LOCUS       NM_177322               2284 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus angiotensin II receptor, type 1a (Agtr1a), mRNA.
ACCESSION   NM_177322
VERSION     NM_177322.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2284)
  AUTHORS   Pan,Y., Wang,C., Zhou,W., Shi,Y., Meng,X., Muhammad,Y.,
            Hammer,R.D., Jia,B., Zheng,H., Li,D.P., Liu,Z., Hildebrandt,G. and
            Kang,X.
  TITLE     Inhibiting AGTR1 reduces AML burden and protects the heart from
            cardiotoxicity in mouse models
  JOURNAL   Sci Transl Med 16 (752), eadl5931 (2024)
   PUBMED   38896605
  REMARK    GeneRIF: Inhibiting AGTR1 reduces AML burden and protects the heart
            from cardiotoxicity in mouse models.
REFERENCE   2  (bases 1 to 2284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2284)
  AUTHORS   Baumer-Harrison,C., Elsaafien,K., Johnson,D.N., Penaloza
            Aponte,J.D., de Araujo,A., Patel,S., Bruce,E.B., Harden,S.W.,
            Frazier,C.J., Scott,K.A., de Lartigue,G., Krause,E.G. and de
            Kloet,A.D.
  TITLE     Alleviating Hypertension by Selectively Targeting Angiotensin
            Receptor-Expressing Vagal Sensory Neurons
  JOURNAL   J Neurosci 44 (9), e1154232023 (2024)
   PUBMED   38242697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2284)
  AUTHORS   Duan,X.P., Xiao,Y., Su,X.T., Zheng,J.Y., Gurley,S., Emathinger,J.,
            Yang,C.L., McCormick,J., Ellison,D.H., Lin,D.H. and Wang,W.H.
  TITLE     Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in
            Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2),
            Kir4.1, and Epithelial Na+ Channel (ENaC)
  JOURNAL   Hypertension 81 (1), 126-137 (2024)
   PUBMED   37909221
  REMARK    GeneRIF: Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal
            Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2
            (Kir4.2), Kir4.1, and Epithelial Na[+] Channel (ENaC).
REFERENCE   5  (bases 1 to 2284)
  AUTHORS   Vermeiren,S., Cabochette,P., Dannawi,M., Desiderio,S., San
            Jose,A.S., Achouri,Y., Kricha,S., Sitte,M., Salinas-Riester,G.,
            Vanhollebeke,B., Brunet,J.F. and Bellefroid,E.J.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2284)
  AUTHORS   Sugaya,T., Nishimatsu,S., Tanimoto,K., Takimoto,E., Yamagishi,T.,
            Imamura,K., Goto,S., Imaizumi,K., Hisada,Y., Otsuka,A. et al.
  TITLE     Angiotensin II type 1a receptor-deficient mice with hypotension and
            hyperreninemia
  JOURNAL   J Biol Chem 270 (32), 18719-18722 (1995)
   PUBMED   7642517
REFERENCE   7  (bases 1 to 2284)
  AUTHORS   Ito,M., Oliverio,M.I., Mannon,P.J., Best,C.F., Maeda,N.,
            Smithies,O. and Coffman,T.M.
  TITLE     Regulation of blood pressure by the type 1A angiotensin II receptor
            gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3521-3525 (1995)
   PUBMED   7724593
REFERENCE   8  (bases 1 to 2284)
  AUTHORS   Kakuchi,J., Ichiki,T., Kiyama,S., Hogan,B.L., Fogo,A., Inagami,T.
            and Ichikawa,I.
  TITLE     Developmental expression of renal angiotensin II receptor genes in
            the mouse
  JOURNAL   Kidney Int 47 (1), 140-147 (1995)
   PUBMED   7731139
REFERENCE   9  (bases 1 to 2284)
  AUTHORS   Yoshida,H., Kakuchi,J., Guo,D.F., Furuta,H., Iwai,N., van der
            Meer-de Jong,R., Inagami,T. and Ichikawa,I.
  TITLE     Analysis of the evolution of angiotensin II type 1 receptor gene in
            mammals (mouse, rat, bovine and human)
  JOURNAL   Biochem Biophys Res Commun 186 (2), 1042-1049 (1992)
   PUBMED   1497638
REFERENCE   10 (bases 1 to 2284)
  AUTHORS   Sasamura,H., Hein,L., Krieger,J.E., Pratt,R.E., Kobilka,B.K. and
            Dzau,V.J.
  TITLE     Cloning, characterization, and expression of two angiotensin
            receptor (AT-1) isoforms from the mouse genome
  JOURNAL   Biochem Biophys Res Commun 185 (1), 253-259 (1992)
   PUBMED   1599461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066917.1 and AL607131.15.
            
            On Oct 31, 2007 this sequence version replaced NM_177322.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036175.1, BG969022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               CJ066917.1         3-429
            428-2284            AL607131.15        128456-130312
FEATURES             Location/Qualifiers
     source          1..2284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.19 cM"
     gene            1..2284
                     /gene="Agtr1a"
                     /gene_synonym="1810074K20Rik; AG2S; Agt1ar; Agtr-1a;
                     Agtr1; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A"
                     /note="angiotensin II receptor, type 1a"
                     /db_xref="GeneID:11607"
                     /db_xref="MGI:MGI:87964"
     exon            1..234
                     /gene="Agtr1a"
                     /gene_synonym="1810074K20Rik; AG2S; Agt1ar; Agtr-1a;
                     Agtr1; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A"
                     /inference="alignment:Splign:2.1.0"
     exon            235..318
                     /gene="Agtr1a"
                     /gene_synonym="1810074K20Rik; AG2S; Agt1ar; Agtr-1a;
                     Agtr1; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A"
                     /inference="alignment:Splign:2.1.0"
     exon            319..2284
                     /gene="Agtr1a"
                     /gene_synonym="1810074K20Rik; AG2S; Agt1ar; Agtr-1a;
                     Agtr1; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1450
                     /gene="Agtr1a"
                     /gene_synonym="1810074K20Rik; AG2S; Agt1ar; Agtr-1a;
                     Agtr1; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A"
                     /note="angiotensin receptor 1; type-1A angiotensin II
                     receptor; angiotensin II type-1A receptor; angiotensin
                     receptor 1a; AT1 receptor A; angiotensin II type-1
                     receptor A"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor A"
                     /protein_id="NP_796296.1"
                     /db_xref="CCDS:CCDS26415.1"
                     /db_xref="GeneID:11607"
                     /db_xref="MGI:MGI:87964"
                     /translation="MALNSSTEDGIKRIQDDCPRAGRHSYIFVMIPTLYSIIFVVGIF
                     GNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCK
                     IASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLAS
                     LPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLI
                     WKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKI
                     ADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKM
                     STLSYRPSDNMSSAAKKPASCSEVE"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agtr1a"
                     /gene_synonym="1810074K20Rik; AG2S; Agt1ar; Agtr-1a;
                     Agtr1; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A"
                     /note="hexamer: AATAAA"
     polyA_site      2284
                     /gene="Agtr1a"
                     /gene_synonym="1810074K20Rik; AG2S; Agt1ar; Agtr-1a;
                     Agtr1; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A"
                     /note="major polyA site"
ORIGIN      
        1 gaggagtgca aagccttagg gttggaacct gcggagtagc aacgtccccc taggctataa
       61 atatggaagt gcctcgctgc tgatcgccag gcagttggga gggactggat gatgctgtct
      121 ggccggagag gactcgaggc ttgagtcctg gtccacgggt cgctggggtg ggtcgctggg
      181 gtggctgaag ccagtaccag ctctgcggct ctcccagctc tgctgctctc ccggacttaa
      241 catatgaaag attggtataa aatggctggc attttgtctg gataactcac agcaaccctc
      301 caagaaagcc atcaccagat caagtgcatt ttgaacagtg tctgagacca actcaaccca
      361 gaaaagcaaa atggccctta actcttctac tgaagatggc atcaaaagaa ttcaagatga
      421 ctgccccagg gctggcaggc acagttacat atttgtcatg atccctactc tctacagcat
      481 catctttgtg gtgggaatat ttggaaacag cttggtggtg atcgtcatct acttttacat
      541 gaagctgaag actgtggcca gtgtctttct tctaaatctc gccctggctg acttatgctt
      601 tttgctgact ttgcccctgt gggctgtcta taccgctatg gaataccgct ggcccttcgg
      661 caatcaccta tgtaagatcg cttcggccag cgtcagtttc aacctctacg ccagcgtgtt
      721 cctgctcacg tgtctcagca tcgatcgcta cctggccatt gtccacccga tgaagtctcg
      781 cctccgccgc acgatgctgg tggccaaagt cacctgcatc atcatctggc tgatggctgg
      841 cttggccagt ttgccagccg tcatccaccg aaatgtgtat ttcattgaga acaccaatat
      901 cactgtttgc gcttttcatt acgagtcccg gaattcaacg ctccccatag gactgggcct
      961 aaccaagaac atcctgggct tcctgttccc tttcctaatc attcttacca gctatactct
     1021 tatatggaaa gctctaaaga aggcttatga aattcagaag aacaagccaa gaaatgatga
     1081 catctttagg ataattatgg cgattgtgct tttcttcttc ttctcctggg tcccccacca
     1141 aatattcaca ttcctggatg tgctgattca gctgggcgtc atccatgact gtaaaattgc
     1201 cgacatcgtg gacactgcca tgcccataac catctgcata gcgtatttta acaactgcct
     1261 gaaccctctg ttttacggct ttctggggaa aaaatttaaa aagtatttcc tccagctcct
     1321 gaaatatatt cccccaaagg ccaagtcgca ctcaagcctg tctacgaaaa tgagcacgct
     1381 ctcctaccgc ccctcagata acatgagctc agccgccaaa aagcctgcgt cttgttctga
     1441 ggtggagtga caggttcaaa gcttgctggc aatgtaatgc cctgacagaa accagggcag
     1501 catcggacta aatggctcac gaccaaagga ccagtccccc cccccccctc aggatctaag
     1561 cagaaaatgc gttcaacaga ctgtagatat tgtctgaagc tctgagagaa agctttgaag
     1621 aagtaattat gcaaagctgt cttacattaa tagatgatgg ctgccccaag gacaagtcag
     1681 gagctggatg gatttgtggg tttaaaacgg tttgctggca gacacgcaat cgcagcggtc
     1741 tccttttgat ttccacacat aggtatgtag catgtgctaa atatttagac aagaaacaag
     1801 aaatggaagt cgaggttact tgttctgctc agttccccaa gggcaaggaa ccttgtttgt
     1861 ccctttagtc attagcaatg gagacccacg tgtccctgtt actacacata ctttgaaaag
     1921 atctgctaac ctggagtcat caagtttcag gagccctttg taaaattcag ccagtgtctt
     1981 agaaacctgt actgtcccca aacaatgcca gttagtggtg tatttatgta gcagtgtaag
     2041 caaagttaca catcaaagtt gcactgcttg taccaaccgt gacatagtag gtatatcagc
     2101 tttagttcac atctgagaaa cataaacagt cggtggtgaa tagactacat atcatacaat
     2161 ctgccttgtt ctctaaaagt atatatcctc cacatatatg tacatatgta tctctaagct
     2221 gtcatttgat gaagttttgg caatgtatgt ttacctctaa ataaagtaat tttattgtaa
     2281 cgta
//
