LOCUS       NM_153402               7635 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus argonaute RISC catalytic subunit 3 (Ago3), mRNA.
ACCESSION   NM_153402
VERSION     NM_153402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7635)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7635)
  AUTHORS   Guidi,R., Wedeles,C., Xu,D., Kolmus,K., Headland,S.E., Teng,G.,
            Guillory,J., Zeng,Y.J., Cheung,T.K., Chaudhuri,S., Modrusan,Z.,
            Liang,Y., Horswell,S., Haley,B., Rutz,S., Rose,C., Franke,Y.,
            Kirkpatrick,D.S., Hackney,J.A. and Wilson,M.S.
  TITLE     Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain
            type 2 immunity
  JOURNAL   Cell Rep 42 (12), 113515 (2023)
   PUBMED   38096048
  REMARK    GeneRIF: Argonaute3-SF3B3 complex controls pre-mRNA splicing to
            restrain type 2 immunity.
REFERENCE   3  (bases 1 to 7635)
  AUTHORS   Zhang,Y., Tan,Y.Y., Chen,P.P., Xu,H., Xie,S.J., Xu,S.J., Li,B.,
            Li,J.H., Liu,S., Yang,J.H., Zhou,H. and Qu,L.H.
  TITLE     Genome-wide identification of microRNA targets reveals positive
            regulation of the Hippo pathway by miR-122 during liver development
  JOURNAL   Cell Death Dis 12 (12), 1161 (2021)
   PUBMED   34907157
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7635)
  AUTHORS   Adiliaghdam,F., Basavappa,M., Saunders,T.L., Harjanto,D.,
            Prior,J.T., Cronkite,D.A., Papavasiliou,N. and Jeffrey,K.L.
  TITLE     A Requirement for Argonaute 4 in Mammalian Antiviral Defense
  JOURNAL   Cell Rep 30 (6), 1690-1701 (2020)
   PUBMED   32049003
REFERENCE   5  (bases 1 to 7635)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7635)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7635)
  AUTHORS   Liu,J., Carmell,M.A., Rivas,F.V., Marsden,C.G., Thomson,J.M.,
            Song,J.J., Hammond,S.M., Joshua-Tor,L. and Hannon,G.J.
  TITLE     Argonaute2 is the catalytic engine of mammalian RNAi
  JOURNAL   Science 305 (5689), 1437-1441 (2004)
   PUBMED   15284456
REFERENCE   8  (bases 1 to 7635)
  AUTHORS   Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K.
  TITLE     Short-interfering-RNA-mediated gene silencing in mammalian cells
            requires Dicer and eIF2C translation initiation factors
  JOURNAL   Curr Biol 13 (1), 41-46 (2003)
   PUBMED   12526743
REFERENCE   9  (bases 1 to 7635)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7635)
  AUTHORS   Carmell,M.A., Xuan,Z., Zhang,M.Q. and Hannon,G.J.
  TITLE     The Argonaute family: tentacles that reach into RNAi, developmental
            control, stem cell maintenance, and tumorigenesis
  JOURNAL   Genes Dev 16 (21), 2733-2742 (2002)
   PUBMED   12414724
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY235425.1, AK083652.1 and AL606976.25.
            
            On Jun 18, 2009 this sequence version replaced NM_153402.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154436.1, AK035042.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY235425.1         15-48
            35-2536             AK083652.1         2-2503
            2537-3159           AK083652.1         2505-3127
            3160-7635           AL606976.25        57596-62071         c
FEATURES             Location/Qualifiers
     source          1..7635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.39 cM"
     gene            1..7635
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="argonaute RISC catalytic subunit 3"
                     /db_xref="GeneID:214150"
                     /db_xref="MGI:MGI:2446634"
     exon            1..275
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2839
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /EC_number="3.1.26.n2"
                     /note="argonaute 3; eukaryotic translation initiation
                     factor 2C, 3; argonaute RISC catalytic component 3;
                     Piwi/Argonaute family protein meIF2C3; mAgo3; eIF2C 3;
                     eIF-2C 3; argonaute3"
                     /codon_start=1
                     /product="protein argonaute-3"
                     /protein_id="NP_700451.2"
                     /db_xref="CCDS:CCDS18652.1"
                     /db_xref="GeneID:214150"
                     /db_xref="MGI:MGI:2446634"
                     /translation="MEIGSAGPIGAQPLFIVPRRPGYGTMGKPIKLLANCFQVEIPKI
                     DVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVAT
                     TGVDLDVTLPGEGGKDRPFKVSVKFVSRVSWHLLHEALAGGTLPEPLELDKPVSTNPV
                     HAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNI
                     DVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTM
                     RRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQE
                     QKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETD
                     PFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIK
                     MWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRH
                     LKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCL
                     KINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPS
                     RYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLY
                     YELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTD
                     ITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNFFTADELQLLTYQLCHTYVRCTRSV
                     SIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRT
                     MYFA"
     exon            276..447
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..568
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..777
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..914
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1049
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1137
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1285
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1405
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1528
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1662
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1847
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2007
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2098
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2293
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2428
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2530
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2730
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..7635
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3720
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="major polyA site"
     regulatory      5540..5545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="hexamer: AATAAA"
     polyA_site      5558
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="major polyA site"
     regulatory      5595..5600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="hexamer: ATTAAA"
     polyA_site      5616
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
     regulatory      7113..7118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="hexamer: AATAAA"
     polyA_site      7136
                     /gene="Ago3"
                     /gene_synonym="C130014L07Rik; Eif2c3"
                     /note="major polyA site"
ORIGIN      
        1 gaccgggaaa agcgagcggc tgcggcggcg gggcggctgg cgggtcggga agctgcacgc
       61 gtcagcatct gtgggcgacg caagttccgg acctggttcc agcgtcctca ctcaggactg
      121 tcgccgctct tacctcgctg caggctgtct gtctctcccg actgtgcctc ttgtgcccgg
      181 agctttccga gggcgtccgc tcctcgcctc tgtggtggca cccttctctc gtgaagcact
      241 ccccccagct ccatgaatgg aaatcggctc cgcaggaccc attggggccc agcccctatt
      301 catcgtgccc agaagacctg ggtatggcac tatgggcaaa cccattaaac tgttggctaa
      361 ctgttttcaa gttgaaatcc caaagattga tgtctacctc tatgaagttg acatcaaacc
      421 agacaagtgt cctcgaagag tgaacagaga agtagttgat tcaatggttc agcattttaa
      481 agtgactata tttggagacc gtagaccagt ttatgatgga aaaagaagcc tttatacagc
      541 caatccactt cctgtggcaa ccactggggt agatttagat gttacattac ctggggaagg
      601 tggaaaagat cgacctttca aggtgtcagt caaatttgtg tctcgagtca gctggcacct
      661 actacatgaa gcactggctg gagggacttt gcctgagcca ctggaattag acaagcctgt
      721 cagcactaac cccgtccatg ccgttgacgt ggtgctccga catctgccct ctatgaaata
      781 tacgcctgtg gggcgttcct ttttctcagc tccagaagga tatgaccacc ctctgggagg
      841 gggcagggaa gtatggtttg gattccatca gtctgttcgg cctgccatgt ggaaaatgat
      901 gctaaatatt gatgtttctg ccactgcctt ttacaaagca caacctgtaa ttcagttcat
      961 gtgtgaagtt cttgacattc acaacattga tgaacaaccc agacccctga ctgattctca
     1021 tcgggtaaaa ttcactaagg agataaaagg tctgaaagtt gaagtgactc attgtggaac
     1081 aatgagacgg aaataccgtg tttgtaatgt aacgagaagg cctgccagcc accaaacctt
     1141 tcctttacag ctagaaaatg gccaaactgt ggagaggact gtggctcagt atttcagaga
     1201 aaagtacacg ctgcagctga agtacccaca ccttccctgc ctgcaagtgg ggcaggagca
     1261 gaagcataca tacctgccac tagaagtctg taatattgtg gctgggcaaa ggtgtatcaa
     1321 gaaactaacg gacaatcaga cttctacaat gataaaggca acagcaagat ctgcaccaga
     1381 tagacaagag gaaattagca gattggtaag aagtgcaaat tatgaaacag atccatttgt
     1441 tcaggagttt cagtttaaag tgcgggatga aatggcccat gtgacaggac gtgtacttcc
     1501 agcacctatg ctccagtacg gaggacggaa ccggacagta gccacaccca gccacggagt
     1561 atgggacatg cgaggaaaac agttccacac aggagtcgaa atcaaaatgt gggctattgc
     1621 ttgctttgcc acacagaggc agtgcagaga agaaatacta aaaggtttca cagaccagct
     1681 tcggaagatt tccaaggatg cagggatgcc catccagggt cagccatgct tctgcaaata
     1741 cgcacagggg gcagacagcg tggagcccat gttccggcat ctcaagaaca cctactcagg
     1801 actgcagctc attatcgtca tcctgcccgg gaagacacca gtgtatgcgg aagtgaaacg
     1861 tgtgggagat acacttttgg gtatggccac acagtgtgta caagtcaaga atgtaataaa
     1921 aacatctcct caaactcttt caaacttgtg cctaaagatc aatgttaaac ttggaggaat
     1981 caataatatt cttgtacctc atcaaagacc ttctgtgttc cagcaaccag tgatcttcct
     2041 gggcgcagat gtcacacacc cgcctgctgg tgacggaaaa aagccctcca ttgctgctgt
     2101 tgtaggtagt atggatgccc atccaagcag atactgtgcc acagtaagag ttcagagacc
     2161 ccgacaggaa atcatccagg acttggcctc catggtccgg gaactgctca tccaatttta
     2221 taaatcaacc cgattcaaac ctactcgtat aatcttctat cgggatggtg tttcagaagg
     2281 acagttcaga caggtattat attatgagct actggcaatt cgagaagcct gtatcagttt
     2341 ggaaaaagac tatcaacctg gaataaccta cattgttgtt cagaagagac atcatacacg
     2401 gttgttctgt gctgatagga cagaaagggt tggaagaagc ggcaacatcc cagctggaac
     2461 cacggtggat accgacatta ctcacccata tgaattcgac ttttatctct gtagccatgc
     2521 tggaatacag ggtaccagcc gtccttcaca ctatcatgtt ttatgggatg acaacttctt
     2581 tactgcagat gaacttcagc tgctcactta ccagctctgt cacacttacg tacgctgtac
     2641 aagatctgtt tctatccctg caccagcata ttacgctcac ctggtggcat tcagagccag
     2701 atatcatctt gtggacaagg aacatgacag tgctgaagga agccatgttt caggacagag
     2761 caatgggcga gatccacaag ctcttgccaa ggctgtacag attcaccaag ataccttacg
     2821 cacaatgtac ttcgcttaac aagtccaagt ttattctccg tgacaaagag atgaaaagtg
     2881 aatcaacata caatgtatgt ttccaatgga gtcaatttgc tggggaggcc tccagccata
     2941 cagaagccag tactatgtag aggtcaggtc cttatgttga tccaaggaaa atcgtttaca
     3001 ctgtcaaaga acgcagcacc attgtacact agggagccag ccgctgcttt tttgcagtct
     3061 cctgtagaag atgcatcacc attgtttatt ctcacttctt acagtctaac ccttttaatg
     3121 cctttacctc aagttgctta gcagcacaac tatctctgca aaaaagtaaa gaaaaattga
     3181 atggtggttt aaaaacacac aattacacaa ataatgattg ttcagttata tgtgcagaaa
     3241 aagtaatgtg catctattct tgtaaaggag tctgtatttt caataccctc acattacttc
     3301 atgtgcatat gtatctagat ctaggttact gatgtatatg tgtctgtgtg tatatcttat
     3361 agttcatttc cctggagaac tctttccttg tatccctcct taggccgcac tcgtttcctt
     3421 tactgtctcc cttgccttca gcatctatac tttggtccct atagctacaa gtgacattcc
     3481 tatgttcaca catatggttc acttgaagga aggtttgaca aattagactt ctggttttct
     3541 ttatgtccct attcctagct cctttcactc acacaggagt cctcagctcc tgacgccatg
     3601 tttgtgagcg tctgctccct tttgctctgg atttaccaca tgtgcactgt gtttggaaac
     3661 agtggcaacc tggggattct tttttgtagt gagtttgtta aagctgctct aaatacgaaa
     3721 ccttgtcgga catctttctg atcagtgcaa atgttctaaa gcctctgttt gtatgagtta
     3781 tacctggaaa tccctccaaa actcgatagg atggaaaaag gaaggaatta gggttggttt
     3841 ggtttgtttt ttgctagttt actcactgcc cttatacctt aatgtgattt tctcacatat
     3901 aaatatatac atacacacac acacattgaa gtatagctcc ctttgccttt atgttcatta
     3961 gaatagtgct ttaataatta taaactatat aggctatatc ttttctagaa ctagaatcgt
     4021 gtttaagaat ggagacagtt ttttgctctc ttttagtgca ataagcagtt ttacaggaaa
     4081 gttctgtctg tcatcctcac cgtggatagc aggaagaaca gacatccgta gtttaaaggg
     4141 aacaaagtaa tacagcctta atttcagaag gagagcttca taattttcag ttttaaagca
     4201 attccttaaa ataattttag ccaaaggagt aaaaccgatc aaaggcgcct cagctgtgag
     4261 gtcagaagca tagttgaact taagttttta aaaatgacag tgaacagctt aagatttaaa
     4321 tattctttct tacttattga agaattgtgc ttctttgact aacaggaatt gagaaaatac
     4381 aggatgattt ttttctatct ttttaccagt ataactttct ctttaaaaat aagatggcaa
     4441 tgatgaagga aattaggact ttggtcattt aaaattagta aaatttccga aatacagtga
     4501 aaactttgca aaaacttagt tttctccact tctttaatca ataaccttaa taacgttgga
     4561 gctgtcaaag ctgagtgtct cagtaatggc aggttcaggg aactttgcac tttgtaagtc
     4621 atgaacattg catgtgagtt ttctctgttg tccccaccct ggctctgagg acagacacta
     4681 cagatgtttg tggaatgcac tgtcggcctt tcagaagccc caccccgcca tgaacaggaa
     4741 tgcagttatg tcttcatttg ctctctttag tccacattgt agccaattta ctacatttca
     4801 atataaaatc tgagccatgt cctacaggca tgaattcttc tgtccctttg ccagaacata
     4861 aagaaagtac tgtattttat atttttattg cttgaagtat ctaaaattcg attctcaata
     4921 ctgttttaaa gctgtttact gtttacaaag gattttcatg tggtttatac atttttctcc
     4981 ttccaaaata ttcccatctc aaccctggca aaagaaaact ccttacaaca tatttggggt
     5041 gggttggttt gcttgcttgt tttggagaca acgtctctct ctattgccca tgctggcctc
     5101 caacccctgg gctccagcag tcttcttaac ctctctggta gttggaacca ttgggctcct
     5161 tccatcatgc ctggctgtcg gggagcatgg ccaaaagaat agagtggtgc aggctccatg
     5221 gtaaaagtct ttgcctgggt tgtgtttgct cagtagaagt aaacatgttt ttcagcccct
     5281 gcacattcac atgaggagct ttagggagtc gcatgggccc tgtccctttc ctgacctttg
     5341 gtctcacaca tgccagagtg aagcccttac ttttaattct tatttaaaag gattttttaa
     5401 ggggaagaat tttttttcta aaatataagg ttttatcttt taaatggctt cttttttaga
     5461 atgcatttat attattcagt cttgctagtt taagataatt aacttaggat atgtatagtg
     5521 tatttctgtt ttgcctacta ataaattgtt ataccaaact taatgccaac aaactttatg
     5581 cttagaattt taagattaaa aggcctatag aaaatacttc ttgaaattta tactattttt
     5641 ccatttctgg ttagaattcc taatcttttt cttaagttcc tttcagttta aacatcatga
     5701 agccatagta acatttctcc tctaccgtac tcttgctcct agctgatgaa tgtcagcttg
     5761 tggggttttt ttgtttttta tggtatggct tataaaactg actaaaatgt caatctgaac
     5821 aacttataga atcgattctc ttgttaagaa gagttgagag tttaatgtat attcttgatg
     5881 gcaaatgtgt ctgtagagtg tgcatgttac atgtctatat tacagtatct aagcactggc
     5941 attgatacca tatattaata attctgtagc tgctatattt attgaggcag agtctgacat
     6001 ttactgcact aaacaatgag acaagcaaga tgccaggcag tcagacactt ttggtttctt
     6061 aggtaagttt aaggacataa aacatgaagg taacgaacag cgggtacttg aaacagtgct
     6121 ggcttcagtt tagtaacaga atacctttgc tttagaaacg tggggttttt acattgacat
     6181 ccacatgagg gtcttcagtc ttctcagtcc tgggcttggg cacatttcta cataaatacg
     6241 gatgaccttt tattttatta atagataatt atcttttaac aattttccag gaaaaaatag
     6301 tctggaaata cctctgctta tgacctatta gtttattttt gttcctaaag agaatctgga
     6361 agggactcca gtaggaatgt tctatgtgtt ttggaaggca tttgataaag attcatctct
     6421 accttctagc agagagactc ctcaccttca aaagacccaa caacttttct aagccaggct
     6481 ctctatggtg ccagtagcct aataatgact ttcatcgtgt cttgtagatc gcagggtggc
     6541 aagtgtgtct tggggaatta aaaccagatg ctgctgagta gaaatggctc gagatctcag
     6601 tcacaggcgg tgtgagcact tggagcccag ccatagaagt gaagcccaga gagctatcca
     6661 tccaaaacac gtggtgggcc tttcagatgc ttaattctta ggaaattcac tttggacact
     6721 ggtagaatag tttgttccct ttctgattaa aatttttaga gtaatgtttt gccaggaagt
     6781 ttaactgaca tctctgcata attttgactg ggtgtcagta aactaagtta tatgttcagt
     6841 taagccaagt taaggtacac ctataagccc agccctcagg agcatcagta attcaaagcc
     6901 agcctcagca acatgagacc atgcctcaaa acacagcaaa cactttgttt acctcagccc
     6961 tgcaggtatt ctcctgctgc agttccgtgt agttcacttg tctcttagaa gttgtgtgag
     7021 tgcctcaaag aaagacagct cacttgtcaa cattcgtgaa gtgttggtcc ctttcatcct
     7081 ttttgagaat tcatagatat tttcgaagct ttaataaaaa tagctggaga acttaacttg
     7141 agtgaggtct tcctgagtct tgttataatc ctgacttgag tatcttcatt ttcctttcca
     7201 cttaacacag aatatttctg tgattctatg agtcaaaaac taagccagga atacttatgt
     7261 aaaggtcaat acagaggaca aggggacggc taagcaggta aaggcacacc cctgcaagcc
     7321 tgaaaacctg agctcaatcc ttggaaccca aacggtggaa agacagaacc agctcccata
     7381 acttgccctc tgaccttcat acacatgcca tggcaccacc catcgggctc aagcacacgg
     7441 gcgtgcgcgg gcacacacac actcacgcgt acttttaaat gtaattttta agtctataga
     7501 aatcagaaaa gcagctgggt ttagtgcttg cctgtgatcc taaccagaag atctggagct
     7561 caggaccagc ctgggcagtt tgtctaggat acatagtgac actgtgtccc ccgactttgc
     7621 caaccccctg ccccc
//
