LOCUS       NM_007428               1838 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus angiotensinogen (Agt), transcript variant 2, mRNA.
ACCESSION   NM_007428
VERSION     NM_007428.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Jang,H.S., Noh,M.R., Ha,L., Kim,J. and Padanilam,B.J.
  TITLE     Effect of Tissue-derived Angiotensinogen on Kidney Injury and
            Fibrosis in Obstructive Nephropathy
  JOURNAL   In Vivo 38 (5), 2107-2114 (2024)
   PUBMED   39187331
  REMARK    GeneRIF: Effect of Tissue-derived Angiotensinogen on Kidney Injury
            and Fibrosis in Obstructive Nephropathy.
REFERENCE   2  (bases 1 to 1838)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1838)
  AUTHORS   Cao,M., Zhao,Q., Xia,H., Lyu,S., Luo,J., Fu,K., Chen,R. and Yuan,W.
  TITLE     Intracellular and extracellular Cyclophilin a promote cardiac
            fibrosis through TGF-beta signaling in response to angiotensin
  JOURNAL   Biochem Pharmacol 225, 116271 (2024)
   PUBMED   38723722
  REMARK    GeneRIF: Intracellular and extracellular Cyclophilin a promote
            cardiac fibrosis through TGF-beta signaling in response to
            angiotensin .
REFERENCE   4  (bases 1 to 1838)
  AUTHORS   Dutka,M., Garczorz,W., Kosowska,A., Buczek,E., Godek,P.,
            Wojakowski,W. and Francuz,T.
  TITLE     Osteoprotegerin Is Essential for the Development of Endothelial
            Dysfunction Induced by Angiotensin II in Mice
  JOURNAL   Int J Mol Sci 25 (12), 6434 (2024)
   PUBMED   38928140
  REMARK    GeneRIF: Osteoprotegerin Is Essential for the Development of
            Endothelial Dysfunction Induced by Angiotensin II in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1838)
  AUTHORS   Zhong,X., Wang,K., Wang,Y., Wang,L., Wang,S., Huang,W., Jia,Z.,
            Dai,S.S. and Huang,Z.
  TITLE     Angiotension II directly bind P2X7 receptor to induce myocardial
            ferroptosis and remodeling by activating human antigen R
  JOURNAL   Redox Biol 72, 103154 (2024)
   PUBMED   38626575
  REMARK    GeneRIF: Angiotension II directly bind P2X7 receptor to induce
            myocardial ferroptosis and remodeling by activating human antigen
            R.
REFERENCE   6  (bases 1 to 1838)
  AUTHORS   Jeunemaitre,X., Soubrier,F., Kotelevtsev,Y.V., Lifton,R.P.,
            Williams,C.S., Charru,A., Hunt,S.C., Hopkins,P.N., Williams,R.R.,
            Lalouel,J.M. et al.
  TITLE     Molecular basis of human hypertension: role of angiotensinogen
  JOURNAL   Cell 71 (1), 169-180 (1992)
   PUBMED   1394429
REFERENCE   7  (bases 1 to 1838)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 1838)
  AUTHORS   Clouston,W.M.
  TITLE     The angiotensinogen gene of Swiss mice is closely linked to a
            retrovirus-like element
  JOURNAL   DNA Cell Biol 9 (9), 623-630 (1990)
   PUBMED   2175614
REFERENCE   9  (bases 1 to 1838)
  AUTHORS   Clouston,W.M., Lyons,I.G. and Richards,R.I.
  TITLE     Tissue-specific and hormonal regulation of angiotensinogen
            minigenes in transgenic mice
  JOURNAL   EMBO J 8 (11), 3337-3343 (1989)
   PUBMED   2573515
REFERENCE   10 (bases 1 to 1838)
  AUTHORS   Clouston,W.M. and Richards,R.I.
  TITLE     An allelic polymorphism of the angiotensinogen gene in mice
  JOURNAL   Nucleic Acids Res 17 (2), 822 (1989)
   PUBMED   2563581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139179.1 and BM899343.1.
            
            On Feb 22, 2019 this sequence version replaced NM_007428.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139179.1, SRR7345562.1487413.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1778              AK139179.1         1-1778
            1779-1838           BM899343.1         18-77               c
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.81 cM"
     gene            1..1838
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /note="angiotensinogen"
                     /db_xref="GeneID:11606"
                     /db_xref="MGI:MGI:87963"
     exon            1..31
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /inference="alignment:Splign:2.1.0"
     exon            32..890
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1495
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /note="angiotensin I; angiotensin ll; serpin A8;
                     angiotensinogen (serpin peptidase inhibitor, clade A,
                     member 8)"
                     /codon_start=1
                     /product="angiotensinogen precursor"
                     /protein_id="NP_031454.4"
                     /db_xref="CCDS:CCDS40513.2"
                     /db_xref="GeneID:11606"
                     /db_xref="MGI:MGI:87963"
                     /translation="MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYHNKSTCAQ
                     LENPSVETLPESTFEPVPIQAKTSPVNEKTLHDQLVLAAEKLEDEDRKRAAQVAMIAN
                     FVGFRMYKMLNEAGSGASGAILSPPALFGTLVSFYLGSLDPTASQLQTLLDVPVKEGD
                     CTSRLDGHKVLAALRAIQGLLVTQGGSSSQTPLLQSIVVGLFTAPGFRLKHSFVQSLA
                     LFTPALFPRSLDLSTDPVLATEKINRFIKAVTGWKMNLPLEGVSTDSTLLFNTYVHFQ
                     GTMRGFSQLPGVHEFWVDNSISVSVPMISGTGNFQHWSDTQNNFSVTCVPLGERATLL
                     LIQPHCTSDLDRVEALIFRNDLLTWIENPPPRAIRLTLPQLEIRGSYNLQDLLAEDKL
                     PTLLGAEANLNNIGDTNPRVGEVLNSILLELKAGEEEQPTTSVQQPGSPEALDVTLSS
                     PFLFAIYEQDSGTLHFLGRVNNPQSVV"
     exon            891..1158
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1303
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1838
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /note="hexamer: AATAAA"
     polyA_site      1652
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /note="major polyA site"
     regulatory      1815..1820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
                     /note="hexamer: ATTAAA"
     polyA_site      1838
                     /gene="Agt"
                     /gene_synonym="AngI; AngII; Aogen; Serpina8"
ORIGIN      
        1 atagctgtgc ttgtctaggt tggcgctgaa ggatacacag aagcaaatgc acagatcgga
       61 gatgactccc acgggggcag gcctgaaggc caccatcttc tgcatcttga cctgggtcag
      121 cctgacggct ggggaccgcg tatacatcca ccccttccat ctcctttacc acaacaagag
      181 cacctgcgcc cagctggaga accccagtgt ggagacactc ccagagtcaa cgttcgagcc
      241 tgtgcccatt caggccaaga cctcccctgt gaatgagaag accctgcatg atcagctcgt
      301 gctggccgcc gagaagctag aggatgagga ccggaagcgg gctgcccagg tcgcaatgat
      361 cgccaacttc gtgggcttcc gcatgtacaa gatgctgaat gaggcaggaa gtggggccag
      421 tggggccatc ctctcaccac cagctctctt tggcaccctg gtctctttct accttggatc
      481 cttagatccc acggccagcc agctgcagac gctgctggat gtccctgtga aggagggaga
      541 ctgcacctcc cgactagatg gacacaaggt cctcgctgcc ctgcgggcca ttcagggctt
      601 gctggtcacc cagggtggga gcagcagcca gacacccctg ctacagtcca ttgtggtggg
      661 gctcttcact gctccaggct ttcgtctaaa gcactcattt gttcagagcc tggctctctt
      721 tacccctgcc ctcttcccac gctctctgga tttatccact gacccagttc ttgccactga
      781 gaaaatcaac aggttcataa aggctgtgac agggtggaag atgaacttgc cactggaggg
      841 ggtcagtaca gacagcaccc tacttttcaa cacctacgtt cacttccaag gaacgatgag
      901 aggtttctct cagctgcctg gagtccatga attctgggtg gacaacagca tctcggtgtc
      961 tgtgcccatg atctccggca ctggcaactt ccagcactgg agtgacaccc agaacaactt
     1021 ctccgtgacg tgcgtgcccc taggtgagag agccaccctg ctgctcatcc agccccactg
     1081 cacctcagat ctcgacaggg tggaggccct catcttccgg aacgacctcc tgacttggat
     1141 agagaacccg cctcctcggg ccatccgcct gactctgccc cagctggaaa tccgaggatc
     1201 ctacaatctg caggacctgc tggctgagga caagctgccc acccttttgg gtgcggaggc
     1261 aaatctgaac aacattggtg acaccaaccc ccgagtggga gaggttctca atagcatcct
     1321 cctcgaactc aaagcaggag aggaggaaca gccgaccacg tctgtccagc agcctggctc
     1381 accggaggca ctggatgtga ccctgagcag ccccttcctg ttcgccatct acgagcagga
     1441 ctcaggcacg ctgcactttc tgggcagagt gaataacccc cagagtgtgg tgtgaggcct
     1501 tgtgcctagc catggagaca aggccggtgt cggagaaccg ttctgggcaa aactcagtgc
     1561 tgtcacccct ggctccccat cacgccttgt agcgcggcag aggccgtctc cttggagact
     1621 gcgctgaccg agaataaatg atgagcagca gagcctcctg ggatgtgggt ttgtttggat
     1681 actggggtga cagccagaag ctggcactct gcacaggact gccactctgg aagaaatttg
     1741 gaccaaaaaa ctgtttgtga caccaaaaag caccccccct tttttttatt tgaggacaga
     1801 aattgggttt taacattaaa atgcacatta tcccctta
//
