LOCUS       NM_009642               4046 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus angiotensin II, type I receptor-associated protein
            (Agtrap), transcript variant 1, mRNA.
ACCESSION   NM_009642
VERSION     NM_009642.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4046)
  AUTHORS   Wang,B., Yu,W., Zhang,W., Zhang,M., Niu,Y., Jin,X., Zhang,J.,
            Sun,D., Li,H., Zhang,Z., Luo,Q., Cheng,X., Niu,J., Cai,G., Chen,X.
            and Chen,Y.
  TITLE     Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling
            contributes to mitochondrial dysfunction in renal tubular
            epithelial cells in D-galactose-induced accelerated aging mice
  JOURNAL   Aging Cell 23 (6), e14130 (2024)
   PUBMED   38415902
  REMARK    GeneRIF: Enhanced TRPC3 transcription through AT1R/PKA/CREB
            signaling contributes to mitochondrial dysfunction in renal tubular
            epithelial cells in D-galactose-induced accelerated aging mice.
REFERENCE   2  (bases 1 to 4046)
  AUTHORS   Li,D., Zhang,Q., Yang,X., Zhang,G., Wang,J., Zhang,R. and Liu,Y.
  TITLE     Microglial AT1R Conditional Knockout Ameliorates Hypoperfusive
            Cognitive Impairment by Reducing Microglial Inflammatory Responses
  JOURNAL   Neuroscience 545, 125-140 (2024)
   PUBMED   38484837
  REMARK    GeneRIF: Microglial AT1R Conditional Knockout Ameliorates
            Hypoperfusive Cognitive Impairment by Reducing Microglial
            Inflammatory Responses.
REFERENCE   3  (bases 1 to 4046)
  AUTHORS   Hirota,K., Yamashita,A., Abe,E., Yamaji,T., Azushima,K., Tanaka,S.,
            Taguchi,S., Tsukamoto,S., Wakui,H. and Tamura,K.
  TITLE     miR-125a-5p/miR-125b-5p contributes to pathological activation of
            angiotensin II-AT1R in mouse distal convoluted tubule cells by the
            suppression of Atrap
  JOURNAL   J Biol Chem 299 (12), 105478 (2023)
   PUBMED   37981211
  REMARK    GeneRIF: miR-125a-5p/miR-125b-5p contributes to pathological
            activation of angiotensin II-AT1R in mouse distal convoluted tubule
            cells by the suppression of Atrap.
REFERENCE   4  (bases 1 to 4046)
  AUTHORS   Tsukamoto,S., Suzuki,T., Wakui,H., Uehara,T., Ichikawa,J.,
            Okuda,H., Haruhara,K., Azushima,K., Abe,E., Tanaka,S., Taguchi,S.,
            Hirota,K., Kinguchi,S., Yamashita,A., Tamura,T. and Tamura,K.
  TITLE     Angiotensin II type 1 receptor-associated protein in immune cells:
            a possible key factor in the pathogenesis of visceral obesity
  JOURNAL   Metabolism 149, 155706 (2023)
   PUBMED   37856903
  REMARK    GeneRIF: Angiotensin II type 1 receptor-associated protein in
            immune cells: a possible key factor in the pathogenesis of visceral
            obesity.
REFERENCE   5  (bases 1 to 4046)
  AUTHORS   Meister,T.A., Soria,R., Dogar,A., Messerli,F.H.,
            Paoloni-Giacobino,A., Stenz,L., Scherrer,U., Sartori,C. and
            Rexhaj,E.
  TITLE     Increased Arterial Responsiveness to Angiotensin II in Mice
            Conceived by Assisted Reproductive Technologies
  JOURNAL   Int J Mol Sci 23 (21), 13357 (2022)
   PUBMED   36362144
  REMARK    GeneRIF: Increased Arterial Responsiveness to Angiotensin II in
            Mice Conceived by Assisted Reproductive Technologies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4046)
  AUTHORS   De Paolis,P., Porcellini,A., Savoia,C., Lombardi,A., Gigante,B.,
            Frati,G., Rubattu,S., Musumeci,B. and Volpe,M.
  TITLE     Functional cross-talk between angiotensin II and epidermal growth
            factor receptors in NIH3T3 fibroblasts
  JOURNAL   J Hypertens 20 (4), 693-699 (2002)
   PUBMED   11910305
  REMARK    GeneRIF: in the expressing AT1R, the EGF-induced MAPK pathway was
            enhanced in the presence of Ang II in a synergistic fashion
REFERENCE   7  (bases 1 to 4046)
  AUTHORS   Kaplan,M., Aviram,M., Knopf,C. and Keidar,S.
  TITLE     Angiotensin II reduces macrophage cholesterol efflux: a role for
            the AT-1 receptor but not for the ABC1 transporter
  JOURNAL   Biochem Biophys Res Commun 290 (5), 1529-1534 (2002)
   PUBMED   11820795
  REMARK    GeneRIF: The inhibitory effect of angiotensin II (Ang-II) on
            macrophage cholesterol efflux is mediated by the Ang-II type 1
            (AT1) receptor, as shown by the addition of the AT1 receptor
            antagonist losartan on peritoneal macrophages prelabeled with [3H]
            cholesterol.
REFERENCE   8  (bases 1 to 4046)
  AUTHORS   Wang,W., Huang,Y., Zhou,Z., Tang,R., Zhao,W., Zeng,L., Xu,M.,
            Cheng,C., Gu,S., Ying,K., Xie,Y. and Mao,Y.
  TITLE     Identification and characterization of AGTRAP, a human homolog of
            murine Angiotensin II Receptor-Associated Protein (Agtrap)
  JOURNAL   Int J Biochem Cell Biol 34 (1), 93-102 (2002)
   PUBMED   11733189
  REMARK    GeneRIF: interact specifically with the carboxyl-terminal
            cytoplasmic region of the angiotensin II type 1 (AT(1)) receptor to
            regulate different aspects of AT(1) receptor physiology
REFERENCE   9  (bases 1 to 4046)
  AUTHORS   Akishita,M., Yamada,H., Dzau,V.J. and Horiuchi,M.
  TITLE     Increased vasoconstrictor response of the mouse lacking angiotensin
            II type 2 receptor
  JOURNAL   Biochem Biophys Res Commun 261 (2), 345-349 (1999)
   PUBMED   10425188
REFERENCE   10 (bases 1 to 4046)
  AUTHORS   Daviet,L., Lehtonen,J.Y., Tamura,K., Griese,D.P., Horiuchi,M. and
            Dzau,V.J.
  TITLE     Cloning and characterization of ATRAP, a novel protein that
            interacts with the angiotensin II type 1 receptor
  JOURNAL   J Biol Chem 274 (24), 17058-17062 (1999)
   PUBMED   10358057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152467.1, AL606929.13 and CO040736.1.
            
            On Sep 8, 2016 this sequence version replaced NM_009642.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152467.1, AK036598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1818              AK152467.1         1-1818
            1819-1819           AL606929.13        79192-79192         c
            1820-3519           AK152467.1         1820-3519
            3520-4046           CO040736.1         1-527               c
FEATURES             Location/Qualifiers
     source          1..4046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.67 cM"
     gene            1..4046
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /note="angiotensin II, type I receptor-associated protein"
                     /db_xref="GeneID:11610"
                     /db_xref="MGI:MGI:1339977"
     exon            1..148
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..607
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     type-1 angiotensin II receptor-associated protein; AT1
                     receptor-associated protein"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor-associated
                     protein isoform 1"
                     /protein_id="NP_033772.2"
                     /db_xref="CCDS:CCDS18930.1"
                     /db_xref="GeneID:11610"
                     /db_xref="MGI:MGI:1339977"
                     /translation="MELPAVNLKVILLVHWLLTTWGCLVFSSSYAWGNFTILALGVWA
                     VAQRDSIDAIGMFLGGLVATIFLDIIYISIFYSSVATGDTGRFGAGMAILSLLLKPFS
                     CCLVYHMHRERGGELPLRPDFFGPSQEHSAYQTIDSSSDAAADPFASLENKGQAVPRG
                     Y"
     exon            149..183
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /inference="alignment:Splign:2.1.0"
     exon            184..289
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /inference="alignment:Splign:2.1.0"
     exon            290..485
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /inference="alignment:Splign:2.1.0"
     exon            486..4029
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1176
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /note="major polyA site"
     regulatory      3501..3506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /note="hexamer: AATAAA"
     polyA_site      3522
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /note="major polyA site"
     regulatory      4007..4012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /note="hexamer: AATAAA"
     polyA_site      4029
                     /gene="Agtrap"
                     /gene_synonym="3300002E14Rik; AT1R; Atrap; D4Wsu124e"
                     /note="major polyA site"
ORIGIN      
        1 gagttggcct cccgccgttg gaactggcgc aacgcgacgg gcggggccag gaagtttgtt
       61 cccgagttcg gagcccagga gtccccgcgg ccgtcgctca ggtgccctcc gccgggtcgg
      121 gatggagctg cctgccgtga acttgaaggt tattctcctg gttcactggc tgttgacaac
      181 ctggggctgc ttggtgttct caagctccta tgcttggggc aacttcacta tcctggccct
      241 gggtgtgtgg gctgtggccc agcgggactc tatagatgcc ataggcatgt ttcttggtgg
      301 cttggttgcc accatcttcc tggacattat ctacattagc atcttctact cgagtgttgc
      361 cactggggac actggccgct tcggcgccgg catggccatc ctcagcttgc tgctgaagcc
      421 cttctcttgc tgcctcgtct accacatgca ccgtgaacga gggggtgagc tccccctccg
      481 ccccgatttc ttcggaccct ctcaggagca cagtgcctac cagacaattg actcatcatc
      541 agacgctgct gcagacccct ttgcaagcct ggagaacaag ggccaagctg tcccccgggg
      601 gtactgaagc tgtccctggt cgtcctggtc cccagcagga ttcttgttca aaccttcttt
      661 acctggacct acagtggggc atccgccatt ccctatcaca gaggtggcct gagtcatgtg
      721 cccttggagg tcaagagcct ctagcttctc agtggagaag agcccagtcc taattctcca
      781 ggctacccct cccttcaaga cacctgttaa cccctgggct agagctgtgg ttggtttttt
      841 cccctcctac cccataacta taacacactc ctactgaact gcccagagtg ctcagggcca
      901 gccaggcctc atgggttagt gatcactgcc gctcgggctg ccccatggtg atcagccctt
      961 cctagaagct ctgtgagctt gtggtcccgc tcagcctgct ctgcaaaggg gcaaagttcc
     1021 tgtgcctgtc acggcctcat gacttggtgt ctgagaaccc caggcctgga tgcagtagtt
     1081 cttcagaggc ccctctcaga gtgctggcat taaaaattca ggggttctgt ggctgctctg
     1141 tgtctgagcc acgattgagc tccaagcaca gacccaccct gctgtcttgg tatgattttt
     1201 gcctttgagt caagagcctg atggaaggaa gggctacctg tgggcctgtg gggggagcct
     1261 gactgtggcc aaacggtcag tgtggcatgt ggacagacat ctgtcctctg aatctaagtg
     1321 actatcactg cctctgatac tgacccatga ggcagggcat gggtgactcc ctctatctcc
     1381 tgcgttctta ccacagtcga ctgcctcctg aggttccagg gcccctattc ttactgccag
     1441 atctctgggg acagatactt gaagacttat ggggaaccac aggctgaggt gactgtcctg
     1501 aaaggactgt ctgcacacct gtggacaggc agggaggctg agtgacagca tctgtgaaaa
     1561 gtgaacccca ccccccaccc ccgcctctgg acagggtcac tgtggaacac catcccatac
     1621 aatcagcatc ccatacaatc agcatcctga gcccagtgtg agcagagtga ggagcagcgt
     1681 gtgccactag agggaggtag ttgtgaggca acctctcaca aaacccttag gtttgtttag
     1741 gttgtatgca gcacagtata aaacatgagc cggggcccag agacgaggct cagcagcagg
     1801 tgaaaggagt cagtctacta cttagcgtga caatctgtgt ttagttttgg accgacttga
     1861 gaaagttgtc ctctgacctc cacacatact cttgtcatgg tatgaggttt tacacacaaa
     1921 cagagagaag agagagagag agaaagaaag aaagatagat aaaaacaaac aatccagaat
     1981 attaaaaacc tgcctggtgg gtggttaatc ccagcactcg ggaggcagag gcaagtgaat
     2041 gtcagagatt gaggccaggc ctggtctaca gagtgaattc caggtcagcc agggctacac
     2101 agagaaaccc tgtctacaaa aaaataacaa aaaagctctg ggatgcatgt caagttcctg
     2161 actgcagagg ccttggggga gaagggaaca tgaggcctgc ggcaaggaag atggaaaacc
     2221 cagggtgttt ctcctgtttc tgggcagttt ctaggcagaa ggaaggcctg gagtatcagt
     2281 gccgtgtctc ttggaatagg tcatgcttgc agagacgaat aaggtgaggc aggggctcag
     2341 cctaagtagc taagacaggt cccagagcct gcatccctca gatccagctg accttaggga
     2401 aaggtggagg aggaatatct ctggaagagc cccaaaagca gactagagca ggggagctgg
     2461 gctttctcat tggtcaatgg ctgtcccaca gtggatgaca aacttccagc tgatggagga
     2521 gaggccccga ggcaagcaga ataggtgggt gaagagaaga gacatgccct agaggcagca
     2581 gtgggctaga gagggtctaa gtggaggggc agccccccag gaaggctggc ctggaacact
     2641 ggccagcatg tggttaggaa gtggtgtggc tggagcgctt agtgtcagat agcagaagag
     2701 caggttggga gccaccatgg ggactgcctt ccactgagta agaactcaag agagcatgca
     2761 tcggtatccg aatctgaatg tgactggttg atactcccta gaaggatact ttgtacttgt
     2821 tggctgtggg aatgtgacaa ctgtcacctc ctggacacac tctgaaggtg ggcctgcggg
     2881 aactgctgat gcaccgaaga gagaagccag gaatactaac agtaggattg gggctgtacc
     2941 ctgtagttgc cactgactgg aaagccaaga ggagcacaca ggctggtggg gcacaggatg
     3001 gccaggcagg gtccagaagg ctgtgcttgt gggacggggc tcttcaacca gctgctctca
     3061 cgggcacctg cctttgtgcc acaaggcccc gtggtggttt ggaaacaggc tggcccccag
     3121 gttttagtct agagcctgcc gttcttggga ggtctcttac ctgttgcctg cagagctgaa
     3181 gtctcttgtc ctgtttgcaa gtctattgct tgcttgttga gttgaatctt cctgagaaac
     3241 tgcccctgag gcactcagtg ttctgtctgc caaactgctg gtgtgcccta ctcagtctcc
     3301 agaacagccc tgtaggtcca gccctctctg caaccagaga accttgtttt aaatttcaaa
     3361 ggaccagtga gatggcctgt tggggaaggg ccttgtcact aaaatatgag tttgatctct
     3421 gggtcccata gggtggaact gactcctgca agttgtcctc tgacctccat gttagtactg
     3481 tggcacatgc ctcctccaca aataaacgta attaaatcta aaggtaccct gagatttctg
     3541 tataggaaac aactgtttta aaaaatctca ctgtggggag gcagagacag gcagatttct
     3601 gagttcgagg ccagcctggt ctacaaagtg agttccggga cagccaggac tatacaggga
     3661 aaccctgtct caaaaaaaca aaaacaaaaa accaacaaaa acaaacaaaa aaatctcact
     3721 gtgtctcagt ttcctgttct gaaaagtggg gataagatgg gccattgaga tagctcagtg
     3781 ggtagagggt acatactgcc aggtctgatg acctgggttc gagtcctagg acatgtataa
     3841 gaagagactt ctcacctcca tataaacacc atggcacttg gcgtgtgtgt gtgtgtgtgt
     3901 gtgtgtggca cacgcacaca cggtaaaaat gtaaaataaa gtgaggataa aaatcgtgtg
     3961 tgactcaggg actagtgaag gttgagaata gtggaacctc gatggtaata aatgttaaag
     4021 cttattgtaa aaaaaaaaaa aaaaaa
//
