LOCUS       NM_001271806             777 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus agouti related neuropeptide (Agrp), transcript variant
            2, mRNA.
ACCESSION   NM_001271806
VERSION     NM_001271806.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 777)
  AUTHORS   Aitken,T.J., Liu,Z., Ly,T., Shehata,S., Sivakumar,N., La Santa
            Medina,N., Gray,L.A., Zhang,J., Dundar,N., Barnes,C. and
            Knight,Z.A.
  TITLE     Negative feedback control of hypothalamic feeding circuits by the
            taste of food
  JOURNAL   Neuron 112 (19), 3354-3370 (2024)
   PUBMED   39153476
REFERENCE   2  (bases 1 to 777)
  AUTHORS   Yuan,M., Cao,Z., Li,Q., Liu,R., Wang,J., Xue,W. and Lyu,Q.
  TITLE     Fasting-induced miR-7a-5p in AgRP neurons regulates food intake
  JOURNAL   Metabolism 158, 155959 (2024)
   PUBMED   38942170
REFERENCE   3  (bases 1 to 777)
  AUTHORS   Kucukdereli,H., Amsalem,O., Pottala,T., Lim,M., Potgieter,L.,
            Hasbrouck,A., Lutas,A. and Andermann,M.L.
  TITLE     Repeated stress triggers seeking of a starvation-like state in
            anxiety-prone female mice
  JOURNAL   Neuron 112 (13), 2130-2141 (2024)
   PUBMED   38642553
REFERENCE   4  (bases 1 to 777)
  AUTHORS   Heyward,F.D., Liu,N., Jacobs,C., Machado,N.L.S., Ivison,R.,
            Uner,A., Srinivasan,H., Patel,S.J., Gulko,A., Sermersheim,T.,
            Tsai,L. and Rosen,E.D.
  TITLE     AgRP neuron cis-regulatory analysis across hunger states reveals
            that IRF3 mediates leptin's acute effects
  JOURNAL   Nat Commun 15 (1), 4646 (2024)
   PUBMED   38821928
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 777)
  AUTHORS   Ilnytska,O. and Argyropoulos,G.
  TITLE     The role of the Agouti-Related Protein in energy balance regulation
  JOURNAL   Cell Mol Life Sci 65 (17), 2721-2731 (2008)
   PUBMED   18470724
  REMARK    Review article
REFERENCE   6  (bases 1 to 777)
  AUTHORS   Mizuno,T.M. and Mobbs,C.V.
  TITLE     Hypothalamic agouti-related protein messenger ribonucleic acid is
            inhibited by leptin and stimulated by fasting
  JOURNAL   Endocrinology 140 (2), 814-817 (1999)
   PUBMED   9927310
REFERENCE   7  (bases 1 to 777)
  AUTHORS   Broberger,C., Johansen,J., Johansson,C., Schalling,M. and
            Hokfelt,T.
  TITLE     The neuropeptide Y/agouti gene-related protein (AGRP) brain
            circuitry in normal, anorectic, and monosodium glutamate-treated
            mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 15043-15048 (1998)
   PUBMED   9844012
REFERENCE   8  (bases 1 to 777)
  AUTHORS   Graham,M., Shutter,J.R., Sarmiento,U., Sarosi,I. and Stark,K.L.
  TITLE     Overexpression of Agrt leads to obesity in transgenic mice
  JOURNAL   Nat Genet 17 (3), 273-274 (1997)
   PUBMED   9354787
REFERENCE   9  (bases 1 to 777)
  AUTHORS   Ollmann,M.M., Wilson,B.D., Yang,Y.K., Kerns,J.A., Chen,Y., Gantz,I.
            and Barsh,G.S.
  TITLE     Antagonism of central melanocortin receptors in vitro and in vivo
            by agouti-related protein
  JOURNAL   Science 278 (5335), 135-138 (1997)
   PUBMED   9311920
  REMARK    Erratum:[Science 1998 Sep 11;281(5383):1615]
REFERENCE   10 (bases 1 to 777)
  AUTHORS   Shutter,J.R., Graham,M., Kinsey,A.C., Scully,S., Luthy,R. and
            Stark,K.L.
  TITLE     Hypothalamic expression of ART, a novel gene related to agouti, is
            up-regulated in obese and diabetic mutant mice
  JOURNAL   Genes Dev 11 (5), 593-602 (1997)
   PUBMED   9119224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151573.2, BC079902.1 and
            AK138796.1.
            
            Summary: This gene encodes a protein that regulates feeding
            behavior and plays a key role in the control of body weight. The
            encoded protein acts as an antagonist of melanocortin receptor
            signaling. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (2) contains an alternate 5' exon,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF900927.1, CF900964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC151573.2         196982-197177       c
            197-774             BC079902.1         84-661
            775-777             AK138796.1         737-739
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..777
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /note="agouti related neuropeptide"
                     /db_xref="GeneID:11604"
                     /db_xref="MGI:MGI:892013"
     exon            1..196
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /inference="alignment:Splign:2.1.0"
     exon            197..317
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /inference="alignment:Splign:2.1.0"
     exon            318..450
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..716
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /note="agouti-related protein; orexigenic neuropeptide"
                     /codon_start=1
                     /product="agouti-related protein precursor"
                     /protein_id="NP_001258735.1"
                     /db_xref="CCDS:CCDS22605.1"
                     /db_xref="GeneID:11604"
                     /db_xref="MGI:MGI:892013"
                     /translation="MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPG
                     LSLNGLKKTTADRAEEVLLQKAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCD
                     PCATCYCRFFNAFCYCRKLGTATNLCSRT"
     exon            451..533
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /inference="alignment:Splign:2.1.0"
     exon            534..777
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctttgttc cttcttgtct atagttattc ccctgtccta gaccttccag aactgatggg
       61 aaactctgac caaatccacc ccctccccaa gaatggactg agcataaaga tggcatgaga
      121 gatgccatct tccacctttg cagcattcca ggctatataa caaaatctgt gagctgggac
      181 tgcagacaac acaatgggag gcacctcatg ccctggctac aggaagcagt cacgtgtgga
      241 ccctttatta ggcactgcca tataagctca gggcacaaga gaccaggaca tccctaggca
      301 aagatcagca agcaaaggcc atgctgactg caatgttgct gagttgtgtt ctgctgttgg
      361 cactgcctcc cacactgggg gtccagatgg gcgtggctcc actgaagggc atcagaaggc
      421 ctgaccaggc tctgttccca gagttcccag gtctaagtct gaatggcctc aagaagacaa
      481 ctgcagaccg agcagaagaa gttctgctgc agaaggcaga agctttggcg gaggtgctag
      541 atccacagaa ccgcgagtct cgttctccgc gtcgctgtgt aaggctgcac gagtcctgct
      601 tgggacagca ggtaccttgc tgcgacccgt gcgctacgtg ctactgccgc ttcttcaatg
      661 ccttttgcta ctgccgcaag ctgggtacgg ccacgaacct ctgtagtcgc acctagccaa
      721 tggatgttgt ttgggcaaag gcaggggatg agaataaagg atgggacggt ttaacct
//
