LOCUS       NM_001368850            7892 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ArfGAP with FG repeats 1 (Agfg1), transcript variant
            4, mRNA.
ACCESSION   NM_001368850 XM_006496433
VERSION     NM_001368850.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7892)
  AUTHORS   Bryant,J.M., Donahue,G., Wang,X., Meyer-Ficca,M., Luense,L.J.,
            Weller,A.H., Bartolomei,M.S., Blobel,G.A., Meyer,R.G., Garcia,B.A.
            and Berger,S.L.
  TITLE     Characterization of BRD4 during mammalian postmeiotic sperm
            development
  JOURNAL   Mol Cell Biol 35 (8), 1433-1448 (2015)
   PUBMED   25691659
REFERENCE   2  (bases 1 to 7892)
  AUTHORS   Khwaja,S.S., Liu,H., Tong,C., Jin,F., Pear,W.S., van Deursen,J. and
            Bram,R.J.
  TITLE     HIV-1 Rev-binding protein accelerates cellular uptake of iron to
            drive Notch-induced T cell leukemogenesis in mice
  JOURNAL   J Clin Invest 120 (7), 2537-2548 (2010)
   PUBMED   20516639
REFERENCE   3  (bases 1 to 7892)
  AUTHORS   Pryor,P.R., Jackson,L., Gray,S.R., Edeling,M.A., Thompson,A.,
            Sanderson,C.M., Evans,P.R., Owen,D.J. and Luzio,J.P.
  TITLE     Molecular basis for the sorting of the SNARE VAMP7 into endocytic
            clathrin-coated vesicles by the ArfGAP Hrb
  JOURNAL   Cell 134 (5), 817-827 (2008)
   PUBMED   18775314
  REMARK    GeneRIF: Study demonstrates that the clathrin-mediated endocytosis
            of the SNARE VAMP7 is directly mediated by Hrb, a clathrin adaptor
            and ArfGAP.
REFERENCE   4  (bases 1 to 7892)
  AUTHORS   Catena,R., Ronfani,L., Sassone-Corsi,P. and Davidson,I.
  TITLE     Changes in intranuclear chromatin architecture induce bipolar
            nuclear localization of histone variant H1T2 in male haploid
            spermatids
  JOURNAL   Dev Biol 296 (1), 231-238 (2006)
   PUBMED   16765935
REFERENCE   5  (bases 1 to 7892)
  AUTHORS   Brockschnieder,D., Sabanay,H., Riethmacher,D. and Peles,E.
  TITLE     Ermin, a myelinating oligodendrocyte-specific protein that
            regulates cell morphology
  JOURNAL   J Neurosci 26 (3), 757-762 (2006)
   PUBMED   16421295
REFERENCE   6  (bases 1 to 7892)
  AUTHORS   Kierszenbaum,A.L., Tres,L.L., Rivkin,E., Kang-Decker,N. and van
            Deursen,J.M.
  TITLE     The acroplaxome is the docking site of Golgi-derived myosin
            Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb
            mutant mouse spermatids
  JOURNAL   Biol Reprod 70 (5), 1400-1410 (2004)
   PUBMED   14724135
  REMARK    GeneRIF: Lack of an acrosome in Hrb mutant spermatids does not
            prevent the development of the acroplaxome. In the Hrb mutant,
            myosin-Va-bound proacrosome vesicles tether to the acroplaxome,
            where they flatten and form a flat sac, designated pseudoacrosome.
REFERENCE   7  (bases 1 to 7892)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7892)
  AUTHORS   Kang-Decker,N., Mantchev,G.T., Juneja,S.C., McNiven,M.A. and van
            Deursen,J.M.
  TITLE     Lack of acrosome formation in Hrb-deficient mice
  JOURNAL   Science 294 (5546), 1531-1533 (2001)
   PUBMED   11711676
  REMARK    GeneRIF: required for docking and/or fusion of proacrosomic
            vesicles during acrosome biogenesis
REFERENCE   9  (bases 1 to 7892)
  AUTHORS   Yamabhai,M., Hoffman,N.G., Hardison,N.L., McPherson,P.S.,
            Castagnoli,L., Cesareni,G. and Kay,B.K.
  TITLE     Intersectin, a novel adaptor protein with two Eps15 homology and
            five Src homology 3 domains
  JOURNAL   J Biol Chem 273 (47), 31401-31407 (1998)
   PUBMED   9813051
REFERENCE   10 (bases 1 to 7892)
  AUTHORS   Coda,L., Salcini,A.E., Confalonieri,S., Pelicci,G., Sorkina,T.,
            Sorkin,A., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Eps15R is a tyrosine kinase substrate with characteristics of a
            docking protein possibly involved in coated pits-mediated
            internalization
  JOURNAL   J Biol Chem 273 (5), 3003-3012 (1998)
   PUBMED   9446614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138214.8 and AC125444.9.
            
            On Mar 4, 2019 this sequence version replaced XM_006496433.3.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (4).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927935.2854473.1,
                                           SRR11927934.1724794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC138214.8         194644-195073
            431-524             AC125444.9         29770-29863
            525-640             AC125444.9         42099-42214
            641-803             AC125444.9         46702-46864
            804-957             AC125444.9         47585-47738
            958-1077            AC125444.9         51422-51541
            1078-1287           AC125444.9         53642-53851
            1288-1468           AC125444.9         54595-54775
            1469-1545           AC125444.9         57525-57601
            1546-1638           AC125444.9         57789-57881
            1639-1797           AC125444.9         64838-64996
            1798-1889           AC125444.9         65890-65981
            1890-7892           AC125444.9         66413-72415
FEATURES             Location/Qualifiers
     source          1..7892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 42.55 cM"
     gene            1..7892
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /note="ArfGAP with FG repeats 1"
                     /db_xref="GeneID:15463"
                     /db_xref="MGI:MGI:1333754"
     exon            1..430
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1949
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /note="isoform 4 is encoded by transcript variant 4;
                     arf-GAP domain and FG repeats-containing protein 1;
                     nucleoporin-like protein RIP; HIV-1 Rev-binding protein
                     homolog; HIV-1 Rev binding protein; arf-GAP domain and FG
                     repeat-containing protein 1"
                     /codon_start=1
                     /product="arf-GAP domain and FG repeat-containing protein
                     1 isoform 4"
                     /protein_id="NP_001355779.1"
                     /db_xref="CCDS:CCDS87854.1"
                     /db_xref="GeneID:15463"
                     /db_xref="MGI:MGI:1333754"
                     /translation="MAASAKRKQEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTV
                     GSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
                     AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPL
                     KSLLGESAPALHLNKGTPSQSPVVGRSQGQQQEKKQFDLLSDLGSDIFAAPAPQSTAT
                     ANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSSFQPQTTGGSAG
                     SVNANFAHFDNFPKSSSADFGTFSTSQSHQTASTVSKVSTNKAGLQTADKYAALANLD
                     NIFSAGQGGDQGSGFGTTGKAPVGSVVSVPSHSSASSDKYAALAELDSVFSSAATSSN
                     AYTPTSNASSSVFGTVPVGASAQTQPASSGPAPFGATPSTNPFVAATGPSAASSTNPF
                     QTNARGATAATFGTASMSMPAGFGTPAQYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQ
                     QPNGAGFATFGQTKPVVTPFGQVAAAGVSSNPFMTGAPTGQLPTGSSSTNPFL"
     exon            431..524
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            525..640
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            641..803
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            804..957
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1077
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1287
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1468
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1545
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1638
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1797
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1889
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..7892
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2547..2552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /note="hexamer: AATAAA"
     polyA_site      2564
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /note="major polyA site"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /note="hexamer: AAGAAA"
     polyA_site      3272
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /note="major polyA site"
     regulatory      7866..7871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
                     /note="hexamer: AATAAA"
     polyA_site      7892
                     /gene="Agfg1"
                     /gene_synonym="C130049H11Rik; D730048C23Rik; Hrb; RAB;
                     Rip"
ORIGIN      
        1 gtctttcccc cttaggagaa gtcgggaagg tggcagcggc ggcggtggcg gttgtcccgc
       61 ccggccggtt ggtgtgaccg gtcggcgcgt gctgcgcagc ttcctcgcct tgtcctgccc
      121 ggcggagccg agcggaggcc gagaccggag tccgcgaggg cggaggcggc ggcggccagg
      181 gcggcccgtg ggaagggagc gcggggcccc ggcagcgccg ccggctcccg gccctgccgg
      241 cctcctcggt cggagccgcg gccatggcgg ccagcgcgaa gcggaagcag gaggagaagc
      301 acctgaagat gctgcgggac atgacggggc tgccgcacaa ccgcaagtgt ttcgactgcg
      361 accagcgcgg ccccacctac gtgaacatga cggtcggctc gttcgtgtgc acctcctgct
      421 ccggcagcct gagagggtta aatccacctc acagggtgaa atctatctcc atgacaacat
      481 ttacacaaca ggaaattgaa ttcctacaaa aacatggaaa tgaagtctgc aaacagatat
      541 ggctaggatt atttgatgac agatcttcag caattccaga cttcagggat ccacaaaaag
      601 tgaaagagtt tctacaagag aaatatgaaa agaaaagatg gtatgttccg ccagagcaag
      661 ccaaagtggt ggcctcggtt catgcgtcta tttcagggtc ttctgccagc agcacaagca
      721 gcaccccgga ggtcaagccc ctgaaatccc tgttgggaga gtctgcaccc gcactgcacc
      781 taaataaggg cacacctagt cagtccccag ttgtaggtcg ctctcaaggg cagcagcagg
      841 agaagaagca gtttgacctt ttgagtgatc ttggctcaga catctttgct gctccagctc
      901 ctcagtcaac agctacagcc aattttgcta actttgcaca ctttaacagt catgcagctc
      961 agaattctgc aaatgcagat tttgcaaact ttgatgcatt tggacagtct agtggttcga
     1021 gtaattttgg aggtttcccc acagcaagtc actcttcttt tcagccccag actacaggtg
     1081 gaagtgctgg atcagtaaat gctaattttg ctcattttga taacttccct aaatcctcca
     1141 gtgctgattt tggaaccttc agtacatccc agagtcatca gacagcatca actgttagta
     1201 aagtttcaac aaacaaagct ggtttacaga cagcagacaa atatgcggca cttgctaatt
     1261 tagacaatat cttcagtgct gggcaaggag gtgatcaagg gagtggtttt gggaccacgg
     1321 gtaaagctcc tgttggttct gtggtttcag ttcccagtca ttcaagtgca tcttcagaca
     1381 agtatgcagc cctggcagag ttagacagcg tgttcagctc tgcagccacc tccagtaatg
     1441 cgtacacgcc caccagtaat gctagcagca gtgtctttgg aacagtgcct gtgggtgcct
     1501 ctgctcagac acaacctgct tcaagtggtc ctgctccgtt tggggctacg ccttctacga
     1561 atccatttgt tgctgctact ggtccttctg cggcatcgtc tacaaaccca tttcagacca
     1621 atgccagagg agcaacagcg gcaacctttg gcaccgcatc tatgagtatg ccagcaggat
     1681 ttggcactcc tgcccagtat agtctcccta ccagctttag tggcagtttc cagcagcctg
     1741 ccttcccagc ccaagcagct ttccctcagc agacagcctt ttctcaacag cccaatggtg
     1801 caggtttcgc cacgtttgga caaacaaaac cagtggtaac ccctttcggt caagtagcag
     1861 ctgctggagt gtctagtaat ccttttatga ctggtgcgcc gacaggacaa cttccaacag
     1921 gaagctcatc caccaaccct ttcttatagc cttacttaga ctctgtaccg gaacgaacgt
     1981 ttatgtgacc atattacatc tcttcgcctc ttgcactgtt gtcttgtttc actgatctta
     2041 gctttaaaca tgaaagaagt ccttaaaatg cctgcactgt gtattaaaca ccaggtaata
     2101 tgtgcaaaac agagggctca gcaacaactt ttcacttgtg aattggcagg aaaaggtagc
     2161 ggcatcatgt aagttaaaaa ttggctaatg ttaagttatt gcagatccca cattcattat
     2221 gctgcagtac tgtacatatt tttcttagaa attagctatt tgtgcatatc agtatttgta
     2281 actttaacac attgttatgt gagaaatgtt actggggaaa tagatgagcc acttttaagg
     2341 tgctgtcata tagcttggaa tgaatgatta aaatcatttg aagcattgct tctgggaaat
     2401 tcaaattgga aggttttatt cattcttgaa tttttccttc tcaagagctc ttctattcat
     2461 acacggctaa gttctttaaa gatgtggagg acacctgtct gcggaataaa gctgatcatg
     2521 ttttgctaca gtttgcaggt gaacaaaata aatcttagaa aatatgctat tgtttttgtg
     2581 ttcttgctgc aatgccttta ccaaagtggc cttaaatgta atgagtagtg agttgagaac
     2641 atcttgaact cttaaagact tctagtgact aacttttttt aaaaggccat gtagaaaatt
     2701 tattaaaact actaggactg ctatattcag gaatgtgaca gtggaaaagc atttaaatgt
     2761 agcttgtcag attcaccatg ctacttctaa tttctctgca acttcttaat tttgtgaaat
     2821 ttgtaaatat ggagaatttg catgtatgtg tatttacaaa tattttttaa agatcttgaa
     2881 ttctcagact gcaaaaggcc tactttaact attttcccct ctgttttcat tgtctttgaa
     2941 tgtattggaa gcagacatgc attgactgtg acatggttgc acctgaggtt cccccctcac
     3001 tttctggaca gactgatact atctatcaaa catttgtttc tgttggtttg gggataaaga
     3061 aaaaggaacc caatgttacc ttaaagtgat gaaatacttg tgtaaaaagg tagcaatact
     3121 aattttagtt tatctttttg ttaatattca aatgaactgt ttaaatattt atatgtagta
     3181 atgcctcgtt catcccagga taatctggcc ctttcatcaa aaccaaatac aactaagaat
     3241 tgaaatgatt aaaaagaaat ctttgaacaa tacccctaag ttatgaattt tgtatgtaga
     3301 gtatatgcat ttctttgaat gtgtttaata gtttggtaac ttgatttatt ggtccatagc
     3361 atattaatgt taacgaaagg aagggtccag aacaaggatg gaaagcacgt cctgccaaag
     3421 gctccgtagg gacagccagc ccagttgaga agtagtaact ctgtgccatc aaaaaagctg
     3481 aaattgcata cacagtatgt aatgcctgtt agaaagtaac ttaaaaaaat tttaaagcat
     3541 tggtttaagt gatataagca tcacttttct cacatgttgt atttatagtg gatgtatttt
     3601 tgcagtgatg gctgtctatt ctcatactct aaagtcgcgg tgtttacttt aagcactgca
     3661 gttgggtgcc atccttactg ggaagttgtg ctttgtatgt acttgacagg tgacgtgcct
     3721 gagacttagt cccctctgac caacctgcca ctgagaatct agctggtgtt gttgaggctt
     3781 gcctgcattt tgggcatagt cttgaactct ttgtacattt tggggatctc atctgttttc
     3841 atggagggaa aacttaaatc tttaaacttt ggtttgagat tgtgtcagat ccaaatcaat
     3901 tcatatgtac aagttaaact atataattat aggccattac ccagatgacc caccaggctt
     3961 tccatctatt gagtaaatta aacagttatc aaaataactt taaagactat tttttcaaaa
     4021 agctctgagg tgtataatga agtgggggtg gagggactgt tctgacttcc agtgagtgcc
     4081 tatagtaaaa atagaagttc ttaggttcag agcagttcca gtgtcacagt gggtcttcgc
     4141 atggtttttg tcttttaaaa ttccccatct tttaggctta aatttggggt tgcttctagt
     4201 tttcggcact gtgttgagca ttgaaagggt agtgctcaga gtgatggctg agggtcttca
     4261 cagtgtgggc tcagtgctca cagcacactt cctgctctgt ctctcatcag aagtgaagtt
     4321 ctgtgttgat aaatttaaaa tcatcttggt ctttatgatt taaggaatgt tttattttag
     4381 actttttttt ttttaaatag aggttagttt gtcatctccc ataagatcat ttgttctgta
     4441 aattaaatac ccgttctatg gggggtactt ggtaactctt cccgtcagtt gcaaagtgga
     4501 gagagtggct ggctgtgtac agacagtcac tgtgctggca tttatgaaac aagctgtttc
     4561 acagtcatag ttcttataac tgttgatggt cccggcagga gctttagttt atgagacttg
     4621 acgctttcat aaggttagta tattacaaat aaatacagag ggatttctaa agcacacctt
     4681 ttagatttga ctgtaatagc cctattactt gttaccatag atatttgatg taaaataact
     4741 tccaaaatga caacaaacac tatttatatt ttgcccacct tttcaatgtc aggcttaata
     4801 gaaactgaag atagtcatac tacttgcatt cagacttttc aggtaccaca gcagggaggc
     4861 actggaaact gtacttgtgg aatccagatg gtgagaaagg cacaaaccac cttagaatta
     4921 gtagaaaagc agctagacct ggtacaggta ttcagggtcc ccagataaca ttttgagaac
     4981 acagcacttt aaatttgtgt gttcctgata tatttacctc tgtctgggga aaccttgctc
     5041 cttctgaact taaggggttg tttcctttgg tgaaattcca gttgaaatca ttgttaaata
     5101 ttttaaagaa ctaatggtaa tggtgtgggt gtggtgtttt tttacaccct aagtggtttt
     5161 cttctatcag ctcatgtatt ggcatagaac aggtaagcta gcaacagttt ttatccttgg
     5221 gagacagtac tgttgggttg aagtgtgctt tcatagttag gtgttagtag acccgtctct
     5281 ttaccaagtt actcacttcc tgtattctca aaaatactta aatcatgtaa catgaattct
     5341 tttacactgt gatgaaagta ctatttgctc cgtagagtct tgttttgttt gcttttttaa
     5401 atggcaggat ctttacatag ccctggctgt cctggaactc cagcctcaga ctcacagaaa
     5461 tcatctgcct ctgccaccac acccagccag cccactgtag agtagtgggg tgagatggaa
     5521 cagcttggca cctcaggctg acagtggcac attgcatggg acggcttacc tttatttatg
     5581 tagtctgttc cccctacagt ttcaaaattt gcttttttaa aggtaattaa aagtttgtat
     5641 aaattagctt attgtattga atttatcagt tagttgaacc ttgtgtattt taaagcggtg
     5701 ttattacttt gctttttgta tggttgtgtt tgaacaaatg aagatgtgag cgtaaccagg
     5761 cctgtgtggt gggtgtttca cagccatctc tgaagaaaag atgaaggaac cagctttgta
     5821 gtagcaggct tatttttact agtggtctgg ggtcttgaaa tgctgccatt gaaacgaaca
     5881 ggagtggatc tgctgagcct gcgctagaca gctgcagcat agccctggtg tgtgacccca
     5941 gaactgacta ggtttactgc tcctttcatg actacatccg ggctttgaaa accttcagtt
     6001 tatattttta atgatgcatt ctataagctt atttctgaaa gttcactata atttggaaat
     6061 gtccaagtgc tgggaaagat tggggcagat gctagtcttc cccggtgtgg ggctgtacag
     6121 gtgcttgctg tctgcagatg tgccggtaga gaactcctag aactgggttc agatcccaca
     6181 ggagcagagc atgcgcttgc aaagggctcc tgactccatg tccttcctcg ggcagctttg
     6241 cttccttccg ttttaggagt ttgggttagt gtttccagtg aagacttctg ccgagaaggt
     6301 ctatctgata tcttacccat tctgcatggt ttatgcctgt agttgagccc attgttgtga
     6361 aatctgtcct tgtccagtac ctagatctgt ggaggtcaat gaaaacggaa tgtttgattc
     6421 agaatttcat aaaaagaaaa tcctagacag aacattttaa ttgcctatag acatgcccat
     6481 tagttaattt ttaaattgtt ttgttctcca gagtcttgag cacttgttgt ctgagtcaca
     6541 atcttaaaca agtagccttc tgattataac acttgaggta gggaaggtta taaactactg
     6601 ttccacagtg ttcctagaaa gtggtgaata gagccagatt tttacagact tagaagtctt
     6661 tatatgttct aaataacatg cttaggagtt ttacacaggg tagaaggtaa atgcagaatg
     6721 tttccctctg cacgtcaggg ggctacttcc tcttccttgt cttcgtagtg ttgaggaatg
     6781 ctttctatta tgtctgtcta cacatctgtg catgcctttc atggttctgc cttttaaaaa
     6841 tgcagacttt tcagctttct cctttgtttt aacgtggaca cctttccatt tgccatgtgc
     6901 agcactatct cattgtgtga atggcatcag gatccaggag tggatgtcct ttgcaggaac
     6961 atttttgcac gtatatgcat atacatatat acatgtttat atgcatatgt atacacacat
     7021 atattacata catgtgcatg cttacatgga aattcttgat tttggcagat agggaacttt
     7081 caacaaaaca gataattcta ttttgaggct catcagctat ttatatatgg tattttattt
     7141 cttcctgaga aaaatttcag gtctttcaaa tagttgtaaa atgccagcat ttacattaaa
     7201 ctgtgtgggc agtcagtgca ctcactgaga gactatggaa tctcatgtct tattttatat
     7261 cttactcttt ctgtcacccc tacctgtgac cctaaagttt ctaaaagaac agcttgaaag
     7321 cttcctcttc cagtttgtca gtattgtgaa tctcctcatt cccacgagct tggaatgaat
     7381 gaaccctata tttatgaaag aaagtacaag tctatttttt cacaactaga gtcttcagaa
     7441 ttagcttttg ctttgggaaa caactcataa aagttttggg ttttggcttc ttaccgaaat
     7501 atgcatttag tactagttgt acatagaact tgcttcctag aaaagtttgt ttttcatgag
     7561 gaacacttac ctactaactg acttgaaaac ccctctgcat gtggagggta ggagtgaggg
     7621 aagttcaaag ggcagtagtc aggggctggc ttctgtgggc tgtgtttgga aaatgttgac
     7681 atgctgaggt ctttgaggct cagttttggt gcaggaagtg gttttagata ctgattttga
     7741 taattgtttc ttttctcttt tggagatgct gaggattgaa ccctcagtgt tgcacatgaa
     7801 tgctctacaa ctaagtccag ctaatttctt gttcattgta aaatattgtt gaaataattt
     7861 tttaaaataa agatatgact ttgtgtaccc tt
//
