LOCUS       NM_016661               2560 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus S-adenosylhomocysteine hydrolase (Ahcy), mRNA.
ACCESSION   NM_016661
VERSION     NM_016661.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Boczki,P., Colombo,M., Weiner,J., Rapohn,I., Lacher,M., Kiess,W.,
            Hanschkow,M., Korner,A. and Landgraf,K.
  TITLE     Inhibition of AHCY impedes proliferation and differentiation of
            mouse and human adipocyte progenitor cells
  JOURNAL   Adipocyte 13 (1), 2290218 (2024)
   PUBMED   38064408
  REMARK    GeneRIF: Inhibition of AHCY impedes proliferation and
            differentiation of mouse and human adipocyte progenitor cells.
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Jiang,Q., Lan,S., Tan,F., Liang,Y., Guo,Z., Hou,Y., Zhang,H., Wu,G.
            and Liu,Z.
  TITLE     Adenosylhomocysteinase plays multiple roles in maintaining the
            identity and pluripotency of mouse embryonic stem cellsdagger
  JOURNAL   Biol Reprod 110 (3), 450-464 (2024)
   PUBMED   38035769
  REMARK    GeneRIF: Adenosylhomocysteinase plays multiple roles in maintaining
            the identity and pluripotency of mouse embryonic stem cellsdagger.
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Vande Voorde,J., Steven,R.T., Najumudeen,A.K., Ford,C.A.,
            Dexter,A., Gonzalez-Fernandez,A., Nikula,C.J., Xiang,Y., Ford,L.,
            Maneta Stavrakaki,S., Gilroy,K., Zeiger,L.B., Pennel,K.,
            Hatthakarnkul,P., Elia,E.A., Nasif,A., Murta,T., Manoli,E.,
            Mason,S., Gillespie,M., Lannagan,T.R.M., Vlahov,N., Ridgway,R.A.,
            Nixon,C., Raven,A., Mills,M., Athineos,D., Kanellos,G., Nourse,C.,
            Gay,D.M., Hughes,M., Burton,A., Yan,B., Sellers,K., Wu,V., De
            Ridder,K., Shokry,E., Huerta Uribe,A., Clark,W., Clark,G.,
            Kirschner,K., Thienpont,B., Li,V.S.W., Maddocks,O.D.K., Barry,S.T.,
            Goodwin,R.J.A., Kinross,J., Edwards,J., Yuneva,M.O., Sumpton,D.,
            Takats,Z., Campbell,A.D., Bunch,J. and Sansom,O.J.
  TITLE     Metabolic profiling stratifies colorectal cancer and reveals
            adenosylhomocysteinase as a therapeutic target
  JOURNAL   Nat Metab 5 (8), 1303-1318 (2023)
   PUBMED   37580540
  REMARK    GeneRIF: Metabolic profiling stratifies colorectal cancer and
            reveals adenosylhomocysteinase as a therapeutic target.
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Mehrabian,M., Wen,P.Z., Fisler,J., Davis,R.C. and Lusis,A.J.
  TITLE     Genetic loci controlling body fat, lipoprotein metabolism, and
            insulin levels in a multifactorial mouse model
  JOURNAL   J Clin Invest 101 (11), 2485-2496 (1998)
   PUBMED   9616220
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Bethin,K.E., Petrovic,N. and Ettinger,M.J.
  TITLE     Identification of a major hepatic copper binding protein as
            S-adenosylhomocysteine hydrolase
  JOURNAL   J Biol Chem 270 (35), 20698-20702 (1995)
   PUBMED   7657650
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Miller,M.W., Duhl,D.M., Winkes,B.M., Arredondo-Vega,F., Saxon,P.J.,
            Wolff,G.L., Epstein,C.J., Hershfield,M.S. and Barsh,G.S.
  TITLE     The mouse lethal nonagouti (a(x)) mutation deletes the
            S-adenosylhomocysteine hydrolase (Ahcy) gene
  JOURNAL   EMBO J 13 (8), 1806-1816 (1994)
   PUBMED   8168479
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Seo,H.C. and Ettinger,M.J.
  TITLE     Purification and properties of a self-associating, 50-kDa
            copper-binding protein from brindled mouse livers
  JOURNAL   J Biol Chem 268 (2), 1160-1165 (1993)
   PUBMED   8419320
REFERENCE   10 (bases 1 to 2560)
  AUTHORS   Pilz,A., Le Tissier,P., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Mapping of the structural gene for S-adenosyl homocysteine
            hydrolase to mouse chromosome 2, and related sequences to
            chromosomes 8 and X
  JOURNAL   Mamm Genome 3 (11), 633-636 (1992)
   PUBMED   1450513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ929555.1, AK169331.1, BC086781.1 and AA237720.1.
            
            On Oct 31, 2009 this sequence version replaced NM_016661.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086781.1, BC108367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BQ929555.1         1-41
            42-2120             AK169331.1         2-2080
            2121-2485           BC086781.1         2050-2414
            2486-2560           AA237720.1         371-445
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.94 cM"
     gene            1..2560
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /note="S-adenosylhomocysteine hydrolase"
                     /db_xref="GeneID:269378"
                     /db_xref="MGI:MGI:87968"
     exon            1..133
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1404
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /EC_number="3.13.2.1"
                     /note="adoHcyase; liver copper-binding protein;
                     S-adenosyl-L-homocysteine hydrolase"
                     /codon_start=1
                     /product="adenosylhomocysteinase"
                     /protein_id="NP_057870.3"
                     /db_xref="CCDS:CCDS16942.1"
                     /db_xref="GeneID:269378"
                     /db_xref="MGI:MGI:87968"
                     /translation="MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKP
                     LKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAW
                     KGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTG
                     VHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVV
                     AGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTT
                     GCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGR
                     RIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDE
                     AVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY"
     exon            134..324
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            325..400
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            401..550
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            551..663
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            664..871
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            872..959
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1077
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1272
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..2543
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /note="hexamer: AATACA"
     polyA_site      2127
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /note="major polyA site"
     regulatory      2138..2143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /note="hexamer: ATTAAA"
     polyA_site      2163
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /note="major polyA site"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
                     /note="hexamer: AACAAG"
     polyA_site      2543
                     /gene="Ahcy"
                     /gene_synonym="CuBP; SAHH"
ORIGIN      
        1 aaataagaag atatttaaag acgccggcgc caggcgtaga tccctgcccc gcgccgcccg
       61 gcccccttca ctgagttcat cagtcctagc ggaagcgccg ccagcatgtc tgataaactg
      121 ccctacaaag tcgcggacat cggactggcc gcctggggac ggaaggctct ggatatagct
      181 gagaatgaga tgccaggatt gatgcgcatg cgggagatgt actcagcctc caagccactg
      241 aagggtgctc gcattgctgg ctgcctgcac atgaccgtgg agactgctgt tctcattgag
      301 actctcgtgg ccctgggtgc tgaggtgcgg tggtccagct gcaacatctt ctctactcag
      361 gaccatgcag cggctgccat tgccaaggct ggcattccag tgtttgcctg gaagggcgag
      421 acagatgagg agtacctgtg gtgcattgag cagacgctgc acttcaagga cggacccctc
      481 aacatgattc tggatgatgg tggtgacctt actaacctca tccacaccaa atacccacag
      541 cttctgtcag gcatccgagg tatctctgag gagaccacga ctggggtcca caacctctac
      601 aagatgatgt ccaatgggat actgaaggtg cctgccatca atgtcaacga ttctgtcacc
      661 aagagcaagt ttgacaacct ctatggctgc cgggagtccc tcatagatgg catcaaacgg
      721 gccacagatg tgatgattgc gggcaaggtg gcggtggtgg caggctatgg tgatgtgggc
      781 aagggctgtg cccaggccct gaggggtttt ggggcccgag tcatcatcac cgagatcgac
      841 cccatcaatg cactgcaagc tgccatggag ggctatgagg taaccactat ggacgaagcc
      901 tgtaaggagg gcaacatctt tgtcaccacc acaggctgtg tggatatcat ccttggccgg
      961 cactttgagc agatgaagga tgacgccatt gtctgtaaca ttggacactt cgatgtggag
     1021 attgatgtga agtggctcaa tgagaacgcg gtggagaaag tgaacatcaa gccccaggtg
     1081 gaccgctact ggctaaagaa tgggcgccgc atcatcttgc tggctgaagg ccgtctggtc
     1141 aacctgggtt gtgccatggg acaccccagc ttcgtgatga gcaactcctt cacaaaccag
     1201 gtgatggcac agattgagct gtggacccac ccagataaat accctgttgg ggttcacttc
     1261 ctgcctaaga agctggatga ggcggtggct gaagcccacc tgggcaagct gaatgtgaag
     1321 ctgaccaagc tgactgagaa gcaggcccag tacctgggca tgcccatcaa cggccccttc
     1381 aagcctgatc actaccgcta ctgagtgctg gggctgtcct tcaccttcca gctgccatcc
     1441 ttgttccggg ccctatctct cgttcccaag agcaaatgtc accaactttg cagtagcctg
     1501 gacagtgctt ctcccacaca gccctcccct tacaccctct ggggctggtc actctgtctt
     1561 tgacctctgc tgtatccctc atactgttcc aggtgtggag ggggaatgga gaggtacctg
     1621 gtaggcatcc acaggggaca tgatctcaga agtcttggaa gtcctgaggc tggatgttgc
     1681 tagtgatggt cacaagccat gcaccttatc aatgagaccc tcacttggtc tttagatctg
     1741 tgtgcctggt ttgcagatcc attggtttct cagtccagga cccaagaacg agctccacca
     1801 aagagcagga acccctggag tttgaaggcc cccgagagct gggccttttt actgttgggc
     1861 agtctcttaa acctcatgat actgagttgg tacttttttt ggtccctatt tcacaagggt
     1921 taggatagat taaccaagaa aggacaagtg acagactgaa aggggctgga aaaacaaaga
     1981 ggaaaaggcc tgtcacttct gtatagttga tggttcctgt cacaagccca ggtcacaaac
     2041 agattaattt gttttataat gtttatatgc tatttagaat gttaacaaag gaaggtggat
     2101 aaaatacagt ttctactgcc taaagaattt tggctctatt aaaatgtaag tgtgtggctg
     2161 gaatatgtgc atgtatgtgg ctgacatatg tgcatgtgtg tgcagacact gtacctgtga
     2221 ttctggagga caccagatgt cccatcgctt tcttccatat tcctgagaca gggtccctca
     2281 ctggactaga gtgaggccat ttctgctctt cccagatccc tcaccctaga gctggggtta
     2341 aagtcaagca tggccatgtg tagcttctac aagtgcaaac ggtcttaccc actgagccat
     2401 ctcttcacgg atcgcataat gtgaatcaca caaaaaagta tgagaaattg aactccctct
     2461 tatttgccca agtgatcaat ttactgaacc catttgacct ggaaagcaaa taaaaacaag
     2521 ccccgtgcac aggatggcta aaaaaaaaaa aaaaaaaaaa
//
