LOCUS       NM_007429               2872 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus angiotensin II receptor, type 2 (Agtr2), mRNA.
ACCESSION   NM_007429
VERSION     NM_007429.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2872)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2872)
  AUTHORS   Abadir,P., Cosarderelioglu,C., Damarla,M., Malinina,A., Dikeman,D.,
            Marx,R., Nader,M.M., Abadir,M., Walston,J. and Neptune,E.
  TITLE     Unlocking the protective potential of the angiotensin type 2
            receptor (AT2R) in acute lung injury and age-related pulmonary
            dysfunction
  JOURNAL   Biochem Pharmacol 220, 115978 (2024)
   PUBMED   38081369
  REMARK    GeneRIF: Unlocking the protective potential of the angiotensin type
            2 receptor (AT2R) in acute lung injury and age-related pulmonary
            dysfunction.
REFERENCE   3  (bases 1 to 2872)
  AUTHORS   Alvarez-Gallego,F., Gonzalez-Blazquez,R., Gil-Ortega,M., Somoza,B.,
            Calderon-Dominguez,M., Moratinos,J., Garcia-Garcia,V.,
            Fernandez,P., Gonzalez-Moreno,D., Viana,M. and Alcala,M.
  TITLE     Angiotensin II type 2 receptor as a novel activator of brown
            adipose tissue in obesity
  JOURNAL   Biofactors 49 (6), 1106-1120 (2023)
   PUBMED   37286331
  REMARK    GeneRIF: Angiotensin II type 2 receptor as a novel activator of
            brown adipose tissue in obesity.
REFERENCE   4  (bases 1 to 2872)
  AUTHORS   Xu,Q., Chen,J., Ye,W., Zhang,C., Wang,D., Wei,W. and Hu,S.
  TITLE     Activation of angiotensin II type 2 receptor attenuates lung injury
            of collagen-induced arthritis by alleviating endothelial cell
            injury and promoting Ly6Clo monocyte transition
  JOURNAL   Eur J Pharmacol 941, 175466 (2023)
   PUBMED   36528072
  REMARK    GeneRIF: Activation of angiotensin II type 2 receptor attenuates
            lung injury of collagen-induced arthritis by alleviating
            endothelial cell injury and promoting Ly6C[lo] monocyte transition.
            Erratum:[Eur J Pharmacol. 2023 Sep 5;954:175907. doi:
            10.1016/j.ejphar.2023.175907.. PMID: 37460388]
REFERENCE   5  (bases 1 to 2872)
  AUTHORS   Vieira,T.N., Saraiva,A.L.L., Guimaraes,R.M., Luiz,J.P.M.,
            Pinto,L.G., de Melo Rodrigues Avila,V., Goulart,L.R.,
            Cunha-Junior,J.P., McNaughton,P.A., Cunha,T.M., Ferreira,J. and
            Silva,C.R.
  TITLE     Angiotensin type 2 receptor antagonism as a new target to manage
            gout
  JOURNAL   Inflammopharmacology 30 (6), 2399-2410 (2022)
   PUBMED   36173505
REFERENCE   6  (bases 1 to 2872)
  AUTHORS   Koike,G., Winer,E.S., Horiuchi,M., Brown,D.M., Szpirer,C.,
            Dzau,V.J. and Jacob,H.J.
  TITLE     Cloning, characterization, and genetic mapping of the rat type 2
            angiotensin II receptor gene
  JOURNAL   Hypertension 26 (6 Pt 1), 998-1002 (1995)
   PUBMED   7490161
REFERENCE   7  (bases 1 to 2872)
  AUTHORS   Ichiki,T., Labosky,P.A., Shiota,C., Okuyama,S., Imagawa,Y.,
            Fogo,A., Niimura,F., Ichikawa,I., Hogan,B.L. and Inagami,T.
  TITLE     Effects on blood pressure and exploratory behaviour of mice lacking
            angiotensin II type-2 receptor
  JOURNAL   Nature 377 (6551), 748-750 (1995)
   PUBMED   7477267
REFERENCE   8  (bases 1 to 2872)
  AUTHORS   Hein,L., Barsh,G.S., Pratt,R.E., Dzau,V.J. and Kobilka,B.K.
  TITLE     Behavioural and cardiovascular effects of disrupting the
            angiotensin II type-2 receptor in mice
  JOURNAL   Nature 377 (6551), 744-747 (1995)
   PUBMED   7477266
  REMARK    Erratum:[Nature 1996 Mar 28;380(6572):366]
REFERENCE   9  (bases 1 to 2872)
  AUTHORS   Horiuchi,M., Koike,G., Yamada,T., Mukoyama,M., Nakajima,M. and
            Dzau,V.J.
  TITLE     The growth-dependent expression of angiotensin II type 2 receptor
            is regulated by transcription factors interferon regulatory
            factor-1 and -2
  JOURNAL   J Biol Chem 270 (34), 20225-20230 (1995)
   PUBMED   7650042
REFERENCE   10 (bases 1 to 2872)
  AUTHORS   Tsutsumi,K. and Saavedra,J.M.
  TITLE     Heterogeneity of angiotensin II AT2 receptors in the rat brain
  JOURNAL   Mol Pharmacol 41 (2), 290-297 (1992)
   PUBMED   1538709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140941.1 and AK086334.1.
            
            On Oct 24, 2012 this sequence version replaced NM_007429.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086334.1, AK140941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-693               AK140941.1         3-695
            694-1612            AK086334.1         693-1611
            1613-2872           AK086334.1         1613-2872
FEATURES             Location/Qualifiers
     source          1..2872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.71 cM"
     gene            1..2872
                     /gene="Agtr2"
                     /note="angiotensin II receptor, type 2"
                     /db_xref="GeneID:11609"
                     /db_xref="MGI:MGI:87966"
     exon            1..71
                     /gene="Agtr2"
                     /inference="alignment:Splign:2.1.0"
     exon            72..131
                     /gene="Agtr2"
                     /inference="alignment:Splign:2.1.0"
     exon            132..2872
                     /gene="Agtr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1259
                     /gene="Agtr2"
                     /note="angiotensin II type-2 receptor; AT2 receptor"
                     /codon_start=1
                     /product="type-2 angiotensin II receptor"
                     /protein_id="NP_031455.1"
                     /db_xref="CCDS:CCDS40889.1"
                     /db_xref="GeneID:11609"
                     /db_xref="MGI:MGI:87966"
                     /translation="MKDNFSFAATSRNITSSRPFDNLNATGTNESAFNCSHKPSDKHL
                     EAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLALADLLLLATLPLWAT
                     YYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQA
                     SYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNIL
                     GFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLT
                     FLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
                     VPITWLQGKRETMSCRKGSSLREMDTFVS"
     regulatory      2847..2852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agtr2"
                     /note="hexamer: AATAAA"
     polyA_site      2865
                     /gene="Agtr2"
                     /note="major polyA site"
ORIGIN      
        1 gcagttacat ctcagaggct ggcgatggag ggagctcgga actgaaagct tacttcagcc
       61 tgcattttaa ggagtgcatg cgggagctga gtaagctgat ttatgataac tgctttaaac
      121 actggcaact aaaaaggtgt aagaatttgg agttgctgca gttcaatatg aaggacaact
      181 tcagttttgc tgccaccagc agaaacatta ccagcagccg tccttttgat aatctcaacg
      241 caactggcac caatgagtcc gcctttaatt gctcacacaa accatcagat aagcatttgg
      301 aagcaattcc tgttctctac tacatgattt ttgtgattgg gtttgctgtt aatattgttg
      361 tggtctcact gttttgttgt caaaagggcc ctaaaaaggt gtccagcatt tacatcttca
      421 atctggcctt ggctgactta ctccttttgg ctaccctccc tctctgggca acctattact
      481 cttatagata tgattggctt tttggacctg tgatgtgcaa agtgtttggt tcttttctga
      541 ctctgaacat gtttgcaagc atttttttta ttacctgcat gagtgtcgat aggtaccaat
      601 cggtcatcta cccttttctg tctcaaagaa ggaatccctg gcaagcatct tatgtagttc
      661 cccttgtttg gtgtatggct tgtctatcct cattgccaac attttatttc cgggatgtca
      721 gaaccattga atacttaggt gtgaatgctt gtattatggc tttcccaccc gagaaatatg
      781 ctcagtggtc tgctgggatt gccttaatga aaaatattct tggctttatt attcctttaa
      841 tattcatagc aacgtgttac tttggaatca gaaaacatct gctgaagact aatagctatg
      901 ggaagaacag aattacccgt gaccaagtcc tgaagatggc agctgctgtt gtgttggcat
      961 tcatcatttg ctggcttccc ttccatgttc tgaccttctt ggatgctctg acctggatgg
     1021 gtatcattaa tagctgtgaa gttatagcag tcattgacct ggcacttcct tttgccatcc
     1081 tcctgggatt caccaacagc tgtgttaatc ccttcctgta ttgttttgtt ggaaaccgct
     1141 tccaacagaa gctccgcagt gtgtttagag ttcccattac ttggctccaa ggcaagagag
     1201 agactatgtc ttgcagaaaa ggcagttctc ttagagaaat ggacaccttt gtgtcttaaa
     1261 tctgttagtg ggatgcatgt aatcagccta gccattggtt tggaggccca cacaaatgat
     1321 ctttaagtgg catcagtata atacagttct ttgctttatc taatctttac ttactccccc
     1381 gagaacagga agtcaagtag aactgtaaat ctttatactc caccagcttt cagtgatagt
     1441 gccttctttt gctggtcctt tggcatgaga ttgtcatatg tgagctagat ctataatcta
     1501 gaagtatctg ggggaattat cccaacttat aattaacaac aaattatgag tggtgatttg
     1561 acatctcaga cttctccctg gaaaatgctg gcatttctta gtggagtttt ttgtccattt
     1621 tcatcagatt tcttttttct tgaacaaagg ccaatttaaa cttcttatac tatccaacca
     1681 tatgatatag catgagaggt gagcactaag tttagcatga tatactcttc tatatatgcc
     1741 ataggttggt agtggcttat tcagtctcta ggtatagagt ttctcctttt aaagaaattg
     1801 taagttgtgt tccttttcca tttcactcaa gtatagcttt tgtacttatt ctacagctac
     1861 acactgagca gatctagaat gtagattaaa tcacacatct gtcttagctt attcttgcag
     1921 ttatagaaag tacactattt agtaaaacag aactgcaatg aaaagtattt tagtatccac
     1981 aaaactgaat atacactttg aaaatttttc atccattttg actcttgttt attctattct
     2041 cttctgatga tttttgaata caacaacaaa acactgtatt atgacactac gtaaaggtca
     2101 ctttttaaat ttttaacctt ttgaacatgg tgctttgata tattcaatga tgacttgagt
     2161 ttaattattc atgcttttgt tctgggcttc gtcccaaaat atctctttga ccctgaaaaa
     2221 gagagcattc tttaattctt taactttgta ataaagtgca aactggcatg ggaaaaggtt
     2281 atgtcagact ggaagtttga tgccttcttg ggggtaaaca gacccagcaa atggcaagtt
     2341 tggtgtccaa caaggaactt gtcagaacaa agactccctg gggagtagtt tgaatctgca
     2401 tttctgggca cagttccaga atgtataaga gtctgtgaag gtgatttaaa gcaagcccag
     2461 gtccacagaa ctcattctta acacgagtac atctcttaca ttagaggaat ataatacctg
     2521 aagctgtgtt acctaaagtt tactcaaact tctcaataaa tattaattca gaagttaaag
     2581 atgtcattct ctgcctgtcc catattatac caggtcacct aagaccttcc tggattgatg
     2641 ctgacctatg aggtagattc aaagttctgg gaacttaaca tttctgtcag attccaggcg
     2701 ttttaggttg aagaatcctc tcatacccct tccttggaaa accctgattt catgtattca
     2761 tgttaatttt tagtaaaaac aaatagctaa atatgtaatc agttatgact ttgtgtttta
     2821 agcaatttta cacaaaatct cgtaaaaata aaatcattac tgggagacca tg
//
