LOCUS       NM_178767               2155 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus alkylglycerol monooxygenase (Agmo), mRNA.
ACCESSION   NM_178767
VERSION     NM_178767.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Lackner,K., Sailer,S., van Klinken,J.B., Wever,E., Pras-Raves,M.L.,
            Dane,A.D., Honsho,M., Abe,Y., Keller,M.A., Golderer,G.,
            Werner-Felmayer,G., Fujiki,Y., Vaz,F.M., Werner,E.R. and
            Watschinger,K.
  TITLE     Alterations in ether lipid metabolism and the consequences for the
            mouse lipidome
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (4), 159285 (2023)
   PUBMED   36690320
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Sailer,S., Lackner,K., Pras-Raves,M.L., Wever,E.J.M., van
            Klinken,J.B., Dane,A.D., Geley,S., Koch,J., Golderer,G.,
            Werner-Felmayer,G., Keller,M.A., Zwerschke,W., Vaz,F.M.,
            Werner,E.R. and Watschinger,K.
  TITLE     Adaptations of the 3T3-L1 adipocyte lipidome to defective ether
            lipid catabolism upon Agmo knockdown
  JOURNAL   J Lipid Res 63 (6), 100222 (2022)
   PUBMED   35537527
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Schmitz,K., Trautmann,S., Hahnefeld,L., Fischer,C., Schreiber,Y.,
            Wilken-Schmitz,A., Gurke,R., Brunkhorst,R., Werner,E.R.,
            Watschinger,K., Wicker,S., Thomas,D., Geisslinger,G. and Tegeder,I.
  TITLE     Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice
  JOURNAL   Neurotherapeutics 18 (3), 1862-1879 (2021)
   PUBMED   33844153
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Sailer,S., Coassin,S., Lackner,K., Fischer,C., McNeill,E.,
            Streiter,G., Kremser,C., Maglione,M., Green,C.M., Moralli,D.,
            Moschen,A.R., Keller,M.A., Golderer,G., Werner-Felmayer,G.,
            Tegeder,I., Channon,K.M., Davies,B., Werner,E.R. and Watschinger,K.
  TITLE     When the genome bluffs: a tandem duplication event during
            generation of a novel Agmo knockout mouse model fools routine
            genotyping
  JOURNAL   Cell Biosci 11 (1), 54 (2021)
   PUBMED   33726865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Watschinger,K., Keller,M.A., McNeill,E., Alam,M.T., Lai,S.,
            Sailer,S., Rauch,V., Patel,J., Hermetter,A., Golderer,G., Geley,S.,
            Werner-Felmayer,G., Plumb,R.S., Astarita,G., Ralser,M.,
            Channon,K.M. and Werner,E.R.
  TITLE     Tetrahydrobiopterin and alkylglycerol monooxygenase substantially
            alter the murine macrophage lipidome
  JOURNAL   Proc Natl Acad Sci U S A 112 (8), 2431-2436 (2015)
   PUBMED   25675482
  REMARK    GeneRIF: These results demonstrate a central role of
            tetrahydrobiopterin and alkylglycerol monooxygenase in ether lipid
            metabolism of murine macrophages.
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Tokuoka,S.M., Kita,Y., Shindou,H. and Shimizu,T.
  TITLE     Alkylglycerol monooxygenase as a potential modulator for PAF
            synthesis in macrophages
  JOURNAL   Biochem Biophys Res Commun 436 (2), 306-312 (2013)
   PUBMED   23743196
  REMARK    GeneRIF: Results suggest a possible mechanism for Alkylglycerol
            monooxygenase (AGMO) in modulating macrophage platelet-activating
            factor (PAF) production by regulating cellular lyso-PAF levels.
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Watschinger,K., Keller,M.A., Golderer,G., Hermann,M., Maglione,M.,
            Sarg,B., Lindner,H.H., Hermetter,A., Werner-Felmayer,G., Konrat,R.,
            Hulo,N. and Werner,E.R.
  TITLE     Identification of the gene encoding alkylglycerol monooxygenase
            defines a third class of tetrahydrobiopterin-dependent enzymes
  JOURNAL   Proc Natl Acad Sci U S A 107 (31), 13672-13677 (2010)
   PUBMED   20643956
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK040702.1.
            
            On Dec 29, 2010 this sequence version replaced NM_178767.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040702.1, SRR1660811.168282.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2155              AK040702.1         2-2156
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.84 cM"
     gene            1..2155
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /note="alkylglycerol monooxygenase"
                     /db_xref="GeneID:319660"
                     /db_xref="MGI:MGI:2442495"
     exon            1..529
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1747
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /EC_number="1.14.16.5"
                     /note="transmembrane protein 195"
                     /codon_start=1
                     /product="alkylglycerol monooxygenase"
                     /protein_id="NP_848882.2"
                     /db_xref="CCDS:CCDS49052.1"
                     /db_xref="GeneID:319660"
                     /db_xref="MGI:MGI:2442495"
                     /translation="MRSPGAQDNVSVSQGMRAMFYMMEPSETAFQTVEEVPDYVKKAT
                     PFFIFLILLELVISWILKGKPSGRLDDALTSISAGVVSRLPSLFFRSLEVTSYIYIWE
                     NYRLLELPWDSTWTWYFTFLGVDFGYYWFHRMAHEINIFWAAHQAHHSSEDYNLSTAL
                     RQSVLQQYSSWVFYCPLALFIPPSVFAVHIQFNLLYQFWIHTEIIRTLGPLEVILNTP
                     SHHRVHHGRNRYCIDKNYAGTLIIWDRIFGTFEAENEQVIYGLTHPIGTFEPFNVQFH
                     HLLYIWTTFWTTPGFCHKFSVLFKGPGWGPGKPRLGLSEEIPEVTGQEVPFSSSASQL
                     LKIYTVLQFAVMLAFYEETFANTAVLSQVTLLLRIFFFILTLTSIGFLLDQRSKAATM
                     ETFRCLLFLTLHRFGHLKPLIPSLSFAFEIFFSVCIAFWGVRSITQLTSGSWKKP"
     exon            530..660
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            661..812
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            813..916
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1012
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1079
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1145
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1225
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1360
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1477
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1560
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1666
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..2155
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1946..1951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /note="hexamer: ACTAAA"
     polyA_site      1966
                     /gene="Agmo"
                     /gene_synonym="A530016O06Rik; Tmem195"
                     /note="major polyA site"
ORIGIN      
        1 acttgttcaa aaactggttt gtttgctggg ttacctcttt cattttcaaa ggcacagtta
       61 cgtaagcttt atttgttttt ctttacttct cgtttcagtt gttgattagt tacttaagca
      121 acaggcaaac tgcattgttt gcttgtttct gtacgtcttc cttgttcccc cacttcctct
      181 tcctggggaa tcttccactg aactgtgaac ctactcttgc tgctagtgtt ctgtgccttt
      241 gcacacaaac tctgctgttg gctgaggtct ctgtggatct ttgttctcag ctcttctctg
      301 acaaggctcg ctctgtgcta cactgttcct tttctttgtt cagtcttgca cttctgccac
      361 agaaccacaa atatctccag ctggaaatca gacaggaaca gaaatgagga gcccaggagc
      421 ccaagacaat gtttcagttt ctcagggtat gcgagcgatg ttttacatga tggagcccag
      481 tgaaactgcc ttccaaactg ttgaagaggt gcctgattac gtaaaaaagg cgactccatt
      541 ttttatcttc ttgattctgc ttgaactagt catcagctgg attctcaaag ggaaaccatc
      601 aggtcgtttg gatgatgctc tcacatctat atcagctggt gttgtgtctc ggcttccaag
      661 tctgttcttc aggagccttg aagtgaccag ttatatttat atctgggaaa actacagact
      721 tttggaattg ccttgggatt ctacctggac gtggtatttc actttcttag gagttgactt
      781 tggctactac tggttccacc gcatggctca tgagattaat attttctggg cagcacacca
      841 agcacaccac agttctgaag actataactt atccacagca ctgagacagt ctgtcttgca
      901 gcagtatagt tcctgggttt tctactgtcc actggccctt ttcataccac cttcagtgtt
      961 tgctgttcat attcaattca atctcctcta ccaattttgg atccacacag agatcatcag
     1021 aacccttggc cctttggaag tgatccttaa tactcctagc catcacagag ttcatcatgg
     1081 tagaaatcgt tactgcattg ataaaaacta tgctggcact cttattattt gggatagaat
     1141 ttttgggaca tttgaagcag agaatgagca ggtcatatat ggtctaaccc atcccattgg
     1201 tacatttgag ccattcaacg tgcagtttca ccatttactt tatatatgga ctacattctg
     1261 gaccacacct ggattctgcc ataagttttc tgtcctattt aaaggaccag gatggggtcc
     1321 aggtaaacca agacttggcc tgagtgaaga aattccagag gttacaggac aggaagtccc
     1381 cttctcatcc tcagcatccc agcttttaaa gatctacact gtcctccagt ttgcagtaat
     1441 gctggcattt tatgaagaga cctttgcaaa cacagcggta ctgtcccagg tcactcttct
     1501 tctgagaatc ttcttcttta tcctgacctt gacgtccatt ggttttcttc tggaccaaag
     1561 atccaaggca gctactatgg aaactttccg gtgcctgttg ttcctaaccc tgcacagatt
     1621 tggtcactta aagcctctta ttccatcttt atcttttgca tttgagattt tcttttcggt
     1681 ttgcattgct ttctggggcg taagaagcat aacacaactc acctctggct cttggaaaaa
     1741 gccttaatgc atacagatcc accggtcctg tcagttctcc gtcctgcatc accatagtac
     1801 atcatcacag agaaagagtg gtatcttaca tggtacctac aagagcaact tagttaatga
     1861 aaaatgaaaa catttcttta cctatgctgt tcacatttgt ttttctgttg aaattactat
     1921 gaattattat ttttattttg ctctcactaa aacctatcca tatccattga ggctatattc
     1981 atttctctct gtggcaatga ataaggaaag gaaacagggg cataaatttg tttaaagagt
     2041 gaaaattatg tttgtcttct tggtttgata gctgatcctt taacattttt taaaagtata
     2101 tacatagata catctctgtt gtatttaaaa tatattgttg tgtgtgtgaa cctgc
//
