LOCUS       NM_011783                760 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus anterior gradient 2 (Agr2), mRNA.
ACCESSION   NM_011783
VERSION     NM_011783.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 760)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 760)
  AUTHORS   Cloots,E., Guilbert,P., Provost,M., Neidhardt,L., Van de Velde,E.,
            Fayazpour,F., De Sutter,D., Savvides,S.N., Eyckerman,S. and
            Janssens,S.
  TITLE     Activation of goblet-cell stress sensor IRE1beta is controlled by
            the mucin chaperone AGR2
  JOURNAL   EMBO J 43 (5), 695-718 (2024)
   PUBMED   38177501
REFERENCE   3  (bases 1 to 760)
  AUTHORS   Tian,S., Chu,Y., Hu,J., Ding,X., Liu,Z., Fu,D., Yuan,Y., Deng,Y.,
            Wang,G., Wang,L. and Wang,Z.
  TITLE     Tumour-associated neutrophils secrete AGR2 to promote colorectal
            cancer metastasis via its receptor CD98hc-xCT
  JOURNAL   Gut 71 (12), 2489-2501 (2022)
   PUBMED   35086885
  REMARK    GeneRIF: Tumour-associated neutrophils secrete AGR2 to promote
            colorectal cancer metastasis via its receptor CD98hc-xCT.
REFERENCE   4  (bases 1 to 760)
  AUTHORS   Viladomiu,M., Khounlotham,M., Dogan,B., Lima,S.F., Elsaadi,A.,
            Cardakli,E., Castellanos,J.G., Ng,C., Herzog,J., Schoenborn,A.A.,
            Ellermann,M., Liu,B., Zhang,S., Gulati,A.S., Sartor,R.B.,
            Simpson,K.W., Lipkin,S.M. and Longman,R.S.
  TITLE     Agr2-associated ER stress promotes adherent-invasive E. coli
            dysbiosis and triggers CD103+ dendritic cell IL-23-dependent
            ileocolitis
  JOURNAL   Cell Rep 41 (7), 111637 (2022)
   PUBMED   36384110
  REMARK    GeneRIF: Agr2-associated ER stress promotes adherent-invasive E.
            coli dysbiosis and triggers CD103[+] dendritic cell IL-23-dependent
            ileocolitis.
REFERENCE   5  (bases 1 to 760)
  AUTHORS   Merugu,S.B., Zhou,B., Mangukiya,H.B., Negi,H., Ghulam,R., Roy,D.,
            Qudsia,S., Wang,Z., Mashausi,D.S., Yunus,F.U., Liu,G.S. and Li,D.
  TITLE     Extracellular AGR2 activates neighboring fibroblasts through
            endocytosis and direct binding to beta-catenin that requires AGR2
            dimerization and adhesion domains
  JOURNAL   Biochem Biophys Res Commun 573, 86-92 (2021)
   PUBMED   34399098
  REMARK    GeneRIF: Extracellular AGR2 activates neighboring fibroblasts
            through endocytosis and direct binding to beta-catenin that
            requires AGR2 dimerization and adhesion domains.
REFERENCE   6  (bases 1 to 760)
  AUTHORS   Que,J., Okubo,T., Goldenring,J.R., Nam,K.T., Kurotani,R.,
            Morrisey,E.E., Taranova,O., Pevny,L.H. and Hogan,B.L.
  TITLE     Multiple dose-dependent roles for Sox2 in the patterning and
            differentiation of anterior foregut endoderm
  JOURNAL   Development 134 (13), 2521-2531 (2007)
   PUBMED   17522155
REFERENCE   7  (bases 1 to 760)
  AUTHORS   Shen,J., Liu,J., Xie,Y., Diwan,B.A. and Waalkes,M.P.
  TITLE     Fetal onset of aberrant gene expression relevant to pulmonary
            carcinogenesis in lung adenocarcinoma development induced by in
            utero arsenic exposure
  JOURNAL   Toxicol Sci 95 (2), 313-320 (2007)
   PUBMED   17077188
REFERENCE   8  (bases 1 to 760)
  AUTHORS   Shroyer,N.F., Wallis,D., Venken,K.J., Bellen,H.J. and Zoghbi,H.Y.
  TITLE     Gfi1 functions downstream of Math1 to control intestinal secretory
            cell subtype allocation and differentiation
  JOURNAL   Genes Dev 19 (20), 2412-2417 (2005)
   PUBMED   16230531
REFERENCE   9  (bases 1 to 760)
  AUTHORS   Komiya,T., Tanigawa,Y. and Hirohashi,S.
  TITLE     Cloning of the gene gob-4, which is expressed in intestinal goblet
            cells in mice
  JOURNAL   Biochim Biophys Acta 1444 (3), 434-438 (1999)
   PUBMED   10095068
REFERENCE   10 (bases 1 to 760)
  AUTHORS   Thompson,D.A. and Weigel,R.J.
  TITLE     hAG-2, the human homologue of the Xenopus laevis cement gland gene
            XAG-2, is coexpressed with estrogen receptor in breast cancer cell
            lines
  JOURNAL   Biochem Biophys Res Commun 251 (1), 111-116 (1998)
   PUBMED   9790916
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT030196.9.
            
            On Nov 17, 2006 this sequence version replaced NM_011783.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF044262.1, DV058683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                CT030196.9         111550-111594       c
            46-191              CT030196.9         108864-109009       c
            192-255             CT030196.9         108561-108624       c
            256-308             CT030196.9         108392-108444       c
            309-382             CT030196.9         107023-107096       c
            383-446             CT030196.9         105873-105936       c
            447-530             CT030196.9         102750-102833       c
            531-760             CT030196.9         100438-100667       c
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.18 cM"
     gene            1..760
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /note="anterior gradient 2"
                     /db_xref="GeneID:23795"
                     /db_xref="MGI:MGI:1344405"
     exon            1..45
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            46..191
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..580
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /note="anterior gradient protein 2 homolog; AG-2; protein
                     Gob-4; secreted cement gland protein XAG-2 homolog;
                     anterior gradient 2 homolog"
                     /codon_start=1
                     /product="anterior gradient protein 2 homolog precursor"
                     /protein_id="NP_035913.1"
                     /db_xref="CCDS:CCDS25881.1"
                     /db_xref="GeneID:23795"
                     /db_xref="MGI:MGI:1344405"
                     /translation="MEKFSVSAILLLVAISGTLAKDTTVKSGAKKDPKDSRPKLPQTL
                     SRGWGDQLIWTQTYEEALYRSKTSNRPLMVIHHLDECPHSQALKKVFAEHKEIQKLAE
                     QFVLLNLVYETTDKHLSPDGQYVPRIVFVDPSLTVRADITGRYSNRLYAYEPSDTALL
                     YDNMKKALKLLKTEL"
     exon            192..255
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..308
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            309..382
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..446
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            447..530
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..760
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      738..743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /note="hexamer: AATAAA"
     polyA_site      760
                     /gene="Agr2"
                     /gene_synonym="Agr2h; Gob-4; HAG-2; mAG-2; XAG-2"
                     /note="major polyA site"
ORIGIN      
        1 ggcaaccctt gcggctcaca caaagcagga gggtgggaag cccagatttg ccatggagaa
       61 attttcagtg tctgcaatcc tgcttcttgt ggccatttct ggtaccttgg ccaaagacac
      121 cacagtcaaa tctggagcca aaaaggaccc aaaggactct cggcccaaac tacctcagac
      181 actctccaga ggttggggcg atcagctcat ctggactcag acatacgaag aagctttata
      241 cagatccaag acaagcaaca gacccttgat ggtcattcat cacttggacg aatgcccaca
      301 cagtcaagcc ttaaagaaag tgtttgctga acataaagaa atccagaaat tggcagagca
      361 gtttgttctc ctcaacctgg tctatgaaac aactgacaag cacctttctc ctgatggcca
      421 gtatgtcccc agaattgtgt ttgtagaccc atccctgacg gtgagggcag acatcactgg
      481 acgatactca aaccggctct acgcttatga accttctgac acagctctgt tgtacgacaa
      541 catgaagaaa gctctcaagc tgctaaagac agaattgtag agccaactgc gcaccgggtc
      601 aggagaccag aaggcagaag cactgtggac ttgcagatta cagtacagtt taatgttaca
      661 acagatatat tttttaaaca cccacaggtg gggaaacaat attattatct actacagtga
      721 agcatgattt tctagaaaat aaagtcttgt gagaactcca
//
