LOCUS       NM_175086               2147 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus angiotensin II receptor, type 1b (Agtr1b), mRNA.
ACCESSION   NM_175086
VERSION     NM_175086.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Cavinato,C., Spronck,B., Caulk,A.W., Murtada,S.I. and Humphrey,J.D.
  TITLE     AT1b receptors contribute to regional disparities in angiotensin II
            mediated aortic remodelling in mice
  JOURNAL   J R Soc Interface 21 (217), 20240110 (2024)
   PUBMED   39192727
  REMARK    GeneRIF: AT1b receptors contribute to regional disparities in
            angiotensin II mediated aortic remodelling in mice.
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Yadav,V.K., Berger,J.M., Singh,P., Nagarajan,P. and Karsenty,G.
  TITLE     Embryonic osteocalcin signaling determines lifelong adrenal
            steroidogenesis and homeostasis in the mouse
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34905510
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Rianto,F., Hoang,T., Revoori,R. and Sparks,M.A.
  TITLE     Angiotensin receptors in the kidney and vasculature in hypertension
            and kidney disease
  JOURNAL   Mol Cell Endocrinol 529, 111259 (2021)
   PUBMED   33781840
  REMARK    GeneRIF: Angiotensin receptors in the kidney and vasculature in
            hypertension and kidney disease.
            Review article
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Lima,M.L.S., Medeiros,C.A.C.X., Guerra,G.C.B., Santos,R., Bader,M.,
            Pirih,F.Q., Araujo Junior,R.F., Chan,A.B., Cruz,L.J., Brito,G.A.C.,
            Leitao,R.F.C., Silveira,E.J.D.D., Garcia,V.B., Martins,A.A. and
            Araujo,A.A.
  TITLE     AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density
            in Mice in Periodontal Inflammation Experimental Model
  JOURNAL   Int J Mol Sci 22 (10), 5217 (2021)
   PUBMED   34069164
  REMARK    GeneRIF: AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone
            Density in Mice in Periodontal Inflammation Experimental Model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   Yamasaki,E., Thakore,P., Krishnan,V. and Earley,S.
  TITLE     Differential expression of angiotensin II type 1 receptor subtypes
            within the cerebral microvasculature
  JOURNAL   Am J Physiol Heart Circ Physiol 318 (2), H461-H469 (2020)
   PUBMED   31886721
  REMARK    GeneRIF: AT1Rb and total AT1R expression levels are much lower in
            parenchymal arterioles compared with pial arteries and that
            parenchymal arterioles are less sensitive to the vasoconstrictive
            effects of the endogenous AT1R ligand angiotensin II (ANG II)
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   MacTaggart,T.E., Ito,M., Smithies,O. and John,S.W.
  TITLE     Mouse angiotensin receptor genes Agtr1a and Agtr1b map to
            chromosomes 13 and 3
  JOURNAL   Mamm Genome 8 (4), 294-295 (1997)
   PUBMED   9096120
REFERENCE   7  (bases 1 to 2147)
  AUTHORS   Chen,X., Li,W., Yoshida,H., Tsuchida,S., Nishimura,H., Takemoto,F.,
            Okubo,S., Fogo,A., Matsusaka,T. and Ichikawa,I.
  TITLE     Targeting deletion of angiotensin type 1B receptor gene in the
            mouse
  JOURNAL   Am J Physiol 272 (3 Pt 2), F299-F304 (1997)
   PUBMED   9087671
REFERENCE   8  (bases 1 to 2147)
  AUTHORS   Burson,J.M., Aguilera,G., Gross,K.W. and Sigmund,C.D.
  TITLE     Differential expression of angiotensin receptor 1A and 1B in mouse
  JOURNAL   Am J Physiol 267 (2 Pt 1), E260-E267 (1994)
   PUBMED   8074205
REFERENCE   9  (bases 1 to 2147)
  AUTHORS   Yoshida,H., Kakuchi,J., Guo,D.F., Furuta,H., Iwai,N., van der
            Meer-de Jong,R., Inagami,T. and Ichikawa,I.
  TITLE     Analysis of the evolution of angiotensin II type 1 receptor gene in
            mammals (mouse, rat, bovine and human)
  JOURNAL   Biochem Biophys Res Commun 186 (2), 1042-1049 (1992)
   PUBMED   1497638
REFERENCE   10 (bases 1 to 2147)
  AUTHORS   Sasamura,H., Hein,L., Krieger,J.E., Pratt,R.E., Kobilka,B.K. and
            Dzau,V.J.
  TITLE     Cloning, characterization, and expression of two angiotensin
            receptor (AT-1) isoforms from the mouse genome
  JOURNAL   Biochem Biophys Res Commun 185 (1), 253-259 (1992)
   PUBMED   1599461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087228.1 and BC109153.1.
            
            On Sep 6, 2007 this sequence version replaced NM_175086.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087228.1, BC109152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AK087228.1         1-279
            280-280             BC109153.1         227-227
            281-1612            AK087228.1         281-1612
            1613-1613           BC109153.1         1542-1542
            1614-2012           AK087228.1         1614-2012
            2013-2147           AK087228.1         2014-2148
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.37 cM"
     gene            1..2147
                     /gene="Agtr1b"
                     /gene_synonym="Agtr-1b; Angtr-1b; AT1B; AT2R1B"
                     /note="angiotensin II receptor, type 1b"
                     /db_xref="GeneID:11608"
                     /db_xref="MGI:MGI:87965"
     exon            1..144
                     /gene="Agtr1b"
                     /gene_synonym="Agtr-1b; Angtr-1b; AT1B; AT2R1B"
                     /inference="alignment:Splign:2.1.0"
     exon            145..2147
                     /gene="Agtr1b"
                     /gene_synonym="Agtr-1b; Angtr-1b; AT1B; AT2R1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1259
                     /gene="Agtr1b"
                     /gene_synonym="Agtr-1b; Angtr-1b; AT1B; AT2R1B"
                     /note="type-1B angiotensin II receptor; AT1 receptor B;
                     AT3; angiotensin II type-1B receptor; angiotensin II
                     type-1 receptor B"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor B"
                     /protein_id="NP_780295.2"
                     /db_xref="CCDS:CCDS17264.1"
                     /db_xref="GeneID:11608"
                     /db_xref="MGI:MGI:87965"
                     /translation="MILNSSIEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIF
                     GNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYQWPFGNHLCK
                     IASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLAS
                     LPAVIHRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFVIILTSYTLI
                     WKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFSFLDVLIQLGVIHDCEI
                     ADVVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKARSHAGLSTKM
                     STLSYRPSDNMSSSARKSAYCFEVE"
ORIGIN      
        1 agctgcaggc agcctggatc ccaggcagca gggagtaaca gagaccagac aagacacgca
       61 cagcctctcc agcgccagca gcactgtaga tggggagcag ccaagaggcg tgaaagaagc
      121 ccggagctgg ggcaccgtgc acgggtgcat tttgaattca ccccctccaa caaagagaca
      181 tgatccttaa ctcttctatt gaagatggaa ttaaaagaat ccaagatgac tgccccaagg
      241 ctggcaggca caattacata tttgtcatga tccctactct ctacagcatc atctttgtgg
      301 tgggaatatt tggaaacagt ttggtggtaa ttgtcattta cttttacatg aagctaaaga
      361 ctgtggccag tgttttcctt ctgaatcttg ccctggctga tttatgcttt ttgttgactt
      421 tgcctctgtg ggcagtttat accgctatgg aataccagtg gcccttcggc aatcacctat
      481 gtaagatcgc ttcggccagc gtcagtttca acctctacgc cagtgtgttc ctgctcacgt
      541 gtctcagcat cgatcgctac ctagccattg tccacccaat gaagtctcgc ctccgacgca
      601 caatgctggt cgccaaagtc acctgcatca tcatctggct gatggctggc ttggctagtt
      661 tgccggccgt catccaccga aatgtgtatt tcatcgagaa caccaatatc acagtttgtg
      721 cttttcatta tgaatctcag aactcaacac tccccattgg actgggtctg accaagaaca
      781 ttctgggctt cgtgttccct ttcgttatta ttctcaccag ctatactctg atttggaaag
      841 ccctaaagaa ggcttacaaa attcagaaga atacgccaag gaatgatgac atctttagga
      901 taatcatggc gattgtgctt ttcttcttct tttcctgggt tccccaccaa atattcagtt
      961 ttctggatgt gctcattcag ctgggcgtca tccatgactg tgaaattgcg gacgtagtgg
     1021 acactgctat gcccatcacc atctgcatag cttattttaa caattgcctg aaccctctgt
     1081 tttatggctt tctggggaaa aaatttaaaa gatatttcct ccagcttctg aaatatattc
     1141 ccccaaaggc caggtcgcat gcagggttat caacaaaaat gagtactctt tcctaccgcc
     1201 cttcagataa catgagctcg tctgccagga agtctgcgta ttgttttgaa gtggagtgag
     1261 agggttcaaa gcctgctagt gacatgatcc cctgacagta gaagccagag cagcatttag
     1321 ctagacagtt cactcactat taaaggaatg gtcaacttcc agccttttca ggcttgaagc
     1381 agagaaagga ctctggactg tacatggttt ataaagtgct aaacaaaact attttcccca
     1441 gagcaaagct actgttcacc acctttttgt tgttgttgtt gttgttgttg ttgttttgtt
     1501 gttttgttgt tgactgaata actgatttaa gaacagtgtc acaaactgag tgactattga
     1561 tttgggggag ggggaaatgt actggcagaa ataccatgtc ttcaatgccc tctcaattct
     1621 tttattttga tttccacatg aacataatta gtcggtatta actctgttga caagcaaaaa
     1681 gaagatgaga agtcaagagt ttccaaggga caaggaagca acacatcagt ttatctacta
     1741 gtggctatga tacccttgtc cccaacacta cacattgtgt gttaagattt gctaggcaat
     1801 agtcatcaac tttcaaaact ttttgtgaag ttcagccagt gtcttaagaa ttcgaaacag
     1861 tgtaccacaa acaatgtgga cagaacagct tacctgtagc atgcattacc tcagtcataa
     1921 agtcaaactg ctgtgattct ctcccaggta actgtgtctt catagttgga ccagttttat
     1981 ttcatatcta agaaatgtag tctttgctaa gcagatttat cataaagtat gttttatggt
     2041 tctaaaaata tatgtattat atgtgtatat gtgtagctat atctctaagc taatgtttta
     2101 ttaaagtcta gcaaagttat atttatcttg aaataaaaat ttatcat
//
