LOCUS       NM_178162               2920 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ArfGAP with FG repeats 2 (Agfg2), transcript variant
            2, mRNA.
ACCESSION   NM_178162
VERSION     NM_178162.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Panaro,M.A., Acquafredda,A., Calvello,R., Lisi,S., Dragone,T. and
            Cianciulli,A.
  TITLE     Organization patterns of the AGFG genes: an evolutionary study
  JOURNAL   Immunopharmacol Immunotoxicol 33 (1), 111-123 (2011)
   PUBMED   21284487
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Coda,L., Salcini,A.E., Confalonieri,S., Pelicci,G., Sorkina,T.,
            Sorkin,A., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Eps15R is a tyrosine kinase substrate with characteristics of a
            docking protein possibly involved in coated pits-mediated
            internalization
  JOURNAL   J Biol Chem 273 (5), 3003-3012 (1998)
   PUBMED   9446614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124730.5 and BC046788.1.
            
            On Dec 25, 2014 this sequence version replaced NM_178162.2.
            
            Summary: This gene encodes a paralog of the HIV-1 Rev binding
            proteins that serve as cellular co-factors for HIV-1 Rev protein in
            shuttling viral pre-mRNAs from the nucleus to the cytoplasm. The
            encoded protein contains an ADP-ribosylation factor GTPase
            activating protein (Arf-GAP) zinc finger domain, several
            phenylalanine-glycine (FG) motifs and
            asparagine-proline-phenylalanine (NPF) motifs. Alternate splicing
            of this gene results in multiple transcript variants. [provided by
            RefSeq, Dec 2014].
            
            Transcript Variant: This variant (2) encodes the shortest isoform
            (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046788.1, SRR13422598.878413.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC124730.5         145730-145865       c
            137-2541            BC046788.1         1-2405
            2542-2920           AC124730.5         111575-111953       c
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.59 cM"
     gene            1..2920
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /note="ArfGAP with FG repeats 2"
                     /db_xref="GeneID:231801"
                     /db_xref="MGI:MGI:2443267"
     exon            1..395
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1614
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /note="isoform 2 is encoded by transcript variant 2;
                     arf-GAP domain and FG repeats-containing protein 2; HIV-1
                     Rev-binding protein-like protein; rev/Rex activation
                     domain-binding protein related"
                     /codon_start=1
                     /product="arf-GAP domain and FG repeat-containing protein
                     2 isoform 2"
                     /protein_id="NP_835456.1"
                     /db_xref="CCDS:CCDS19774.1"
                     /db_xref="GeneID:231801"
                     /db_xref="MGI:MGI:2443267"
                     /translation="MVMAAKKGPGPGGGVGGSKAEAEAASEVWCRRVRELGGCSQAGN
                     RHCFECAQRGVTYVDITVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVLFLQSR
                     GNEVCRKIWLGLFDARTSLIPDSRDPQKVKEFLQEKYEKKRWYVPPEQVKGPSYSKGS
                     VSATPVQGSVPEGKPIRTLLGDPVPSLSDPASTSSQPGSQSQARSSSQARSSQPPSHS
                     STKKASTDLLADIGGDPFAAPQVVPAFASFPGFGVGQTPAHGGFANFDAFSSSPSSST
                     FGSLPPSVQAPFQAQPTPAGSGQMSAFGVAPLAAASQPNNLADVGGLLGPRMAAGGLP
                     GSVFGMPSQVPALQSAVPGVSGSGGLPFGAYTNPFATPAQAQLPSTNPFQPNGLASGP
                     GFGMSSVRPGLLQPVPPSGAFASPFSAPVFPTQAGLADQQNGSSFGDLGTSKLGQRPL
                     SQPAGISTNPFMTGSSAFASKPPTTNPFL"
     exon            396..489
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            490..605
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            606..762
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            763..931
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1060
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1181
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1264
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1345
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1474
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1560
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..2920
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /note="hexamer: AATATA"
     polyA_site      2411
                     /gene="Agfg2"
                     /gene_synonym="A630095P14Rik; Hrbl; RAB-R; RABR"
                     /note="major polyA site"
ORIGIN      
        1 aatcagcgtg ccgaacagga cgaggaaggg ggcggcagag tctctcgcgg tcgtggtcgg
       61 ggctgcagga gctggtgtca gggttgccgg gcgtgcgaag gcggcggagg cgggaaaggc
      121 agcgagcggt taaaggggag cgaccgctga cttgcagagg aacctggagg agagatggtg
      181 atggcggcta agaagggccc gggcccgggt ggcggggtcg gagggagcaa agcggaggct
      241 gaagccgctt cggaggtgtg gtgccgccga gtgcgggagc tgggcggctg cagccaggcc
      301 gggaaccgcc actgtttcga gtgcgcccag cgcggggtca cgtatgtgga catcaccgtg
      361 ggcagcttcg tctgcaccac ctgctccggc ctcctgagag gcctgaaccc ccctcatcga
      421 gtcaagtcaa tctccatgac aactttcact gagcctgaag tcctgttcct ccaatctcgt
      481 ggaaatgagg tctgtcggaa aatctggctc ggtctttttg atgctcggac atcgttgata
      541 ccagattcca gggatcctca gaaggtgaag gagtttctcc aagaaaaata tgagaaaaaa
      601 agatggtacg tccccccaga gcaagtcaag gggccctctt acagcaaagg cagtgtctct
      661 gctacccctg tccagggctc tgtcccagaa gggaaaccca ttcggacact tctgggagac
      721 cctgtgccat ctctctctga tcctgcttcc acttcaagcc agcctgggag ccagtcgcag
      781 gcacgcagca gctcgcaggc caggagctcc cagcctcctt cccattcatc caccaagaaa
      841 gccagcactg acctgctggc ggatatcggg ggagacccct ttgctgctcc ccaggtggtg
      901 ccagcctttg cctcattccc aggctttgga gtaggccaga ctcctgccca tggaggcttt
      961 gccaacttcg atgccttcag cagcagccct agctcttcca ccttcggaag cctccctcca
     1021 tccgtccaag cgccattcca ggcccagccg acccctgcag gaagtggcca gatgtctgcg
     1081 tttggtgtgg caccccttgc agctgccagt caacccaaca accttgcaga tgtgggcggc
     1141 ctcctgggtc ccaggatggc tgctggaggt ctccctggca gtgtttttgg gatgccgagc
     1201 caggttcctg ccctgcagtc ggccgtgcca ggtgttagcg gcagtggagg gctccccttt
     1261 ggagcctaca ccaacccctt cgccacccct gcccaagccc agctgccttc taccaaccca
     1321 ttccaaccca atggtctagc ctcagggcct ggctttggga tgagcagtgt tcggcctggc
     1381 cttctccagc cagtgccacc ctccggggcc tttgccagtc ccttctctgc acccgtgttc
     1441 cccacacagg ctggactggc cgaccagcag aatggatctt cctttggcga cttggggacc
     1501 tctaagctgg ggcagaggcc actgagccag ccggctggga tctctaccaa tcctttcatg
     1561 actggatcct cagcgtttgc ctccaaacct ccaaccacaa acccattctt gtagcactgt
     1621 gtcattgggg gaagaagggg ctctcccctc ctgggggtgt ggggaacaac ttctacttct
     1681 gcacccctca gagctctggt gaccatttgc ctgtggggca tttctgtggg tctgaggctg
     1741 ggattgggcc tgggttgcgg ggcttctgga tctgggaaga ggggaggttt agaagtgtga
     1801 cttggagatg actcagactc tagcctcctg gtctgccgcc caggggcttc ctcttccttg
     1861 ctggacacct acccaggaag aagcccacaa ggagcaaaga tactctcacc aggagacccc
     1921 atagtggtgt atttctgtca gattattaat tatgaagaca gtcttcgatc ctgtccctcc
     1981 tggcctgtgg ggagagaagc taggcacagc cccagccgca acttcctcca cacccaacct
     2041 tccaaagctg ccgctgtcct cccagatgga agcaaagctc gaatgtaggg taaagatgag
     2101 gcctggtgtt gaaagccacc agatagccct gggactgcgg agcttctggt gtctagtgtt
     2161 tttgtttgcc aggctcggcc acacccactt ctctccacct cagttcttcc tagctgcccc
     2221 ctcatcttgt ccgtcagggt gggggagttt gacctacaga gtatgcgtgc ccgcctcctg
     2281 tcaagcactt tagttagccc tgtcatgttt ggataccagt gttttatatt tataaataga
     2341 gacttttcta atatagccta ttatatacat aaataaatat atatatgcat acacatatgt
     2401 aaacagataa acaccgctgg ccattctttt tctcctagac aacccttgaa cttgggggac
     2461 ttgggtagga ggatcacaag ttcaagacta gcctggacaa ttttgggacc ctccgtctca
     2521 aaggaagaaa aaaaaaaaaa acaaaacgat aaaaagtaaa aacagagaac tcaggatgta
     2581 gttcagtggt agagcacttg tctagactcc tcctgggaac ttgaagaata gggtaactcc
     2641 tgcctgtgcc tggataatca aacccggagc cccagggctc aggggaggac aaccaagtgt
     2701 cctgacgctt tccacaatac acacgagaag gggtacccca gaggctaggc ttttccaatg
     2761 aaaagtctgc gattggctgg ggagtttggt tttttttttt tttttttctt cttttttcca
     2821 cattcctccc tctgttctca aatatctgca ccaaagcttg tttggaggca atgtcggaaa
     2881 agattgcgtt tgaaaggatt aaaaaaaaaa aaaaaaaaaa
//
