LOCUS       NM_025630               3262 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus angiogenic factor with G patch and FHA domains 1
            (Aggf1), mRNA.
ACCESSION   NM_025630
VERSION     NM_025630.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3262)
  AUTHORS   Da,X., Li,Z., Huang,X., He,Z., Yu,Y., Tian,T., Xu,C., Yao,Y. and
            Wang,Q.K.
  TITLE     AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing
            integrin alpha7-mediated inhibition of TGF-beta1 maturation and
            ERK1/2 signaling
  JOURNAL   Nat Commun 14 (1), 2265 (2023)
   PUBMED   37081014
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3262)
  AUTHORS   Yu,Y., Li,Y., Peng,H., Song,Q., Da,X., Li,H., He,Z., Ren,X., Xu,C.,
            Yao,Y. and Wang,Q.K.
  TITLE     Angiogenic factor AGGF1 blocks neointimal formation after vascular
            injury via interaction with integrin alpha7 on vascular smooth
            muscle cells
  JOURNAL   J Biol Chem 298 (4), 101759 (2022)
   PUBMED   35202649
  REMARK    GeneRIF: Angiogenic factor AGGF1 blocks neointimal formation after
            vascular injury via interaction with integrin alpha7 on vascular
            smooth muscle cells.
REFERENCE   3  (bases 1 to 3262)
  AUTHORS   Wang,J., Peng,H., Timur,A.A., Pasupuleti,V., Yao,Y., Zhang,T.,
            You,S.A., Fan,C., Yu,Y., Jia,X., Chen,J., Xu,C., Chen,Q. and
            Wang,Q.
  TITLE     Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial
            Cell Functions and Angiogenesis
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (11), 2756-2769 (2021)
   PUBMED   34551592
  REMARK    GeneRIF: Receptor and Molecular Mechanism of AGGF1 Signaling in
            Endothelial Cell Functions and Angiogenesis.
REFERENCE   4  (bases 1 to 3262)
  AUTHORS   Li,R., Yao,G., Zhou,L., Zhang,M., Yan,J., Wang,X. and Li,Y.
  TITLE     Autophagy is required for the promoting effect of angiogenic factor
            with G patch domain and forkhead-associated domain 1 (AGGF1) in
            retinal angiogenesis
  JOURNAL   Microvasc Res 138, 104230 (2021)
   PUBMED   34339727
  REMARK    GeneRIF: Autophagy is required for the promoting effect of
            angiogenic factor with G patch domain and forkhead-associated
            domain 1 (AGGF1) in retinal angiogenesis.
REFERENCE   5  (bases 1 to 3262)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3262)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3262)
  AUTHORS   Lu,Q., Yao,Y., Yao,Y., Liu,S., Huang,Y., Lu,S., Bai,Y., Zhou,B.,
            Xu,Y., Li,L., Wang,N., Wang,L., Zhang,J., Cheng,X., Qin,G., Ma,W.,
            Xu,C., Tu,X. and Wang,Q.
  TITLE     Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a
            mouse limb ischemia model
  JOURNAL   PLoS One 7 (10), e46998 (2012)
   PUBMED   23110058
REFERENCE   8  (bases 1 to 3262)
  AUTHORS   Li,M.H., Hla,T. and Ferrer,F.
  TITLE     Sphingolipid modulation of angiogenic factor expression in
            neuroblastoma
  JOURNAL   Cancer Prev Res (Phila) 4 (8), 1325-1332 (2011)
   PUBMED   21576349
  REMARK    GeneRIF: Sphingolipid modulation of angiogenic factor expression in
            neuroblastoma
REFERENCE   9  (bases 1 to 3262)
  AUTHORS   Mueller,C.F., Berger,A., Zimmer,S., Tiyerili,V. and Nickenig,G.
  TITLE     The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor
            gene expression via transcriptional and posttranscriptional
            mechanisms
  JOURNAL   Arch Biochem Biophys 488 (1), 76-82 (2009)
   PUBMED   19508861
REFERENCE   10 (bases 1 to 3262)
  AUTHORS   Tian,X.L., Kadaba,R., You,S.A., Liu,M., Timur,A.A., Yang,L.,
            Chen,Q., Szafranski,P., Rao,S., Wu,L., Housman,D.E.,
            DiCorleto,P.E., Driscoll,D.J., Borrow,J. and Wang,Q.
  TITLE     Identification of an angiogenic factor that when mutated causes
            susceptibility to Klippel-Trenaunay syndrome
  JOURNAL   Nature 427 (6975), 640-645 (2004)
   PUBMED   14961121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132575.1, BC052410.1 and AA138180.1.
            
            On Aug 9, 2013 this sequence version replaced NM_025630.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052410.1, AY500995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AK132575.1         2-24
            24-3221             BC052410.1         1-3198
            3222-3262           AA138180.1         1-41                c
FEATURES             Location/Qualifiers
     source          1..3262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.41 cM"
     gene            1..3262
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /note="angiogenic factor with G patch and FHA domains 1"
                     /db_xref="GeneID:66549"
                     /db_xref="MGI:MGI:1913799"
     exon            1..512
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2435
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /note="angiogenic factor VG5Q"
                     /codon_start=1
                     /product="angiogenic factor with G patch and FHA domains
                     1"
                     /protein_id="NP_079906.2"
                     /db_xref="CCDS:CCDS26697.1"
                     /db_xref="GeneID:66549"
                     /db_xref="MGI:MGI:1913799"
                     /translation="MASEAPSPPSPSPPPPASPEPELAQLRRKVEKLERELRSCRRQV
                     REVEKLLQHTERLYRNAESDNQELRTQVEELSKILHCGKNEDNPKSDVEVQTESQAPW
                     AISDYYYQTCYNDDSLPSKETELCVQQSQCAQASALDPQDESHIDSGSYAGADATEGV
                     SHRQEDAVTSDSQESVSALAEGPALEGSSLAESLRAAAEAAVSQTGFTYDESTGLYFD
                     HSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSSTKPNRERRLKK
                     RRKEPGFYTANEEKDLSSEDQKVCSVEYINCSEDEHSGNVKKKARTDTSHKSSPLQLT
                     VAVSGDTVESPGDDNSASSKDERIGESESEPEEGEITDSQSEKSYDGDSSSGDRETSE
                     ESDDEDEERIWPPCIRVIVIRSPVLQMGSLFIITAVSPATIGREKDMEHTVRIPEVAV
                     SKFHAEVYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETV
                     LSFHIHPGSETCDGCEPGQVRAHLRLDRKDEPLVGPALSKEEKELERRKALKKIRVKY
                     GLQNTDYEAEKALKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKML
                     EKMGWKRGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKLSSIDDVHLIQNKSKKHWDKA
                     RERFAETFTENKPRKETPGAVPWVTGTAE"
     exon            513..615
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            616..818
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            819..980
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1169
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1491
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1603
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1655
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1757
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1923
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2006
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2134
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2234
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..3254
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3200..3205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /note="hexamer: AATAAA"
     polyA_site      3223
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /note="hexamer: AATAAA"
     polyA_site      3254
                     /gene="Aggf1"
                     /gene_synonym="2010009L17Rik; 2310029P06Rik; Peg3; VG5Q"
                     /note="major polyA site"
ORIGIN      
        1 ccggctcagc ccggaactag aggcttccgc tgggttcgct ttagttctcc cgtccgctgg
       61 cttcccggag actgtcaccg ggcgggtgtc cgcgcggccc gggtagagtc ggcttcgtcc
      121 ccaagctcgc agtcccggcc gccgtcttcg ggggcgacat ggccggggcc cgctgcggtc
      181 gtccgagcgt gaggccgccc ctcgcagccc gcgcgctcca gtggcccctg ggccagtggg
      241 ccccggtgtc gtcctaagca gcccggtccg cgccccgcgg gctcggcgct cacggccgca
      301 tggcctccga ggcgccctcg ccgccttcgc cttctccgcc gccgcccgcc tctccggagc
      361 cggagctggc gcagctcagg cggaaggtgg agaagttgga gcgcgagctg cggagctgcc
      421 ggaggcaggt gcgggaggtg gagaagctgc tgcagcacac ggagcgactc taccgcaacg
      481 ccgagagcga caaccaggag ctccgcacgc aggtagaaga acttagtaaa atactccatt
      541 gtgggaaaaa tgaagataat ccgaagtctg atgtagaagt acagacagag agccaagctc
      601 cttgggcgat ttcagattat tactatcaga catgttataa tgacgacagt cttcccagta
      661 aagagacgga gctgtgtgta cagcagagtc agtgtgctca ggcttccgct cttgatcctc
      721 aggacgagtc acacatagac agcgggagtt atgctggtgc tgatgccaca gaaggtgtta
      781 gccatagaca ggaggacgcc gtcacctctg actcacagga gagtgtgtcc gcgctagcag
      841 aaggcccagc actcgaaggg tcctcgcttg ctgagagctt gagagctgca gcggaggctg
      901 ctgtgtcgca gaccggcttc acctacgacg agagcacggg cttatatttt gaccacagca
      961 ctggtttcta ttatgattct gaaaaccagc tgtattatga cccttccacg gggatttatt
     1021 actactgcga tgtggagagt ggtcggtacc agtttcactc tcgcgtagac ctgcagcctt
     1081 accagacctc tagcacaaaa ccaaacagag aaagaagact gaagaagaga agaaaggagc
     1141 caggttttta tacagcaaat gaagaaaagg atttgagctc agaagatcag aaagtctgca
     1201 gtgtagaata tataaactgc agtgaggatg aacattctgg aaatgtgaaa aagaaggcca
     1261 gaacagacac ttctcacaaa agcagtccct tacagctcac ggtggcagtt agtggagaca
     1321 ctgtggagtc tcctggagat gataactcag cgtcatctaa ggatgagaga atcggagaga
     1381 gtgagagcga gccggaagaa ggtgagatca cagactctca gagtgagaag agctatgatg
     1441 gagacagtag cagtggggac agggagacct cagaagaatc cgacgatgaa gatgaggaaa
     1501 gaatttggcc gccctgtatt cgcgtgattg tcattaggtc tccagtgttg cagatgggct
     1561 cgctgttcat catcaccgct gtgagcccag ccaccattgg gagagagaag gacatggagc
     1621 atactgtgag aatccctgaa gtcgctgtta gtaagttcca cgcagaagtt tacttcgacc
     1681 atgacttgca aagctacgtt cttgtggatc agggcagcca gaatggtacc attgtcaacg
     1741 ggaaacagat tcttcagcca aaaactaaat gtgatcctta cgtcctcgaa cacggcgacg
     1801 aagtgaaaat tggggagact gtgctgtctt ttcacattca ccctggcagt gagacgtgcg
     1861 atggctgtga gccggggcag gtcagagctc acctccgcct cgatagaaag gacgagcctc
     1921 tggtcggtcc agcactaagt aaggaggaaa aagagttgga aagaagaaaa gcactcaaga
     1981 aaatacgagt aaagtatggc ttgcagaata cagattatga agctgaaaaa gcgttgaaga
     2041 atcctaagta taaagacaga gctggaaaac gcagggagca ggtgggaagc gaagggactt
     2101 tccaaagaga tgacgcccct gcgtctgttc actctgaaat tacagatagc aacaaaggcc
     2161 gaaagatgtt ggagaagatg gggtggaaac ggggagaagg cctgggaaag gacggtggag
     2221 ggatgaaaac gccgatccag cttcagcttc gacggacaca tgctggcttg gggacaggga
     2281 agctgtcctc gattgatgac gttcacctca tccagaataa gagcaaaaaa cactgggaca
     2341 aagcccggga gcggtttgcg gaaactttca cagaaaacaa acctcggaaa gagaccccag
     2401 gggcagtgcc gtgggtgaca gggactgcag agtaaaggcc tgtctgtcac acgggaactt
     2461 ggagcttcaa aagagaaaga gtttgaaaac ttcagtgtag aagctgtgtt cctagaaagt
     2521 cagtcactgg aggaactctt aagatggcta cctgatcgac acatgtgtgg ggacatgtgg
     2581 tttgtagctt gtagaaagca gttcttaagt gggctcaagg tgacaggcac aggagagctg
     2641 ccagaccttt gttgttgtgg cctgtcactc accctgtgga gagcagctga ccatgtgagc
     2701 agcgcacata accactaatg acttcagcgc gcgtgtcctg tctctgtcat cattaccatg
     2761 acacacagat atcagacatt tataaaacaa ttctatgtgt atacttgttt acacctttta
     2821 gagcttaggt ttttttttta aaaagtcgag aaaccatggg tagtggagcc taattttact
     2881 atccttgaaa taactgcagt aataatagtg aagaattgat gacaggtgac agattgtagg
     2941 aaattagtct cacactattt tcttctgtga agaatgttgt ttgtactaca gagtcagctt
     3001 tgcctttggt ttgtcctagc tgatggagta tttcatatag acgactgagt gcagtgctgg
     3061 catattcagt atgctagcat ttttagtttt gataaatacc attgcaggca atgggactgt
     3121 gctcgagaaa tctgatgact agggcagatg ggttactagg ccaaggcttc aaacatttac
     3181 tggaaatgtc ttcaaatgca ataaaaaaaa acatttttaa agacttgatt tcttgaataa
     3241 atgatataaa cataaaaaaa aa
//
