LOCUS       NM_001377097            4498 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus ATP/GTP binding protein 1 (Agtpbp1), transcript
            variant 6, mRNA.
ACCESSION   NM_001377097 XM_006517335
VERSION     NM_001377097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4498)
  AUTHORS   Lin,Y.H., Wang,Y.Y., Lai,T.H., Teng,J.L., Lin,C.W., Ke,C.C.,
            Yu,I.S., Lee,H.L., Chan,C.C., Tung,C.H., Conrad,D.F., O'Bryan,M.K.
            and Lin,Y.H.
  TITLE     Deleterious genetic changes in AGTPBP1 result in teratozoospermia
            with sperm head and flagella defects
  JOURNAL   J Cell Mol Med 28 (2), e18031 (2024)
   PUBMED   37937809
  REMARK    GeneRIF: Deleterious genetic changes in AGTPBP1 result in
            teratozoospermia with sperm head and flagella defects.
REFERENCE   2  (bases 1 to 4498)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   3  (bases 1 to 4498)
  AUTHORS   Pang,B., Araki,A., Zhou,L., Takebayashi,H., Harada,T. and Kadota,K.
  TITLE     CCP1, a Regulator of Tubulin Post-Translational Modifications,
            Potentially Plays an Essential Role in Cerebellar Development
  JOURNAL   Int J Mol Sci 24 (6), 5335 (2023)
   PUBMED   36982413
  REMARK    GeneRIF: CCP1, a Regulator of Tubulin Post-Translational
            Modifications, Potentially Plays an Essential Role in Cerebellar
            Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4498)
  AUTHORS   Lewis,T.R., Phan,S., Kim,K.Y., Jha,I., Castillo,C.M., Ding,J.D.,
            Sajdak,B.S., Merriman,D.K., Ellisman,M.H. and Arshavsky,V.Y.
  TITLE     Microvesicle release from inner segments of healthy photoreceptors
            is a conserved phenomenon in mammalian species
  JOURNAL   Dis Model Mech 15 (12) (2022)
   PUBMED   36420970
REFERENCE   5  (bases 1 to 4498)
  AUTHORS   Zhou,L., Konno,K., Yamazaki,M., Abe,M., Natsume,R., Watanabe,M.,
            Takebayashi,H. and Sakimura,K.
  TITLE     Nna1, Essential for Purkinje Cell Survival, Is also Associated with
            Emotion and Memory
  JOURNAL   Int J Mol Sci 23 (21), 12961 (2022)
   PUBMED   36361749
  REMARK    GeneRIF: Nna1, Essential for Purkinje Cell Survival, Is also
            Associated with Emotion and Memory.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4498)
  AUTHORS   Takeda,H., Yoshiki,A., Nishikawa,S., Nishikawa,S., Kunisada,T.,
            Sakakura,T., Amanuma,H. and Kusakabe,M.
  TITLE     Expression of c-kit, a proto-oncogene of the murine W locus, in
            cerebella of normal and neurological mutant mice:
            immunohistochemical and in situ hybridization analysis
  JOURNAL   Differentiation 51 (2), 121-127 (1992)
   PUBMED   1282111
REFERENCE   7  (bases 1 to 4498)
  AUTHORS   Landis,S.C. and Mullen,R.J.
  TITLE     The development and degeneration of Purkinje cells in pcd mutant
            mice
  JOURNAL   J Comp Neurol 177 (1), 125-143 (1978)
   PUBMED   200636
REFERENCE   8  (bases 1 to 4498)
  AUTHORS   Mullen,R.J.
  TITLE     Site of pcd gene action and Purkinje cell mosaicism in cerebella of
            chimaeric mice
  JOURNAL   Nature 270 (5634), 245-247 (1977)
   PUBMED   593342
REFERENCE   9  (bases 1 to 4498)
  AUTHORS   Mullen,R.J., Eicher,E.M. and Sidman,R.L.
  TITLE     Purkinje cell degeneration, a new neurological mutation in the
            mouse
  JOURNAL   Proc Natl Acad Sci U S A 73 (1), 208-212 (1976)
   PUBMED   1061118
REFERENCE   10 (bases 1 to 4498)
  AUTHORS   Mullen,R.J. and LaVail,M.
  TITLE     Two types of retinal degeneration in cerebellar mutant mice
  JOURNAL   Nature 258 (5535), 528-530 (1975)
   PUBMED   1196386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135469.4.
            
            On Dec 13, 2019 this sequence version replaced XM_006517335.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.18409.1,
                                           SRR7974084.19309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC135469.4         124633-124837       c
            206-270             AC135469.4         111922-111986       c
            271-395             AC135469.4         103784-103908       c
            396-463             AC135469.4         100707-100774       c
            464-527             AC135469.4         99548-99611         c
            528-674             AC135469.4         98592-98738         c
            675-806             AC135469.4         95922-96053         c
            807-900             AC135469.4         92681-92774         c
            901-938             AC135469.4         85188-85225         c
            939-1147            AC135469.4         81622-81830         c
            1148-1325           AC135469.4         79859-80036         c
            1326-1423           AC135469.4         75494-75591         c
            1424-1540           AC135469.4         71729-71845         c
            1541-2229           AC135469.4         67549-68237         c
            2230-2313           AC135469.4         64511-64594         c
            2314-2400           AC135469.4         63098-63184         c
            2401-2549           AC135469.4         62868-63016         c
            2550-2637           AC135469.4         50052-50139         c
            2638-2782           AC135469.4         44529-44673         c
            2783-2936           AC135469.4         43195-43348         c
            2937-3117           AC135469.4         42067-42247         c
            3118-3247           AC135469.4         41223-41352         c
            3248-3379           AC135469.4         33520-33651         c
            3380-3556           AC135469.4         29532-29708         c
            3557-3717           AC135469.4         28004-28164         c
            3718-4498           AC135469.4         17069-17849         c
FEATURES             Location/Qualifiers
     source          1..4498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..4498
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /note="ATP/GTP binding protein 1"
                     /db_xref="GeneID:67269"
                     /db_xref="MGI:MGI:2159437"
     exon            1..205
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            206..270
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..3895
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /EC_number="3.4.17.24"
                     /note="isoform 1 is encoded by transcript variant 6;
                     nuclear ATP/GTP-binding protein; Purkinje cell
                     degeneration; cytosolic carboxypeptidase 1; protein
                     deglutamylase CCP1; nervous system nuclear protein induced
                     by axotomy protein 1"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 1 isoform 1"
                     /protein_id="NP_001364026.1"
                     /db_xref="GeneID:67269"
                     /db_xref="MGI:MGI:2159437"
                     /translation="MSKLKVVGEKSLTNSSRVVGLLAQLEKINTDSTESDTARYVTSK
                     ILHLAQSQEKTRREMTTKGSTGMEVLLSTLENTKDLQTVLNILSILIELVSSGGGRRA
                     SFLVAKGGSQILLQLLMNASKDSPPHEEVMVQTHSILAKIGPKDKKFGVKARVNGALT
                     VTLNLVKQHFQNYRLVLPCLQLLRVYSTNSVNSVSLGKNGVVELMFKIIGPFSKKNSG
                     LMKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSL
                     KSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLP
                     TIKSSFHFQLPIIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDLEVENELENEDDLDQ
                     SFKNDDIETDINKLRPQQVPGRTIEELKMYEHLFPELVDDFQDYELISKEPKPFVFEG
                     KARGPIVVPTAGEEVPGNSGSVKKGVVMKERASPKGEEAKEDPKGHDRTLPQQLGGQS
                     RVAPSAHSFNNDLVKALDRITLQNVPSQVASGLNAGMRKDFGLPLTVLSCTKACPHVA
                     KCGSTLFEGRTVHLGKLCCTGVETEDDEDTESHSSTEQAPSVEASDGPTLHDPDLYIE
                     IVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQNDIID
                     RVVYDLDNPTYTTPEEGDTLKFNSKFESGNLRKVIQIRKSEYDLILNSDINSNHYHQW
                     FYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICY
                     YKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLES
                     AHNPQQIYFRKDVLCETLSGNICPLVTITAMPESNYYEHICQFRTRPYIFLSARVHPG
                     ETNASWVMKGTLEYLMSNSPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNR
                     QWQSPNPELHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWH
                     THDNSASCDIVEDMGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQ
                     RSYTMESTLCGCDQGRYKGLQIGTRELEEMGAKFCVGLLRLKRLTSSLEYNLPSNLLD
                     FENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDVELAENTGDYEPSAQE
                     EALSDSEVSRTHLI"
     exon            271..395
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            396..463
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            464..527
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            528..674
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            675..806
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            807..900
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            901..938
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1147
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1325
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1423
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1540
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..2229
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2313
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2400
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2549
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2637
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2782
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2936
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3117
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3247
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3379
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3556
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3717
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..4498
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4474..4479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /note="hexamer: AATAAA"
     polyA_site      4498
                     /gene="Agtpbp1"
                     /gene_synonym="1700020N17Rik; 2310001G17Rik;
                     2900054O13Rik; 4930445M19Rik; 5730402G09Rik; atms; CCP1;
                     nmf243; Nna1; pcd"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgccgc gctgacgttg cccgggatgc gggcatgttc cgcggccgtc ttcgccgcct
       61 ccgcctctcc tgccacccgg gtttgtatga aaacggcggg ccgcgggcgg cggacggcgg
      121 gagaagggcg gcgggcggcg aggaaccgcc gtgcgccccg ggagtcccgg gcgcggaggc
      181 cgagcgcagc gcccaagccg agccgattat ctgcaatgct ggaatgaagt aactcaagat
      241 gagcaagcta aaagtggtgg gagagaaaag ccttaccaat agttctcggg ttgtgggact
      301 cctggctcag ctggagaaga tcaatacgga ttccacagag tcagatactg ccagatatgt
      361 tacatccaaa attcttcatt tggctcaaag tcaagaaaaa acaagaaggg aaatgacaac
      421 caaaggttct acaggcatgg aagttctgtt gtcaacattg gagaacacga aagatcttca
      481 gactgtactt aatatcctaa gcattctcat tgagctggtg tcatcgggtg ggggtcgaag
      541 agcgagtttc ttagttgcca aaggtggttc acaaatactg ttgcaactgc ttatgaatgc
      601 cagcaaagac tctcctccac atgaggaggt gatggtgcag actcactcca ttcttgccaa
      661 gattgggcca aaagataaga aatttggagt gaaagctcga gttaacgggg cactgactgt
      721 gactctgaac ttggtaaagc agcactttca gaactaccgc ttggttcttc cttgtcttca
      781 gctcttgcga gtctattcta ccaactctgt gaactcagta tctttaggta aaaatggagt
      841 tgtggagttg atgtttaaaa tcattgggcc attcagtaag aagaattcgg gtctcatgaa
      901 ggttgcttta gacactcttg ctgcattgct aaaatcaaag acaaacgcca ggagagcggt
      961 ggacagaggg tacgttcaag tgcttctaac catctatgta gattggcacc ggcatgataa
     1021 tcggcataga aacatgctca ttcggaaggg gattctacag agcttaaaaa gtgtcacgaa
     1081 catcaagttg ggcagaaaag catttattga tgcgaatggg atgaaaattc tgtataacac
     1141 ttctcaagag tgcttggcgg tcaggactct tgatcctctt gtcaacacat ccagtctgat
     1201 aatgagaaaa tgcttcccca aaaaccgcct tccgctcccc accattaaaa gttctttcca
     1261 cttccaattg ccaattatcc ctgtgactgg acctgtggcc cagctctaca gcttgccgcc
     1321 tgaagtggac gatgtggtgg acgagagtga cgacaacgac gacattgatt tagaagtgga
     1381 aaatgaactc gagaatgaag atgacctaga tcagagtttt aagaatgatg atattgaaac
     1441 agatattaat aaattaagac ctcagcaagt accaggacga acaatagaag aactaaaaat
     1501 gtacgagcac cttttccccg agcttgttga tgattttcag gactatgaac tgatctctaa
     1561 ggaacccaaa ccttttgtgt ttgaggggaa ggctcggggc cccattgtag ttcccacagc
     1621 tggagaggag gtacctggga attcagggag cgtaaagaaa ggagtggtaa tgaaggagag
     1681 agcaagtcct aaaggagagg aagccaagga agaccctaag ggccacgaca ggacactgcc
     1741 gcagcagctg ggtggccaga gcagagtggc cccctcagcc cacagcttca acaatgatct
     1801 tgtgaaggcc ctagaccgaa tcacactgca gaatgttcct tcgcaagtag cctcgggctt
     1861 gaacgcagga atgaggaagg actttggtct ccctctcact gtcctctcat gcacgaaagc
     1921 ttgtcctcac gtggctaagt gtggaagtac tctctttgaa gggcggacgg tacatcttgg
     1981 gaagctgtgt tgtactggag ttgaaacgga agatgacgaa gacactgagt cccactcatc
     2041 aacagagcag gccccctctg ttgaagcctc tgatggacca acactgcacg acccagacct
     2101 ctatattgag attgtgaaaa atacgaagtc cgttccagaa tactcagagg tggcttatcc
     2161 tgattatttt ggtcacattc cacctccctt caaagagcct attttagaaa ggccttatgg
     2221 tgtacaaagg acaaaaattg cccaagacat cgagaggctg atacaccaga acgatatcat
     2281 agaccgcgtg gtgtatgact tagacaaccc tacctatacc actccagaag aaggagatac
     2341 tttgaagttt aactcaaaat tcgaatctgg gaatctgcgc aaagtaattc aaattagaaa
     2401 aagcgagtac gaccttatcc tgaactctga tataaacagt aaccattacc accagtggtt
     2461 ctactttgaa gtcagtggga tgcggcctgg tgtggcatat aggttcaaca tcatcaactg
     2521 tgagaagtcc aacagtcagt ttaattatgg tatgcagcca cttatgtatt cagttcagga
     2581 agcactaaat gccagaccat ggtggatccg tatgggcact gacatttgtt actacaaaaa
     2641 tcacttctca cgaagctcag ttgccgcagg cggacagaag ggcaagtcct actacaccat
     2701 caccttcacc gtgaacttcc cgcacaagga cgatgtctgc tatttcgcct atcactatcc
     2761 atacacgtac tcgactctgc agatgcatct tcaaaaattg gaatcggcac acaatcctca
     2821 acaaatctat tttcgaaaag acgtgttgtg tgaaaccttg tctggaaaca tctgtccttt
     2881 ggtgaccata acagcaatgc cagagtccaa ttactatgaa catatctgtc agttcagaac
     2941 tcgcccttat attttcttgt ctgctcgggt ccatcctgga gaaaccaatg caagctgggt
     3001 aatgaaagga acactggagt acctcatgag caatagcccg actgcccaga gcctacggga
     3061 gtcttacatt tttaaaattg tccccatgct aaatccagat ggtgtcatca atggaaatca
     3121 ccgctgctcc ttaagtggag aggatttgaa cagacagtgg caaagtccaa acccagagtt
     3181 acaccccacg atttatcatg ccaaggggct gctgcagtac ctggccgcgg tgaagcgcct
     3241 acctctggtt tattgtgatt accatggcca ttctcgaaaa aagaatgtat tcatgtacgg
     3301 ctgcagcatc aaagagacgg tgtggcacac ccatgacaac tcggcttcct gtgatattgt
     3361 ggaagacatg ggatacagga ctttgcctaa gatactgagc cacattgctc cggcattttg
     3421 catgagcagt tgtagctttg tggtggaaaa atctaaagaa tccacagctc gggttgtcgt
     3481 gtggcgggaa attggagttc agaggagcta caccatggag agtactttat gtggctgcga
     3541 tcagggtaga tacaagggtt tacagattgg gactcgagaa ttggaagaga tgggagcaaa
     3601 attttgtgtt ggtttattgc gtttgaaacg actgacttct tcattggaat ataatctgcc
     3661 ctccaacctg cttgactttg aaaatgactt aattgaatca agctgtaaag tgactagccc
     3721 caccacttac gttttggatg aagatgaacc tcggttcctt gaagaagttg attacagtgc
     3781 agaaagcaat gatgagttag atgttgaatt agcggagaac acaggtgatt atgagccttc
     3841 tgcccaagaa gaagcccttt ctgactctga ggtatcaaga acacacctga tttgaaattt
     3901 ctgccatctt tgttaattgc caagaagaaa tgaaatgtct tggttttcat tatgtaggaa
     3961 gtttgagagg gacaagcatt tagacagctg actcaaagaa gacaaaaagg aacttgggcc
     4021 tatttggttt caagacaata aatatattat taattaatga tataattggc atttgtttta
     4081 ttttagatat tcaatgttct ttatatagca ttgaattatc aaatgataga tttactttaa
     4141 aaaaaaaaaa aagaacccaa gaatcattgc atgaattttt atctcctgtg gcactgcatc
     4201 aagtagataa attcagtgtg tccgaataca aaatctaaat tatagagtgt tgaaaatcac
     4261 tatatctgta catggatttc tgcagatgtg tctgtgtgga ggtgggtagt tactgaagat
     4321 aactgtacat ggatttctgc agatgtgtct gtgtggaggt gggtagttac tgaagataac
     4381 tgaccgccca tcagaagcat gtgaactgtg tattgtggct aacctaatct agaatctgcc
     4441 tcgaatccat cccattctac atttatcaag ttaaataaaa actatatcag agtctgca
//
