LOCUS       NM_023538               2225 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus acylglycerol kinase (Agk), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_023538
VERSION     NM_023538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   Jiang,H., Yu,Z., Ding,N., Yang,M., Zhang,L., Fan,X., Zhou,Y.,
            Zou,Q., Hou,J., Zheng,J., Zhang,L., Xu,Y. and Liu,J.
  TITLE     The role of AGK in thrombocytopoiesis and possible therapeutic
            strategies
  JOURNAL   Blood 136 (1), 119-129 (2020)
   PUBMED   32202634
  REMARK    GeneRIF: The role of AGK in thrombocytopoiesis and possible
            therapeutic strategies.
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Hu,Z., Qu,G., Yu,X., Jiang,H., Teng,X.L., Ding,L., Hu,Q., Guo,X.,
            Zhou,Y., Wang,F., Li,H.B., Chen,L., Jiang,J., Su,B., Liu,J. and
            Zou,Q.
  TITLE     Acylglycerol Kinase Maintains Metabolic State and Immune Responses
            of CD8+ T Cells
  JOURNAL   Cell Metab 30 (2), 290-302 (2019)
   PUBMED   31204281
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Wang,X., Lin,C., Zhao,X., Liu,A., Zhu,J., Li,X. and Song,L.
  TITLE     Acylglycerol kinase promotes cell proliferation and tumorigenicity
            in breast cancer via suppression of the FOXO1 transcription factor
  JOURNAL   Mol Cancer 13, 106 (2014)
   PUBMED   24886245
  REMARK    GeneRIF: AGK promotes cell proliferation and tumorigenicity in
            breast cancer via suppression of the FOXO1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2225)
  AUTHORS   Mortensen,M., Ferguson,D.J., Edelmann,M., Kessler,B., Morten,K.J.,
            Komatsu,M. and Simon,A.K.
  TITLE     Loss of autophagy in erythroid cells leads to defective removal of
            mitochondria and severe anemia in vivo
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 832-837 (2010)
   PUBMED   20080761
REFERENCE   5  (bases 1 to 2225)
  AUTHORS   Epand,R.M., Shulga,Y.V., Timmons,H.C., Perri,A.L., Belani,J.D.,
            Perinpanathan,K., Johnson-McIntire,L.B., Bajjalieh,S., Dicu,A.O.,
            Elias,C., Rychnovsky,S.D. and Topham,M.K.
  TITLE     Substrate chirality and specificity of diacylglycerol kinases and
            the multisubstrate lipid kinase
  JOURNAL   Biochemistry 46 (49), 14225-14231 (2007)
   PUBMED   18004883
REFERENCE   6  (bases 1 to 2225)
  AUTHORS   Van Overloop,H., Gijsbers,S. and Van Veldhoven,P.P.
  TITLE     Further characterization of mammalian ceramide kinase: substrate
            delivery and (stereo)specificity, tissue distribution, and
            subcellular localization studies
  JOURNAL   J Lipid Res 47 (2), 268-283 (2006)
   PUBMED   16269826
REFERENCE   7  (bases 1 to 2225)
  AUTHORS   Waggoner,D.W., Johnson,L.B., Mann,P.C., Morris,V., Guastella,J. and
            Bajjalieh,S.M.
  TITLE     MuLK, a eukaryotic multi-substrate lipid kinase
  JOURNAL   J Biol Chem 279 (37), 38228-38235 (2004)
   PUBMED   15252046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153728.1.
            
            On Feb 2, 2010 this sequence version replaced NM_023538.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093525.1, AJ401619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC153728.1         121878-121930       c
            54-160              AC153728.1         117809-117915       c
            161-200             AC153728.1         99957-99996         c
            201-280             AC153728.1         94976-95055         c
            281-356             AC153728.1         90288-90363         c
            357-449             AC153728.1         83041-83133         c
            450-482             AC153728.1         80635-80667         c
            483-577             AC153728.1         78733-78827         c
            578-647             AC153728.1         71117-71186         c
            648-727             AC153728.1         66125-66204         c
            728-785             AC153728.1         63591-63648         c
            786-933             AC153728.1         60447-60594         c
            934-1031            AC153728.1         59867-59964         c
            1032-1102           AC153728.1         54685-54755         c
            1103-1187           AC153728.1         52710-52794         c
            1188-2225           AC153728.1         50646-51683         c
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.82 cM"
     gene            1..2225
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /note="acylglycerol kinase"
                     /db_xref="GeneID:69923"
                     /db_xref="MGI:MGI:1917173"
     exon            1..53
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            54..160
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            161..200
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            201..280
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            281..356
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            357..449
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            450..482
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            483..577
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            578..647
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            648..727
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            728..785
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            786..933
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1031
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1102
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1187
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..2225
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2193..2198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /note="hexamer: AATAAA"
     polyA_site      2225
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /note="major polyA site"
ORIGIN      
        1 gagagttttg tgagagcaca caggaaaggc cgggcgctga gcggcgggca gcggagaaga
       61 tgactgcatt ctttaaaacg cttcgaaatc attggaagaa aactacagct gggctctgtt
      121 tgctgacatg gggaggtcac tggctctacg ggaagcactg tgataacctg ctaagaagag
      181 cagcctgtca agaagctcag gtgtttggca accagctcat tcctcccaat gcacaagtga
      241 agaaagccac cgtctttctc aatcccgcag cttgcaaagg caaagccaga actctatttg
      301 aaaaaaatgc tgctccaatt ttacacctgt ctggcatgga tgtgactgtt gtcaagacgg
      361 attatgaggg acaagccaag aagctcttgg agttgatgga aagcactgat gtgatcattg
      421 ttgctggagg agacggcaca ctgcaggagg ttgttactgg agtactgaga agaacagatg
      481 aggctacctt cagtaagatt cccattggat ttatcccgct gggacagacc agtagtttga
      541 gtcacactct ctttgctgaa agtggaaaca aagtccaaca tattacagac gccacacttg
      601 ccattgtgaa aggagagact gttccacttg atgtcttgca gatcaagggt gaaaaagaac
      661 aacctgtgta tgcaatgact ggcctccggt ggggatcttt cagagatgct ggcgtcaaag
      721 ttagcaagta ctggtatctt ggtccactaa aaaccaaagc agcccacttt ttcagcactc
      781 ttcaggaatg gcctcagact catcaagcct ccatctctta cacgggacct agagagagac
      841 ctcccattga gcctgaagag actcctccca ggccgtctct gtataggaga atattacgca
      901 ggcttgcctc attctgggca cagccacagg atgcctcctc ccgagaggta agccctgagg
      961 tctggaaaga tgtacaactg tccaccattg aactgtccat cacaacccga aacacccaac
     1021 ttgacctgat gagcaaagag gattttatga acatttgcat tgaacctgac actgtcagca
     1081 aaggagattt cataatcata ggaagtaaga aggtgagaga ccctggcctg cgtgcagctg
     1141 gcaccgagtg cctccaagcc agccactgta ctctggttct tcctgaggga actgagggct
     1201 ccttcagcat tgacagcgag gagtacgaag ccatgccggt ggaggtcaaa ctactgccca
     1261 gaaagctgcg gttcttctgt gatccgagga agagagagca aatgctgccg agcacatccc
     1321 agtgagcgac agcgtggcgg gcactcccag gctgcactgc aagccaccag tgggaccaca
     1381 tgggggatgt gtgtgcttct gtccccagag ggtcacagga tcccaaggga attttcatgg
     1441 caagtacccc cagccctcct gtttgcttcc tagagcacat accatgtcat gcacttgttt
     1501 gtggtcagta ccctgttaac cctcgctttc cttatgttga ggtagttgat ccctcttaca
     1561 cagtggttgt ctcaggctgg gtctagaacg ttcttgtact ccctgagttg ggaagggctg
     1621 gagttttgtg attgtcccac agtggagagt ggaatctgta gaccaagttc ctgtttcggt
     1681 tctctgaccg tcctggggca ccccggggag gcagctgctg tctccgggag cctcgccctc
     1741 tttctgggct ctctcatggg tgctgctcct ttgtgagctc tctgctttgg ttggttggtc
     1801 tcatccggaa agcaaatgtg aggttgttcc ctctttagcc atggcagacg tattgtaaaa
     1861 tgctatttta aaacaaacta gtgcttcctc attgttagtt tgcatgtgta caactgaggc
     1921 gcatgttgaa aactaactga cctgggacct acccccaggt tgactttgta actcaacctg
     1981 gcaggaagct agggttcttc atttttaaaa aactgcttcc ccaggtgaat caaccatacc
     2041 gggagaaagt gttttaaatc tacttcataa acttaaatgt attatatata tatatttttt
     2101 aaaatcacat atttgtgttg acatctattg tttccatggg aagttaaaca cttgtcagtg
     2161 tacttactag tattgtgtaa atattgttta aaaataaaaa ctgtttgatc attcttttaa
     2221 acata
//
