LOCUS       NM_026644               1910 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus 1-acylglycerol-3-phosphate O-acyltransferase 4
            (Agpat4), mRNA.
ACCESSION   NM_026644
VERSION     NM_026644.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Zhang,D., Shi,R., Xiang,W., Kang,X., Tang,B., Li,C., Gao,L.,
            Zhang,X., Zhang,L., Dai,R. and Miao,H.
  TITLE     The Agpat4/LPA axis in colorectal cancer cells regulates antitumor
            responses via p38/p65 signaling in macrophages
  JOURNAL   Signal Transduct Target Ther 5 (1), 24 (2020)
   PUBMED   32296017
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Bradley,R.M., Bloemberg,D., Aristizabal Henao,J.J., Hashemi,A.,
            Mitchell,A.S., Fajardo,V.A., Bellissimo,C., Mardian,E.B.,
            Bombardier,E., Pare,M.F., Moes,K.A., Stark,K.D., Tupling,A.R.,
            Quadrilatero,J. and Duncan,R.E.
  TITLE     Lpaatdelta/Agpat4 deficiency impairs maximal force contractility in
            soleus and alters fibre type in extensor digitorum longus muscle
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (7), 700-711 (2018)
   PUBMED   29627383
  REMARK    GeneRIF: Study utilizing Lpaat-delta deficient mice identify an
            important role for murine Lpaat-delta in musculus soleus and
            extensor digitorum longus contractile force generation.
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Bradley,R.M., Mardian,E.B., Bloemberg,D., Aristizabal Henao,J.J.,
            Mitchell,A.S., Marvyn,P.M., Moes,K.A., Stark,K.D., Quadrilatero,J.
            and Duncan,R.E.
  TITLE     Mice Deficient in lysophosphatidic acid acyltransferase delta
            (Lpaatdelta)/acylglycerophosphate acyltransferase 4 (Agpat4) Have
            Impaired Learning and Memory
  JOURNAL   Mol Cell Biol 37 (22), e00245-17 (2017)
   PUBMED   28807933
  REMARK    GeneRIF: Findings indicate that Lpaatdelta deficiency causes
            deficits in learning and memory associated with reduced NMDA and
            AMPA receptors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Mardian,E.B., Bradley,R.M., Aristizabal Henao,J.J., Marvyn,P.M.,
            Moes,K.A., Bombardier,E., Tupling,A.R., Stark,K.D. and Duncan,R.E.
  TITLE     Agpat4/Lpaatdelta deficiency highlights the molecular heterogeneity
            of epididymal and perirenal white adipose depots
  JOURNAL   J Lipid Res 58 (10), 2037-2050 (2017)
   PUBMED   28814640
  REMARK    GeneRIF: Agpat4/Lpaatdelta deficiency highlights the molecular
            heterogeneity of epididymal and perirenal white adipose depots
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Eto,M., Shindou,H. and Shimizu,T.
  TITLE     A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with
            a possible role for incorporating docosahexaenoic acid into brain
            glycerophospholipids
  JOURNAL   Biochem Biophys Res Commun 443 (2), 718-724 (2014)
   PUBMED   24333445
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 1910)
  AUTHORS   Lu,B., Jiang,Y.J., Zhou,Y., Xu,F.Y., Hatch,G.M. and Choy,P.C.
  TITLE     Cloning and characterization of murine 1-acyl-sn-glycerol
            3-phosphate acyltransferases and their regulation by PPARalpha in
            murine heart
  JOURNAL   Biochem J 385 (Pt 2), 469-477 (2005)
   PUBMED   15367102
REFERENCE   10 (bases 1 to 1910)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK005139.1.
            
            On Apr 5, 2007 this sequence version replaced NM_026644.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005139.1, AK166917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1910              AK005139.1         2-1911
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.33 cM"
     gene            1..1910
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 4"
                     /db_xref="GeneID:68262"
                     /db_xref="MGI:MGI:1915512"
     exon            1..132
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            133..390
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1349
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /EC_number="2.3.1.51"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 1
                     (lysophosphatidic acid acyltransferase, delta);
                     lysophosphatidic acid acyltransferase-delta; 1-AGPAT 4;
                     LPAAT-delta; 1-AGP acyltransferase 4;
                     1-acylglycerol-3-phosphate O-acyltransferase 4
                     (lysophosphatidic acid acyltransferase, delta)"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     delta"
                     /protein_id="NP_080920.2"
                     /db_xref="CCDS:CCDS28389.1"
                     /db_xref="GeneID:68262"
                     /db_xref="MGI:MGI:1915512"
                     /translation="MDLIGLLKSQFLCHLVFCYVFIASGLIVNAIQLCTLVIWPINKQ
                     LFRKINARLCYCVSSQLVMLLEWWSGTECTIYTDPKACPHYGKENAIVVLNHKFEIDF
                     LCGWSLAERLGILGNSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLL
                     HLRDYPEKYLFLIHCEGTRFTEKKHQISMQVAQAKGLPSLKHHLLPRTKGFAITVKCL
                     RDVVPAVYDCTLNFRNNENPTLLGVLNGKKYHADCYVRRIPMEDIPEDEDKCSAWLHK
                     LYQEKDAFQEEYYRTGVFPETPWVPPRRPWSLVNWLFWASLLLYPFFQFLVSMVSSGS
                     SVTLASLVLIFCMASMGVRWMIGVTEIDKGSAYGNIDNKRKQTD"
     exon            391..560
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..722
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..876
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..979
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1055
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1254
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1910
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1862..1867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      1892
                     /gene="Agpat4"
                     /gene_synonym="1500003P24Rik"
ORIGIN      
        1 ggagtctcgc tttttctttc cagtgttggc tgacttacag cttctctaaa gtagaggcag
       61 tttctgaacc tcaggctcct gcctcgcagt tctggcttgt gagcaccaat gcaaagaact
      121 gcccggagcg agacactttc ctgagccccg gatctttccc ccttctggaa ctatcccacc
      181 atacggattt atctcttgag aatccccaca ccatggacct catcgggctg ctgaagtccc
      241 agtttctatg tcacctggtc ttctgctacg tgttcatcgc ctcggggctc attgtcaacg
      301 ccatccagct gtgcacgctg gtcatctggc ccatcaacaa gcagctgttc cgcaagatca
      361 atgccagact ctgctactgc gtctccagcc agttggtgat gcttctggag tggtggtcgg
      421 gcacggagtg taccatctac accgacccga aggcctgccc ccactacggg aaggaaaacg
      481 ccatcgtggt cctcaatcac aagtttgaga ttgactttct ctgtggctgg agcctggctg
      541 agcgcctggg gatcctgggg aactccaaag tcctggccaa gaaagaactg gcttatgtcc
      601 caatcattgg ctggatgtgg tacttcgtgg aaatgatctt ttgcacacgc aagtgggagc
      661 aagatcggca gacggttgcc aagagcctgc tgcacctccg ggactaccca gagaagtatc
      721 tgttcctgat ccactgtgag ggcacacggt tcacagagaa gaaacaccaa atcagcatgc
      781 aggtggccca agccaagggg ctgcccagcc tcaaacacca cctgctgccg cgcaccaaag
      841 gctttgctat tactgtgaag tgcttgcgag atgttgtccc agctgtatat gactgtacac
      901 tcaatttcag aaacaatgaa aacccaacac tgctgggagt cttaaatgga aagaaatatc
      961 acgctgactg ctacgttcgg aggatcccca tggaggacat tccggaggat gaggacaagt
     1021 gctctgcctg gttacacaag ctctaccagg agaaggatgc ctttcaggag gaatactaca
     1081 ggacaggggt cttcccagag actccctggg ttcccccacg gcggccctgg tctctggtca
     1141 actggttgtt ctgggcatcg ctgctgctct accctttctt ccagttccta gttagcatgg
     1201 tcagcagcgg ttcctcggtg acgctggcca gcttggtcct catcttctgt atggcctcca
     1261 tgggagttcg atggatgatt ggcgtgacag aaatcgacaa gggctctgcc tacggcaaca
     1321 tcgacaacaa acggaaacaa acggactgat gtgggaaagt cacctccaga gggaaccgtg
     1381 ggggacggct ggcctctgct tagcctttgt agcagggctc agtgatggag actggggggc
     1441 ccttgctggg acaaacacaa accacagccc ctctggtcac ggagttttgc ctcagcgctg
     1501 gatgggaaag gaagacgggt ttagaccttt cccctcccct cctccctgtg tgatatggtt
     1561 tcggttatgt ctcttttcag ttgcgcgtgc gtgcgtgcgt gtgtgtgtgt gtgtgtgtgt
     1621 gtgtgtgtgt gtgtgtgagt gtgtgagaga gagagggaga gagagagaga gagagatggg
     1681 gtgaggagaa tgggtgtgtg gttgcgtgtg cacttgtgac cctgtaacag tagggtctgg
     1741 gaggctgcaa ggaagggcag ggccagggtg gaagggaagg tgtccctgtc accccatggt
     1801 gctgcgtctt ctctaaccct cgattgccgg agacagagtg aaaagtgctt tgggtaagat
     1861 gactaaatta tgcctccaaa taagaaaaag aattaaagtg tttctctggg
//
