 ctgtgctgct ctcaaggccc ttggagcaat tgtctacata acagaaattg accccatctg
     1321 tgctctgcag gcctgcatgg atgggttcag ggtggtgaag ctgaatgaag tcatccggca
     1381 ggtggacgtt gtaattactt gcacaggaaa taagaatgta gtgactcggg agcacttgga
     1441 ccgaatgaaa aatagttgta ttgtgtgcaa tatgggccat tccaacacgg agatcgacgt
     1501 gaccagcctc cgcactccag aactaacatg ggagcgtgta cgttctcagg tggaccatgt
     1561 catctggcct gatggcaaac gggtcgtcct tctagcagag ggccgtttac ttaatctgag
     1621 ctgctccaca gtccctacct ttgttctttc catcacggct acaacacagg ctttggcact
     1681 gatagagctt tacaacgccc cggagggacg ctacaaacag gatgtgtact tgcttcctaa
     1741 gaagatggat gaatatgttg ccagcttgca cttaccatca tttgatgccc acctgacaga
     1801 actgacagat gaccaagcaa agtatctggg actcaacaaa aatgggccat tcaaacctaa
     1861 ttattacaga tactaatgga catagtacag tgaccagtcc acatgaacca cgcaactcta
     1921 atagagtatt ttttaagata acttttattt tcttcttatt actttccttt tgattttttt
     1981 tttctatcat ttcattgttg ttttctcatc tcatcatttg agttttgcag accacacagg
     2041 aacttgctcc atagctcttt aggtgaaact gaggtcaaag gtttctcacc caagtcacta
     2101 aaaggggtta actctgctgc ccagaaagtt gattctttaa ccatttctgg gaactttgat
     2161 cgtatttagt taccttatta acagaaaatg ctaaggcatc ttctatgtgg aacaatctac
     2221 agtgtctaaa ttgccttaaa agagcctgtt cctagctgct ggaactagtg ctctttcact
     2281 tcttcagagg agccaggatg gtacttccca gccaggtagg ttagatgtag gtggtgcatg
     2341 tcagcttccc atagacactc taagccctgt ttcctgtgta aggtggcatg tctggcagag
     2401 atgcgttgct tgttcaactc agtaggttca cttgggtttg tagtccagcc ttccaccagt
     2461 ctctctcatt gttctagttt taactaaact gcattctagc aagttgaatt ttgtccctta
     2521 gcatttattt ctgttttatt tcttttaatt aagaaaaaaa attattgtta accctgagga
     2581 acagctcagg tggttagtta ccaacatctc gtttgaacct ttgaagcaaa gagtgaagag
     2641 ttgaggctag aaaaatacta gtctcagact ctgatgtttc cagctcatag tttatagcat
     2701 cagtgaactg gagccataag caaaatttct cagctctgcc tcacgcagct tatgctgacg
     2761 gctgatttct tgagccatta ctcagtataa aacactgagc cctatcttta gggtttatcc
     2821 tttaagagca aacttgtggg catctgtgct tctgcaacct aaactatttg aagggaagtc
     2881 tatatagatg gaagaaagaa tgataaattg gaccaaggtg aaacaaatat aactatataa
     2941 tctgttcaga actgtagacc ttgtctggtg ttagttttat agaaatggtg ccacttttga
     3001 ttgacacttg ccacaaaaat agaaaataaa aattataaac tgagatctta aagaggactt
     3061 ggagaaagta catcctgatt catgctctaa gagaattcca agaggccctc taaaaatcag
     3121 agagttattc ccaggccacg cacctgcttg ccaatatctc tgcatggtca aatgagcttc
     3181 atgctcacaa gctttaagta tataactatc caggatttta agtcctcaac gtgttctagc
     3241 ttgtgatcct tcaaagatgg gttatgtgtt aatgataggt actagaaatg tttacttctc
     3301 tctttccact gatcagagaa acaggcatta aagacagaat gcaagaacgg aaagctttta
     3361 ccctgcacct tccttgcagg gaacaattat cttgccaaaa cgtctttccc tttcatctcc
     3421 catttctctg tacccagtcc cttcctgctc cttgccaatg tgatcatgct ttcttctcta
     3481 taaatgctaa catttgaaga cccctttcct agggcactta accatccagt cagaccatca
     3541 cattcagtag ggacttgtct tggctaacag cagtgtatcc atctggtcag ctctactgag
     3601 ggaaggggcc aagttactgc tgccctctaa tctgccctct ggtcctatat ctattactgt
     3661 gtccatagga ataataggta agggctagtc tctgtcaagc catgtaacaa aggacactgc
     3721 aaaatgtctg gcatcagagg ggacatttgg agaccaactt gggaggaaaa tattcatttt
     3781 gtattgaatg atttttaatg aatgcaatat taatccttgc agatgagcaa taatcattaa
     3841 aatcagttaa aaatgataag acaaaaaaaa aaaaaaaa
//
