LOCUS       NM_026792               3829 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus 1-acylglycerol-3-phosphate O-acyltransferase 5
            (Agpat5), mRNA.
ACCESSION   NM_026792
VERSION     NM_026792.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3829)
  AUTHORS   Michorowska,S., Vogel,K.R., Jain,R., St Clair,S.L., Simcox,J.A. and
            Parks,B.W.
  TITLE     Liver-specific deletion of Agpat5 protects against liquid
            sucrose-induced hyperinsulinemia and glucose intolerance
  JOURNAL   Biochem Biophys Res Commun 741, 151059 (2024)
   PUBMED   39608054
REFERENCE   2  (bases 1 to 3829)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3829)
  AUTHORS   Strembitska,A., Labouebe,G., Picard,A., Berney,X.P., Tarussio,D.,
            Jan,M. and Thorens,B.
  TITLE     Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for
            insulin-induced hypoglycemia sensing and glucagon secretion
  JOURNAL   Nat Commun 13 (1), 5761 (2022)
   PUBMED   36180454
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3829)
  AUTHORS   Parks,B.W., Sallam,T., Mehrabian,M., Psychogios,N., Hui,S.T.,
            Norheim,F., Castellani,L.W., Rau,C.D., Pan,C., Phun,J., Zhou,Z.,
            Yang,W.P., Neuhaus,I., Gargalovic,P.S., Kirchgessner,T.G.,
            Graham,M., Lee,R., Tontonoz,P., Gerszten,R.E., Hevener,A.L. and
            Lusis,A.J.
  TITLE     Genetic architecture of insulin resistance in the mouse
  JOURNAL   Cell Metab 21 (2), 334-347 (2015)
   PUBMED   25651185
REFERENCE   5  (bases 1 to 3829)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   6  (bases 1 to 3829)
  AUTHORS   Lu,B., Jiang,Y.J., Zhou,Y., Xu,F.Y., Hatch,G.M. and Choy,P.C.
  TITLE     Cloning and characterization of murine 1-acyl-sn-glycerol
            3-phosphate acyltransferases and their regulation by PPARalpha in
            murine heart
  JOURNAL   Biochem J 385 (Pt 2), 469-477 (2005)
   PUBMED   15367102
REFERENCE   7  (bases 1 to 3829)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3829)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062903.1 and AC129567.8.
            
            On Mar 9, 2007 this sequence version replaced NM_026792.2.
            
            CCDS Note: The coding region has been updated to represent a CDS
            sequence that is better supported by available transcript data and
            the reference genome sequence. The protein length is unchanged.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.244398.1, AK082137.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1153              BC062903.1         1-1153
            1154-2837           BC062903.1         1158-2841
            2838-3829           AC129567.8         23551-24542         c
FEATURES             Location/Qualifiers
     source          1..3829
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.3 cM"
     gene            1..3829
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 5"
                     /db_xref="GeneID:52123"
                     /db_xref="MGI:MGI:1196345"
     exon            1..500
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1379
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /EC_number="2.3.1.51"
                     /note="1-AGPAT 5; LPAAT-epsilon; 1-AGP acyltransferase 5;
                     lysophosphatidic acid acyltransferase epsilon;
                     1-acylglycerol-3-phosphate O-acyltransferase 5
                     (lysophosphatidic acid acyltransferase, epsilon)"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     epsilon"
                     /protein_id="NP_081068.1"
                     /db_xref="CCDS:CCDS22126.1"
                     /db_xref="GeneID:52123"
                     /db_xref="MGI:MGI:1196345"
                     /translation="MLLSLVLHTYSMRYLLPSVLLLGSAPTYLLAWTLWRVLSALMPA
                     RLYQRVDDRLYCVYQNMVLFFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIVA
                     DMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYV
                     NAGTPMYLVIFPEGTRYNATYTKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSM
                     KSHLDAIYDVTVVYEGNEKGSGKYSNPPSMTEFLCKQCPKLHIHFDRIDRNEVPEEQE
                     HMKKWLHERFEIKDRLLIEFYDSPDPERRNKFPGKSVHSRLSVKKTLPSVLILGSLTA
                     VMLMTESGRKLYMGTWLYGTLLGCLWFVIKA"
     exon            501..570
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     exon            571..686
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     exon            687..776
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     exon            777..867
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1029
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1153
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..3829
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /note="hexamer: ATTAAA"
     polyA_site      1386
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /note="major polyA site"
     regulatory      1446..1451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /note="hexamer: ATTAAA"
     polyA_site      1468
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
     regulatory      2812..2817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /note="hexamer: AATAAT"
     polyA_site      2837
                     /gene="Agpat5"
                     /gene_synonym="1110013A05Rik; D8Ertd319e"
                     /note="major polyA site"
ORIGIN      
        1 cgcctccccg ctgacaagca cgggtcgcgc ggagcaaagc gagcaccccg aggcgagtgc
       61 gcccggcaag ccgaggcgtg ccctttccaa ggcggcgagc agaggccgtc actgtccccg
      121 ccgggtcccg ggcccccgcg gcccatgctg ggggcggagc cagggcggag ggcggcggcg
      181 cggccggccc cgcgcagtga ttggcgggcg gccggcggtg gctgaggtcc tggtggccgc
      241 gcgggcaacg caggcggagt cgcggctggc gagccgagag gatgctgctg tccctggtgc
      301 tccacacgta ctctatgcgc tacctgctcc ccagcgtcct gttgctgggc tcggcgccca
      361 cctacctgct ggcctggacg ctgtggcggg tgctctccgc gctgatgccc gcccgcctgt
      421 accagcgcgt ggacgaccgg ctttactgcg tctaccagaa catggtgctc ttcttcttcg
      481 agaactacac cggggtccag atattgctat atggagattt gccaaaaaat aaagaaaatg
      541 taatatatct agcgaatcat caaagcacag ttgactggat tgttgcggac atgctggctg
      601 ccagacagga tgccctagga catgtgcgct acgtactgaa agacaagtta aaatggcttc
      661 cgctgtatgg gttctacttt gctcagcatg gaggaattta tgtaaaacga agtgccaaat
      721 ttaatgataa agaaatgaga agcaagctgc agagctatgt gaacgcagga acaccgatgt
      781 atcttgtgat tttcccagag ggaacaaggt ataatgcaac atacacaaaa ctcctttcag
      841 ccagtcaggc atttgctgct cagcggggcc ttgcagtatt aaaacacgta ctgacaccaa
      901 gaataaaggc cactcacgtt gcttttgatt ctatgaagag tcatttagat gcaatttatg
      961 atgtcacagt ggtttatgaa gggaatgaga aaggttcagg aaaatactca aatccaccat
     1021 ccatgactga gtttctctgc aaacagtgcc caaaacttca tattcacttt gatcgtatag
     1081 acagaaatga agttccagag gaacaagaac acatgaaaaa gtggcttcat gagcgctttg
     1141 agataaaaga taggttgctc atagagttct atgattcacc agatccagaa agaagaaaca
     1201 aatttcctgg gaaaagtgtt cattccagac taagtgtgaa gaagacttta ccttcagtgt
     1261 tgatcttggg gagtttgact gctgtcatgc tgatgacgga gtccggaagg aaactgtaca
     1321 tgggcacctg gttgtatgga accctccttg gctgcctgtg gtttgttatt aaagcataag
     1381 caagtagcag gctgcagtca cagtctctta ttgatggcta cacgttgtat cacattgttt
     1441 cctgaattaa ataaggagtt ttcttgttgt tgtttttttg ttttgttttg ttctgtttta
     1501 agccttgatg attgaacact ggataaagta gagtttgtga ccacagccaa catgcatttg
     1561 atttggggca aacacatgtg gcttttcagg tgctggggtt gctggagaca tggaagctaa
     1621 gtggagttta tgctgttttt ttttttttaa tgttttcatg aattaatctc cacttgtaaa
     1681 gattattgga tactttctgt aattcagaag gttgtatttt aacactagtt tgcagtatgt
     1741 ttcgctatat tggttatctt ccatttgact acttggcagc tcagactctt aatactaaag
     1801 tattttacat tttgaagcta tgtgatactg gttttttgtt gttgttgttg ttagtttctg
     1861 aaagtcaatg aaagacactg taatgatgcg ttaagatgtt ccaagaaaaa ggtgagaatt
     1921 attcatggca aaaaagatct gtctagtgta tatttttatt atattgctct atttagctaa
     1981 ttttctttat atttgcaaaa taatgaacat ttttaatatt tattaaaatg cttgatttgc
     2041 atacccccga ttctacagag aataatgtgt aaagtgtcag aatagacttg aagctctgct
     2101 gtgactcagt ctcctttgtc agagcttcta gtagcccagc tactgagctg ctttgttagt
     2161 acctccagca cctgagccgt taagtactta taaatgcaag ggacccgtta tcttcatatc
     2221 ggaatagaca tgaacagagc tctaaggcga tgaaagtctg ccagcatcct ctctgtcctc
     2281 gcacgtgcct tctgcctggc tccatttgct ttggcactgc gttcgatcta gagtgtaggt
     2341 gctcactgct tatttcagcc ctggctctgt ggttttgtgt cctccagtgg tgctgttcac
     2401 tgttggggtg caggtggtgc tgccctgact cagaggggca gctccctggc tcctgagggt
     2461 gagccttctt ggctactaca gaagtattgt gcgtttgttt atggcaagaa ccatcaggat
     2521 tggataaatg tgttatttct ctttgatttc catggagcca cactgttggt acatgtcccc
     2581 tgtgaacaga gctacctttc aggagcacat catactgtcg tgagtcacgg cacggtgtgt
     2641 cctgtgagaa gaggctttct aacgtgtgat ttgccgtgtt tctatgttgt gatttaagcg
     2701 tgattgccta ctagtcattc aaggtaacat ttctgcaaat ttcatacaga tttttgtcac
     2761 aaaattacta taccaatgat ctagttgaaa tagaccaatt gaatcacaat aaataatttt
     2821 ttttaattga gggaaaattt gcttcttgtt ttttcaaagc cagaaaacga gccatttcaa
     2881 acatctttga agagtcatgt gctgtcactt gttttctatg tgttagtgtc tatattcatg
     2941 tatggataca catgaacatg tatattcata cacacacgcc aatagaatat aacagcctaa
     3001 aaacaatcca gcttgtgtat catgttactg tgctgaattg taatggtttt tacttacaaa
     3061 gtgaggctaa aatcgatttc atgtctttgt taaatacgtt ttttcagcaa tcctattaga
     3121 gcttattttg accagatcaa aataagtaca agttcagaga ctttaaatat ggctgaggtc
     3181 tagagcgata gctcagtagt taggaacaca tgccactctt tcaagggctt cagttcccag
     3241 cactcatatg gaggctcaca gaaggctgga attccagctt catggaattg gacacatcct
     3301 ctagcttcca tggatctgtc tgtctgtctc tcccttctct ctctctctct ctctctctct
     3361 ctctctctct ctctctctct cactcactct ttaaatatca tggatatgct gtgcatttaa
     3421 attttaagac acagaaccat tggaattaca tggattatag ctgattctct ttgaacaggg
     3481 cacagtgttc tgcgtaagat ctcttgatca ttagcactgg actcactctc ctcacaagta
     3541 gcctatcaaa tgtggtatta gaaaatacat tgtgtcaaaa tctttgaaag atgagaagaa
     3601 tctcctaaac atgtttattt tgacttgaca tcactatttc ctgaaaatta actgtctatg
     3661 attcttttca catagtgtaa gatcttactt gtatcaccat cagcttgcag cttaggggct
     3721 gcagttgttc tccttcataa gactgccatc cgtgtgcatg cttttatgtt tttcagaaag
     3781 gatgttggga tgaaagtaag aaaacaaata aagtctcttc ttgtctctc
//
