LOCUS       NM_026212               1574 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus 1-acylglycerol-3-phosphate O-acyltransferase 2
            (Agpat2), mRNA.
ACCESSION   NM_026212
VERSION     NM_026212.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Peng,K., Chen,X., Pei,K., Wang,X., Ma,X., Liang,C., Dong,Q.,
            Liu,Z., Han,M., Liu,G., Yang,H., Zheng,M., Liu,G. and Gao,M.
  TITLE     Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and
            atherosclerosis in Ldlr-/- mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166850 (2024)
   PUBMED   37591406
  REMARK    GeneRIF: Lipodystrophic gene Agpat2 deficiency aggravates
            hyperlipidemia and atherosclerosis in Ldlr[-/-] mice.
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Agarwal,A.K., Tunison,K., Vale,G., McDonald,J.G., Li,X.,
            Horton,J.D. and Garg,A.
  TITLE     Adipose-specific overexpression of human AGPAT2 in mice causes
            increased adiposity and mild hepatic dysfunction
  JOURNAL   iScience 27 (1), 108653 (2023)
   PUBMED   38274405
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Agarwal,A.K., Tunison,K., Vale,G., McDonald,J.G., Li,X.,
            Scherer,P.E., Horton,J.D. and Garg,A.
  TITLE     Regulated adipose tissue-specific expression of human AGPAT2 in
            lipodystrophic Agpat2-null mice results in regeneration of adipose
            tissue
  JOURNAL   iScience 26 (10), 107806 (2023)
   PUBMED   37752957
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Mak,H.Y., Ouyang,Q., Tumanov,S., Xu,J., Rong,P., Dong,F., Lam,S.M.,
            Wang,X., Lukmantara,I., Du,X., Gao,M., Brown,A.J., Gong,X.,
            Shui,G., Stocker,R., Huang,X., Chen,S. and Yang,H.
  TITLE     AGPAT2 interaction with CDP-diacylglycerol synthases promotes the
            flux of fatty acids through the CDP-diacylglycerol pathway
  JOURNAL   Nat Commun 12 (1), 6877 (2021)
   PUBMED   34824276
  REMARK    GeneRIF: AGPAT2 interaction with CDP-diacylglycerol synthases
            promotes the flux of fatty acids through the CDP-diacylglycerol
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1574)
  AUTHORS   Gonzalez-Hodar,L., McDonald,J.G., Vale,G., Thompson,B.M.,
            Figueroa,A.M., Tapia,P.J., Robledo,F., Agarwal,A.K., Garg,A.,
            Horton,J.D. and Cortes,V.
  TITLE     Decreased caveolae in AGPAT2 lacking adipocytes is independent of
            changes in cholesterol or sphingolipid levels: A whole cell and
            plasma membrane lipidomic analysis of adipogenesis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (9), 166167 (2021)
   PUBMED   33989739
REFERENCE   6  (bases 1 to 1574)
  AUTHORS   Beigneux,A.P., Vergnes,L., Qiao,X., Quatela,S., Davis,R.,
            Watkins,S.M., Coleman,R.A., Walzem,R.L., Philips,M., Reue,K. and
            Young,S.G.
  TITLE     Agpat6--a novel lipid biosynthetic gene required for
            triacylglycerol production in mammary epithelium
  JOURNAL   J Lipid Res 47 (4), 734-744 (2006)
   PUBMED   16449762
REFERENCE   7  (bases 1 to 1574)
  AUTHORS   Lu,B., Jiang,Y.J., Man,M.Q., Brown,B., Elias,P.M. and Feingold,K.R.
  TITLE     Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate
            acyltransferases in the epidermis
  JOURNAL   J Lipid Res 46 (11), 2448-2457 (2005)
   PUBMED   16150824
  REMARK    GeneRIF: mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse
            skin after acute permeability barrier disruption
REFERENCE   8  (bases 1 to 1574)
  AUTHORS   Lu,B., Jiang,Y.J., Zhou,Y., Xu,F.Y., Hatch,G.M. and Choy,P.C.
  TITLE     Cloning and characterization of murine 1-acyl-sn-glycerol
            3-phosphate acyltransferases and their regulation by PPARalpha in
            murine heart
  JOURNAL   Biochem J 385 (Pt 2), 469-477 (2005)
   PUBMED   15367102
REFERENCE   9  (bases 1 to 1574)
  AUTHORS   Magre,J., Delepine,M., Van Maldergem,L., Robert,J.J., Maassen,J.A.,
            Meier,M., Panz,V.R., Kim,C.A., Tubiana-Rufi,N., Czernichow,P.,
            Seemanova,E., Buchanan,C.R., Lacombe,D., Vigouroux,C., Lascols,O.,
            Kahn,C.R., Capeau,J. and Lathrop,M.
  TITLE     Prevalence of mutations in AGPAT2 among human lipodystrophies
  JOURNAL   Diabetes 52 (6), 1573-1578 (2003)
   PUBMED   12765973
  REMARK    GeneRIF: There is a prevalence of mutations in this enzymes among
            human lipodystrophies
REFERENCE   10 (bases 1 to 1574)
  AUTHORS   Agarwal,A.K., Arioglu,E., De Almeida,S., Akkoc,N., Taylor,S.I.,
            Bowcock,A.M., Barnes,R.I. and Garg,A.
  TITLE     AGPAT2 is mutated in congenital generalized lipodystrophy linked to
            chromosome 9q34
  JOURNAL   Nat Genet 31 (1), 21-23 (2002)
   PUBMED   11967537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB871777.1, BC125530.1, AK002422.1 and AL732311.13.
            
            On Feb 13, 2013 this sequence version replaced NM_026212.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010891.1, BC137840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BB871777.1         2-127
            127-1089            BC125530.1         1-963
            1090-1569           AK002422.1         211-690
            1570-1574           AL732311.13        3803-3807           c
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.96 cM"
     gene            1..1574
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 2"
                     /db_xref="GeneID:67512"
                     /db_xref="MGI:MGI:1914762"
     exon            1..389
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            390..523
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            524..699
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            700..795
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            796..868
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1574
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1529..1534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /note="hexamer: AATGAA"
     polyA_site      1552
                     /gene="Agpat2"
                     /gene_synonym="1-AGPAT 2; 2510002J07Rik; BSCL; BSCL1;
                     LPAAB; LPAAT-beta"
                     /note="major polyA site"
ORIGIN      
        1 ggggtccgcg tccaggacgc ggcggggcgg agcggggcgc gatgcccccc ggcagggcca
       61 ggcccggagg ggcgggaaca gggcgggacg gccgcaccta gctctgggct tccagcctgg
      121 cccgccctct accctcggcg ctcctcaaaa ggggcgcggg cggcgggtgg agggcggcgg
      181 cgccgtcggg gctggggtgc ggccgccatg gacccgtggc catggctgac ggcggcgctg
      241 ctgctgctgt tgctgcttgt gcagctgagc cgcacagcca ggttctacgc caaggtcggt
      301 ctctactgcg tgctctgcct gtccttctcc gccgcggcct cgatcgtctg cctgctgcgc
      361 cacggcggcc gcaccgtgga taacatgagc atcatcagct ggttcgttcg gtccttcaag
      421 tacgtgtatg gccttcgctt tgaggtcagc ggacagaaga aactggaggt ggatggtccc
      481 tgtgtcatca tctctaatca ccagagcatc ctggacatga tgggtctcat ggaaatactc
      541 cctaagcgct gtgtgcagat cgccaagcgt gagctaatgt tcacagggcc tgtgggcctc
      601 atcatgtacc ttgggggtgt ctacttcatc aaccgccagc aagccagaac tgccatgtct
      661 gtgatggccg acctgggcga cctcatggtc aaggagaatc tcaaagtgtg gatctaccca
      721 gagggtacac gcaacgacaa tggggacctg ttgcccttta aaaaaggagc cttctacttg
      781 gccatccagg cccaggtgcc catcatcccc gtggtgtact cgtctttctc ttccttctac
      841 aatgtcaaga cgaagctctt cacctcagga acaatcaagg tacaagtgct ggatgctgtc
      901 cctaccaatg gtctgacaga tgctgatgtc accaagctgg tggacacttg ctaccagtcc
      961 atgagggcca cctttctaca gatttctcag attccccaag agaactctgc cattaaggag
     1021 cctggggtct tgccagccca gtagcccagg ctacaggggc aggggagctg gggaaagagc
     1081 agaggctgaa ggatggacag aaggccacgc cctcccactt accaaccatc accttatcct
     1141 gctcccctgc tggcctggct ctctcgttgg ggcctggaaa caggaagccc tttctagcac
     1201 aggccttaga tccaggaccc tatgtaactt cccacctcaa gcctgtgcct ccagcatcca
     1261 gatgtggcca tccagcaggt gggctggccc acaagaccac aaggcaccta ggagtgcaca
     1321 acacattacc caaggcccac cccatcgtgc aggacaaatg ttcagaaacc aagcagtggc
     1381 ctgtatcagg ccatcatgaa gaggagaaac ttggtctccc agtctcaagg aagcctggct
     1441 cacacagcac cagagggcag agcctgccgc ccgcaccgtc cgacggcctc agtcacaaat
     1501 cactgctgtg tttggttctt tttctataaa tgaactctca gaagtgcctg gagaccagag
     1561 gtctctttca gaga
//
