LOCUS       NP_076027                421 aa            linear   ROD 31-MAY-2024
DEFINITION  acylglycerol kinase, mitochondrial precursor [Mus musculus].
ACCESSION   NP_076027
VERSION     NP_076027.1
DBSOURCE    REFSEQ: accession NM_023538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 421)
  AUTHORS   Jiang,H., Yu,Z., Ding,N., Yang,M., Zhang,L., Fan,X., Zhou,Y.,
            Zou,Q., Hou,J., Zheng,J., Zhang,L., Xu,Y. and Liu,J.
  TITLE     The role of AGK in thrombocytopoiesis and possible therapeutic
            strategies
  JOURNAL   Blood 136 (1), 119-129 (2020)
   PUBMED   32202634
  REMARK    GeneRIF: The role of AGK in thrombocytopoiesis and possible
            therapeutic strategies.
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Hu,Z., Qu,G., Yu,X., Jiang,H., Teng,X.L., Ding,L., Hu,Q., Guo,X.,
            Zhou,Y., Wang,F., Li,H.B., Chen,L., Jiang,J., Su,B., Liu,J. and
            Zou,Q.
  TITLE     Acylglycerol Kinase Maintains Metabolic State and Immune Responses
            of CD8+ T Cells
  JOURNAL   Cell Metab 30 (2), 290-302 (2019)
   PUBMED   31204281
REFERENCE   3  (residues 1 to 421)
  AUTHORS   Wang,X., Lin,C., Zhao,X., Liu,A., Zhu,J., Li,X. and Song,L.
  TITLE     Acylglycerol kinase promotes cell proliferation and tumorigenicity
            in breast cancer via suppression of the FOXO1 transcription factor
  JOURNAL   Mol Cancer 13, 106 (2014)
   PUBMED   24886245
  REMARK    GeneRIF: AGK promotes cell proliferation and tumorigenicity in
            breast cancer via suppression of the FOXO1.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 421)
  AUTHORS   Mortensen,M., Ferguson,D.J., Edelmann,M., Kessler,B., Morten,K.J.,
            Komatsu,M. and Simon,A.K.
  TITLE     Loss of autophagy in erythroid cells leads to defective removal of
            mitochondria and severe anemia in vivo
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 832-837 (2010)
   PUBMED   20080761
REFERENCE   5  (residues 1 to 421)
  AUTHORS   Epand,R.M., Shulga,Y.V., Timmons,H.C., Perri,A.L., Belani,J.D.,
            Perinpanathan,K., Johnson-McIntire,L.B., Bajjalieh,S., Dicu,A.O.,
            Elias,C., Rychnovsky,S.D. and Topham,M.K.
  TITLE     Substrate chirality and specificity of diacylglycerol kinases and
            the multisubstrate lipid kinase
  JOURNAL   Biochemistry 46 (49), 14225-14231 (2007)
   PUBMED   18004883
REFERENCE   6  (residues 1 to 421)
  AUTHORS   Van Overloop,H., Gijsbers,S. and Van Veldhoven,P.P.
  TITLE     Further characterization of mammalian ceramide kinase: substrate
            delivery and (stereo)specificity, tissue distribution, and
            subcellular localization studies
  JOURNAL   J Lipid Res 47 (2), 268-283 (2006)
   PUBMED   16269826
REFERENCE   7  (residues 1 to 421)
  AUTHORS   Waggoner,D.W., Johnson,L.B., Mann,P.C., Morris,V., Guastella,J. and
            Bajjalieh,S.M.
  TITLE     MuLK, a eukaryotic multi-substrate lipid kinase
  JOURNAL   J Biol Chem 279 (37), 38228-38235 (2004)
   PUBMED   15252046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153728.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093525.1, AJ401619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.82 cM"
     Protein         1..421
                     /product="acylglycerol kinase, mitochondrial precursor"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.94"
                     /EC_number="2.7.1.138"
                     /note="multiple substrate lipid kinase; acylglycerol
                     kinase, mitochondrial; multi-substrate lipid kinase"
                     /calculated_mol_wt=46845
     Site            6
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q53H12; propagated from
                     UniProtKB/Swiss-Prot (Q9ESW4.1)"
     Region          15..31
                     /region_name="Hydrophobic.
                     /evidence=ECO:0000250|UniProtKB:Q53H12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESW4.1)"
     Region          62..195
                     /region_name="DAGK_cat"
                     /note="Diacylglycerol kinase catalytic domain; pfam00781"
                     /db_xref="CDD:425868"
     Region          206..420
                     /region_name="AGK_C"
                     /note="Acylglycerol kinase C-terminal; pfam19712"
                     /db_xref="CDD:466156"
     Region          252..271
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESW4.1)"
     CDS             1..421
                     /gene="Agk"
                     /gene_synonym="2610037M15Rik; 6720408I04Rik; Mulk"
                     /coded_by="NM_023538.2:60..1325"
                     /db_xref="CCDS:CCDS20027.1"
                     /db_xref="GeneID:69923"
                     /db_xref="MGI:MGI:1917173"
ORIGIN      
        1 mtaffktlrn hwkkttaglc lltwgghwly gkhcdnllrr aacqeaqvfg nqlippnaqv
       61 kkatvflnpa ackgkartlf eknaapilhl sgmdvtvvkt dyegqakkll elmestdvii
      121 vaggdgtlqe vvtgvlrrtd eatfskipig fiplgqtssl shtlfaesgn kvqhitdatl
      181 aivkgetvpl dvlqikgeke qpvyamtglr wgsfrdagvk vskywylgpl ktkaahffst
      241 lqewpqthqa sisytgprer ppiepeetpp rpslyrrilr rlasfwaqpq dassrevspe
      301 vwkdvqlsti elsittrntq ldlmskedfm niciepdtvs kgdfiiigsk kvrdpglraa
      361 gteclqashc tlvlpegteg sfsidseeye ampvevkllp rklrffcdpr kreqmlpsts
      421 q
//
